- Job Title: Post Doctoral Scholar
- Job ID: 457860
- Location: James Cancer Hospital/CCC
- Department: Comprehensive Cancer Center
- Full/Part Time: Full-Time
- Regular/Temporary: Term
- Shift: Shift Varies
- FTE %: 100
- Salary Range Min: $50,004.00
- Salary Range Max: $54,759.00
Post Doctoral Scholar (Job Opening 457860) - The research project is centered on the metabolic reprogramming that regulates tumor-infiltrating myeloid cells and their interplay with T cells in mouse model and in humans. The Post Doctoral Researcher will pursue specialized research training and experience under the guidance of a scientific mentor; conducts research to characterize the immunologic and genetic basis of human cancers; develops, adopts and implements new experimental methods to achieve further characterization of various human immune cell types, their respective developmental pathways; delineates mechanisms of tumor resistance to immunotherapy, such as immune checkpoint inhibitors (ICI), identifies novel genes and examines their role in the development of immunologic approaches to disease treatment; analyzes changes in mRNA or protein expression, flow cytometric analysis, gene cloning and mutation detection; integrate cutting edge single-cell RNA sequencing and multi-parametric flow cytometry with traditional molecular biology based approaches; participates in analyzing data for reports for the purpose of grants submissions; designs and conducts pre-clinical studies using a variety of disease models in mice; trains staff, focuses efforts to generate a better understanding of resistance to ICI, to conceive and develop novel treatments/combinations and biomarkers, identify new targets for novel therapeutics, use multi-color flow cytometry, cell isolation and primary cell and tissue culture. Experience with high dimensional data analysis (e.g. single-cell RNA-Seq) is highly desirable. Previous experience working with research animals (mice), DNA/RNA/Protein isolation, purification, PCR/qPCR, Western and Northern blot techniques, training others in molecular biology techniques such as cloning, real time PCR, complex data analyses.
Education and experience
A Doctoral degree in an appropriate discipline is required. Previous experience working with research animals (mice), DNA/RNA/Protein isolation, purification, PCR/qPCR, Western blot techniques, molecular cloning, mammalian cell culture, flow cytometric data collection and analysis preferred. Requires successful completion of a background check; qualified candidates may be asked to complete a pre-employment physical including a drug screen.