Research Assistant Professor, Cardiovascular Medicine

The Dorothy M. Davis Heart and Lung Research Institute, 601
473 W. 12th Ave.
Columbus, OH 43210


PhD: Wuhan University, 1992

Zeng Zhaolun Chemistry Prize, Wuhan University, 1992 - present

Journal Articles

Liu X, Liu Q, Gupta E, Zorko N, Brownlee E, Zweier JL.. "Quantitative measurements of NO reaction kinetics with a Clark-type electrode." Nitric Oxide. Vol. 13, no. 1. (January 2005.): 68-77

H. Li, X. Liu, H. Cui, Y.R. Chen, A.J. Cardounel, J.L. Zweier.. "Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates.." J Biol Chem.. Vol. 281, no. 18. (January 2006.): 12546-12554

Y.R. Chen, C.L. Chen, A. Yeh, X. Liu, J.L. Zweier.. "Direct and indirect roles of cytochrome b in the mediation of superoxide generation and NO catabolism by mitochondrial succinate-cytochrome c reductase.." J Biol Chem.. Vol. 281, no. 19. (May 2006.): 13159-13168

Liu X, Yan Q, Baskerville KL, Zweier JL. "Estimation of nitric oxide concentration in blood for different rates of generation. Evidence that intravascular nitric oxide levels are too low to exert physiological effects.." Journal Biol Chem. Vol. 282, no. 12. (January 2007.): 8831-8336

Yan Q, Liu Q, Zweier JL, Liu X. "Potency of authentic nitric oxide in inducing aortic relaxation.." Pharmacological Res. Vol. 55, no. 4. (January 2007.): 329-34

Alzawahra, Wael, F; Talukder, M A Hassan; Liu, Xiaoping; Samouilov, Alexandre; Zweier, Jay L. "Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.." American journal of physiology. Heart and circulatory physiology. Vol. 295, no. 2. (January 2008.): H499-508

X. Liu, P. Srinivasan, E. Collard, P. Grajdeanu, J. L. Zweier and A. Friedman.. "Nitric oxide diffusion rate is reduced in the aortic wall." Biophysical Journal. Vol. 94, no. 5. (January 2008.): 1880-1889

Presley T, Vedam K, Liu X, Zweier JL, Ilangovan G.. "Activation of Hsp90/NOS and increased NO generation does not impair mitochondrial respiratory chain by competitive binding at cytochrome c oxidase in low oxygen concentrations.." Cell Stress Chaperones. Vol. 14, no. 6. (January 2009.): 611-627

Liu X, Srinivasan P, Collard E, Grajdeanu P, Lok K, Boyle SE, Friedman A, Zweier JL.. "Oxygen regulates the effective diffusion distance of nitric oxide in the aortic wall." Free Radic Biol Med.. Vol. 48, no. 4. (January 2010.): 554-559

Liu X, El-Sherbiny GA, Collard E, Huang X, Follmer D, El-Mahdy M, Zweier JL.. "Application of carbon fiber composite minielectrodes for measurement of kinetic constants of nitric oxide decay in solution." Nitric Oxide. Vol. 23, no. 4. (January 2010.): 311-318

Zweier JL, Li H, Samouilov A, Liu X.. "Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall." Nitric Oxide. Vol. 22, no. 2. (January 2010.): 83-90

Talukder MA, Johnson WM, Varadharaj S, Lian J, Kearns PN, El-Mahdy MA, Liu X, Zweier JL.. "Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice." Am J Physiol Heart Circ Physiol. Vol. 300, no. 1. (January 2011.): H388-H396