chenHui-Zi.Chen@osumc.edu

I was born and raised in China until the age of ten, when I moved with my family to Lund, Sweden, where my father was completing his graduate studies in the Department of Medicine at the University of Lund. After two years, the family uprooted again, this time across the Atlantic Ocean to Shreveport, Louisiana USA, where I cultivated a love for Creole cooking and Southern hospitality. After another two years, my family finally settled in Columbus, Ohio.

I went on to receive my B.A. in molecular and cellular biology in the College of Arts and Sciences at the Cornell University in Ithaca, NY, where I performed research with Dr. Robert Weiss studying the role of Hus1 protein in cell cycle arrest in response to DNA damage. I made the decision to come back to OSU and began my training as a physician scientist in 2005. I performed my graduate studies from 2007 - 2011 under the mentorship of Dr. Gustavo Leone in the Comprehensive Cancer Center. I defended my PhD thesis in August 2011 entitled “Atypical E2Fs link mammalian endocycle control to cancer.” Subsequent to graduating from The Ohio State University College of Medicine in May 2013, I was thrilled to have matched with the Internal Medicine Physician Scientist Training Program Residency at OSU.

I am looking forward to continuing the next stages of my training as a clinician scientist with the talented and innovative faculty at the James Cancer Hospital. As a Physician Scientist Training Program trainee, I completed my residency in internal medicine and am currently in the process of completing a fellowship in medical oncology. My research interests include identifying molecular mechanisms of tumorigenesis and the generation of targeted therapies in the context of personalized medicine.

Education:

MD: The Ohio State University, 2013

PhD: Cancer genetics, The Ohio State University, 2011

Internal medicine resident (ABIM Research Track), The Ohio State University, board certified in 2016 , 2013-2015

Hematology and Oncology fellow (ABIM Research Track) The Ohio State University, plan to board certify in medical oncology.

BA: Molecular and cell biology, Cornell University, 2005


Honors:
  • Pelotonia Postdoctoral Research Fellowship, 2017 - 2018
  • Pelotonia Graduate Research Fellowship, 2010 - 2011
  • Summer Undergraduate Research fellow, American Heart Association, Ohio Valley Affiliate, 2004
  • Summer Undergraduate Research fellow, American Heart Association, Ohio Valley Affiliate, 2003
  • Pauline and Irving Tanner Dean’s Scholar for Academic Excellence, 2001 - 2005
  • National Merit Achievement Scholar, 2001
Professional activities:
  • American Society of Clinical Oncology, 2015 - present
  • American Association of Cancer Research, 2015 - present
  • American College of Physicians, 2013 - 2015
  • American Physician Scientist Association (APSA), 2011 - 2013
  • President, OSU Medical Scientist Student Organization, 2009 - 2010
  • Treasurer, OSU Medical Scientist Student Organization, 2008 - 2009
  • OSU Medical Scientist Student Organization, 2005 - 2013
  • Columbus and Asian Free Clinics, 2005 - 2007

Publications

  • Zhang X, Chen X, Song H, Chen HZ, Rovin BH. Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol. 2005 Nov;35(11):3258-67. PMID: 16220540. Impact factor 2015: 2.568; Ranking in Immunology: 31st

  • Zhang X, Chen HZ, Rovin BH. Unexpected sensitivity of synthetic Renilla luciferase control vectors to treatment with a cyclopentenone prostaglandin. Biotechniques. 2003 Dec;35(6):1144-6, 1148. PMID: 14682047. Impact factor 2015: 1.132; Ranking in Biotechnology: 48th

  • Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadee W. Regulatory polymorphisms in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood. 2008 Aug 15;112(4):1013-21. PMID: 18523153. Impact factor 2015: 6.395; Ranking in Hematology: second

  • Li J, Ran C, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell. 2008 Jan;14(1):62-75. PMID: 18194653. Impact factor 2015: 7.338; Ranking in Developmental Biology: third

  • Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer. 2009 Nov;9(11):785-97. PMID: 19851314. Impact Factor 2015: 25.467; Ranking in Oncology: 2nd. Curriculum Vitae | Huizi Chen, MD, PhD 2

  • Chong JL, Wenzel P, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature. 2009 Dec 17;462(7275):930-4. PMID: 20016602. Impact factor 2015: 21.936; Ranking in Multidisciplinary: first

  • Martinez LA, Goluszko E, Chen HZ, Leone G, Post SM, Lozano G, Chen Z, Chauchereau A. E2F3a is a mediator of DNA damage-induced apoptosis. Mol Cell Biol. 2010 Jan;30(2):524-36. PMID: 19917728. Impact factor 2015: 3.806; Ranking in Cell Biology: 28th

  • Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski M, Leone G. Allele-specific tumor spectrum in Pten knockin mice. Proc Natl Acad Sci USA. 2010 Mar 16;107(11):5142-7. PMID: 20194734. Impact factor 2015: 6.883; Ranking in Multidisciplinary: third

  • Wenzel P, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G. Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):34-45. PMID: 21185283. Impact factor 2015: 2.554; Ranking in Developmental Biology: 15th

  • Ouseph M, Li J, Chen HZ, Comstock G, Pecot T, Thompson J, Forde B, Chong JL, Leone G. Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62. PMID: 22516201. Impact factor 2015: 7.338; Ranking in Developmental Biology: third

  • Chen HZ*, Ouseph M*, Li J, Comstock G, Trikha P, Huang YW, Liu B, Pecot T, Senapati S, Chokshi V, Byrne M, Duran C, Gandhi S, Wilson N, Thompson J, Singh S, Raman S, Wenzel P, Yan P, Jin V, Machiraju R, Leone G. Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol. 2012 Nov;14(11):1192-202. PMID: 23064266. (*denotes equal contribution) Impact factor 2015: 14.131; Ranking in Cell Biology: third

  • Kent LN*, Rakijas JB*, Pandit SK*, Westendorp B*, Chen HZ*, Huntington JT*, Tang X, Bae S, Srivastava A, Senapati S, Koivisto C, Martin CK, Cuitino MC, Perez M, Clouse JM, Chokshi V, Shinde N, Kladney R, Sun D, Perez-Castro A, Matondo RB, Nantasanti S, Mokry M, Huang K, Machiraju R, Fernandez S, Rosol TJ, Coppola V, Pohar KS, Pipas JM, Schmidt CR, de Bruin A, Leone G. E2f8 mediates tumor suppression in postnatal liver development. J Clin Invest. 2016 Aug 1;126(8):2955-69. PMID: 27454291. (*denotes equal contribution) Impact factor 2015: 8.764; Ranking in Medicine (miscellaneous): 11th

  • Chen HZ, Bertino E, He, K. Tumor Spread Through Air Space (STAS) is an Important Predictor of Clinical Outcome in Stage IA Lung Adenocarcinoma. Invited Editorial. Journal of Thoracic Disease. Accepted July 2017. Curriculum Vitae | Huizi Chen, MD, PhD 3

  • Bonneville R, Krook MA, Kautto EA, Miya J, Wing MR, Chen HZ, Reeser JW, Yu LB, Roychowdhury S. Landscape of Microsatellite Instability Across 39 Cancer Types. J Clin Oncol Precision Oncology. In revision. July 2017

  • Chen HZ, Roychowdhury S. “Translational Cancer Genomics”. Seminars in Cancer Biology. Invited Review. To be submitted in October 2017

Posters and Oral Presentations

  • Speaker, 2011 Great Lakes Mammalian Development Meeting, Toronto, Canada. Title of presentation: Mammalian Atypical E2Fs link Endocycle with Cancer. March 3-5, 2011

  • Chen HZ, Wang H, Wu L, de Bruin A, House M, Ng S, Johnson J, Goldenberg LE, Fang X, Fernandez SA, Stephens JA, Naidu S, Stromberg P, Rosol TJ, Shapiro CL, Leone G. Suppression of anti-tumor immunity by E2F3. Days of Molecular Medicine Conference (Human genetics, stem cells and physiology: the future of individualized medicine), Harvard Medical School, Boston, MA, May 7-9, 2009

  • Chen HZ, Levitt P, Levy J, Xu X, Han L, Fan M, Weiss RW. Mutational analysis of the mouse Hus1 cell cycle checkpoint protein. Cornell University 20th Annual Undergraduate Research Forum, Ithaca, NY, 2005

  • Rovin BH, Zhang X, Chen HZ, Song H, Chen X. A novel regulator of chemokine expression: linking oxidative stress to inflammation. American Society of Nephrology 37th Annual Meeting and Scientific Exposition, 2004

  • Chen HZ, Krook M, Bonneville R, Kautto E, Miya J, Wing M, Reeser J, Freud A, Allenby P, Yu L, Roychowdhury S. Characterization of tumor heterogeneity through utilization of rapid research autopsy. OSUMC Annual Trainee Research Day, Columbus, OH, 2017

  • Chen HZ, Krook M, Bonneville R, Kautto E, Miya J, Wing M, Reeser J, Freud A, Allenby P, Yu L, Roychowdhury S. Characterization of tumor heterogeneity through utilization of rapid research autopsy. OSUCCC Annual Scientific Meeting, Columbus, OH, 2017

Meetings Attended

  • 2017 AACR International Conference on Translational Cancer Medicine. Sao Paulo, Brazil
  • 2017 APSA panelist speaker on “transitioning”, Chicago, Illinois
  • 2017 ASCO Annual Meeting, Chicago, Illinois
  • 2016 ASCO Annual Meeting, Chicago, Illinois
  • 2014 EMBO Symposia: Tumor Microenvironment, Heidelberg, Germany
  • 2012 Annual Physician Scientists Association (APSA) Meeting, Chicago, Illinois
  • 2011 Great Lakes Mammalian Development Meeting, Toronto, Canada
  • 2009 First International RB Tumor Suppressor Meeting, Toronto, Canada
  • 2009 Mouse Models of Cancer (AACR), San Francisco, California

Undergraduate Research and Work Experience

Department of Entomology, College of Agriculture and Life Sciences, Cornell University, 2001 - 2005

  • Laboratory research assistant (federal work study program)
    • Work supervisor: Jeffrey G. Scott, PhD (jgs5@cornell.edu)
    • Work duties: design and implementation of genetic experiments that assisted in clarifying the complex mating behaviors of the female housefly Musca domestica
Department of Biomedical Sciences, Cornell Genomics Initiative, Cornell University, 2002 - 2005
  • Undergraduate Research Student
    • Research advisor: Robert S. Weiss, PhD (rsw26@cornell.edu)
    • Research project: The study of Hus1 mutants in elucidating mechanisms of cell cycle control
Division of Nephrology, Department of Internal Medicine, College of Medicine and Public Health, Ohio State University, 2002 - 2004
  • Summer AHA undergraduate research fellow
    • Research advisor: Brad H. Rovin, MD, FACP (brad.rovin@osumc.edu)
    • Research projects:
      • AHA fellowship – Genetic regulation of inflammation: Interleukin-8 polymorphisms, 2003
      • AHA fellowship – NRF2 Regulation of Inflammation Through Transcriptional Control of Pro-Inflammatory Mediators, 2004