UniversityHospitalImproving patients' lives through research

Research holds a place of prominence in the Department of Internal Medicine. In keeping with the overall mission of The Ohio State University Wexner Medical Center to “improve patients’ lives through research,” the department has a committed faculty of clinical, translational and basic scientists working to discover breakthroughs to end human suffering.

Research Studies


The PROCEED study is seeking patients with acute and chronic pancreatitis. This study will also enroll control patients (those with no pancreas disease and with chronic upper abdominal pain). Participants will be asked to complete surveys, provide biological specimens, and undergo abdominal imaging or endoscopy. Patients will be contacted annually for 5 years to collect follow-up data.

This study is seeking patients who are currently experiencing moderate pain from chronic pancreatitis. Participants will take oral placebo or NI-03 pill three times a day for two months and document any differences in mood, behavior, or pain. The study requires a weekly study visit for 7 weeks.

National Pancreas Foundation (NPF) Registry

The NPF has a national database used to track the health and treatments of people with any pancreatic diseases. The registry collects information from healthcare providers and patients through a secure web-based portal. No extra visits are required to participate.

Inflammatory Bowel Disease

This study is seeking patients who have been diagnosed with Crohn’s Disease but either failed or were intolerant to biologic therapy. Patients will be given MEDI2070 or placebo either by IV infusion or injection underneath the skin. This study requires monthly study visits for 1 year.

True North
This study seeks patients with Ulcerative Colitis to test oral Ozanimod (RPC1063) treatment. Ozanimod works like an immunomodulator. Patients will take placebo or Ozanimod for 10 weeks. Those patients showing remission will continue in the second phase of the trial lasting 42 weeks.

Comprehensive Gastroenterology

Short Bowel Syndrome (SBS) Registry

The SBS Registry is seeking patients with a history of SBS, there is no exclusion criteria. The purpose of the registry is to observe each patients disease over a long period of time. All data is collected by chart review and there are no extra visits for the registry.
Recent Publications

Recent Publications

Clinical Studies

Racial Inequities in Health Care Utilization and Costs for Immigrant Minorities with Pancreatic Disorders - Jean R. Park, Kyle Porter, Darwin L. Conwell, Somashekar G. Krishna

Race and Gender Differences in Chronic Pancreatitis (CP): Analysis of Nationwide Inpatient Sample (NIS) from 2003 to 2011- Jennifer Behzadi, Darwin L. Conwell, Alice Hinton, Somashekar G. Krishna

Type 2 Diabetes Mellitus Increases Economic Burden of Colorectal Cancer Surgery - Hisham Hussan, Darrell M. Gray, Somashekar G. Krishna, Alice Hinton, Jeffery R. Groce, Darwin L. Conwell, Peter P. Stanich

Diabetes is Associated with Socioeconomic Disparities and More Co-morbidities in Colorectal Cancer Surgery - a Nationwide Inpatient Sample Study -Hisham Hussan, Peter P. Stanich, Darwin L. Conwell, Samer El-Dika, Somashekar G. Krishna, Alice Hinton, Darrell M. Gray

A High Body Mass Index (BMI) is Associated with Incremental Health Care Utilization and Surgical Complications in Patients Undergoing Colorectal Cancer Surgery - Hisham Hussan, Darrell M. Gray, Cheng Zhang, Alice Hinton, Somashekar G. Krishna, Sheetal Sharma, Darwin L. Conwell, Peter P. Stanich

Groove Pancreatitis, a masquerading yet distinct clinicopathological entity: Analysis of Risk Factors and Differentiation -Veeral M. Oz1, Jacob M. Skean1, Peter Muscarella, Brett C. Sklaw, Kevin M. Cronley, Jon Walker, Samer El-Dika, Benjamin Swanson, Alice Hinton, Darwin L. Conwell, Somashekar G. Krishna

Early Naso-Enteral Tube (NET) is Associated with Higher Mortality Compared to Early PEG Tube in Stroke Patients Admitted with Dysphagia in the United States -Samer S. El-Dika, Somashekar G. Krishna, Jeffery R. Groce, Peter P. Stanich, Hisham Hussan, Alice Hinton, Darwin L. Conwell

Efficacy of Endoscopic Ultrasound Fine Needle Aspiration (EUS-FNA) in Obtaining Optimal Samples for Immunohistochemistry (IHC) in Pancreatic Ductal Adenocarcinoma (PDA) - Reshi Kanuru MD, Michael Wellner MD, Ming Jin MD, Kyle Porter MAS, Jon P Walker MD, Somashekar Krishna MBBS MPH, Adrian Suarez MD, and Samer El-Dika MD MS

The Increasing Prevalence of Human Cytomegalovirus (CMV) Disease Among Hospitalized Patients with Inflammatory Bowel Disease (IBD) in the United States - Cheng Zhang, Edward J. Levine, Somashekar G. Krishna, Alice Hinton, Darwin Conwell, Razvan Arsenescu

Health Outcomes of Ulcerative Colitis (UC) and Crohn’s Disease (CD) Patients Hospitalized with Human Cytomegalovirus (CMV) Disease - Cheng Zhang, Edward J. Levine, Somashekar G. Krishna, Alice Hinton, Darwin Conwell, Razvan Arsenescu

Acute pancreatitis (AP) in post-bariatric surgery (BRS) status: Analysis of national trends, complications and outcomes from 2007 to 2011 - Somashekar G. Krishna, Jennifer Behzadi, Alice Hinton, Samer El-Dika, Jeffery R. Groce, Hisham Hussan, Darwin L. Conwell

The Impact of Sphincter of Oddi Dysfunction (SOD) on Health Care Utilization in Patients Admitted for Abdominal Pain - Jeffery R. Groce, Somashekar G. Krishna, Samer El-Dika, Sheetal Sharma, Alice Hinton, Darwin Conwell

Biliary intervention after bariatric surgery (BRS): Inferences from a nationwide population-based study - Somashekar G. Krishna, Alecia Blaszczak, Samer El-Dika, Jeffery R. Groce, Hisham Hussan, Cheng Zhang, Jeffrey Wenzke, Sheetal Sharma, Darwin L. Conwell

Morbid Obesity (MO) is Associated with Increased Healthcare Utilization and is an Independent Predictor of Mortality of Acute Pancreatitis (AP) - Somashekar G. Krishna, Samer El-Dika, Alice Hinton, Jeffery R. Groce, Hisham Hussan, Cheng Zhang, Peter P. Stanich, Na Li, Darwin L. Conwell

Diverticulitis in HIV/AIDS Patients is Associated with Increased Mortality - Kevin M. Cronley, Jeffrey Wenzke, Hisham Hussan, Alice Hinton, Darwin L. Conwell1, Somashekar G. Krishna, Peter P. Stanich

Video Capsule Endoscopy is Safe and Effective in Hospitalized Patients with Implantable Cardiac Devices and Left Ventricular Assist Devices - John M Guido MD, Peter P Stanich MD, Bryan Kleinman DO, Nishaki Mehta Oza MD, Kavita Betkerur BS, Kyle Porter MS and Marty M Meyer MD

Video capsule endoscopy completion rates and total transit times are similar with oral or endoscopic delivery - John Guido MD, Peter P Stanich MD, Bryan Kleinman DO, Kavita Betkerur BS, Kyle M Porter MS and Marty M Meyer MD

Prevalence and severity of cytopenias in hospitalized patients with cirrhosis - Brett Sklaw, Eric Kraut

Protocol for Coronary Artery Disease Screening among Orthotopic Liver Transplant Candidates - Bryan Lee, Feng Li, Scott M. Lilly, A. James Hanje

Pre-transplant characteristics in patients evaluated for orthotopic liver transplant (OLT) associated with positive stress test - Feng Li, Bryan Lee, Kyle Porter, Nicole O'Bleness, Scott M. Lilly, A. James Hanje

Post-transplant cardiac events among patients receiving orthotopic liver transplant (OLT) - Feng Li, Bryan Lee, Kyle Porter, Nicole O'Bleness, Scott M. Lilly, A. James Hanje

Use of Bayesian Analysis to Predict Pancreatic Fibrosis with the Secretin Endoscopic Pancreatic Function Test (ePFT): Comparison to Histopathology Gold Standards – Feng Li, Wendy Frankel, Alice Hinton, Philip Hart, Darwin Conwell

Derivation of a Non-invasive, Chronic Pancreatitis (CP) Risk Score- Darwin L. Conwell, Linda S. Lee, Vivek Kadiyala, Shadeah Suleiman, Peter Banks

Urban Hospitalization Increases Costs and Healthcare Utilization for Diverticulitis in the United States – Sheryl Pfeil, Kyle Porter, Darwin Conwell

Gender disparities of acute liver injury in the United States: analysis of the National Inpatient Sample from 2006-2011- Na Li, Alice Hinton, Somashekar Krishna, James Hanje, Darwin Conwell

Clinical Vignettes

Cryptosporidium Enteritis in a Liver Transplant Patient – Jean R. Park, Jeffrey Kuo, Anthony Michaels

A Case of Mistaken Identity: Disseminated Bartonella as Pancreatic Mass – Jennifer Behzadi, Mohamed S. Naem, Somashekar G. Krishna

Iatrogenic Superior Mesenteric Arterio-venous Fistula as an Unusual Cause of Refractory Ascites: A Case Report – Jager Jasem, Jean R. Park, Gabriel C. Lockhart, A. James Hanje

Ovarian Cancer Metastatic to the Stomach: A “Reverse Krukenberg” Tumor – John M. Guido, MD, Peter P. Stanich, MD, Edward Levine, MD

Ovarian Cancer Despite Previous Oophorectomy in Liver Transplant Patient – Jennifer Behzadi, MD, Peter P. Stanich, MD, and Robert Kirkpatrick, MD

Intraoperative enteroscopy remains a useful modality in obscure gastrointestinal bleeding – Feng Li, Jeffrey Kuo, Samer El-Dika, Marty Meyer, Peter Stanich

Broncho-esophageal Fistula: Imaging versus Endoscopy – Reshi Kanuru, MD, Someshakar Krishna, MD, and Peter Stanich, MD

Recurrent acute pancreatitis following Roux-en-Y gastric bypass (RYGB): The afferent loop syndrome – Feng Li, Jonathan Congeni, Somashekar G. Krishna

Gastrostomy tube migration causing acute pancreatitis – Feng Li, Mohamed S. Naem, Cheng Zhang, Somashekar G. Krishna