Studying the impact of "medicine of the future"

The Ohio State University Wexner Medical Center Division of Infectious Diseases engages in a wide spectrum of clinical and basic research sponsored by the pharmaceutical industry. These include phase one to three clinical trials of anti-infective agents and vaccines.

Use of these agents, which are not yet marketed, gives both patients and investigators exposure to "medicine of the future." Such therapeutic or pharmacologic studies are selected to meet patient and investigator needs and research interests.

Recent pharmaceutical industry-supported trials include:

  • Phase two and three trials of tipranavir, an experimental HIV protease inhibitor, for drug resistant HIV infections
  • Phase three trial of VaxGen's gp120 HIV vaccine in high risk gay men
  • Phase two study of Merck's combination DNA plus adenoviral vector HIV vaccine in low risk subjects
  • Pharmacokinetic study of plasma and intracellular drug levels of abacavir (nucleoside analogue-used BID for HIV infections), when dosed every 24 hours
  • Phase four study of lamivudine dosed every 24 hours vs. every 12 hours was also performed to give uninsured patients access to free medication and laboratory

Contact

Michael F. Para, MD
Professor of Internal Medicine and Molecular
Virology, Immunology and Medical Genetics
Michael.Para@osumc.edu
614-293-5666

N. 1143 Doan Hall
410 W. 10th Avenue
Columbus, Ohio 43210