Faculty Emeritus, Nephrology

395 W. 12th Ave.
Columbus, OH 43210

614-293-4997 
Dan.Birmingham@osumc.edu


Education:

PhD: The Ohio State University, Columbus, OH, 1989
MS: The Ohio State University, Columbus, OH, 1981
BS: The Ohio State University, Columbus, OH, 1978
Post-doctorate: Washington University (HHMI), St. Louis, MO, 1990

Professional activities:

  • NIH PBKD study section, 2008-present
B.S., The Ohio State University

View CV

Publications

Cornacoff, J, B; Hebert, L, A; Smead, W, L; VanAman, M, E; Birmingham, D, J; Waxman, F J. "Primate erythrocyte-immune complex-clearing mechanism.." The Journal of clinical investigation. Vol. 71, no. 2. (January 1983.): 236-47

Waxman, F, J; Hebert, L, A; Cornacoff, J, B; VanAman, M, E; Smead, W, L; Kraut, E, H; Birmingham, D, J; Taguiam, J M. "Complement depletion accelerates the clearance of immune complexes from the circulation of primates.." The Journal of clinical investigation. Vol. 74, no. 4. (January 1984.): 1329-40

Cornacoff, J, B; Hebert, L, A; Birmingham, D, J; Waxman, F J. "Factors influencing the binding of large immune complexes to the primate erythrocyte CR1 receptor.." Clinical immunology and immunopathology. Vol. 30, no. 2. (January 1984.): 255-64

Waxman, F, J; Hebert, L, A; Cosio, F, G; Smead, W, L; VanAman, M, E; Taguiam, J, M; Birmingham, D J. "Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo. Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli.." The Journal of clinical investigation. Vol. 77, no. 1. (January 1986.): 82-9

Cosio, F, G; Hebert, L, A; Birmingham, D, J; Dorval, B, L; Bakaletz, A, P; Kujala, G, A; Edberg, J, C; Taylor, R P. "Clearance of human antibody/DNA immune complexes and free DNA from the circulation of the nonhuman primate.." Clinical immunology and immunopathology. Vol. 42, no. 1. (January 1987.): 1-9

Cosio, F, G; Birmingham, D, J; Sexton, D, J; Hebert, L A. "Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes.." Journal of immunology (Baltimore, Md. : 1950). Vol. 138, no. 8. (January 1987.): 2587-92

Birmingham, D, J; Cosio, F G. "Characterization of the baboon erythrocyte C3b-binding protein.." Journal of immunology (Baltimore, Md. : 1950). Vol. 142, no. 9. (January 1989.): 3140-4

Dorval, B, L; Cosio, F, G; Birmingham, D, J; Hebert, L A. "Human erythrocytes inhibit complement-mediated solubilization of immune complexes.." Journal of immunology (Baltimore, Md. : 1950). Vol. 142, no. 8. (January 1989.): 2721-7

Birmingham, D, J; Hebert, L, A; Cosio, F, G; VanAman, M E. "Immune complex erythrocyte complement receptor interactions in vivo during induction of glomerulonephritis in nonhuman primates.." The Journal of laboratory and clinical medicine. Vol. 116, no. 2. (January 1990.): 242-52

Cosio, F, G; Shen, X, P; Birmingham, D, J; Van Aman, M; Hebert, L A. "Evaluation of the mechanisms responsible for the reduction in erythrocyte complement receptors when immune complexes form in vivo in primates.." Journal of immunology (Baltimore, Md. : 1950). Vol. 145, no. 12. (January 1990.): 4198-206

Shibata, T; Cosio, F, G; Birmingham, D J. "Complement activation induces the expression of decay-accelerating factor on human mesangial cells.." Journal of immunology (Baltimore, Md. : 1950). Vol. 147, no. 11. (January 1991.): 3901-8

Hebert, L, A; Cosio, F, G; Birmingham, D, J; Mahan, J, D; Sharma, H, M; Smead, W, L; Goel, R. "Experimental immune complex-mediated glomerulonephritis in the nonhuman primate.." Kidney international. Vol. 39, no. 1. (January 1991.): 44-56

Hebert, L, A; Cosio, F, G; Birmingham, D, J; Mahan, J D. "Biologic significance of the erythrocyte complement receptor: a primate perquisite.." The Journal of laboratory and clinical medicine. Vol. 118, no. 4. (January 1991.): 301-8

Hebert, L, A; Cosio, F, G; Birmingham, D J. "The role of the complement system in renal injury.." Seminars in nephrology. Vol. 12, no. 5. (January 1992.): 408-27

Hebert, L, A; Birmingham, D, J; Shen, X, P; Cosio, F G. "Stimulating erythropoiesis increases complement receptor expression on primate erythrocytes.." Clinical immunology and immunopathology. Vol. 62, no. 3. (January 1992.): 301-6

Mahan, J, D; Hebert, L, A; McAllister, C; Birmingham, D, J; Shen, X, P; Cosio, F, G; Brandt, J. "Platelet involvement in experimental immune complex-mediated glomerulonephritis in the nonhuman primate.." Kidney international. Vol. 44, no. 4. (January 1993.): 716-25

Hebert, L, A; Birmingham, D, J; Shen, X, P; Cosio, F, G; Fryczkowski, A. "Rate of antigen entry into the circulation in experimental versus naturally occurring immune complex glomerulonephritis.." Journal of the American Society of Nephrology : JASN. Vol. 5, no. 5 Suppl 1. (January 1994.): S70-5

Hebert, L, A; Birmingham, D, J; Shen, X, P; Brandt, J, T; Sedmak, D, D; Dillon, J J. "Effect of recombinant erythropoietin therapy on autoimmunity in systemic lupus erythematosus.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 24, no. 1. (January 1994.): 25-32

Hebert, L, A; Birmingham, D, J; Dillon, J, J; Cosio, F, G; Shen, X P. "Erythropoietin therapy in humans increases erythrocyte expression of complement receptor type 1 (CD35).." Journal of the American Society of Nephrology : JASN. Vol. 4, no. 10. (January 1994.): 1786-91

Hebert LA, Mahan JD, Birmingham DJ, Cosio FG, Dillon JJ, Sedmak DD, Shen X-P, McAllister C. "Enalapril therapy decreases glomerular accumulation of immune complexes and mesangial matrix in a model of glomerulonephritis in the nonhuman primate." Kidney Int. no. 46. (January 1994.): 986-992

Atkinson JP, Krych M, Nickells M, Birmingham D, Subramanian B, Clemenza L, Alvarez J, Liszewski K. "Complement receptors and regulatory proteins: Immune adherence revisited and abuse by microorganisms." Clin Exp Immunol. no. 2. (January 1994.): 1-3

Cosio, F, G; Shibata, T; Rovin, B, H; Birmingham, D J. "Effects of complement activation products on the synthesis of decay accelerating factor and membrane cofactor protein by human mesangial cells.." Kidney international. Vol. 46, no. 4. (January 1994.): 986-92

Sedmak, D, D; Guglielmo, A, M; Knight, D, A; Birmingham, D, J; Huang, E, H; Waldman, W J. "Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.." The American journal of pathology. Vol. 144, no. 4. (January 1994.): 683-92

Birmingham DJ, Shen X-P, Hourcade D, Nickells MW, Atkinson JP. "Primary sequence of an alternatively spliced form of chimpanzee CR1: A candidate for the 75,000 Mr complement receptor expressed on chimpanzee erythrocytes." J Immunol. no. 153. (January 1994.): 691-700

Hebert, L, A; Birmingham, D, J; Mahan, J, D; Shen, X, P; McAllister, C; Cosio, F, G; Dillon, J J. "Effect of chronically increased erythrocyte complement receptors on immune complex nephritis.." Kidney international. Vol. 45, no. 2. (January 1994.): 493-9

Birmingham, D J. "Erythrocyte complement receptors.." Critical reviews in immunology. Vol. 15, no. 2. (January 1995.): 133-54

Birmingham, D, J; Shen, X, P; Hartman, J, A; Dillon, J, J; Hebert, L A. "Effect of chronic human recombinant erythropoietin therapy on antibody responses to immunization in chronic hemodialysis patients.." Kidney international. Vol. 50, no. 2. (January 1996.): 543-9

Birmingham DJ, Logar CM, Shen XP, Chen W. "Baboon erythrocyte complement receptor is a glycophospatidylinositol-linked protein encoded by a homologue of the human CR1-like genetic element." J Immunol. no. 157. (January 1996.): 2586-2592

Hebert, L, A; Birmingham, D, J; Mahan, J, D; Cosio, F, G; Dillon, J, J; Sedmak, D, D; Shen, X, P; McAllister, C. "Effect of enalapril therapy on glomerular accumulation of immune complexes and mesangial matrix in experimental glomerulonephritis in the nonhuman primate.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 30, no. 2. (January 1997.): 243-52

Orosz, C, G; Huang, E, H; Bergese, S, D; Sedmak, D, D; Birmingham, D, J; Ohye, R, G; VanBuskirk, A M. "Prevention of acute murine cardiac allograft rejection: anti-CD4 or anti-vascular cell adhesion molecule one monoclonal antibodies block acute rejection but permit persistent graft-reactive alloimmunity and chronic tissue remodelling.." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. Vol. 16, no. 9. (January 1997.): 889-904

Birmingham, D, J; Hebert, L, A; Shen, X, P; Higgins, P; Yeh, C, G; Creasey, A A. "Effects of immune complex formation and complement activation on circulating platelets in the primate.." Clinical immunology (Orlando, Fla.). Vol. 91, no. 1. (January 1999.): 99-105

Chen, W; Logar, C, M; Shen, X, P; Birmingham, D J. "The chimpanzee and cynomolgus monkey erythrocyte immune adherence receptors are encoded by CR1-like genes.." Immunogenetics. Vol. 52, no. 1-2. (January 2000.): 46-52

Moulds, J, M; Zimmerman, P, A; Doumbo, O, K; Kassambara, L; Sagara, I; Diallo, D, A; Atkinson, J, P; Krych-Goldberg, M; Hauhart, R, E; Hourcade, D, E; McNamara, D, T; Birmingham, D, J; Rowe, J, A; Moulds, J, J; Miller, L H. "Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.." Blood. Vol. 97, no. 9. (January 2001.): 2879-85

Birmingham, D, J; Rovin, B, H; Yu, C, Y; Hebert, L A. "Of mice and men: the relevance of the mouse to the study of human SLE.." Immunologic research. Vol. 24, no. 2. (January 2001.): 211-24

Birmingham, D, J; Hebert, L A. "CR1 and CR1-like: the primate immune adherence receptors.." Immunological reviews. Vol. 180, (January 2001.): 100-11

Birmingham, Daniel, J; Chen, Wei; Liang, Grace; Schmitt, Holly, C; Gavit, Katie; Nagaraja, Haikady N. "A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b.." Immunology. Vol. 108, no. 4. (January 2003.): 531-8

Moulds, J, M; Thomas, B, J; Doumbo, O; Diallo, D, A; Lyke, K, E; Plowe, C, V; Rowe, J, A; Birmingham, D J. "Identification of the Kna/Knb polymorphism and a method for Knops genotyping.." Transfusion. Vol. 44, no. 2. (January 2004.): 164-9

Yang, Yan; Chung, Erwin, K; Zhou, Bi; Lhotta, Karl; Hebert, Lee, A; Birmingham, Daniel, J; Rovin, Brad, H; Yu, C Yung. "The intricate role of complement component C4 in human systemic lupus erythematosus.." Current directions in autoimmunity. Vol. 7, (January 2004.): 98-132

Logar, Christine, M; Chen, Wei; Schmitt, Holly; Yu, Chack Yung; Birmingham, Daniel J. "A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue.." Molecular immunology. Vol. 40, no. 11. (January 2004.): 831-40

Rovin, Brad, H; Song, Huijuan; Birmingham, Dan, J; Hebert, Lee, A; Yu, Chack Yung; Nagaraja, Haikady N. "Urine chemokines as biomarkers of human systemic lupus erythematosus activity.." Journal of the American Society of Nephrology : JASN. Vol. 16, no. 2. (January 2005.): 467-73

Wu, Hui; Cantor, Rita, M; Graham, Deborah S Cunninghame; Lingren, Cecilia, M; Farwell, Lisa; Jager, Philip L De; Bottini, Nunzio; Grossman, Jennifer, M; Wallace, Daniel, J; Hahn, Bevra, H; Julkunen, Heikki; Hebert, Lee, A; Rovin, Brad, H; Birmingham, Dan, J; Rioux, John, D; Yu, C Yung; Kere, Juha; Vyse, Timothy, J; Tsao, Betty P. "Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.." Arthritis and rheumatism. Vol. 52, no. 8. (January 2005.): 2396-402

Rovin, Brad, H; Song, Huijuan; Hebert, Lee, A; Nadasdy, Tibor; Nadasdy, Gyongyi; Birmingham, Daniel, J; Yung Yu, Chack; Nagaraja, Haikady N. "Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus.." Kidney international. Vol. 68, no. 4. (January 2005.): 1825-33

Rovin, Brad, H; Tang, Yuxiao; Sun, Junfeng; Nagaraja, Haikady, N; Hackshaw, Kevin, V; Gray, Linda; Rice, Robert; Birmingham, Daniel, J; Yu, Chack-Yung; Spetie, Dan, N; Aziz, Amy; Hebert, Lee A. "Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapy.." Kidney international. Vol. 68, no. 2. (January 2005.): 747-59

Birmingham DJ, Irshaid F, Nagaraja HN, Zou X, Tsao BP, Wu H, Yu CY, Hebert LA, Rovin BH. "The complex nature of serum C3 and C4 as biomarkers of lupus renal flare." Lupus, epub ahead. (January 2006.)

Wu, Yee-Ling; Higgins, Gloria, C; Rennebohm, Robert, M; Chung, Erwin, K; Yang, Yan; Zhou, Bi; Nagaraja, Haikady, N; Birmingham, Dan, J; Rovin, Brad, H; Hebert, Lee, A; Yu, C Yung. "Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.." Advances in experimental medicine and biology. Vol. 586, (January 2006.): 227-47

Birmingham, Daniel, J; Nagaraja, H, N; Rovin, Brad, H; Spetie, Lacramioara; Zhao, Yanxing; Li, Xiaobai; Hackshaw, Kevin, V; Yu, C Yung; Malarkey, William, B; Hebert, Lee A. "Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele.." Arthritis and Rheumatism. Vol. 54, no. 10. (January 2006.): 3291-3299

Birmingham, D, J; Gavit, K, F; McCarty, S, M; Yu, C, Y; Rovin, B, H; Nagaraja, H, N; Hebert, L A. "Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flare.." Clinical and experimental immunology. Vol. 143, no. 2. (January 2006.): 274-80

Rovin, B.H., D.J. Birmingham, H.N. Nagaraja, C.Y. Yu, and L.A. Hebert.. "Biomarker discovery in human SLE nephritis.." Bull. NYU Hosp. Joint Dis.. Vol. 65, (January 2007.): 187-193

Birmingham, D. J., F. Irshaid, K. F. Gavit, H. N. Nagaraja, C. Y. Yu, B. H. Rovin, and L. A. Hebert. "A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding." Molecular Immunology. Vol. 44, (January 2007.): 3510

Wang, L., S. Lin, K.W. Rammohan, Z. Liu, J.-Q. Liu, R.-H. Liu, N. Guinther, J. Lima, Q. Zhou, T. Wang, Z. Zheng, D.J. Birmingham, B.H. Rovin, L.A. Hebert, Y. Wu, J. Lynn, G. Cooke, C.Y. Yu, P. Zheng, and Y. Liu. "A di-nucleotide deletion in CD24 confers protection against autoimmune diseases." PLoS Genetics. Vol. 3e:49, (January 2007.)

Wu, Y.L., S.L. Savelli, Y. Yang, B. Zhou, B.H. Rovin, D.J. Birmingham, H.N. Nagaraja, L.A. Hebert, and C.Y. Yu. "Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short and RCCX modules: Elucidation of C4 CNVs in 50 consanguineous subjects with defined HLA." Journal of Immunology. Vol. 176, (January 2007.): 3012-3025

Y.Yang, E.Chung, Y.Wu, S.Savelli, H.Nagaraja, B.Zhou, M.Hebert, K.Jones, Y.Shu, K.Kitzmiller, C.Blanchong, K.McBride, G.Higgins, R.Rennebohm, R.Rice, K.Hackshaw, R.Roubey, J.Grossman, B.Tsao, D.J.Birmingham, B.H. Rovin, L.A.Hebert, C.Yung Yu. "Gene copy number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus: Low copy number is a risk factor for, high copy number is a protective factor against, Caucasian SLE disease susceptibility." American Journal of Human Genetics. (January 2007.): 1037-1054

Wu, Hui; Boackle, Susan, A; Hanvivadhanakul, Punchong; Ulgiati, Daniela; Grossman, Jennifer, M; Lee, Youngho; Shen, Nan; Abraham, Lawrence, J; Mercer, Timothy, R; Park, Elly; Hebert, Lee, A; Rovin, Brad, H; Birmingham, Dan, J; Chang, Deh-Ming; Chen, Chung Jen; McCurdy, Deborah; Badsha, Humeira, M; Thong, Bernard Y, H; Chng, Hiok, H; Arnett, Frank, C; et al.. "Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 10. (January 2007.): 3961-6

Birmingham, D.J., B.H. Rovin, G. Shidham, H.N. Nagaraja, X. Zou, M. Bissel, and L.A. Hebert. "Spot urine protein/creatinine ratios are unreliable estimates of 24 hour proteinuria in most systemic lupus erythematosus nephritis flares." Kidney International. Vol. 72, (January 2007.): 865-870

Wu, H., D.J. Birmingham, B.H. Rovin, K.V. Hackshaw, N. Haddad, D. Haden, C.Y. Yu, L.A. Hebert.. "D-dimer level and the risk of thrombosis in SLE.." Clin J Am Soc Nephrol. Vol. 3, (January 2008.): 1628-1636

Wu YL, Yang Y, Chung EK, Zhou B, Kitzmiller KJ, Savelli SL, Nagaraja HN, Birmingham DJ, Tsao BP, Rovin BH, Hebert LA, Yu CY. "Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus." Cytogenet Genome Res. no. 123. (January 2008.): 131-141

Birmingham, D., B. Rovin, G. Shidham, M. Bissell, H. Nagaraja, and L. Hebert.. "Relationship between albuminuria and total proteinuria in SLE nephritis: diagnostic and therapeutic implication.." Clin J Am Soc Nephrol. Vol. 3, (January 2008.): 1028-1033

Zhang, X., M. Jin, H. Wu, T. Nadasdy, G. Nadasdy, N. Harris, K. Green-Church, H. Nagaraja, D. J. Birmingham, C. Y. Yu, L. A. Hebert, and B. H. Rovin. "Biomarkers of lupus nephritis determined by serial urine proteomics." Kidney Int. Vol. 74, (January 2008.): 799-807

Hebert LA, Birmingham DJ, Shidham G, Rovin B, Nagaraja HN, Yu CY. "Random Spot Urine Protein/Creatinine Ratio Is Unreliable for Estimating 24-Hour Proteinuria in Individual Systemic Lupus Erythematosus Nephritis Patients." Nephron Clin Pract. Vol. 113, (January 2009.): c177-c182

Brodsky, S. V., G. M. Nadasdy, R. Pelletier, A. Satoskar, D. J. Birmingham, G. A. Hadley, K. Obeidat, and T. Nadasdy. "Expression of the decay-accelerating factor (CD55) in renal transplants--a possible prediction marker of allograft survival." Transplantation. Vol. 88, (January 2009.): 457

Rovin, B. H., A. M. McKinley, and D. J. Birmingham. "Can we personalize treatment for kidney diseases?." Clin J Am Soc Nephrol. Vol. 4, (January 2009.): 1670

Budu-Grajdeanu, P., R. C. Schugart, A. Friedman, D. J. Birmingham, and B. H. Rovin. "Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkers." Theor Biol Med Model. Vol. 7, (January 2010.): 14

Ardoin, S., D. J. Birmingham, P. L. Hebert, C. Y. Yu, B. H. Rovin, and L. A. Hebert. "An approach to validating criteria for proteinuric flare in systemic lupus erythematosus glomerulonephritis.." Arthritis and Rheumatism. Vol. 63, (July 2011.): 2031-2037

Satoskar AA, Shapiro JP, Bott CN, Song H, Nadasdy GM, Brodsky SV, Hebert LA, Birmingham DJ, Nadasdy T, Freitas MA, Rovin BH. "Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli." ModernPathology. Vol. 25, (May 2012.): 709-721

Birmingham DJ, Hebert LA, Song H, Noonan WT, Rovin BH, Nagaraja HN, Yu CY. "Evidence that abnormally large seasonal declines in vitamin D status may trigger SLE flare in non-African Americans." Lupus. Vol. 21, (July 2012.): 855-864

Mok, C. C., D. J. Birmingham, L. Y. Ho, L. A. Hebert, H. Song, and B. H. Rovin. "Vitamin D deficiency as marker for disease activity and damage in systemic lupus erythematosus: a comparison with anti-dsDNA and anti-C1q." Lupus. Vol. 21, (January 2012.): 36-42

Mok CC, Birmingham DJ, Leung HW, Hebert LA, Song H, Rovin BH. "Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis." Rheumatology. Vol. 51, (April 2012.): 644-652.

Ganesan LP, Kim J, Wu Y, Mohanty S, Phillips GS, Birmingham DJ, Robinson JM, Anderson CL. 2012. FcgammaRIIb on liver sinusoidal endothelium clears small immune complexes. J Immunol 189:4981-4988.

Mok C, Birmingham D, Ho L, Hebert L, Rovin B. 2013. High sensitivity C-reactive protein, disease activity and cardiovascular risk factors in systemic lupus erythematosus. Arthritis Care Res (Hoboken) 65:441-447

Young NA, Friedman AK, Kaffenberger B, Rajaram MV, Birmingham DJ, Rovin BH, Hebert LA, Schlesinger LS, Wu LC, Jarjour WN. 2013. Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus. Molec Immunol 54: 23-31.

Birmingham DJ, Shidham G, Perna A, Fine DM, Bissell M, Rodby R, et al. 2014. Spot PC ratio estimates of 24-hour proteinuria are more unreliable in lupus nephritis than in other forms of chronic glomerular disease. Ann Rheum Dis. 73(2):475-6

Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, et al. 2014. End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1. Arthritis Rheumatol. 66(2):390-6. 

Caster DJ, Korte EA, Merchant ML, Klein JB, Wilkey DW, Rovin BH, Birmingham DJ, Harley JB, Cobb BL, Namjou B, McLeish KR, Powell DW. 2015. Autoantibodies targeting glomerular annexin A2 identify patients with proliferative lupus nephritis. Proteomics Clinical Applications. 9(11-12):1012-20.

Birmingham DJ, Bitter JE, Ndukwe EG, Dials S, Gullo TR, Conroy S, Nagaraja HN, Rovin BH, Hebert LA. 2016. Relationship of Circulating Anti-C3b and Anti-C1q IgG to Lupus Nephritis and Its Flare. Clinical J Am Soc Nephrol. 11(1):47-53.

Cartin-Ceba R, Indrakanti D, Specks U, Stone JH, Hoffman GS, Kallenberg CG, et al. The Pharmacogenomic Association of Fcgamma Receptors and Cytochrome P450 Enzymes With Response to Rituximab or Cyclophosphamide Treatment in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol. 2017;69(1):169-75.

Rovin BH, Birmingham D, Cartin-Ceba R, Specks U, Stone JH. Reply. Arthritis Rheumatol. 2017.

Almaani S, Hebert LA, Rovin BH, Birmingham DJ. The Urine Preservative Acetic Acid Degrades Urine Protein: Implications for Urine Biorepositories and the AASK Cohort Study. J Am Soc Nephrol. 2017;28(5):1394-8.

Parikh, SV, Malvar, A, Song, H, Alberton, V, Lococo, B, Vance, J, Zhang, J, Yu, L, Birmingham, D, Rovin, BH: Molecular imaging of the kidney in lupus nephritis to characterize response to treatment. Translational Res. 182: 1-13, 2017.

Abstracts

Note: Only those in which Dr. Birmingham is principle investigator are listed.

Birmingham DJ, Cosio FG: C3b binding proteins of primate erythrocytes (E). Complement and Inflam. 6:315A, 1989. Presented at the 13th International Complement Workshop, San Diego, CA.

Birmingham DJ, Cosio FG: Determination of factor I cofactor function of nonhuman primate erythrocyte (E) C3b receptors. FASEB J. 4:A2188. 1990. Presented at the 1990 AAI (FASEB) Meeting, New Orleans, LA.

Birmingham DJ, Cosio FG, McCourt DW, Atkinson JP. 1991. N-terminus amino acid analysis of the baboon erythrocyte C3b receptor. FASEB J. 5:A1716. 1991. Presented at the 1991 AAI (FASEB) Meeting, Atlanta, GA.

Birmingham DJ, Atkinson JP: Identification of an alternatively spliced transcript of the chimpanzee type one complement receptor (CR1). J. Immunol. 150:224A. 1993. Presented at the 1993 AAI (FASEB) Meeting, Denver, CO.

Birmingham DJ, Shen XP: Identification of a CR1-like transcript in the baboon bone marrow. Presented at the 1995 Experimental Biology Meeting, Atlanta, GA.

Birmingham, D.J., Logar, C.M., Shen, X.P.: Baboon CR1b, a homologue of the human CR1-like element, encodes the baboon erythrocyte complement receptor. Mol. Immunol. 33:38, 1996. Presented at the 16th International Complement Workshop, Boston, MA.

Logar CM, Birmingham DJ: CR1-like, a C3b binding protein of non-human primate erythrocytes, is expressed in human bone marrow. 1997 Presented at the 1997 International Society of Developmental and Comparative Immunology, Willimasburg, VA.

Allred LK, Birmingham DJ: Polymorphisms of FcγRIIIa and the associated γ subunit in normals and SLE patients. Presented at the 1998 Experimental Biology Meeting (AAI).

Birmingham DJ, Chen W, Shen XP: Certain mutations of CR1 segregate with normals or SLE patients with nephritis. Molecular Immunology 35:334, 1998. Presented at the 17th International Complement Workshop, Rhodes Greece.

Birmingham DJ, Moulds JM, Chen W. A CR1 polymorphism associates with the B allele and with SLE patients. 1998. Presented at the 17th International Complement Workshop, Rhodes Greece.

Birmingham DJ, Chen W, Shen XP, Liang G: A CR1 polymorphism associates with SLE Nephritis and Juvenile-onset IgA Nephritis. Mol Immunol 36:304, 1999, Presented at the 7th European Meeting on Complement in Human Disease-EC99, Helsinki, Finland

Birmingham DJ, Liang G, Shen XP. CR1 polymorphisms associated with SLE. Immunopharmacology 49:29, 2000. Presented at the 18th International Complement Workshop, Salt Lake City, Utah.

Birmingham DJ, Logar CM, Chen W. Characterization of the human CR1-like transcript. Immunopharmacology 49:11, 2000. Presented at the 18th International Complement Workshop, Salt Lake
City, Utah.

Birmingham DJ, Chen W, Liang G, Schmitt HC. A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians. 2001. Presented at the Complement Associated Diseases, Animal Models, and Therapeutics Workshop, Santorini, Greece.

Logar CM, Chen W, and Birmingham DJ. Human CR1-like express a transcript in bone marrow for a C4b binding protein. Presented at the 7th International Workshop on MHC evolution and VIII Complement Genetics Workshop and Conference. October 2002, Perth, Western Australia.

Birmingham DJ, Chen W, Schmitt HC, Gavit K. A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b Presented at the 7th International Workshop on MHC evolution and VIII Complement Genetics Workshop and Conference. October 2002, Perth, Western
Australia.

Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA, Birmingham DJ. Erythrocyte CR1 levels and SLE flare. Presented at the 7th International Lupus Congress, May 9-13, 2004, New York, NY.

Birmingham DJ, Gavit KF, McCarty S, Yu CY, Rovin BH, Hebert, LA. Erythrocyte CR1 levels and SLE flare. Presented at the Annual American Society of Nephrology Meeting, August 14-18, 2004, New York City, NY.

Gavit KF, Tong J, Nagaraja HN, Birmingham DJ. Two CR1 polymorphism in SCR 8 independently affect binding to C4b and/or C3b. Presented at the 20th International Complement Workshop, June 13-18, 2004, Honolulu, HI.

Irshaid F, Yu CY, Birmingham DJ. Human fetal liver and bone marrow express a transcript that encodes the two N terminal SCRs of CR1-like. Presented at the 20th International Complement Workshop, June 13-18, 2004, Honolulu, HI.

Birmingham, DJ. Gavit KF, McCarty S, Tong J, Yu CY, Rovin BH, Nagaraja HN, Hebert, LA, Consumption of erythrocyte CR1 is associated with protection against SLE renal flare. Presented at the 10th European Meeting on Complement in Human Disease, September 9-13, 2005, Heidelberg, Germany.

Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Malarkey WB, Hebert LA. Fluctuation in Self-Perceived Stress Increases Risk of Flare in SLE Nephritis Patients Carrying the 5-HT1A-1019G Allele. Presented at the 2006 American Society of Nephrology, Nov 14-19, 2006, San Diego Ca

Birmingham DJ, Rovin BH, Zou X, Yu CY, Tsao BP, Wu H, Nagaraja HN, Hebert LA. Multivariate Analysis of Traditional Biomarkers Identifies Markers and Forecasters of Lupus Nephritis Flare. Presented at the 8th International congress on SLE, May 23-27, 2007, Shanghai, China

Bitter J, Dials S, Nagaraja HN,, Yu CY, Rovin BH, Hebert LA, Birmingham DJ.. Changes in Anti-C1q IgG Levels Neither Forecast nor Mark a Lupus Nephritis Flare. Presented at the 9th International congress on SLE. June 23-27, 2010, Vancouver BC, at the 23rd International Complement Workshop, Aug 1-5, 2010, New York NY, and at the American Society of Nephrology, Nov 16-21, Denver, Co.

Birmingham DJ, Hebert LA, Song H, Nagaraja HN, Noonan WT, Rovin BH, Yu CY. Evidence that Decline in Vitamin D Status may be Mechanistically Related to SLE Flare. Presented at the 9th International congress on SLE. June 23-27, 2010, Vancouver BC, and at the American Society of Nephrology, Nov 16-21, Denver, CO.

Chapters in Books

Hebert LA, Cosio FG, Birmingham DJ, Sedmak DD: Circulating immune complexes. Chapter in: Immunochemistry, Carel van Oss (Ed), Marcel Dekker, New York, 1994, pp 653-680.

Hebert LA, Cosio FG, Birmingham DJ: The role of complement in glomerular and vascular injury. In: Textbook of Nephrology. Massry SG, Glassock RJ (Eds), 3rd Ed, Williams and Wilkins, Baltimore, 1995, pp 659-670.

Birmingham DJ. The type one complement receptor (CR1) and human SLE. Chapter in: Lupus: Cellular and
Molecular Pathogenesis. Kammer GM, Tsokos GC, (Eds), Humana Press Inc, Totowa, NJ, 1999.

Hebert LA, Cosio FG, Birmingham DJ. Complement and complement regulatory proteins in renal disease. Chapter in: Immunologic Renal Diseases. Neilson EG, Couser, WG (Eds) 2nd Ed, Lippincott-Raven, Philadelphia, 2001

Yang Y, Chung EK, Lhotta K, Wu YL, Higgins GC, Rennebohm RM, Hebert LA, Birmingham DJ, Rovin BH, and Yu CY. Complement components C4A and C4B in human lupus. Chapter in Molecular Autoimmunity. Moncef Zouli (Ed). Kluwer Academic Publishers, Dordrecht, Netherlands, 2005

Hauptmann G, Yu CY, Yang Y, Wu YL, Birmingham DJ, Rovin BH, and Hebert LA. Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis. In SLE Companion to
Rheumatology, Elsevier 2005.

Yu CY, Hauptmann G, Yang Y, Wu YL, Birmingham DJ, Rovin BH and Hebert LA: Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis: epidemiology and pathogenesis. In: Tsokos GC, Gordon C and Smolen JS (eds) Systemic Lupus Erythematosus: a Companion to Rheumatology. Philadelphia: Elsevier, pp183-193, 2007

Rovin BH, Birmingham DJ, Nadasdy T. "Renal Involvement in Systemic Lupus Erythematosus." In Diseases of the Kidney and Urinary Tract. Edited by Schrier R, Nelson E, Molitoris B, Coffman T, Falk R, 2012

Rovin BH, Birmingham DJ, Nadasdy T. "Systemic Lupus Nephritis and the Kidney." In Core Concepts in Parenchymal Kidney Disease. Edited by Fervenza F, Li J, Singh AK, 2012.

Birmingham DJ. "Complement Regulation in the Kidney." In Encyclopedia of Medical Immunology. Edited by MacKay I, Rose NR, 2012.

Editorial Activities

Editorial Service
  • Associate Editor, Journal of Immunology, 1999-2004  
Ad Hoc Reviewer
  • Journal of Immunology                          
  • Arthritis and Rheumatism
  • Journal of the American Society of Nephrology
  • Clinical Journal of the American Society of Nephrology
  • Genes and Immunity
  • Journal of Immunological Methods
  • Kidney International
  • Arthritis Research & Therapy
  • Journal of Clinical Immunology
  • Scandinavian Journal of Immunology
  • Clinical Immunology and Immunopathology
  • Archives of Biochemistry and Biophysics
  • Trends in Molecular Medicine
  • Lupus
  • Arthritis Care & Research
  • Translational Research
  • Journal of Rheumatology

Reference Works

January 2010:
  • Birmingham DJ, Hebert LA, Song H, Nagaraja HN, Noonan WT, Rovin BH, Yu CY."Evidence that Decline in Vitamin D Status may be Mechanistically Related to SLE Flare"
  • Birmingham DJ, Shen XP."Identification of a CR1-like transcript in the baboon bone marrow"
  • Bitter J, Dials S, Nagaraja HN,, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Changes in Anti-C1q IgG Levels Neither Forecast nor Mark a Lupus Nephritis Flare" .
January 2007:
  • Birmingham DJ, Rovin BH, Zou X, Yu CY, Tsao BP, Wu H, Nagaraja HN, Hebert LA."Multivariate Analysis of Traditional Biomarkers Identifies Markers and Forecasters of Lupus Nephritis Flare"
January 2006:
  • Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Malarkey WB, Hebert LA."Fluctuation in Self-Perceived Stress Increases Risk of Flare in SLE Nephritis Patients Carrying the 5-HT1A-1019G Allele"
January 2005:
  • Birmingham, DJ. Gavit KF, McCarty S, Tong J, Yu CY, Rovin BH, Nagaraja HN, Hebert, LA."Consumption of erythrocyte CR1 is associated with protection against SLE renal flare"
January 2004:
  • Irshaid F, Yu CY, Birmingham DJ."Human fetal liver and bone marrow express a transcript that encodes the two N terminal SCRs of CR1-like"
  • Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Erythrocyte CR1 levels and SLE flare"
  • Gavit KF, Tong J, Nagaraja HN, Birmingham DJ."Two CR1 polymorphism in SCR 8 independently affect binding to C4b and/or C3b"
  • Birmingham DJ, Gavit KF, McCarty S, Yu CY, Rovin BH, Hebert, LA."Erythrocyte CR1 levels and SLE flare"
January 2002:
  • Birmingham DJ, Chen W, Schmitt HC, Gavit K."A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b"
  • Logar CM, Chen W, and Birmingham DJ."Human CR1-like express a transcript in bone marrow for a C4b binding protein"
January 2001:
  • Birmingham DJ, Chen W, Liang G, Schmitt HC."A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians"
January 2000:
  • Birmingham DJ, Liang G, Shen XP."CR1 polymorphisms associated with SLE" . : 29
  • Birmingham DJ, Logar CM, Chen W."Characterization of the human CR1-like transcript" . : 11
January 1999:
  • Birmingham DJ, Chen W, Shen XP, Liang G."A CR1 polymorphism associates with SLE Nephritis and Juvenile-onset IgA Nephritis" . : 304
January 1998:
  • Allred LK, Birmingham DJ."Polymorphisms of FcRIIIa and the associated  subunit in normals and SLE patients"
  • Birmingham DJ, Chen W, Shen XP."Certain mutations of CR1 segregate with normals or SLE patients with nephritis"
January 1997:
  • Birmingham DJ, Moulds JM, Chen W."A CR1 polymorphism associates with the B allele and with SLE patients"
  • Logar CM, Birmingham DJ."CR1-like, a C3b binding protein of non-human primate erythrocytes, is expressed in human bone marrow"
January 1996:
  • Birmingham, D.J., Logar, C.M., Shen, X.P."Baboon CR1b, a homologue of the human CR1-like element, encodes the baboon erythrocyte complement receptor"
January 1993:
  • Birmingham DJ, Atkinson JP."Identification of an alternatively spliced transcript of the chimpanzee type one complement receptor (CR1)" . : 224A
January 1991:
  • Birmingham DJ, Cosio FG, McCourt DW, Atkinson JP."N-terminus amino acid analysis of the baboon erythrocyte C3b receptor" . : A1716
January 1990:
  • Birmingham DJ, Cosio FG."Determination of factor I cofactor function of nonhuman primate erythrocyte (E) C3b receptors" . : A2188
January 1989:
  • Birmingham DJ, Cosio FG."C3b binding proteins of primate erythrocytes (E)" . : 315A

Presentations

Ohio State


Presentations (~ 3/yr) at the Nephrology Research Conference series. 1991-present

Yearly presentations at the College of Medicine/Pathology Immunobiology Seminar Program. 1994-2005

“The Complement System”. Presented at the Nephrology Fellows Research Conference, January 3rd, 2001

“The physiology of immune adherence”. Presented at the HLRI lecture series. May 2, 2001

“The Ohio SLE Study”. Presented at the OSU Internal Medicine Grand Rounds. August 23, 2001

“Is FcgRIIIa pro- or anti-inflammatory? Deciphering its true role in human immune complex disease”. Presented at the HLRI Research in Progress lecture series. October 3, 2001

“Update on CR1 and SLE”. Presented at the SLE seminar series, February 22nd, 2002

“Genetic variation of immune complex receptors: Does it play a role in immune complex disease?”. Presented to the Department of Statistics research group, April 16th, 2002.

“CR1L, a new member of the Regulators of Complement Activation (RCA) gene cluster”. Presented at the HLRI Research in Progress lecture series. February 7th, 2003.

“Complement and kidney disease”. Presented at the Nephrology Fellows Reunion conference, September 26, 2003.

Stats?

“Where there's smoke...Pursuing a novel complement receptor”. Present at the Department of Pathology Immunology Seminar Program, September 28th, 2004.

“Erythrocyte CR1 consumption is associated with protection against SLE renal flare”. Presented at the HLRI Research in Progress lecture series, April 15th, 2005.

“Genetic and Clinical Risk Factors for Human SLE Nephritis”. Presented at the Nephrology Fellows Research Conference, July 29th, 2005

“The role of complement in health and disease”. Presented at OSU Internal Medicine Grand Rounds. October 27th, 2005.

“Fluctuation in Self-Perceived Stress and Increased Risk of Flare in Patients with Lupus Nephritis Carrying the Serotonin Receptor 1A (5HT1A) -1019 G Allele”. Presented at the Nephrology Fellows Research Conference, July 28th, 2006.

“The Ohio SLE Study, form bench to bedside and back again”. Presented at the HLRI Research in Progress lecture series, June 29th, 2007.

The Ohio SLE Study: A study of the pathogenesis of SLE renal flare”. Presented at the Nephrology Fellows Research Conference, September 7th, 2007.

“The Ohio SLE Study: Characterizing renal flare in patients with systemic lupus erythematosus (SLE)”. Presented at the Comprehensive Transplant Conference, April 16th, 2008

“Deciphering the complex role of the complement system in the pathogenesis and prediction of lupus nephritis flare”. Present at the Department of Pathology Immunology Seminar Program, January 27, 2009

“Complement activation and regulation: How this balance influences SLE nephritic flare”. Presented at the Nephrology Fellows Research Conference, March 6th, 2009.

“Is a declining vitamin D level a risk factor for SLE flare?”. Present at the Department of Pathology Immunology Seminar Program, April 23rd, 2010.

“Understanding the role of anti-C1q autoantibodies in lupus nephritis flare: Crossed up by cross-sectional studies”. Presented at the HLRI Research in Progress lecture series, August 13th, 2010.

“Autoantibodies to complement in lupus nephritis (LN) and its flares”. Presented at the Everett D. Reese Immunology and Rheumatology Research Seminar Series, April 20th, 2011.

“Anti-C3b autoantibodies define the role of anti-C1q autoantibodies as a biomarker of lupus nephritis flare” Presented at the Nephrology Fellows Research Conference, October 21st, 2011.

“T cell transcripts in Lupus Nephritis Flare”. Presented at the Nephrology Fellows Research Conference, April 6th, 2012.

“Interrogating 30 different urine analytes as biomarkers of lupus nephritis flare”. Presented at the Nephrology Fellows Research Conference, May 24th, 2013.

“Changing complement phenotypes during lupus nephritis flare: The OSS experience” Presented at the Ohio State University Reese Seminar Series, September 13, 2016.

Other academic institutions


"Effect of erythropoiesis on circulating levels of erythrocyte complement receptors". Presented at the Washington University Complement Seminar Series, Washington University, St Louis MO, May 10, 1991

“CR1 isoforms expressed in primates". Presented at the Cincinnati Complement Club, March 26, 1992

“Immune complex receptor polymorphisms in SLE and SLE nephritis”. Presented at the MCP Hahnemann University School of Medicine the Dept. of Microbiology & Immunology Seminar Series, Philadelphia, PA, January 31, 2001

“A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians”. Presented at the International Meeting on Complement Associated Diseases, Animal Models, and Therapeutics, Santorini Greece, October 14th, 2001

“Primate immune adherence receptors”. Presented at the 7th International Workshop On MHC, Evolution, and Complement Genetics Workshop, Perth, Western Australia, October 2002

“A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b”. Presented at the 7th International Workshop On MHC, Evolution, and Complement Genetics Workshop, Perth, Western Australia, October 2002

“The Ohio SLE Study”. Presented to the Ohio Arthritis Consortium, Columbus, OH, September 22, 2003

“Identifying biomarkers of Lupus Nephritis (LN) Flare: The role of anti-C1q (and others). :Presented to Nephrology and Urology Research Affinity Group, Nationwide Children’s Hospital, Columbus, OH, May 19, 2010
Advising

Advising

Academic Advisees

  • Dissertation advisor: Laura Allred, PhD, Pathology, 2001
  • Dissertation advisor: Fawzi Irshaid, MCDB, 2005
  • Dissertation Committee member: Kristi Rupert, OSBP, 1999
  • Dissertation Committee member: Craig A. McClure, molecular Genetics (University of. Australia), 2005
  • Dissertation Committee member: Kathryn Kitzmiller, IBGP, 2009
  • Dissertation Committee member: Ashley Carpenter, IBGP, 2016
  • Lab mentor, Chris Logar, Medical Student, recipient of the Bertha Bouroncle Research Award, 1996
  • Lab mentor, Katie Gavit, Masters of Epidemiology, 2002 - 2004
  • Lab mentor, Scott McCarty, undergraduate student, 2003 - 2005
  • Lab mentor, Kate Sasser, IBGP lab rotation, 2004
  • Lab mentor, Mahvish Ahmed, undergraduate student, 2005 - 2006 
  • Lab mentor, Ruo-Qi Hu, Nephrology Fellow, 2006
  • Lab mentor, Sarah Dials, undergraduate student (Otterbein biology honors project), 2008
  • Lab mentor, Josh Bitter, Nephrology Fellow, 2009
  • Lab mentor, Sanya Dosani, undergraduate student, 2009 - 2010
  • Lab mentor, Ezinne Nduke, undergraduate student, 2010 - 2011
  • Lab mentor, Terese Gullo, undergraduate student, 2012 - 2013
  • Lab mentor, Nicole Reyes, undergraduate student, 2012 - 2013
  • Lab mentor, Maria Khan, Nephrology Fellow, 2013-2014
  • Lab mentor, Salem Almaani, Nephrology Fellow, 2015-2016