Faculty Emeritus, Nephrology

395 W. 12th Ave.
Columbus, OH 43210

614-293-4997 
Dan.Birmingham@osumc.edu


Education:

PhD: The Ohio State University, Columbus, OH, 1989
MS: The Ohio State University, Columbus, OH, 1981
BS: The Ohio State University, Columbus, OH, 1978

Professional activities:

  • NIH PBKD study section, (2008-present)
B.S., The Ohio State University

Chapters in Books

Hebert LA, Cosio FG, Birmingham DJ, Sedmak DD. "Circulating immune complexes." In Immunochemistry. Edited by Carel van Oss. 653-680. New York: Marcel Dekker, January 1994

Hebert LA, Cosio FG, Birmingham DJ. "The role of complement in glomerular and vascular injury." In Textbook of Nephrology. Edited by Massry SG, Glassock RJ. 659-670. Baltimore: Williams and Wilkins, January 1995

Birmingham DJ. "The type one complement receptor (CR1) and human SLE." In Lupus: Cellular and Molecular Pathogenesis. Edited by Kammer GM, Tsokos GC. -. Totowa, NJ: Humana Press Inc, January 1999

Hebert LA, Cosio FG, Birmingham DJ. "Complement and complement regulatory proteins in renal disease." In Immunologic Renal Diseases. Edited by Neilson EG, Couser, WG. -. Philadelphia: Lippincott-Raven, January 2001

Hauptmann G, Yu CY,. "Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis." In SLE Companion to Rheumatology. -. Elsivier, January 2005

Yang Y, Chung EK, Lhotta K, Wu YL, Higgins GC, Rennebohm RM, Hebert LA, Birmingham DJ, Rovin BH, and Yu CY. "Complement components C4A and C4B in human lupus.." In Molecular Autoimmunity. Edited by Moncef Zouli. -. Dordrecht, Netherlands, 2005: Kluwer Academic Publisher, January 2005

Yu, C.Y., G. Hauptmann, Y. Yang, Y.L. Wu, D.J. Birmingham, B.H. Rovin, and L.A. Hebert. "Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis: epidemiology and pathogenesis." In Systemic Lupus Erythematosus: A Companion to Rheumatology. Edited by Tsokos, G.C., Gordon, C., and Smolen, J.S.. 183-193. Philadelphia: Elsevier, January 2007

Rovin BH, Birmingham DJ, Nadasdy T. "Systemic Lupus Nephritis and the Kidney." In Core Concepts in Parenchymal Kidney Disease. Edited by Fervenza F, Li J, Singh AK

Birmingham DJ. "Complement Regulation in the Kidney." In Encyclopedia of Medical Immunology. Edited by MacKay I, Rose NR

Rovin BH, Birmingham DJ, Nadasdy T. "Renal Involvement in Systemic Lupus Erythematosus." In Diseases of the Kidney and Urinary Tract. Edited by Schrier R, Nelson E, Molitoris B, Coffman T, Falk R

Editorial Activities

Present activities:
  • Clinical Immunology and Immunopathology
  • Archives of Biochemistry and Biophysics
  • Trends in Molecular Medicine
  • Scandinavian Journal of Immunology
  • Journal of Clinical Immunology
  • Arthritis Research and Therapy
  • Journal of Immunological Methods
  • Genes and Immunity
  • Journal of American Society of Nephrology
  • Arthritis and Rheumatism
  • Kidney International

Past activities:

Journal of Immunology, 1999 - 2004
  • Journal of Immunology, (1999 - 2004)

Journal Articles

Cornacoff, J, B; Hebert, L, A; Smead, W, L; VanAman, M, E; Birmingham, D, J; Waxman, F J. "Primate erythrocyte-immune complex-clearing mechanism.." The Journal of clinical investigation. Vol. 71, no. 2. (January 1983.): 236-47

Waxman, F, J; Hebert, L, A; Cornacoff, J, B; VanAman, M, E; Smead, W, L; Kraut, E, H; Birmingham, D, J; Taguiam, J M. "Complement depletion accelerates the clearance of immune complexes from the circulation of primates.." The Journal of clinical investigation. Vol. 74, no. 4. (January 1984.): 1329-40

Cornacoff, J, B; Hebert, L, A; Birmingham, D, J; Waxman, F J. "Factors influencing the binding of large immune complexes to the primate erythrocyte CR1 receptor.." Clinical immunology and immunopathology. Vol. 30, no. 2. (January 1984.): 255-64

Waxman, F, J; Hebert, L, A; Cosio, F, G; Smead, W, L; VanAman, M, E; Taguiam, J, M; Birmingham, D J. "Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo. Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli.." The Journal of clinical investigation. Vol. 77, no. 1. (January 1986.): 82-9

Cosio, F, G; Hebert, L, A; Birmingham, D, J; Dorval, B, L; Bakaletz, A, P; Kujala, G, A; Edberg, J, C; Taylor, R P. "Clearance of human antibody/DNA immune complexes and free DNA from the circulation of the nonhuman primate.." Clinical immunology and immunopathology. Vol. 42, no. 1. (January 1987.): 1-9

Cosio, F, G; Birmingham, D, J; Sexton, D, J; Hebert, L A. "Interactions between precipitating and nonprecipitating antibodies in the formation of immune complexes.." Journal of immunology (Baltimore, Md. : 1950). Vol. 138, no. 8. (January 1987.): 2587-92

Birmingham, D, J; Cosio, F G. "Characterization of the baboon erythrocyte C3b-binding protein.." Journal of immunology (Baltimore, Md. : 1950). Vol. 142, no. 9. (January 1989.): 3140-4

Dorval, B, L; Cosio, F, G; Birmingham, D, J; Hebert, L A. "Human erythrocytes inhibit complement-mediated solubilization of immune complexes.." Journal of immunology (Baltimore, Md. : 1950). Vol. 142, no. 8. (January 1989.): 2721-7

Birmingham, D, J; Hebert, L, A; Cosio, F, G; VanAman, M E. "Immune complex erythrocyte complement receptor interactions in vivo during induction of glomerulonephritis in nonhuman primates.." The Journal of laboratory and clinical medicine. Vol. 116, no. 2. (January 1990.): 242-52

Cosio, F, G; Shen, X, P; Birmingham, D, J; Van Aman, M; Hebert, L A. "Evaluation of the mechanisms responsible for the reduction in erythrocyte complement receptors when immune complexes form in vivo in primates.." Journal of immunology (Baltimore, Md. : 1950). Vol. 145, no. 12. (January 1990.): 4198-206

Shibata, T; Cosio, F, G; Birmingham, D J. "Complement activation induces the expression of decay-accelerating factor on human mesangial cells.." Journal of immunology (Baltimore, Md. : 1950). Vol. 147, no. 11. (January 1991.): 3901-8

Hebert, L, A; Cosio, F, G; Birmingham, D, J; Mahan, J, D; Sharma, H, M; Smead, W, L; Goel, R. "Experimental immune complex-mediated glomerulonephritis in the nonhuman primate.." Kidney international. Vol. 39, no. 1. (January 1991.): 44-56

Hebert, L, A; Cosio, F, G; Birmingham, D, J; Mahan, J D. "Biologic significance of the erythrocyte complement receptor: a primate perquisite.." The Journal of laboratory and clinical medicine. Vol. 118, no. 4. (January 1991.): 301-8

Hebert, L, A; Cosio, F, G; Birmingham, D J. "The role of the complement system in renal injury.." Seminars in nephrology. Vol. 12, no. 5. (January 1992.): 408-27

Hebert, L, A; Birmingham, D, J; Shen, X, P; Cosio, F G. "Stimulating erythropoiesis increases complement receptor expression on primate erythrocytes.." Clinical immunology and immunopathology. Vol. 62, no. 3. (January 1992.): 301-6

Mahan, J, D; Hebert, L, A; McAllister, C; Birmingham, D, J; Shen, X, P; Cosio, F, G; Brandt, J. "Platelet involvement in experimental immune complex-mediated glomerulonephritis in the nonhuman primate.." Kidney international. Vol. 44, no. 4. (January 1993.): 716-25

Hebert, L, A; Birmingham, D, J; Shen, X, P; Cosio, F, G; Fryczkowski, A. "Rate of antigen entry into the circulation in experimental versus naturally occurring immune complex glomerulonephritis.." Journal of the American Society of Nephrology : JASN. Vol. 5, no. 5 Suppl 1. (January 1994.): S70-5

Hebert, L, A; Birmingham, D, J; Shen, X, P; Brandt, J, T; Sedmak, D, D; Dillon, J J. "Effect of recombinant erythropoietin therapy on autoimmunity in systemic lupus erythematosus.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 24, no. 1. (January 1994.): 25-32

Hebert, L, A; Birmingham, D, J; Dillon, J, J; Cosio, F, G; Shen, X P. "Erythropoietin therapy in humans increases erythrocyte expression of complement receptor type 1 (CD35).." Journal of the American Society of Nephrology : JASN. Vol. 4, no. 10. (January 1994.): 1786-91

Hebert LA, Mahan JD, Birmingham DJ, Cosio FG, Dillon JJ, Sedmak DD, Shen X-P, McAllister C. "Enalapril therapy decreases glomerular accumulation of immune complexes and mesangial matrix in a model of glomerulonephritis in the nonhuman primate." Kidney Int. no. 46. (January 1994.): 986-992

Atkinson JP, Krych M, Nickells M, Birmingham D, Subramanian B, Clemenza L, Alvarez J, Liszewski K. "Complement receptors and regulatory proteins: Immune adherence revisited and abuse by microorganisms." Clin Exp Immunol. no. 2. (January 1994.): 1-3

Cosio, F, G; Shibata, T; Rovin, B, H; Birmingham, D J. "Effects of complement activation products on the synthesis of decay accelerating factor and membrane cofactor protein by human mesangial cells.." Kidney international. Vol. 46, no. 4. (January 1994.): 986-92

Sedmak, D, D; Guglielmo, A, M; Knight, D, A; Birmingham, D, J; Huang, E, H; Waldman, W J. "Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.." The American journal of pathology. Vol. 144, no. 4. (January 1994.): 683-92

Birmingham DJ, Shen X-P, Hourcade D, Nickells MW, Atkinson JP. "Primary sequence of an alternatively spliced form of chimpanzee CR1: A candidate for the 75,000 Mr complement receptor expressed on chimpanzee erythrocytes." J Immunol. no. 153. (January 1994.): 691-700

Hebert, L, A; Birmingham, D, J; Mahan, J, D; Shen, X, P; McAllister, C; Cosio, F, G; Dillon, J J. "Effect of chronically increased erythrocyte complement receptors on immune complex nephritis.." Kidney international. Vol. 45, no. 2. (January 1994.): 493-9

Birmingham, D J. "Erythrocyte complement receptors.." Critical reviews in immunology. Vol. 15, no. 2. (January 1995.): 133-54

Birmingham, D, J; Shen, X, P; Hartman, J, A; Dillon, J, J; Hebert, L A. "Effect of chronic human recombinant erythropoietin therapy on antibody responses to immunization in chronic hemodialysis patients.." Kidney international. Vol. 50, no. 2. (January 1996.): 543-9

Birmingham DJ, Logar CM, Shen XP, Chen W. "Baboon erythrocyte complement receptor is a glycophospatidylinositol-linked protein encoded by a homologue of the human CR1-like genetic element." J Immunol. no. 157. (January 1996.): 2586-2592

Hebert, L, A; Birmingham, D, J; Mahan, J, D; Cosio, F, G; Dillon, J, J; Sedmak, D, D; Shen, X, P; McAllister, C. "Effect of enalapril therapy on glomerular accumulation of immune complexes and mesangial matrix in experimental glomerulonephritis in the nonhuman primate.." American journal of kidney diseases : the official journal of the National Kidney Foundation. Vol. 30, no. 2. (January 1997.): 243-52

Orosz, C, G; Huang, E, H; Bergese, S, D; Sedmak, D, D; Birmingham, D, J; Ohye, R, G; VanBuskirk, A M. "Prevention of acute murine cardiac allograft rejection: anti-CD4 or anti-vascular cell adhesion molecule one monoclonal antibodies block acute rejection but permit persistent graft-reactive alloimmunity and chronic tissue remodelling.." The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. Vol. 16, no. 9. (January 1997.): 889-904

Birmingham, D, J; Hebert, L, A; Shen, X, P; Higgins, P; Yeh, C, G; Creasey, A A. "Effects of immune complex formation and complement activation on circulating platelets in the primate.." Clinical immunology (Orlando, Fla.). Vol. 91, no. 1. (January 1999.): 99-105

Chen, W; Logar, C, M; Shen, X, P; Birmingham, D J. "The chimpanzee and cynomolgus monkey erythrocyte immune adherence receptors are encoded by CR1-like genes.." Immunogenetics. Vol. 52, no. 1-2. (January 2000.): 46-52

Moulds, J, M; Zimmerman, P, A; Doumbo, O, K; Kassambara, L; Sagara, I; Diallo, D, A; Atkinson, J, P; Krych-Goldberg, M; Hauhart, R, E; Hourcade, D, E; McNamara, D, T; Birmingham, D, J; Rowe, J, A; Moulds, J, J; Miller, L H. "Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.." Blood. Vol. 97, no. 9. (January 2001.): 2879-85

Birmingham, D, J; Rovin, B, H; Yu, C, Y; Hebert, L A. "Of mice and men: the relevance of the mouse to the study of human SLE.." Immunologic research. Vol. 24, no. 2. (January 2001.): 211-24

Birmingham, D, J; Hebert, L A. "CR1 and CR1-like: the primate immune adherence receptors.." Immunological reviews. Vol. 180, (January 2001.): 100-11

Birmingham, Daniel, J; Chen, Wei; Liang, Grace; Schmitt, Holly, C; Gavit, Katie; Nagaraja, Haikady N. "A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b.." Immunology. Vol. 108, no. 4. (January 2003.): 531-8

Moulds, J, M; Thomas, B, J; Doumbo, O; Diallo, D, A; Lyke, K, E; Plowe, C, V; Rowe, J, A; Birmingham, D J. "Identification of the Kna/Knb polymorphism and a method for Knops genotyping.." Transfusion. Vol. 44, no. 2. (January 2004.): 164-9

Yang, Yan; Chung, Erwin, K; Zhou, Bi; Lhotta, Karl; Hebert, Lee, A; Birmingham, Daniel, J; Rovin, Brad, H; Yu, C Yung. "The intricate role of complement component C4 in human systemic lupus erythematosus.." Current directions in autoimmunity. Vol. 7, (January 2004.): 98-132

Logar, Christine, M; Chen, Wei; Schmitt, Holly; Yu, Chack Yung; Birmingham, Daniel J. "A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue.." Molecular immunology. Vol. 40, no. 11. (January 2004.): 831-40

Rovin, Brad, H; Song, Huijuan; Birmingham, Dan, J; Hebert, Lee, A; Yu, Chack Yung; Nagaraja, Haikady N. "Urine chemokines as biomarkers of human systemic lupus erythematosus activity.." Journal of the American Society of Nephrology : JASN. Vol. 16, no. 2. (January 2005.): 467-73

Wu, Hui; Cantor, Rita, M; Graham, Deborah S Cunninghame; Lingren, Cecilia, M; Farwell, Lisa; Jager, Philip L De; Bottini, Nunzio; Grossman, Jennifer, M; Wallace, Daniel, J; Hahn, Bevra, H; Julkunen, Heikki; Hebert, Lee, A; Rovin, Brad, H; Birmingham, Dan, J; Rioux, John, D; Yu, C Yung; Kere, Juha; Vyse, Timothy, J; Tsao, Betty P. "Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease.." Arthritis and rheumatism. Vol. 52, no. 8. (January 2005.): 2396-402

Rovin, Brad, H; Song, Huijuan; Hebert, Lee, A; Nadasdy, Tibor; Nadasdy, Gyongyi; Birmingham, Daniel, J; Yung Yu, Chack; Nagaraja, Haikady N. "Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus.." Kidney international. Vol. 68, no. 4. (January 2005.): 1825-33

Rovin, Brad, H; Tang, Yuxiao; Sun, Junfeng; Nagaraja, Haikady, N; Hackshaw, Kevin, V; Gray, Linda; Rice, Robert; Birmingham, Daniel, J; Yu, Chack-Yung; Spetie, Dan, N; Aziz, Amy; Hebert, Lee A. "Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapy.." Kidney international. Vol. 68, no. 2. (January 2005.): 747-59

Birmingham DJ, Irshaid F, Nagaraja HN, Zou X, Tsao BP, Wu H, Yu CY, Hebert LA, Rovin BH. "The complex nature of serum C3 and C4 as biomarkers of lupus renal flare." Lupus, epub ahead. (January 2006.)

Wu, Yee-Ling; Higgins, Gloria, C; Rennebohm, Robert, M; Chung, Erwin, K; Yang, Yan; Zhou, Bi; Nagaraja, Haikady, N; Birmingham, Dan, J; Rovin, Brad, H; Hebert, Lee, A; Yu, C Yung. "Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects.." Advances in experimental medicine and biology. Vol. 586, (January 2006.): 227-47

Birmingham, Daniel, J; Nagaraja, H, N; Rovin, Brad, H; Spetie, Lacramioara; Zhao, Yanxing; Li, Xiaobai; Hackshaw, Kevin, V; Yu, C Yung; Malarkey, William, B; Hebert, Lee A. "Fluctuation in self-perceived stress and increased risk of flare in patients with lupus nephritis carrying the serotonin receptor 1A -1019 G allele.." Arthritis and Rheumatism. Vol. 54, no. 10. (January 2006.): 3291-3299

Birmingham, D, J; Gavit, K, F; McCarty, S, M; Yu, C, Y; Rovin, B, H; Nagaraja, H, N; Hebert, L A. "Consumption of erythrocyte CR1 (CD35) is associated with protection against systemic lupus erythematosus renal flare.." Clinical and experimental immunology. Vol. 143, no. 2. (January 2006.): 274-80

Rovin, B.H., D.J. Birmingham, H.N. Nagaraja, C.Y. Yu, and L.A. Hebert.. "Biomarker discovery in human SLE nephritis.." Bull. NYU Hosp. Joint Dis.. Vol. 65, (January 2007.): 187-193

Birmingham, D. J., F. Irshaid, K. F. Gavit, H. N. Nagaraja, C. Y. Yu, B. H. Rovin, and L. A. Hebert. "A polymorphism in the type one complement receptor (CR1) involves an additional cysteine within the C3b/C4b binding domain that inhibits ligand binding." Molecular Immunology. Vol. 44, (January 2007.): 3510

Wang, L., S. Lin, K.W. Rammohan, Z. Liu, J.-Q. Liu, R.-H. Liu, N. Guinther, J. Lima, Q. Zhou, T. Wang, Z. Zheng, D.J. Birmingham, B.H. Rovin, L.A. Hebert, Y. Wu, J. Lynn, G. Cooke, C.Y. Yu, P. Zheng, and Y. Liu. "A di-nucleotide deletion in CD24 confers protection against autoimmune diseases." PLoS Genetics. Vol. 3e:49, (January 2007.)

Wu, Y.L., S.L. Savelli, Y. Yang, B. Zhou, B.H. Rovin, D.J. Birmingham, H.N. Nagaraja, L.A. Hebert, and C.Y. Yu. "Sensitive and specific real-time polymerase chain reaction assays to accurately determine copy number variations (CNVs) of human complement C4A, C4B, C4-long, C4-short and RCCX modules: Elucidation of C4 CNVs in 50 consanguineous subjects with defined HLA." Journal of Immunology. Vol. 176, (January 2007.): 3012-3025

Y.Yang, E.Chung, Y.Wu, S.Savelli, H.Nagaraja, B.Zhou, M.Hebert, K.Jones, Y.Shu, K.Kitzmiller, C.Blanchong, K.McBride, G.Higgins, R.Rennebohm, R.Rice, K.Hackshaw, R.Roubey, J.Grossman, B.Tsao, D.J.Birmingham, B.H. Rovin, L.A.Hebert, C.Yung Yu. "Gene copy number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus: Low copy number is a risk factor for, high copy number is a protective factor against, Caucasian SLE disease susceptibility." American Journal of Human Genetics. (January 2007.): 1037-1054

Wu, Hui; Boackle, Susan, A; Hanvivadhanakul, Punchong; Ulgiati, Daniela; Grossman, Jennifer, M; Lee, Youngho; Shen, Nan; Abraham, Lawrence, J; Mercer, Timothy, R; Park, Elly; Hebert, Lee, A; Rovin, Brad, H; Birmingham, Dan, J; Chang, Deh-Ming; Chen, Chung Jen; McCurdy, Deborah; Badsha, Humeira, M; Thong, Bernard Y, H; Chng, Hiok, H; Arnett, Frank, C; et al.. "Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 10. (January 2007.): 3961-6

Birmingham, D.J., B.H. Rovin, G. Shidham, H.N. Nagaraja, X. Zou, M. Bissel, and L.A. Hebert. "Spot urine protein/creatinine ratios are unreliable estimates of 24 hour proteinuria in most systemic lupus erythematosus nephritis flares." Kidney International. Vol. 72, (January 2007.): 865-870

Wu, H., D.J. Birmingham, B.H. Rovin, K.V. Hackshaw, N. Haddad, D. Haden, C.Y. Yu, L.A. Hebert.. "D-dimer level and the risk of thrombosis in SLE.." Clin J Am Soc Nephrol. Vol. 3, (January 2008.): 1628-1636

Wu YL, Yang Y, Chung EK, Zhou B, Kitzmiller KJ, Savelli SL, Nagaraja HN, Birmingham DJ, Tsao BP, Rovin BH, Hebert LA, Yu CY. "Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus." Cytogenet Genome Res. no. 123. (January 2008.): 131-141

Birmingham, D., B. Rovin, G. Shidham, M. Bissell, H. Nagaraja, and L. Hebert.. "Relationship between albuminuria and total proteinuria in SLE nephritis: diagnostic and therapeutic implication.." Clin J Am Soc Nephrol. Vol. 3, (January 2008.): 1028-1033

Zhang, X., M. Jin, H. Wu, T. Nadasdy, G. Nadasdy, N. Harris, K. Green-Church, H. Nagaraja, D. J. Birmingham, C. Y. Yu, L. A. Hebert, and B. H. Rovin. "Biomarkers of lupus nephritis determined by serial urine proteomics." Kidney Int. Vol. 74, (January 2008.): 799-807

Hebert LA, Birmingham DJ, Shidham G, Rovin B, Nagaraja HN, Yu CY. "Random Spot Urine Protein/Creatinine Ratio Is Unreliable for Estimating 24-Hour Proteinuria in Individual Systemic Lupus Erythematosus Nephritis Patients." Nephron Clin Pract. Vol. 113, (January 2009.): c177-c182

Brodsky, S. V., G. M. Nadasdy, R. Pelletier, A. Satoskar, D. J. Birmingham, G. A. Hadley, K. Obeidat, and T. Nadasdy. "Expression of the decay-accelerating factor (CD55) in renal transplants--a possible prediction marker of allograft survival." Transplantation. Vol. 88, (January 2009.): 457

Rovin, B. H., A. M. McKinley, and D. J. Birmingham. "Can we personalize treatment for kidney diseases?." Clin J Am Soc Nephrol. Vol. 4, (January 2009.): 1670

Budu-Grajdeanu, P., R. C. Schugart, A. Friedman, D. J. Birmingham, and B. H. Rovin. "Mathematical framework for human SLE Nephritis: disease dynamics and urine biomarkers." Theor Biol Med Model. Vol. 7, (January 2010.): 14

Ardoin, S., D. J. Birmingham, P. L. Hebert, C. Y. Yu, B. H. Rovin, and L. A. Hebert. "An approach to validating criteria for proteinuric flare in systemic lupus erythematosus glomerulonephritis.." Arthritis and Rheumatism. Vol. 63, (July 2011.): 2031-2037

Satoskar AA, Shapiro JP, Bott CN, Song H, Nadasdy GM, Brodsky SV, Hebert LA, Birmingham DJ, Nadasdy T, Freitas MA, Rovin BH. "Characterization of glomerular diseases using proteomic analysis of laser capture microdissected glomeruli." ModernPathology. Vol. 25, (May 2012.): 709-721

Birmingham DJ, Hebert LA, Song H, Noonan WT, Rovin BH, Nagaraja HN, Yu CY. "Evidence that abnormally large seasonal declines in vitamin D status may trigger SLE flare in non-African Americans." Lupus. Vol. 21, (July 2012.): 855-864

Mok, C. C., D. J. Birmingham, L. Y. Ho, L. A. Hebert, H. Song, and B. H. Rovin. "Vitamin D deficiency as marker for disease activity and damage in systemic lupus erythematosus: a comparison with anti-dsDNA and anti-C1q." Lupus. Vol. 21, (January 2012.): 36-42

Mok CC, Birmingham DJ, Leung HW, Hebert LA, Song H, Rovin BH. "Vitamin D levels in Chinese patients with systemic lupus erythematosus: relationship with disease activity, vascular risk factors and atherosclerosis." Rheumatology. Vol. 51, (April 2012.): 644-652.

Reference Works

January 2010:
  • Birmingham DJ, Hebert LA, Song H, Nagaraja HN, Noonan WT, Rovin BH, Yu CY."Evidence that Decline in Vitamin D Status may be Mechanistically Related to SLE Flare"
  • Birmingham DJ, Shen XP."Identification of a CR1-like transcript in the baboon bone marrow"
  • Bitter J, Dials S, Nagaraja HN,, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Changes in Anti-C1q IgG Levels Neither Forecast nor Mark a Lupus Nephritis Flare" .
January 2007:
  • Birmingham DJ, Rovin BH, Zou X, Yu CY, Tsao BP, Wu H, Nagaraja HN, Hebert LA."Multivariate Analysis of Traditional Biomarkers Identifies Markers and Forecasters of Lupus Nephritis Flare"
January 2006:
  • Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Malarkey WB, Hebert LA."Fluctuation in Self-Perceived Stress Increases Risk of Flare in SLE Nephritis Patients Carrying the 5-HT1A-1019G Allele"
January 2005:
  • Birmingham, DJ. Gavit KF, McCarty S, Tong J, Yu CY, Rovin BH, Nagaraja HN, Hebert, LA."Consumption of erythrocyte CR1 is associated with protection against SLE renal flare"
January 2004:
  • Irshaid F, Yu CY, Birmingham DJ."Human fetal liver and bone marrow express a transcript that encodes the two N terminal SCRs of CR1-like"
  • Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Erythrocyte CR1 levels and SLE flare"
  • Gavit KF, Tong J, Nagaraja HN, Birmingham DJ."Two CR1 polymorphism in SCR 8 independently affect binding to C4b and/or C3b"
  • Birmingham DJ, Gavit KF, McCarty S, Yu CY, Rovin BH, Hebert, LA."Erythrocyte CR1 levels and SLE flare"
January 2002:
  • Birmingham DJ, Chen W, Schmitt HC, Gavit K."A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b"
  • Logar CM, Chen W, and Birmingham DJ."Human CR1-like express a transcript in bone marrow for a C4b binding protein"
January 2001:
  • Birmingham DJ, Chen W, Liang G, Schmitt HC."A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians"
January 2000:
  • Birmingham DJ, Liang G, Shen XP."CR1 polymorphisms associated with SLE" . : 29
  • Birmingham DJ, Logar CM, Chen W."Characterization of the human CR1-like transcript" . : 11
January 1999:
  • Birmingham DJ, Chen W, Shen XP, Liang G."A CR1 polymorphism associates with SLE Nephritis and Juvenile-onset IgA Nephritis" . : 304
January 1998:
  • Allred LK, Birmingham DJ."Polymorphisms of FcRIIIa and the associated  subunit in normals and SLE patients"
  • Birmingham DJ, Chen W, Shen XP."Certain mutations of CR1 segregate with normals or SLE patients with nephritis"
January 1997:
  • Birmingham DJ, Moulds JM, Chen W."A CR1 polymorphism associates with the B allele and with SLE patients"
  • Logar CM, Birmingham DJ."CR1-like, a C3b binding protein of non-human primate erythrocytes, is expressed in human bone marrow"
January 1996:
  • Birmingham, D.J., Logar, C.M., Shen, X.P."Baboon CR1b, a homologue of the human CR1-like element, encodes the baboon erythrocyte complement receptor"
January 1993:
  • Birmingham DJ, Atkinson JP."Identification of an alternatively spliced transcript of the chimpanzee type one complement receptor (CR1)" . : 224A
January 1991:
  • Birmingham DJ, Cosio FG, McCourt DW, Atkinson JP."N-terminus amino acid analysis of the baboon erythrocyte C3b receptor" . : A1716
January 1990:
  • Birmingham DJ, Cosio FG."Determination of factor I cofactor function of nonhuman primate erythrocyte (E) C3b receptors" . : A2188
January 1989:
  • Birmingham DJ, Cosio FG."C3b binding proteins of primate erythrocytes (E)" . : 315A

Presentations

"Effect of Erythropoiesis on circulating levels of erythrocyte complement receptors." Presented at Washington University Complement Seminar Series, . (May 1991)

"CR1 Isoforms Expressed in Primates." Presented at Cincinnati Complement Club, (March 1992)

"Immune Complex Receptor Polymorphisms in SLE and SLE Nephritis." Presented at MCP Hahnemann University School of Medicine, . (January 2001)

"The physiology of immune adherence." Presented at HLRI lecture series, (January 2001)

"The Ohio SLE Study." Presented at OSU Internal Medicine Grand Rounds, (January 2001)

"The Complement System." Presented at Nephrology Fellows Research Conference, (January 2001)

"Is FcgRIIIa pro- or anti-inflammatory? Deciphering its true role in human immune complex disease." (January 2001)

"A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians." Presented at International Meeting on Complement Associated Diseases, Animal Models, and Therapeutics, (January 2001)

"Update on CR1 and SLE." Presented at SLE seminar series, (January 2002)

"Primate immune adherence receptors." Presented at 7th International Workshop On MHC, Evolution, and Complement Genetics Workshop, . (January 2002)

"Genetic variation of immune complex receptors: Does it play a role in immune complex disease." Presented at Department of Statistics research group, . (January 2002)

"A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b." Presented at 7th International Workshop On MHC, Evolution, and Complement Genetics Workshop, (January 2002)

"The Ohio SLE Study." Presented at Ohio Arthritis Consortium, (September 2003)

"CR1L, a new member of the Regulators of Complement Activation (RCA) gene cluster." Presented at HLRI Research in Progress lecture series, (January 2003)

"Complement and kidney disease." (January 2003)

"Where there's smoke...Pursuing a novel complement receptor." Presented at Department of Pathology Immunology Seminar Program, (January 2004)

"The role of complement in health and disease." Presented at OSU Internal Medicine Grand Rounds, (January 2005)

"Genetic and Clinical Risk Factors for Human SLE Nephritis." Presented at Nephrology Fellows Research Conference, (January 2005)

"Erythrocyte CR1 consumption is associated with protection against SLE renal flare." Presented at HLRI Research in Progress lecture series, (January 2005)

"Erythrocyte CR1 consumption is associated with protection against SLE renal flare." Presented at HLRI Research in Progress Lecture Series, (April 2005)

"The role of complement in health and disease." Presented at OSU Internal Medicine Grand Rounds, (October 2005)

"Fluctuation in Self-Perceived Stress and Increased Risk of Flare in Patients with Lupus Nephritis Carrying the Serotonin Receptor 1A (5HT1A) -1019 G Allele." Presented at Nephrology Fellows Research Conference, (January 2006)

"Understanding the role of anti-C1q autoantibodies in lupus nephritis flare: Crossed up by cross-sectional studies." Presented at HLRI Research in Progress lecture series, (January 2007)

"The Ohio SLE Study: A study of the pathogenesis of SLE renal flare." Presented at Nephrology Fellows Research Conference, (January 2007)

"The Ohio SLE Study, form bench to bedside and back again." Presented at HLRI Research in Progress lecture series, (January 2007)

"The Ohio SLE Study: Characterizing renal flare in patients with systemic lupus erythematosus (SLE)." Presented at Comprehensive Transplant Conference, (January 2008)

"Deciphering the complex role of the complement system in the pathogenesis and prediction of lupus nephritis flare." Presented at Department of Pathology Immunology Seminar Program, (January 2009)

"Complement activation and regulation: How this balance influences SLE nephritic flare." Presented at Nephrology Fellows Research Conference, (January 2009)

"Is a declining vitamin D level a risk factor for SLE flare?" Presented at Department of Pathology Immunology Seminar Program, (January 2010)

"Identifying biomarkers of Lupus Nephritis (LN) Flare: The role of anti-C1q (and others)." Presented at Nephrology and Urology Research Affinity Group, (January 2010)
Advising

Advising

Academic Advisees

  • Nicole Reyes, The Ohio State University – T cell transcript changes during lupus nephritis flare, (2012 - present)
  • Terese Gullo, The Ohio State University College of Medicine, (2011 - present)
  • Kathryn Kitzmiller, The Ohio State University – graduated 2009. Gene copy number variation in complement factor H, (2006 - 2009)

Contact

Division of Nephrology

Andrea Wissman
Division Administrator
Andrea.Wissman@osumc.edu
Phone: 614-293-9979

Fax: 614-293-3073

Division’s office:
395 W. 12th Avenue, Ground Floor
Columbus, OH 43210

Schedule an appointment: 614-293-4997