• Abstracts

  Note: Only those in which Dr. Birmingham is principle investigator are listed.
  
  Birmingham DJ, Cosio FG: C3b binding proteins of primate erythrocytes (E). Complement and Inflam. 6:315A, 1989. Presented at the 13th International Complement Workshop, San Diego, CA.
  
  Birmingham DJ, Cosio FG: Determination of factor I cofactor function of nonhuman primate erythrocyte (E) C3b receptors. FASEB J. 4:A2188. 1990. Presented at the 1990 AAI (FASEB) Meeting, New Orleans, LA.
  
  Birmingham DJ, Cosio FG, McCourt DW, Atkinson JP. 1991. N-terminus amino acid analysis of the baboon erythrocyte C3b receptor. FASEB J. 5:A1716. 1991. Presented at the 1991 AAI (FASEB) Meeting, Atlanta, GA.
  
  Birmingham DJ, Atkinson JP: Identification of an alternatively spliced transcript of the chimpanzee type one complement receptor (CR1). J. Immunol. 150:224A. 1993. Presented at the 1993 AAI (FASEB) Meeting, Denver, CO.
  
  Birmingham DJ, Shen XP: Identification of a CR1-like transcript in the baboon bone marrow. Presented at the 1995 Experimental Biology Meeting, Atlanta, GA.
  
  Birmingham, D.J., Logar, C.M., Shen, X.P.: Baboon CR1b, a homologue of the human CR1-like element, encodes the baboon erythrocyte complement receptor. Mol. Immunol. 33:38, 1996. Presented at the 16th International Complement Workshop, Boston, MA.
  
  Logar CM, Birmingham DJ: CR1-like, a C3b binding protein of non-human primate erythrocytes, is expressed in human bone marrow. 1997 Presented at the 1997 International Society of Developmental and Comparative Immunology, Willimasburg, VA.
  
  Allred LK, Birmingham DJ: Polymorphisms of FcγRIIIa and the associated γ subunit in normals and SLE patients. Presented at the 1998 Experimental Biology Meeting (AAI).
  
  Birmingham DJ, Chen W, Shen XP: Certain mutations of CR1 segregate with normals or SLE patients with nephritis. Molecular Immunology 35:334, 1998. Presented at the 17th International Complement Workshop, Rhodes Greece.
  
  Birmingham DJ, Moulds JM, Chen W. A CR1 polymorphism associates with the B allele and with SLE patients. 1998. Presented at the 17th International Complement Workshop, Rhodes Greece.
  
  Birmingham DJ, Chen W, Shen XP, Liang G: A CR1 polymorphism associates with SLE Nephritis and Juvenile-onset IgA Nephritis. Mol Immunol 36:304, 1999, Presented at the 7th European Meeting on Complement in Human Disease-EC99, Helsinki, Finland
  
  Birmingham DJ, Liang G, Shen XP. CR1 polymorphisms associated with SLE. Immunopharmacology 49:29, 2000. Presented at the 18th International Complement Workshop, Salt Lake City, Utah.
  
  Birmingham DJ, Logar CM, Chen W. Characterization of the human CR1-like transcript. Immunopharmacology 49:11, 2000. Presented at the 18th International Complement Workshop, Salt Lake
  City, Utah.
  
  Birmingham DJ, Chen W, Liang G, Schmitt HC. A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians. 2001. Presented at the Complement Associated Diseases, Animal Models, and Therapeutics Workshop, Santorini, Greece.
  
  Logar CM, Chen W, and Birmingham DJ. Human CR1-like express a transcript in bone marrow for a C4b binding protein. Presented at the 7th International Workshop on MHC evolution and VIII Complement Genetics Workshop and Conference. October 2002, Perth, Western Australia.
  
  Birmingham DJ, Chen W, Schmitt HC, Gavit K. A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b Presented at the 7th International Workshop on MHC evolution and VIII Complement Genetics Workshop and Conference. October 2002, Perth, Western
  Australia.
  
  Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA, Birmingham DJ. Erythrocyte CR1 levels and SLE flare. Presented at the 7th International Lupus Congress, May 9-13, 2004, New York, NY.
  
  Birmingham DJ, Gavit KF, McCarty S, Yu CY, Rovin BH, Hebert, LA. Erythrocyte CR1 levels and SLE flare. Presented at the Annual American Society of Nephrology Meeting, August 14-18, 2004, New York City, NY.
  
  Gavit KF, Tong J, Nagaraja HN, Birmingham DJ. Two CR1 polymorphism in SCR 8 independently affect binding to C4b and/or C3b. Presented at the 20th International Complement Workshop, June 13-18, 2004, Honolulu, HI.
  
  Irshaid F, Yu CY, Birmingham DJ. Human fetal liver and bone marrow express a transcript that encodes the two N terminal SCRs of CR1-like. Presented at the 20th International Complement Workshop, June 13-18, 2004, Honolulu, HI.
  
  Birmingham, DJ. Gavit KF, McCarty S, Tong J, Yu CY, Rovin BH, Nagaraja HN, Hebert, LA, Consumption of erythrocyte CR1 is associated with protection against SLE renal flare. Presented at the 10th European Meeting on Complement in Human Disease, September 9-13, 2005, Heidelberg, Germany.
  
  Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Malarkey WB, Hebert LA. Fluctuation in Self-Perceived Stress Increases Risk of Flare in SLE Nephritis Patients Carrying the 5-HT1A-1019G Allele. Presented at the 2006 American Society of Nephrology, Nov 14-19, 2006, San Diego Ca
  
  Birmingham DJ, Rovin BH, Zou X, Yu CY, Tsao BP, Wu H, Nagaraja HN, Hebert LA. Multivariate Analysis of Traditional Biomarkers Identifies Markers and Forecasters of Lupus Nephritis Flare. Presented at the 8th International congress on SLE, May 23-27, 2007, Shanghai, China
  
  Bitter J, Dials S, Nagaraja HN,, Yu CY, Rovin BH, Hebert LA, Birmingham DJ.. Changes in Anti-C1q IgG Levels Neither Forecast nor Mark a Lupus Nephritis Flare. Presented at the 9th International congress on SLE. June 23-27, 2010, Vancouver BC, at the 23rd International Complement Workshop, Aug 1-5, 2010, New York NY, and at the American Society of Nephrology, Nov 16-21, Denver, Co.
  
  Birmingham DJ, Hebert LA, Song H, Nagaraja HN, Noonan WT, Rovin BH, Yu CY. Evidence that Decline in Vitamin D Status may be Mechanistically Related to SLE Flare. Presented at the 9th International congress on SLE. June 23-27, 2010, Vancouver BC, and at the American Society of Nephrology, Nov 16-21, Denver, CO.

• Chapters in Books

  Hebert LA, Cosio FG, Birmingham DJ, Sedmak DD: Circulating immune complexes. Chapter in: Immunochemistry, Carel van Oss (Ed), Marcel Dekker, New York, 1994, pp 653-680.
  
  Hebert LA, Cosio FG, Birmingham DJ: The role of complement in glomerular and vascular injury. In: Textbook of Nephrology. Massry SG, Glassock RJ (Eds), 3rd Ed, Williams and Wilkins, Baltimore, 1995, pp 659-670.
  
  Birmingham DJ. The type one complement receptor (CR1) and human SLE. Chapter in: Lupus: Cellular and
  Molecular Pathogenesis. Kammer GM, Tsokos GC, (Eds), Humana Press Inc, Totowa, NJ, 1999.
  
  Hebert LA, Cosio FG, Birmingham DJ. Complement and complement regulatory proteins in renal disease. Chapter in: Immunologic Renal Diseases. Neilson EG, Couser, WG (Eds) 2nd Ed, Lippincott-Raven, Philadelphia, 2001
  
  Yang Y, Chung EK, Lhotta K, Wu YL, Higgins GC, Rennebohm RM, Hebert LA, Birmingham DJ, Rovin BH, and Yu CY. Complement components C4A and C4B in human lupus. Chapter in Molecular Autoimmunity. Moncef Zouli (Ed). Kluwer Academic Publishers, Dordrecht, Netherlands, 2005
  
  Hauptmann G, Yu CY, Yang Y, Wu YL, Birmingham DJ, Rovin BH, and Hebert LA. Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis. In SLE Companion to
  Rheumatology, Elsevier 2005.
  
  Yu CY, Hauptmann G, Yang Y, Wu YL, Birmingham DJ, Rovin BH and Hebert LA: Complement deficiencies in human systemic lupus erythematosus (SLE) and SLE nephritis: epidemiology and pathogenesis. In: Tsokos GC, Gordon C and Smolen JS (eds) Systemic Lupus Erythematosus: a Companion to Rheumatology. Philadelphia: Elsevier, pp183-193, 2007
  
  Rovin BH, Birmingham DJ, Nadasdy T. "Renal Involvement in Systemic Lupus Erythematosus." In Diseases of the Kidney and Urinary Tract. Edited by Schrier R, Nelson E, Molitoris B, Coffman T, Falk R, 2012
  
  Rovin BH, Birmingham DJ, Nadasdy T. "Systemic Lupus Nephritis and the Kidney." In Core Concepts in Parenchymal Kidney Disease. Edited by Fervenza F, Li J, Singh AK, 2012.
  
  Birmingham DJ. "Complement Regulation in the Kidney." In Encyclopedia of Medical Immunology. Edited by MacKay I, Rose NR, 2012.

• Editorial Activities

  Editorial Service
  

  • Associate Editor, Journal of Immunology, 1999-2004  

  Ad Hoc Reviewer
  

  • Journal of Immunology                          
  • Arthritis and Rheumatism
  • Journal of the American Society of Nephrology
  • Clinical Journal of the American Society of Nephrology
  • Genes and Immunity
  • Journal of Immunological Methods
  • Kidney International
  • Arthritis Research & Therapy
  • Journal of Clinical Immunology
  • Scandinavian Journal of Immunology
  • Clinical Immunology and Immunopathology
  • Archives of Biochemistry and Biophysics
  • Trends in Molecular Medicine
  • Lupus
  • Arthritis Care & Research
  • Translational Research
  • Journal of Rheumatology

• Reference Works

  January 2010:
  

  • Birmingham DJ, Hebert LA, Song H, Nagaraja HN, Noonan WT, Rovin BH, Yu CY."Evidence that Decline in Vitamin D Status may be Mechanistically Related to SLE Flare"

  • Birmingham DJ, Shen XP."Identification of a CR1-like transcript in the baboon bone marrow"

  • Bitter J, Dials S, Nagaraja HN,, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Changes in Anti-C1q IgG Levels Neither Forecast nor Mark a Lupus Nephritis Flare" .

  January 2007:
  

  • Birmingham DJ, Rovin BH, Zou X, Yu CY, Tsao BP, Wu H, Nagaraja HN, Hebert LA."Multivariate Analysis of Traditional Biomarkers Identifies Markers and Forecasters of Lupus Nephritis Flare"

  January 2006:
  

  • Birmingham DJ, Nagaraja HN, Rovin BH, Spetie L, Zhao Y, Li X, Hackshaw KV, Malarkey WB, Hebert LA."Fluctuation in Self-Perceived Stress Increases Risk of Flare in SLE Nephritis Patients Carrying the 5-HT1A-1019G Allele"

  January 2005:
  

  • Birmingham, DJ. Gavit KF, McCarty S, Tong J, Yu CY, Rovin BH, Nagaraja HN, Hebert, LA."Consumption of erythrocyte CR1 is associated with protection against SLE renal flare"

  January 2004:
  

  • Irshaid F, Yu CY, Birmingham DJ."Human fetal liver and bone marrow express a transcript that encodes the two N terminal SCRs of CR1-like"

  • Gavit KF, Nagaraja HN, Yu CY, Rovin BH, Hebert LA, Birmingham DJ."Erythrocyte CR1 levels and SLE flare"

  • Gavit KF, Tong J, Nagaraja HN, Birmingham DJ."Two CR1 polymorphism in SCR 8 independently affect binding to C4b and/or C3b"

  • Birmingham DJ, Gavit KF, McCarty S, Yu CY, Rovin BH, Hebert, LA."Erythrocyte CR1 levels and SLE flare"

  January 2002:
  

  • Birmingham DJ, Chen W, Schmitt HC, Gavit K."A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b"

  • Logar CM, Chen W, and Birmingham DJ."Human CR1-like express a transcript in bone marrow for a C4b binding protein"

  January 2001:
  

  • Birmingham DJ, Chen W, Liang G, Schmitt HC."A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians"

  January 2000:
  

  • Birmingham DJ, Liang G, Shen XP."CR1 polymorphisms associated with SLE" . : 29

  • Birmingham DJ, Logar CM, Chen W."Characterization of the human CR1-like transcript" . : 11

  January 1999:
  

  • Birmingham DJ, Chen W, Shen XP, Liang G."A CR1 polymorphism associates with SLE Nephritis and Juvenile-onset IgA Nephritis" . : 304

  January 1998:
  

  • Allred LK, Birmingham DJ."Polymorphisms of FcRIIIa and the associated  subunit in normals and SLE patients"

  • Birmingham DJ, Chen W, Shen XP."Certain mutations of CR1 segregate with normals or SLE patients with nephritis"

  January 1997:
  

  • Birmingham DJ, Moulds JM, Chen W."A CR1 polymorphism associates with the B allele and with SLE patients"

  • Logar CM, Birmingham DJ."CR1-like, a C3b binding protein of non-human primate erythrocytes, is expressed in human bone marrow"

  January 1996:
  

  • Birmingham, D.J., Logar, C.M., Shen, X.P."Baboon CR1b, a homologue of the human CR1-like element, encodes the baboon erythrocyte complement receptor"

  January 1993:
  

  • Birmingham DJ, Atkinson JP."Identification of an alternatively spliced transcript of the chimpanzee type one complement receptor (CR1)" . : 224A

  January 1991:
  

  • Birmingham DJ, Cosio FG, McCourt DW, Atkinson JP."N-terminus amino acid analysis of the baboon erythrocyte C3b receptor" . : A1716

  January 1990:
  

  • Birmingham DJ, Cosio FG."Determination of factor I cofactor function of nonhuman primate erythrocyte (E) C3b receptors" . : A2188

  January 1989:
  

  • Birmingham DJ, Cosio FG."C3b binding proteins of primate erythrocytes (E)" . : 315A

• Presentations

  Ohio State

  
  Presentations (~ 3/yr) at the Nephrology Research Conference series. 1991-present
  
  Yearly presentations at the College of Medicine/Pathology Immunobiology Seminar Program. 1994-2005
  
  “The Complement System”. Presented at the Nephrology Fellows Research Conference, January 3rd, 2001
  
  “The physiology of immune adherence”. Presented at the HLRI lecture series. May 2, 2001
  
  “The Ohio SLE Study”. Presented at the OSU Internal Medicine Grand Rounds. August 23, 2001
  
  “Is FcgRIIIa pro- or anti-inflammatory? Deciphering its true role in human immune complex disease”. Presented at the HLRI Research in Progress lecture series. October 3, 2001
  
  “Update on CR1 and SLE”. Presented at the SLE seminar series, February 22nd, 2002
  
  “Genetic variation of immune complex receptors: Does it play a role in immune complex disease?”. Presented to the Department of Statistics research group, April 16th, 2002.
  
  “CR1L, a new member of the Regulators of Complement Activation (RCA) gene cluster”. Presented at the HLRI Research in Progress lecture series. February 7th, 2003.
  
  “Complement and kidney disease”. Presented at the Nephrology Fellows Reunion conference, September 26, 2003.
  
  Stats?
  
  “Where there's smoke...Pursuing a novel complement receptor”. Present at the Department of Pathology Immunology Seminar Program, September 28th, 2004.
  
  “Erythrocyte CR1 consumption is associated with protection against SLE renal flare”. Presented at the HLRI Research in Progress lecture series, April 15th, 2005.
  
  “Genetic and Clinical Risk Factors for Human SLE Nephritis”. Presented at the Nephrology Fellows Research Conference, July 29th, 2005
  
  “The role of complement in health and disease”. Presented at OSU Internal Medicine Grand Rounds. October 27th, 2005.
  
  “Fluctuation in Self-Perceived Stress and Increased Risk of Flare in Patients with Lupus Nephritis Carrying the Serotonin Receptor 1A (5HT1A) -1019 G Allele”. Presented at the Nephrology Fellows Research Conference, July 28th, 2006.
  
  “The Ohio SLE Study, form bench to bedside and back again”. Presented at the HLRI Research in Progress lecture series, June 29th, 2007.
  
  The Ohio SLE Study: A study of the pathogenesis of SLE renal flare”. Presented at the Nephrology Fellows Research Conference, September 7th, 2007.
  
  “The Ohio SLE Study: Characterizing renal flare in patients with systemic lupus erythematosus (SLE)”. Presented at the Comprehensive Transplant Conference, April 16th, 2008
  
  “Deciphering the complex role of the complement system in the pathogenesis and prediction of lupus nephritis flare”. Present at the Department of Pathology Immunology Seminar Program, January 27, 2009
  
  “Complement activation and regulation: How this balance influences SLE nephritic flare”. Presented at the Nephrology Fellows Research Conference, March 6th, 2009.
  
  “Is a declining vitamin D level a risk factor for SLE flare?”. Present at the Department of Pathology Immunology Seminar Program, April 23rd, 2010.
  
  “Understanding the role of anti-C1q autoantibodies in lupus nephritis flare: Crossed up by cross-sectional studies”. Presented at the HLRI Research in Progress lecture series, August 13th, 2010.
  
  “Autoantibodies to complement in lupus nephritis (LN) and its flares”. Presented at the Everett D. Reese Immunology and Rheumatology Research Seminar Series, April 20th, 2011.
  
  “Anti-C3b autoantibodies define the role of anti-C1q autoantibodies as a biomarker of lupus nephritis flare” Presented at the Nephrology Fellows Research Conference, October 21st, 2011.
  
  “T cell transcripts in Lupus Nephritis Flare”. Presented at the Nephrology Fellows Research Conference, April 6th, 2012.
  
  “Interrogating 30 different urine analytes as biomarkers of lupus nephritis flare”. Presented at the Nephrology Fellows Research Conference, May 24th, 2013.
  
  “Changing complement phenotypes during lupus nephritis flare: The OSS experience” Presented at the Ohio State University Reese Seminar Series, September 13, 2016.
  
  

  Other academic institutions

  
  "Effect of erythropoiesis on circulating levels of erythrocyte complement receptors". Presented at the Washington University Complement Seminar Series, Washington University, St Louis MO, May 10, 1991
  
  “CR1 isoforms expressed in primates". Presented at the Cincinnati Complement Club, March 26, 1992
  
  “Immune complex receptor polymorphisms in SLE and SLE nephritis”. Presented at the MCP Hahnemann University School of Medicine the Dept. of Microbiology & Immunology Seminar Series, Philadelphia, PA, January 31, 2001
  
  “A CR1 polymorphism exhibits enhanced binding to C4b which may contribute to protection against SLE in Caucasians”. Presented at the International Meeting on Complement Associated Diseases, Animal Models, and Therapeutics, Santorini Greece, October 14th, 2001
  
  “Primate immune adherence receptors”. Presented at the 7th International Workshop On MHC, Evolution, and Complement Genetics Workshop, Perth, Western Australia, October 2002
  
  “A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b”. Presented at the 7th International Workshop On MHC, Evolution, and Complement Genetics Workshop, Perth, Western Australia, October 2002
  
  “The Ohio SLE Study”. Presented to the Ohio Arthritis Consortium, Columbus, OH, September 22, 2003
  
  “Identifying biomarkers of Lupus Nephritis (LN) Flare: The role of anti-C1q (and others). :Presented to Nephrology and Urology Research Affinity Group, Nationwide Children’s Hospital, Columbus, OH, May 19, 2010
  

Advising

• Academic Advisees

  • Dissertation advisor: Laura Allred, PhD, Pathology, 2001
  • Dissertation advisor: Fawzi Irshaid, MCDB, 2005
  • Dissertation Committee member: Kristi Rupert, OSBP, 1999
  • Dissertation Committee member: Craig A. McClure, molecular Genetics (University of. Australia), 2005
  • Dissertation Committee member: Kathryn Kitzmiller, IBGP, 2009
  • Dissertation Committee member: Ashley Carpenter, IBGP, 2016
  • Lab mentor, Chris Logar, Medical Student, recipient of the Bertha Bouroncle Research Award, 1996
  • Lab mentor, Katie Gavit, Masters of Epidemiology, 2002 - 2004
  • Lab mentor, Scott McCarty, undergraduate student, 2003 - 2005
  • Lab mentor, Kate Sasser, IBGP lab rotation, 2004
  • Lab mentor, Mahvish Ahmed, undergraduate student, 2005 - 2006 
  • Lab mentor, Ruo-Qi Hu, Nephrology Fellow, 2006
  • Lab mentor, Sarah Dials, undergraduate student (Otterbein biology honors project), 2008
  • Lab mentor, Josh Bitter, Nephrology Fellow, 2009
  • Lab mentor, Sanya Dosani, undergraduate student, 2009 - 2010
  • Lab mentor, Ezinne Nduke, undergraduate student, 2010 - 2011
  • Lab mentor, Terese Gullo, undergraduate student, 2012 - 2013
  • Lab mentor, Nicole Reyes, undergraduate student, 2012 - 2013
  • Lab mentor, Maria Khan, Nephrology Fellow, 2013-2014
  • Lab mentor, Salem Almaani, Nephrology Fellow, 2015-2016