Farkas2Associate Professor of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine

473 W. 12th Avenue
Columbus, OH 43210

My research interest is the pathobiology of pulmonary vascular diseases, particular class I and class III pulmonary hypertension. The focus in my lab is on innate immunity signaling, inflammation and endothelial progenitor cell biology. The particular emphasis is on dysregulated recognition of ribonucleic acids and Toll-like receptor 3 signaling in the pulmonary endothelium, as well as the role of primitive endothelial cell clones in the pulmonary vasculature and in pulmonary hypertension. In addition, we are interested in vascular regeneration in the lung tissue. The goal of the translational research program is to develop novel therapies for pulmonary vascular disease based on new targets that we identify in our work.

Education:

Postdoctoral Research: Virginia Commonwealth University, McMaster University/Firestone Institute for Respiratory Health
Residency training: University Hospital, University of Regensburg, Department of Internal Medicine II
MD: Medical School and Doctoral Thesis (MD/PhD equivalent education) - University of Regensburg

Previous appointments:

  • Assistant Professor of Medicine, Virginia Commonwealth University
  • Instructor of Medicine, Virginia Commonwealth University

Honors and Awards:

Sir John Vane Award for Innovation in pulmonary vascular research related to pulmonary hypertension ERS 2010
The Cell & Molecular Biology Young Investigator Award ERS 2008

Research Interests: 

Endothelial cell and endothelial progenitor cell biology in pulmonary hypertension, innate immunity, focus on RNA recognition

Mechanisms of angiogenesis and vascular regeneration


Relevant Publications:

  • Bhagwani, A.R, Hultman, S., Farkas, D., Moncayo, R., Dandamudi, K., Zadu, A., Cool, C.D., Farkas, L. (2019) Endothelial cells are a source of Nestin expression in Pulmonary Arterial Hypertension. PLoS One 14(3):e0213890. PMID: 30883593 PMCID: PMC6422269
  • Farkas, D., Thompson, A.A.R., Bhagwani, A.R., Hultman, S., Ji, H., Kotha, N., Farr, G., Arnold, N.D., Braithwaite, A., Casbolt, H., Cole, J.E., Sabroe, I., Monaco, C., Cool, C.D., Goncharova, E.A., Lawrie, A., Farkas, L. (2019) Toll-like receptor 3 is a therapeutic target for Pulmonary Hypertension. Am J Respir Crit Care Med 199(2):199-210. PMID: 30211629 PMCID: PMC6353001.
  • Grinnan, D., Farkas, L. (2019) A novel peptide for immunomodulation in pulmonary arterial hypertension. Am J Respir Crit Care Med 2019; doi: 10.1164/rccm.201902-0388ED. [Epub ahead of print]. PMID: 30973752
  • Farkas, L., Kolb, MRJ. (2018) A switch in TGF-β signaling explains contradictory findings in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med 2018;197(2):157-159. PMID: 29096067
  • Farkas, D., Kraskauskas, D., Drake, J.I., Alhussaini, A.A., Kraskauskiene, V., Bogaard, H.J., Cool, C.D., Voelkel, N.F., Farkas, L. (2014) CXCR4 Inhibition Ameliorates Severe Obliterative Pulmonary Hypertension and Accumulation of C-kit+ Cells in Rats. PLos One 9(2): e89810. Pubmed PMID: 24587052. Pubmed Central PMCID: PMC3933653
  • Farkas, D., Alhussaini, A.A., Kraskauskas, D., Kraskauskiene, V., Cool, C.D., Nicolls, M.R., Natarajan, R., Farkas, L. (2014) NF-κB inhibition reduces lung vascular lumen obliteration in severe pulmonary hypertension in rats. Am J Respir Cell Mol Biol 51(3):413-25. Pubmed PMID: 24684441. Pubmed Central PMCID: PMC4189489
  • Nold-Petry, C.A., Rudloff, I., Baumer, Y., Cho, S.X., Zepp, J.A., Dinkel, H., Palmer, B.E., Azam, T., Ruvo, M., Marasco, D., Botti, P., Farkas, L., Boisvert, W.A., Cool, C.D., Kim, S.H., Taraseviciene-Stewart, L., Dinarello, C., Voelkel, N.F., Nold, M.F. (2014) IL- 32 Promotes Angiogenesis. J Immunol 192(2): 589-602. Pubmed PMID: 24337385
  • Tian, W., Jian, X., Tamosiuniene, R., Sung, Y.K., Qian, J., Dhillon, G., Gera, L., Farkas, L., Rabinovitch, M., Zamanian, R., Inayathullah, M., Fridlib, M., Rajadas, J., Peters-Golden, M., Voelkel, N.F., Nicolls, M.R. (2013) Blocking macrophage leukotriene B4 prevents endothelial injury and reverses pulmonary hypertension. Sci Transl Med 5: 200ra117. Pubmed PMID: 23986401
  • Farkas, L., Farkas, D., Gauldie, J., Warburton, D., Shi, W., Kolb, M. (2011) Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. Am J Respir Cell Mol Biol, 44: 870-878. Pubmed PMID: 20705941; Pubmed Central PMCID: PMC3135847
  • Farkas, L., Farkas, D., Warburton, D., Gauldie, J., Shi, W., Stampfli, M.R., Voelkel, N.F., Kolb, M. (2011) Cigarette smoke exposure accelerates airspace enlargement and alveolar cell apoptosis in Smad3 knockout mice. Am J Physiol Lung Cell Mol Physiol 301: L391-L401. Pubmed PMID: 21743024
  • Moeller, A., Gilpin, S.E., Ask, K., Cox, G., Cook, D.J., Gauldie, J., Margetts, P.J., Farkas, L., Dobranowski, J., Boylan, C., O'Byrne, P.M., Strieter, R.M., Kolb, M.R.J. (2009). Circulating Fibrocytes Are an Indicator for Poor Prognosis in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med, 179(7): 588-594. Pubmed PMID: 19151190
  • Farkas, L., Farkas, D., Ask, K., Möller, A., Gauldie, J., Margetts, P., Inman, M., Kolb, M. (2009). VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats. J Clin Invest, 119(5): 1298- 1311. Pubmed PMID: 19381013; Pubmed Central PMCID: PMC2673845.

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