Clinical, translational and basic science research

Research holds a place of prominence in the Department of Internal Medicine. In keeping with the overall mission of The Ohio State University Wexner Medical Center to “improve patients’ lives through research,” the department has a committed faculty of clinical, translational and basic scientists working to discover breakthroughs to end human suffering.

Research programs here encompass understanding basic mechanisms of gene and protein dysregulation that result in disease, through translational projects that endeavor to develop new diagnostics and therapeutics for disease intervention, to clinical trials of new medications in patient populations. In all types of scientific inquiry, the research is patient-centered.

Research

Our Research Faculty

Our Research Faculty

Researcher
Clinical trials by principal investigator

Clinical trials by principal investigator

The Division of Rheumatology-Immunology faculty participates in many clinical research trials.  Our research involves studies on Systemic Lupus Erythematosis (SLE), Vasculitis, Rheumatoid Arthritis, Osteoarthritis, Gout, Scleroderma and others. For more information and to register for one of our trials visit studysearch.osumc.edu or clinicaltrials.gov.

Dr. Wael Jarjour

To participate in a clinical trial conducted by Dr. Wael Jarjour, contact Holly Steigelman at 614-685-6987.

The Ohio State University Rheumatology and Immunology Biorepository

This study is being done to provide resources for future studies involving rheumatic disorders. The samples and data collected will be stored and used in the future to learn more about rheumatic and autoimmune disorders.

Sponsor: The Ohio State University Department of Rheumatology

Stress Moderation Impacting Lupus with Exercise (SMILE)

This study is being done to see if completing a Tai chi program (combining moderate exercise and stress reduction) can help patients with lupus. Originally developed for self-defense, Tai chi has evolved into a graceful form of exercise. It is used for stress reduction and a variety of health conditions. This form of exercise is often described as meditation in motion since it promotes serenity through gentle, flowing movements.

Sponsor: The OSU Center for Integrative Health and Wellness, Division of Immunology and Rheumatology, and Rheumatology Research Foundation (RRF)

Biomarkers in Autoimmune Disease

This study is being done to identify markers in the blood of patients with inflammatory diseases, individuals with degenerative arthritis and healthy volunteers.

Sponsor: Department of Rheumatology

Biomarkers in Synovial Fluid

This study is being done to identify markers in synovial fluid, synovial tissue (fluid/tissue in the joints) and other tissue and blood to measure disease activity of patients who are being treated for arthritic conditions with hopes to find new targets for treatment.

Sponsor: Department of Rheumatology

Multi-Source Examinations of Biomarkers in Autoimmune Diseases

This study is being done to learn more about biological markers in people with autoimmune disorders and in healthy volunteers. These studies can help us to understand more about autoimmune diseases.

Sponsor: Department of Rheumatology

Estrogen Effects in Autoimmunity

Sponsor: Department of Rheumatology

Alexa Meara, MD

To participate in a clinical trial conducted by Alexa Meara, MD, contact Holly Steigelman at 614-685-6987.

Assessing Disease Comprehension in Patients with Lupus

The goal of this study is to assess the understanding that people with lupus have about their disease.

Sponsor: The Ohio State University

Assessing Healthy Friends and Family of Patients with Lupus

The goal of this study is to assess the educational skill set of healthy individuals by measuring health literacy, numeracy and patient activation.

Sponsor: The Ohio State University Wexner Medical Center

Safety and Efficacy of GDC-0853 in Patients with Lupus Erythematosus

GA30044 A Phase II, randomized-double blind, placebo-controlled study of the safety and efficacy of GDC-0853 in patients with moderate to severe active systemic lupus erythematosus.

Sponsor: Genetech

Treatment of Systemic Lupus Erythematosus (SLE) with N-acetylcysteine (NAC)

Sponsor: State University of New York

Ali Ajam, MD

To participate in a clinical trial conducted by Ali Ajam, MD, contact Holly Steigelman at 614-685-6987.

Scleroderma Registry

The purpose of the Ohio State Scleroderma Registry is to collect data, blood and skin biopsies from people with scleroderma. This study is being done to help researchers who are involved in the diagnosis and treatment of this medical condition to better understand the disease and its management, including the long term safety and effectiveness of various treatments. Your samples will be used for future research on scleroderma.

Sponsor: Division of Rheumatology and Immunology

The Safety and Effectiveness of the VaricElla zosteR Vaccine (VERVE) in Anti-TNF Users

Sponsor: UAB

Kevin Hackshaw, MD

To participate in a clinical trial conducted by Kevin Hackshaw, MD, contact Kelly Morris at 614-685-8068.

Spectrophotometric Fingerprint for Central Sensitivity Syndromes

The purpose of this study is to help improve our ability to diagnose chronic pain syndromes for which no diagnostic biomarker is available. A diagnostic biomarker is a test that can predict or determine whether someone is affected by a particular condition.

Sponsor: Department of Rheumatology

CLIP-OA

Sponsor: National Institute of Health and OSU College of Human Education

Stacy Ardoin, MD

To participate in a clinical trial conducted by Stacy Ardoin, MD, contact Kelly Morris at 614-685-8068.

Lupus, Vasculitis and Glomerulonephritis (LVG) Registry

The purpose of this registry is to collect medical information (data), blood, saliva and urine specimens and follow outcomes on persons with lupus, vasculitis or glomerulonephritis. This study is being done to help researchers who are involved in the diagnosis and treatment of these medical conditions to better understand these diseases and their management, including the longterm safety and effectiveness of various treatments. Your samples and data will be used for future research on lupus, vasculitis and glomerulonephritis.

Sponsor: Division of Rheumatology and Immunology

Zhanna Mikulik, MD and Sheryl Mascarenhas, MD

To participate in a clinical trial conducted by Zhanna Mikulik, MD, and Sheryl Mascarenhas, MD, contact Holly Steigelman at 614-685-6987 or Kelly Morris at 614-685-8068.

RADIANCE

A randomized, double-blind, multicenter, three-stage, efficacy and safety study of NI-071 and Remicade (Inflizimab) for the treatment of patients with rheumatoid arthritis.

Sponsor: Nichi-Iko

Contact

Holly Steigelman, CCRP, MACPR
Lead Clinical Research Coordinator
Holly.Steigelman@osumc.edu
614-685-6987

Kelly Morris
Clinical Research Assistant
Kelly.Morris@osumc.edu
614-685-6068