Clinical, translational and basic science research

Research holds a place of prominence in the Department of Internal Medicine. In keeping with the overall mission of The Ohio State University Wexner Medical Center to “improve patients’ lives through research,” the department has a committed faculty of clinical, translational and basic scientists working to discover breakthroughs to end human suffering.

Research programs here encompass understanding basic mechanisms of gene and protein dysregulation that result in disease, through translational projects that endeavor to develop new diagnostics and therapeutics for disease intervention, to clinical trials of new medications in patient populations. In all types of scientific inquiry, the research is patient-centered.

Research

Our Research Faculty

Our Research Faculty

Researcher
Clinical trials by principal investigator

Clinical trials by principal investigator

The Division of Rheumatology-Immunology faculty participates in many clinical research trials.  Our research involves studies on Systemic Lupus Erythematosis (SLE), Vasculitis, Rheumatoid Arthritis, Osteoarthritis, Gout, Scleroderma and others. For more information and to register for one of our trials visit studysearch.osumc.edu or clinicaltrials.gov.

Dr. Wael Jarjour

To participate in a clinical trial conducted by Dr. Wael Jarjour, contact Joseph Miller at 614-685-6987.

The Ohio State University Rheumatology and Immunology Biorepository

This study is being done to provide resources for future studies involving rheumatic disorders. The samples and data collected will be stored and used in the future to learn more about rheumatic and autoimmune disorders.

Sponsor: The Ohio State University Department of Rheumatology

Stress Moderation Impacting Lupus with Exercise (SMILE) Using Tai Chi to explore the effects of daily moderate exercise and stress reduction in patients with systemic lupus erythematosus

This study is being done to see if completing a Tai chi program (combining moderate exercise and stress reduction) can help patients with lupus. Originally developed for self-defense, Tai chi has evolved into a graceful form of exercise. It is used for stress reduction and a variety of health conditions. This form of exercise is often described as meditation in motion since it promotes serenity through gentle, flowing movements.

Sponsor: The OSU Center for Integrative Health and Wellness, Division of Immunology and Rheumatology, and Rheumatology Research Foundation (RRF)

Biomarkers in Autoimmune Disease

This study is being done to identify markers in the blood of patients with inflammatory diseases, individuals with degenerative arthritis and healthy volunteers.

Sponsor: Department of Rheumatology

Biomarkers in Synovial Fluid

This study is being done to identify markers in synovial fluid, synovial tissue (fluid/tissue in the joints) and other tissue and blood to measure disease activity of patients who are being treated for arthritic conditions with hopes to find new targets for treatment.

Sponsor: Department of Rheumatology

Multi-Source Examinations of Biomarkers in Autoimmune Diseases

This study is being done to learn more about biological markers in people with autoimmune disorders and in healthy volunteers. These studies can help us to understand more about autoimmune diseases.

Sponsor: Department of Rheumatology

Estrogen Effects in Autoimmunity

Sponsor: Department of Rheumatology

Alexa Meara, MD

To participate in a clinical trial conducted by Alexa Meara, MD, contact Hilary Kleppel at 614-688-6296 or Emily Sullivan at 614-685-8799.

Assessing Disease Comprehension in Patients with Lupus

The goal of this study is to assess the understanding that people with lupus have about their disease.

Sponsor: The Ohio State University

INFLARX

A Phase II Randomized, controlled, double-blind, multi-center study of InflaRX for ANCA-associated vasculitis (AAV) patients 

Sponsor: InflaRx GmbH

 

The Impact of Arthritis Power on RA Shared Decision Making

This study is being done to try to improve shared decision making between patients and their physicians regarding treatment options. 
Sponsor: Mayo Clinic
 

Treatment of Systemic Lupus Erythematosus (SLE) with N-acetylcysteine (NAC)

Sponsor: State University of New York

Understanding Subglottic Stenosis and the Diseases that Cause it

This study is being done to help researchers better understand the progression of subglottic stenosis in patients with ANCA vasculitis and what factors may cause this development.

Ali Ajam, MD

To participate in a clinical trial conducted by Ali Ajam, MD, contact Joseph Miller at 614-685-6987.

Scleroderma Registry

The purpose of the Ohio State Scleroderma Registry is to collect data, blood and skin biopsies from people with scleroderma. This study is being done to help researchers who are involved in the diagnosis and treatment of this medical condition to better understand the disease and its management, including the long term safety and effectiveness of various treatments. Your samples will be used for future research on scleroderma.

Sponsor: Division of Rheumatology and Immunology

Kevin Hackshaw, MD

To participate in a clinical trial conducted by Kevin Hackshaw, MD, contact Joseph Miller at 614-685-6987.

Spectrophotometric Fingerprint for Central Sensitivity Syndromes

The purpose of this study is to help improve our ability to diagnose chronic pain syndromes for which no diagnostic biomarker is available. A diagnostic biomarker is a test that can predict or determine whether someone is affected by a particular condition.

Sponsor: Department of Rheumatology

CLIP-OA

Sponsor: National Institute of Health and OSU College of Human Education

Stacy Ardoin, MD

To participate in a clinical trial conducted by Stacy Ardoin, MD, contact Hilary Kleppel at 614-688-6296.

Lupus, Vasculitis and Glomerulonephritis (LVG) registry

This study is being done to collect information and to follow outcomes on individuals with Lupus, Vasculitis and Glomerulonephritis. Samples and data collected in this registry will be used on future research to help researchers better understand the diagnosis, management, and treatment and of these diseases.

Sponsor: Division of Rheumatology and Immunology

Zhanna Mikulik, MD

To participate in a clinical trial conducted by Zhanna Mikulik, MD, contact Emily Sullivan at 614-685-8799.

SABLE

A 5-Year Prospective Observational Registry to Assess Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated with or without BENLYSTA™.
Sponsor: Human Genome Sciences