Research Division, Associate Professor

Mohamed Abdel Rahman400 W 12th Ave, Room 202 Wiseman Hall
Columbus, OH, 43210, USA

Office: (614) 292-1396, 
Lab: (614) 292-0709, 
Fax: (614) 247-7153
Mohamed.Abdel-Rahman@osumc.edu

Dr. Abdel-Rahman is a research faculty member specializing in pathology, clinical genetics and molecular genetics. His research interests include molecular diagnosis of ocular melanoma, identifying novel targets for therapy of ocular melanoma and study hereditary predisposition to ocular melanoma and other cancers.

Dr. Abdel-Rahman has an adjunct appointment at the division of human genetics. He is working with Medical and Ocular oncology colleagues to develop a clinical trial for management of uveal melanoma patients with high-risk for systemic metastasis. Additionally, he teaches Ophthalmic Pathology for ophthalmology residents.

Research Interests: Uveal melanomas, Ocular genetics, Clinical cancer genetics, Ocular Pathology

Education and Training:

MB BCh (MD): Cairo University, Cairo, Egypt
PhD: The Ohio State University in Columbus, OH
Pathology Residency: Theodore Bilharz Research Institute in Giza, Egypt
Pathology Residency: Faculty of Medicine, Menoufiya University in Egypt
Pathology Fellowship: National Liver Institute, Menoufiya University, Egypt
Cancer Genetics Post-Doctoral Fellowship: University of Texas in Houston, TX
Ophthalmic Pathology Fellowship: The Ohio State University in Columbus, OH
Clinical Cancer Genetics Fellowship: The Ohio State University in Columbus, OH

Society Memberships:

2000-present The American Society of Human Genetics
2002-present American Association for Cancer Research
2007-present Egyptian Society of Pathology
2003- present Association for Research in Vision and Ophthalmology
2013-present International Liver Cancer Association

Honors and Awards:

07/00-09/00 Loes Jones Endowment for cancer research fellowship award Comprehensive Cancer Center, the Ohio State University
05/01 Travel fellowship from the 10th International Congress of Human Genetics, Vienna, Austria
10/10 Junior Investigator Award, Ocular Melanoma Foundation
02/11 Junior Investigator Award, American Cancer Society

Published Articles in Peer Reviewed Journals

Rush LJ, Heinonen K, Mrózek K, Wolf BJ, Abdel-Rahman M, Szymanska J, Peltomäki P, Kapadia F, Bloomfield CD, Caligiuri M and Plass C. Comprehensive cytogenetic and molecular genetic characterization of the TI-1 acute myeloid leukemia cell line reveals cross-contamination with K-562 cell line. BLOOD, 2002; 99, 5: 1874- 1876

Orosz KE, Gupta S, Hassink M, Abdel-Rahman M, Moldovan L, Davidorf FH, Moldovan NI. Delivery of antiangiogenic and antioxidant drugs of ophthalmic interest through a nanoporous inorganic filter. Mol Vis. 2004 Aug 18;10:555-65.

Abdel-Rahman MH, Craig EL, Davidorf FH, Eng C. Expression of vascular endothelial growth factor in uveal melanoma is independent of 6p21-region copy number. Clin Cancer Res. 2005 Jan 1;11(1):73-8. 

Abdel-Rahman MH, Yang Y, Craig EL, Davidorf FH, and Eng C. High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma, Journal of Clinical Oncology, 2006 Jan 10;24(2) 288-95.

Abdel-rahman MH. PIK3C2B is a candidate oncogene in breast cancers with gains and amplification of chromosome 1q32.1 region. Benha Medical Journal, 2006; 23, 2: 375-90.

Abdel-Rahman MH. Chromogenic in-situ hybridization (CISH) as a potential economic tool in diagnostic pathology. Benha Medical Journal, 2007; 24, 1: 281-93.

Abbas OM, Abdel-Rahman MH, Omar NA, Badran HM, Amir EM.Interleukin-10 promoter polymorphisms in hepatitis C patients with and without Schistosoma mansoni co-infection.Liver Int. 2009;29(9):1422-30.

Abdel-Rahman MH, Boru G, Massengill JB, Salem MM, Davidorf FH. MET oncogene inhibition as a potential target for therapy of uveal melanomas. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3333-9. Epub 2010 Feb 17.

Abdel-Rahman MH, Pilarski R, Ezzat S, Sexton J, Davidorf FH. Cancer family history characterization in an unselected cohort of 121 patients with uveal melanoma. Fam Cancer. 2010 Sep;9(3):431-8.

Abdel-Rahman MH, Yang Y, Salem MM, Meadows S, Massengill B, Li P-K, Davidorf FH. Investigation of the potential utility of a linomide analogue for treatment of choroidal neovascularization. Exp Eye Res. 2010 Dec;91(6):837-43. Epub 2010 Nov 3.

Abdel-Rahman MH, Pilarski R. Hereditary predisposition rather than environmental factor are likely to explain the familial link between uveal melanoma and other cancers. Fam Cancer. 2010 Dec;9(4): 661-2. 12. Abdel-Rahman MH, Pilarski R, Massengill J, Christopher B, Davidorf FH. Lack of GNAQ germline mutations in uveal melanoma patients with high risk for hereditary cancer predisposition. Fam Cancer. 2011 Jun;10(2):319-21.

Abdel-Rahman MH, Pilarski R, Massengill J, Christopher B, Noss R, Davidorf FH. Melanoma Candidate Genes CDKN2A/p16/INK4A, p14ARF and CDK4 sequencing in uveal melanoma patients with relative high-risk for hereditary cancer predisposition Melanoma Res. 2011 Jun;21(3):175-9.

Abdel-Rahman MH, Christopher B, Faramawi M, Said-Ahmed K, Cole C, McFaddin A, Ray-Chaudhury A, Heerema N, Davidorf FH. Frequency, Molecular Pathology and Clinical Significance of Partial Chromosome 3 Alterations in Uveal Melanoma. Mod Pathol. 2011 Jul;24(7):954-62. (Epub 2011 Apr 15)

Olson MC, Collins, ABD, Chaudhury AR, Abdel-Rahman MH and Katz SE. Pyogenic Granuloma Presenting as an Orbital Mass. Orbit. 2011 Dec;30(6):305-7. Epub 2011 Oct

Abdel-Rahman MH, Pilarski R, Cebulla CM, Massengill JB, Christopher B, Boru G, Hovland P, Davidorf FH. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma and other cancers. J Med Genet. 2011 Dec;48(12):856-9. Epub 2011 Sep 22.

Christopher B, Cebulla CM, Wakely Jr. PE, Davidorf FH , Abdel-Rahman MH. Molecular Genetic Testing of Uveal Melanoma from Routinely Processed and Stained Cytology Specimens. Exp Eye Res, 2011 Nov;93(5):720-5. Epub 2011 Sep 17.

Salem MM, Davidorf FH, Abdel-Rahman MH. In vitro anti-uveal melanoma activity of phenolic compounds from the Egyptian medicinal plant Acacia nilotica. Fitoterapia. 2011 Dec;82(8):1279-84. Epub 2011 Aug 28.

Abdel-Rahman. MH, Cebulla. CM, Verma. V, Carson WE III, Olencki T, Davidorf FH. Monosomy 3 status of uveal melanoma metastases is associated with rapidly progressive tumors and short survival. Exp Eye Res. 2012 Jul;100:26-31

Buzzacco DM, Abdel-Rahman MH, Park S, Davidorf F, Olencki T, Cebulla CM. Long-Term Survivors with Metastatic Uveal Melanoma. The Open Ophthalmology Journal, 2012, 6, 54-58

Clark SA, Lubow M,Ray-Chaudhury A, Davidorf FH, Abdel-Rahman MH, Cebulla CM. Optic Disc Edema From Remote Uveal Melanoma. JAMA Ophthalmol. 2013;131(1):115-117.

Cebulla CM, Davidorf FH, Abdel-Rahman MH. Editorial: Uveal melanoma: Beyond a BAPtism. JSM Ophthalmology.JSM Ophthalmology, 2013, 1: 1008-9.

Martorano LM., Winkelmann RR, Cebulla CM, Abdel-Rahman MH and Campbell SM. Ocular melanoma and the BAP1 hereditary cancer syndrome: Implications for
the dermatologist. Int J Dermatol. 2014 Apr 2. doi: 10.1111/ijd.12386. [Epub ahead of print]

Pilarski R, Cebulla CM, Massengill JB, Rai K, Rich T, Strong L, McGillivray B, Asrat M-J, Davidorf FH, Abdel-Rahman MH. Expanding the clinical phenotype of hereditary BAP1 cancer predisposition syndrome, reporting three new cases. Genes Chromosomes and Cancer, 2014 Feb;53(2):177-82.

Kim P, Abdel-Rahman MH, Wang T, Pouly S, Mahmoud AM, CebullaCM. Retinal MMP-12, MMP-13, TIMP-1, and TIMP-2 Expression In Murine Experimental Retinal Detachment. Invest Ophthalmol Vis Sci. 2014 Apr 3;55(4):2031-40.

Abdel-Rahman MH, Agour AA, El-Azab DS.Tissue microarray as a research tool to study non-neoplastic liver diseases. Egyptian Liver Journal 4 (3), 69-74

Cebulla CM, Binkley EM, Pilarski R, Massengill JB, Rai K, Liebner DA, Marino MJ, Singh AD, Abdel-Rahman MH. Analysis of BAP1 germline gene mutation in young uveal melanoma patients Ophthalmic Genet. 2015 Jun;36(2):126-31.

Rai K, Pilarski R, Cebulla CM, Abdel-Rahman MH. Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases. Clin Genet. 2015 Jun 22. doi: 10.1111/cge.12630.

Abdel-Rahman MH, Rai K, Pilarski R, Davidorf FH, Cebulla CM. Germline BAP1mutations misreported as somatic based on tumor-only testing. Fam Cancer. 2016 Jan 9. [Epub ahead of print] PubMed PMID: 26748926.

Selected Abstracts and Presentations at International Conferences

Christopher B, Cebulla CM, Wakely Jr. PE, Davidorf FH , Abdel-Rahman MH. Molecular Genetic Testing of Uveal Melanoma from Routinely Processed and Stained Cytology Specimens ARVO Meeting Abstracts April 22, 2011 52:4757

Verma V, Christopher B, Cebulla CM, Davidorf FH , Abdel-Rahman MH. Monosomy 3 status of metastatic uveal melanomas is associated with rapidly
progressive, therapy-resistant tumors ARVO Meeting Abstracts April 22, 2011
52:5383.

Salem MM, Davidorf FH, Abdel-Rahman MH. Biological activity and molecular mechanism of action of gallocatechin 5-O-gallate and epigallocatechin 3-O-gallate on uveal melanoma. American Society of Pharmacognosy annual meeting , San Diego,
CA, July 29-August, 2011

Salem MM, Vaidaya N, Said-Ahmed K, Massengill JB, El-Garf I, Davidorf FH, AbdelRahman MH. Antiangiogenic plant extracts for potential treatment of ocular neovascularization. American Society of Pharmacognosy annual meeting , San Diego, CA, July 29-August, 2011

Wang TL, Davidorf FH, Abdel-Rahman MH. The Role of Programmed Cell Death 4 in the Pathogenesis of Uveal Melanoma ARVO Meeting Abstracts March 26, 2012 53:3339

Abdel-Rahman MH, Pilarski R, Cebulla CM, Stacey AW, Massengill JB, Davidorf FH. Candidate Gene Testing In Uveal Melanoma Patients With Relative High-risk For Hereditary Cancer Predisposition ARVO Meeting Abstracts March 26, 2012 53:3335

Rasiah S, Wang T, Kim B, Bingham A, Abdel-Rahman MH, Fischer AJ, Cebulla CM. Macrophage Polarization In Experimental Murine Retinal Detachment ARVO Meeting Abstracts March 26, 2012 53:4265

Cebulla CM, Kim B, Wang T, Pouly S, Abdel-Rahman MH, Fischer AJ. Retinal MMP12/MMP13 and TIMP1/TIMP2 Expression In Experimental Murine Retinal Detachment ARVO Meeting Abstracts March 26, 2012 53:6360

Pilarski R, Cebulla CM, Saqr OH, Rai K, Massengill JB, Davidorf FH, AbdelRahman MH. Study of germline BAP1 and VHL mutation in uveal melanoma patients with personal and or family history of renal cell carcinoma. ASHG 2013 annual meeting.

Adam L, Massengill JB, Cebulla CM, Abdel-Rahman MH. Cyclooxygenase-2 (COX2) expression in primary uveal melanoma and the potential role for adjuvant treatment with COX-2 inhibitors ARVO Meeting Abstracts June 16, 2013 54:4212

Abdel-Rahman MH, Pilarski, R, Cebulla CM, Davidorf FH. Hereditary predisposition to uveal melanoma, not just BAP1. ISOO 2013, Cleveland, OH, October 2013

Boru, G, Cebulla, CM, Olencki T, Carson W III, Davidorf, FH, Abdel-Rahman, MH. Heterogeneity in MAPK activation and GNAQ and GNA11 somatic mutations in uveal melanomas. ISOO 2013, Cleveland, OH, October 2013

Binkley EM, Cebulla CM, Pilarski R, Massengill JB, Marino MJ, Singh AD, AbdelRahman MH. Lack of BAP1 germline gene mutation in patients with early onset 7 uveal melanoma ARVO annual meeting 2014. Orlando FL. ARVO meeting abstracts April 30, 2014 55:5077

Kim B, Kusibati R, Binkley E, Abdel-Rahman MH, Cebulla CM. Up-Regulation of VEGF by Hyaluronic Acid in Microglia ARVO Meeting Abstracts April 30, 2014 55:2261

Abdel-Rahman MH, Hedges D, Pilarski R, Boru G, Massengill JB, Rai K, Davidorf FH, Cebulla CM. Whole genome exome sequencing to identify novel candidates for hereditary predisposition to UM uveal melanoma. ASHG annual meeting 2014, San Diego CA. (3484T)

Cebulla CM, Pilarski R, Rai K, Massengill JB, Boru G, Davidorf FH, Abdel-Rahman MH. Two novel germline BAP1 mutations in two unrelated families with features of the BAP1 Tumor Predisposition Syndrome. ASHG annual meeting 2014, San Diego CA. 3274T

Pilarski R, Boru G, Saqr OH, Rai K, Massengill JB, Cebulla CM, Abdel-Rahman MH. Germline epigenetic inactivation of BAP1 in a subset of patients with uveal melanoma. ASHG annual meeting 2014, San Diego CA.

Abdel-Rahman MH, Pilarski R, Rai K, Cebulla CM,. Comprehensive review of BAP1 tumor predisposition syndrome with report of three new cases. International Society of Genetic Eye Diseases and Retinoblastoma, 2015. Halifax, Nova Scotia, Canada.

Abdel-Rahman MH, Rai K, Pilarski R, Davidorf FH, Cebulla CM. Germline BAP1mutations misreported as somatic based on tumor-only testing. ASHG 2015 Annual meeting Baltimore, Maryland

Books and Book Chapters

Davidorf FH, Abdel-Rahman MH, Tweito T, Chorich L.. Enucleation for choroidal melanomas (chapter 37) in Retina; Ryan S, Hinton D, Schachat A and Wilkinson P (Eds.) New York: Springer-Verlag, 2005: 739-746

Malignant Melanoma of the Eye, A symposium. The Ohio State University press 2011

Theses

Abdel-Rahman MH. Study of hepatic histopathological changes in chronic viral hepatitis with and without schistosomiasis. Master degree thesis, July 1995, Faculty of Medicine, Menoufiya Univ. Egypt

Abdel-Rahman MH. Molecular genetic profiling of low-grade gliomas: towards a molecular genetic classification. PhD. thesis, May 2002, The Ohio State University, Columbus, OH, USA

Extramural Funds

NCI R21CA191943-01 Grant: Hereditary Cancer Predisposition Syndromes and uveal melanoma, Abdel-Rahman MH (PI): Direct cost: $250,000, Total: $423,500

American Cancer Society Pilot Grant # IRG-67-003-47 Abdel-Rahman MH (PI): February 1, 2011- January 31, 2012 “Germline Candidate Genes Identification in Patients with Hereditary Uveal Melanoma”. $25,000

Melanoma Know More and Ocular Melanoma Foundations Award Abdel-Rahman MH (PI) research on the Genetics of Uveal Melanoma 11/2012. $12,000 8

Lions Ohio EyeBank: Abdel-Rahman MH (PI): Molecular targets of ocular antiangiogenic agents from natural herbs. 02/2014-06/2016. $17,000

Sustainable Sciences Institute: Abdel-Rahman MH (PI): Study of molecular genetics of primary and metastatic liver cancer. 09/2013-03/2014. $20,000

NCI- TCGA grant (Co-I): 10/2013: $13,000