Improving patients' lives through research


The Department of Otolaryngology - Head and Neck Surgery at The Ohio State University Wexner Medical Center continues to be a national leader in exploration of otolaryngology and human communication disorders. 

The department has made significant recent contributions to:
  • Defining the pathogenesis of otitis media
  • Examining language development in children with hearing loss
  • Understanding the underlying factors contributing to head and neck cancer
  • Understanding areas of postural control and vestibular-ocular mechanisms
  • Studying the genetics of neurofibromatosis and vestibular schwannoma
  • Identifying the underlying mechanisms of Meniere's disease
Active research includes basic and clinically-related studies surrounding the molecular genetics of vestibular schwannomas, delivery systems for drugs to the cochlea and vestibular system and implantable hearing aids and middle ear mechanics. Several faculty serve on NIH study sections or national-level grant review panels. The department also actively participates in clinical trials in treatment of head and neck cancers and other disorders. In addition, groundbreaking work is being done in developing a virtual temporal bone dissection simulator in collaboration with the Ohio Supercomputer Center on the OSU campus.

Our Research Teams


The Department of Otolaryngology includes four research teams. The Buckeye Center for Hearing and Development researches how hearing loss and auditory deprivation affects individuals from infancy through adulthood. BabyTalk, a research projects at the Buckeye Center, studies the language development of young children with and without hearing loss. The Head and Neck Research Group explores issues concerning the head and neck. The Nasal Physiology and Therapeutic Center studies the interplay between nasal airflow, nasal obstruction, loss of smell and nasal sinus disease. The Center for Microbial Pathogens, located within Nationwide Children's Hospital, explores the molecular mechanisms by which microorganisms cause infectious diseases, as well as how the host responds to these disease states.

Research at Nationwide Children's Hospital


As an international leader in pediatric research, science is thriving at Nationwide Children's Hospital. The behavioral, basic and clinician scientists are redefining pediatric health care with best outcomes for every child in mind.

The Center for Microbial Pathogenesis is located at Nationwide Children's. The emphasis of the center is to develop a greater understanding of the molecular mechanisms by which microorganisms cause infectious diseases, as well as how the host responds to these disease states.

Research at Nationwide Children's Center for Microbial Pathogenesis

Publications


Recent publications by The Department of Otolaryngology - Head and Neck Surgery faculty members.

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Oliver Adunka, MD

Beyea JA, McMullen KP, Harris MS, Houston DM, Martin JM, Bolster VA, Adunka OF, Moberly AC. Cochlear implants in adults: effects of age and duration of deafness on speech recognition. Otol Neurol. 2016 Oct;37(9):1238-45. PubMed PMID: 27466894

Amit Agrawal, MD

Leon ME, Santosh N, Agarwal A, Teknos TN, Ozer E, Iwenofu OH. Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (Küttner's Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases. Head Neck Pathol. 2016 Sept;10(3):389-93. PubMed PMID: 26909791

Kumar B, Brown N, Swanson B, Schmitt A, Old M, Ozer E, Agrawal A, Schuller D, Teknos T, Kumar P. High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status. Oncotarget. 2016 Apr 5;7(14):18665-77. PubMed PMID: 26919244

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1794-802. PubMed PMID: 26694981

Knobloch TJ, Uhrig LK, Pearl DK, Casto BC, Warner BM, Clinton SK, Sardo-Molmenti CL, Ferguson JM, Daly BT, Riedl K, Schwartz SJ, Vodovotz Y, Buchta AJ Sr, Schuller DE, Ozer E, Agrawal A, Weghorst CM. Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche. Cancer Prev Res (Phila). 2016 Feb;9(2):159-71. PubMed PMID: 26701664

Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M. Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy. International journal of radiation oncology, biology, physics 94(4):888. Feb 2016

Azmat U, Liebner D, Joehlin-Price A, Agrawal A, Nabhan F. Treatment of Ipilimumab Induced Graves' Disease in a Patient with Metastatic Melanoma. Case Rep Endocrinol. 2016. 2016: 2087525. Epub 2016 Jan 11. PubMed PMID: 26881150

Ricardo Carrau, MD

Langdon C, Herman P, Verillaud B, Carrau RL, Prevedello D, Nicolai P, Schreiber A, Padoan G, Castelnuovo P, Bernal-Sprekelsen M. Expanded endoscopic endonasal surgery for advanced stage juvenile angiofibromas: a retrospective multi-center study. Rhinology. 2016 Sep;54(3):239-46. PubMed PMID: 27059153

Beer-Furlan A, Abi-Hachem R, Jamshidi A, Carrau R, Prevedello D. Endoscopic transsphenoidal surgery for petroclival and clival meningiomas. J Neurosurg Sci. 2016 Jun 9. [Epub ahead of print]

Upadhyay S, Buohliqah L, Vieira Junior G, Otto BA, Prevedello DM, Carrau RL. First olfactory fiber as an anatomical landmark for frontal sinus surgery. Laryngoscope. 2016 May;126(5):1039-45. PubMed PMID 26490546

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN (2016) Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck.  2016 Apr 5;38:E1794-802. PubMed PMID: 26694981

Dolci RL, Upadhyay S, Ditzel Filho LF, Fiore ME, Buohliqah L, Lazarini PR, Prevedello DM, Carrau RL. Endoscopic endonasal study of the cavernous sinus and quadrangular space: Anatomic relationships. Head Neck. 2016 Apr;38 Suppl 1:E1680-7. Epub 2016 Feb 15. PubMed PMID: 26875705

Hachem RA, Elkhatib A, Beer-Furlan A, Prevedello D, Carrau RL. Reconstructive techniques in skull base surgery after resection of malignant lesions: a wide array of choices. Curr Opin Otolaryngol Head Neck Surg. 2016 Apr;24(2):91-7. PubMed PMID: 26900820

Beer-Furlan A, Otto BA, Carrau RL, Prevedello DM. Letter to the Editor: The endoscopic endonasal approach in the treatment of olfactory groove meningiomas. J Neurosurg. 2016 Apr;124(4):1138-40. Epub 2016 Feb 5. PubMed PMID: 26848918

Zeinalizadeh M, Sadrehosseini SM, Barkhoudarian G, Carrau RL. Reconstruction of the denuded nasoseptal flap donor site with a free fascia lata graft: technical note. Eur Arch Otorhinolaryngol. 2016 Oct; 273(10): 3179-82. Epub 2016 Mar 7. PubMed PMID: 26951218

Gun R, Durmus K, Kucur C, Carrau RL, Ozer E. Transoral Surgical Anatomy and Clinical Considerations of Lateral Oropharyngeal Wall, Parapharyngeal Space, and Tongue Base. Otolaryngol Head Neck Surg. 2016 Mar;154(3):480-5. PubMed PMID: 26814206

Soldatova L, Campbell R, Schmidt T, Pinto J, Prevedello D, ElKhatib A, Ditzel Filho L, Otto BA, Carrau RL. Role of Leukocyte Platelet Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction. J Neurol Surg B. 2016 Mar

AlQahtani A, Castelnuovo P, Nicolai P, Prevedello DM, Locatelli D, Carrau RL. Injury of the Internal Carotid Artery during Endoscopic Skull Base Surgery: Prevention and Management Protocol. Otolaryngol Clin North Am. 2016 Feb;49(1):237-52. PubMed PMID: 26614841

Buohliqa L, Upadhyay S, Nicolai P, Cavalieri R, Dolci RL, Prevedello D, Carrau RL. Possible esthesioneuroblastoma metastasis to paranasal sinuses: Clinical report and literature review. Head Neck. 2016 Feb;38(2):E32-6. PubMed PMID: 25946111

Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M. Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy. International journal of radiation oncology, biology, physics. 94(4):888. Feb 2016

Muto J, Prevedello DM, Ditzel Filho LF, Tang IP, Oyama K, Kerr EE, Otto BA, Kawase T, Yoshida K, Carrau RL. Comparative analysis of the anterior transpetrosal approach with the endoscopic endonasal approach to the petroclival region. J Neurosurg. 2016 Feb 5:1-16. PubMed PMID: 26848916

Upadhyay S, Dolci RL, Buohliqah L, Fiore ME, Ditzel Filho LF, Prevedello DM, Otto BA, Carrau RL. Effect of incremental endoscopic maxillectomy on surgical exposure of the pterygopalatine and infratemporal fossae. J Neurol Surg B Skull Base. 2016 Feb;77(1):66-74. PubMed PMID: 26949591

Goulart CR, Upadhyay S, Leo F. Ditzel, Otto BA, Carrau RL, Prevedello LM, Prevedello DM. Newly Diagnosed Sellar Tumors in Patients with Cancer.  Advantages of Surgical Intervention Over Empiric Radiotherapy. J Neurol Surg B. 2016; 77 - A065 DOI: 10.1055/s-0036-1579853

Soldatova L, Campbell R, Carrau RL, Prevedello DM, Ditzel Filho L, Bradley A. Otto. Sinonasal Neuroendocrine Neoplasms: Histopathologic Differentiation and Treatment Outcomes. J Neurol Surg B 2016; 77 - A127

Irina Castellenos, PhD

Castellanos I, Pisoni DB, Kronenberger WG, & Beer J. Early expressive language skills predict long-term neurocognitive outcomes in cochlear implant users: Evidence from the MacArthur-Bates Communicative Development Iinventories. American Journal of Speech–Language Pathology. 2016 Aug 1;25(3):381-92. PubMed PMID: 27390923

Kronenberger WG, Castellanos I, & Pisoni DB. Questionnaire-based assessment of executive functioning in pediatric psychology: Case studies. Appl Neuropsychol Child. 2016 Jul 13:1-11. PubMed PMID: 27411025

Bahrick LE, Lickliter R, Todd JT, Castellanos I, & Sorondo BM. Enhanced attention to speaking faces versus other event types emerges gradually across infancy. Developmental Psychology. Forthcoming 2016

Castellanos I, Pisoni DB, Kronenberger WG, & Beer J. (2016). Neurocognitive function in deaf children with cochlear implants: Early development and long-term outcomes. In M. Marschark, & P. E. Spencer (Eds.), The Oxford Handbook of Deaf Studies in Language (pp. 264–275). New York: Oxford University Press

Tendy Chiang, MD

Chiang T, Prabaker K. ENT Secrets. 4th ed. Elsevier; 2016. Chapter xx, Deep space neck infections; p. xx

Hauser L, Chiang T. ENT Secrets. 4th ed. Elsevier; 2016. Chapter xx, The acute pediatric airway; p. xx

Brad W. deSilva, MD

Soldatova L, Hrelec C, DeSilva B, Matrka L. Can PFTs Differentiate PVFMD from Subglottic Stenosis? Ann Otol Rhinol Laryngol.2016 Aug 3. PubMed PMID 27553595

Charles Elmaraghy, MD

Idicula W, Jurcisek J, Cass ND, Ali S, Goodman SD, Elmaraghy C, Jatana KR, Bakaletz LO. Identification of biofilms intympanostomy tube otorrhea. Laryngoscope. 2016 Aug;126(8):1946-51. PubMed PMID 27426942

Olsen GH, Krishna SG, Jatana KR, Elmaraghy CA, Ruda JM, Tobias JD. Changes in intracuff pressure of cuffed endotracheal tubes while positioning for adenotonsillectomy in children. Paediatr Anesth. 2016 May;26(5):500-3. PubMed PMID 26956620

Sheehan CC, Lind M, Mahida JB, Essig G, Elmaraghy CA.  Outcomes in Pediatric Patients with Recreational Vehicle Related Forceful Head Impact. Int J of Pediatr Otorhinolaryngol. 2016 May; 84: 97-100. PubMed PMID: 27063761

Payne L, Jatana KR, Elmaraghy C, Justice L. Standardization of the triage process in an ambulatory pediatric otolaryngology setting. ORL-Head and Neck Nurs. 2016 Spring;34(2):15-17. PubMed PMID 27305733

Hakim M, Krishna SG, Syed A, Lind M, Elmaraghy C, Tobias JD.  Oropharyngeal oxygen and volatile anesthetic agent concentration during the use of laryngeal mask airway in children.  Pediatric Anesth. 2016 Jan;26(1):72-76. PubMed PMID: 26545067

Garth Essig Jr., MD

Sheehan CC, Lind M, Mahida JB, Essig G, Elmaraghy CA.  Outcomes in Pediatric Patients with Recreational Vehicle Related Forceful Head Impact. Int J of Pediatr Otorhinolaryngol. 2016 May; 84: 97-100. PubMed PMID: 27063761

Essig GF, Jameson MJ, Carter WB, et al. "Parathyroid Physiology." emedicine. Vol. http://emedicine.medscape.com/article/874690-overview, (Mar 2016): 874690

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Derek Houston, PhD

Beyea JA, McMullen KP, Harris MS, Houston DM, Martin JM, Bolster VA, Adunka OF, Moberly AC. Cochlear implants in adults: effects of age and duration of deafness on speech recognition. Otol Neurol. 2016 Oct; 37(9): 1238-45. PubMed PMID: 27466894

Phan, J., Houston, D.M., Ruffin, C., Ting, J., & Holt, Rachael, F. (2016). Factors affecting speech discrimination in children with cochlear implants: Evidence from early-implanted infants. J Am audiol. 2016 Jun; 27(6):480-488. PubMed PMID: 27310406

Segall, O, Houston, DM, & Kishon-Rabin, L. (2016). Auditory discrimination of lexical stress patterns in hearing-impaired infants with cochlear implants compared to normal hearing: Influence of acoustic cues and listening experience to the ambient language. Ear Hear. 2016 Mar-Apr;37(2), 225-34. PubMed PMID: 26627470

Cristia, A., Seidl, A., Singh, L. and Houston, D. (2016), Test–Retest Reliability in Infant Speech Perception Tasks. Infancy, 21: 648–667

Houston, D. M. Comprehensive Handbook of Pediatric Audiology. 2nd Ed.  In A.M. Tharpe and R. Seewald (Eds.); 2016. Chapter 3, San Diego, CA: Plural Publishing, Inc. Infant Speech Perception; p. 49-66

Houston, D.M. & Warner-Czyz, A. (in press). Speech perception and auditory development in infants with and without hearing loss. In Bar-On, Amalia & Ravid, Dorit (eds.). Handbook of Communication Disorders. Theoretical, Empirical, and Applied Linguistics Perspectives. Berlin, Boston: De Gruyter Mouton

Kris Jatana, MD

Idicula W, Jurcisek J, Cass ND, Ali S, Goodman SD, Elmaraghy C, Jatana KR, Bakaletz LO. Identification of biofilms in post-tympanostomy tube otorrhea. Laryngoscope. 2016 Aug;126(8):1946-51. PubMed PMID 27426942

Roxbury CR, Jatana KR, Shah RK, Boss EF. Safety and post-operative adverse events in pediatric airway reconstruction:Analysis of ASC-NSQIP-P 30 day outcomes. Laryngoscope. 2016 Jul 14. PubMed PMID: 27411903

McMullen K, Chalmers JJ, Lang JC, Kumar P, Jatana KR. Circulating tumor cells in head and neck cancer: A review. World J Otorhinolaryngology Head Neck Surg. 2016 Jun;2(2): 109-116

Jatana KR, Balasubramanian P, McMullen K, Lang JC, Teknos TN, Chalmers JJ. Effect of surgical intervention on detection of circulating tumor cells in squamous cell carcinoma of head and neck. Head and Neck. 2016 June 5. PubMed PMID: 27265898

Payne L, Jatana KR, Elmaraghy C, Justice L. Standardization of the triage process in an ambulatory pediatric otolaryngology setting. ORL Head Neck Nurs. 2016 Spring;34(2):15-17. PubMed PMID: 27305733

Raman VT, Splaingard M, Tumin D, Rice J, Jatana KR, Tobias JD. Utility of screening questionnaire, obesity, neck circumference, and sleep polysomnography to predict sleep disordered breathing in children and adolescents. Pediatric Anesthesia. 2016 April;26:655-664

Mahida JB, Asti L, Boss EF, Shah RK, Deans KJ, Minneci PC, Jatana KR. Tracheostomy Placement in Children Younger Than 2 years: 30-day outcomes using NSQIP-Pediatric. JAMA-Otolaryngol Head and Neck Surg 2016 Jan 28:1-6

Olsen GH, Krishna SG, Jatana KR, Elmaraghy CA, Ruda JM, Tobias JD. Changes in intracuff pressure of cuffed endotracheal tubes while positioning for adenotonsillectomy in children. Paediatr Anesth. 2016 May;26(5):500-3. PubMed PMID 26956620

Stephan Kang, MD

Kang SY, Old MO, Teknos TN. Contour and osteotomy of free fibula transplant using a ruler template. Laryngoscope. 2016 Oct;126(10):2288-90. PubMed PMID: 26972482

Carey EG, Deshpande SS, Zheutlin AR, Nelson NS, Donneys A, Kang SY, Gallagher KK, Felice PA, Tchanque-Fossuo CN, Buchman SR. A Comparison of Vascularity, Bone Mineral Density Distribution, and Histomorphometrics in an Isogenic Versus an Outbred Murine Model of Mandibular Distraction Osteogenesis. J Oral Maxillofac Surg. 2016 Oct;74(10):2055-65. PubMed PMID: 27206629

Lin C, Kang SY. Parapharyngeal space mass. JAMA Otolaryngol Head Neck Surg. Jul 1; 142(7):701-2. PubMed PMID: 26986675

Zheutlin, Alexander R; Deshpande, Sagar S; Nelson, Noah S; Kang, Stephen Y; Gallagher, Kathleen K; Polyatskaya, Yekaterina; Rodriguez, Jose J; Donneys, Alexis;  Ranganathan, Kavitha;  Buchman, Steven R. Bone marrow stem cells assuage radiation-induced damage in a murine model of distraction osteogenesis: A histomorophometric evaluation. Cytotherapy. 2016 May;18(5):664-72. PubMed PMID: 27059203

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1794-802. PubMed PMID: 26694981

Spector ME, Chinn SB, Bellile E, Gallagher KK, Kang SY, Moyer JS, Prince ME, Wolf GT, Bradford CR, McHugh JB, Carey TE, Worden FP, Eisbruch A, Ibrahim M, Chepeha DB. Exploration for an algorithm for deintensification to exclude the retropharyngeal site from advanced oropharyngeal squamous cell carcinoma treatment. JAMA Otolaryngol Head Neck Surg. 2016 Apr:142(4):318-8. PubMed PMID: 26892642

Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M. Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy. International journal of radiation oncology, biology, physics 94(4):888. Feb 2016

Leslie Kim, MD, MPH

Kim L, Byrne PJ. Controversies in contemporary facial reanimation. Facial Plast Surg Clin N Am. 2016 Aug;24(3):275-97. PubMed PMID: 27400842

Genther DJ, Kim LR, Loyo MD, Boahene KD. Transposed corrugator supercilii muscle-tendon unit flap for contralateral paralytic medial ectropion repair. JAMA Facial Plast Surg. 2016 May;18(3):231-2. PubMed PMID: 26987020

Kim L, Wisely CE, Lucius S, Weingarten J, Dodson EE. Positive outcomes and surgical strategies for bilateral cochlear implantation in a child with X-linked deafness. Ann Otol Rhinol Laryngol. 2016 Feb;125:173-6. PubMed PMID: 26346280

Kim L, Papel ID. Spreader grafts in functional rhinoplasty. Facial Plast Surg. 2016 Feb;32(1):29-35. PubMed PMID: 26862961

Pawan Kumar, MS, PhD

Kumar B., Yadav A., Brown V.N., Zhao S., Cipolla M.J., Wakely P.E., Yan F., Schmitt A.C., Baiocchi R.A., Teknos T.N., Old M., and Kumar P*. "High expression of PRMT5 and Cyclin D1 predicts poor outcome in oropharyngeal squamous cell carcinoma and is inversely associated with p16 status. 2017, Oncotarget, doi: 10.18632/oncotarget.14682

Yadav A., Kumar B., Teknos T.N. and Kumar P*. Bazedoxifene enhances the anti-tumor effects of cisplatin and radiation treatment by blocking IL-6 signaling in head and neck cancer. 2016, Oncotarget, DOI: 10.18632/oncotarget.11464

McMullen K, Chalmers JJ, Lang JC, Kumar P, Jatana KR. Circulating tumor cells in head and neck cancer: A review. World J Otorhinolaryngology Head Neck Surg. 2016 Jun;2(2): 109-116

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1794-802. PubMed PMID: 26694981

Kumar B, Brown N, Swanson B, Schmitt A, Old M, Ozer E, Agrawal A, Schuller D, Teknos T, Kumar P. High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status. Oncotarget. 2016 Apr 5;7(14):18665-77. PubMed PMID: 26919244

Choudhary M.M., France T.J., Teknos T.N. and Kumar P*. Interleukin-6 (IL-6) role in head and neck squamous cell carcinoma (HNSCC) progression. 2016, World Journal of Otorhinolaryngology - Head and Neck Surgery, In press

Jas C. Lang, PhD

McMullen K, Chalmers JJ, Lang JC, Kumar P, Jatana KR. Circulating tumor cells in head and neck cancer: A review. World J Otorhinolaryngology Head Neck Surg. 2016 Jun;2(2): 109-116

Jatana KR, Balasubramanian P, McMullen K, Lang JC, Teknos TN, Chalmers JJ. Effect of surgical intervention on detection of circulating tumor cells in squamous cell carcinoma of head and neck. Head and Neck. 2016 June 5. PubMed PMID: 27265898

Meredith Lind, MD

Sheikh SI, Handly B, Ryan-Wenger NA, Hayes D Jr, Kirkby SE, McCoy KS, Lind M. Novel Computed Tomography Scoring System for Sinus Disease in Adults With Cystic Fibrosis. Ann Otol Rhinol Laryngol. 2016 Oct;125(10):838-43. PubMed PMID: 27357973

Sheehan CC, Lind M, Mahida JB, Essig G, Elmaraghy CA.  Outcomes in Pediatric Patients with Recreational Vehicle Related Forceful Head Impact. Int J of Pediatr Otorhinolaryngol. 2016 May; 84: 97-100. PubMed PMID: 27063761

Hakim M, Krishna SG, Syed A, Lind M, Elmaraghy C, Tobias JD.  Oropharyngeal oxygen and volatile anesthetic agent concentration during the use of laryngeal mask airway in children.  Pediatric Anesth. 2016 Jan;26(1):72-76. PubMed PMID: 26545067

Laura Matrka, MD

Soldatova L, Hrelec C, DeSilva B, Matrka L. Can PFTs Differentiate PVFMD from Subglottic Stenosis? Ann Otol Rhinol Laryngol.2016 Aug 3. PubMed PMID 27553595

Aaron Moberly, MD

Nittrouer S, Lowenstein JH, Wucinich T, Moberly AC. Verbal working memory in older adults: The roles of phonological capacities and processing speed. Journal of Speech, Language, & Hearing Research. (In Press)

Beyea JA, McMullen KP, Harris MS, Houston DM, Martin JM, Bolster VA, Adunka OF, Moberly AC. Cochlear implants in adults: effects of age and duration of deafness on speech recognition. Otol Neurol. 2016 Oct; 37(9): 1238-45. PubMed PMID: 27466894

Patel T, Shahin AJ, Bhat J, Welling DB, Moberly AC. Cortical auditory evoked potentials to evaluate cochlear implant candidacy in an ear with long-standing hearing loss: a case report. Ann Otol Rhinol Laryngol. 2016 Oct;125(10):858-61. PubMed PMID: 27357975

Oblinger JL, Burns SS, Akhmametyeva EM, Huang J, Pan L, Ren Y, Shen R, Miles-Markley B, Moberly AC, Kinghorn AD, Welling DB. Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas. Neuro Oncol. 2016 Sep;18(9):1265-77. PubMed PMID: 26951381

Moberly AC, Bates C, Harris MS, Pisoni DB. The enigma of poor performance by adults with cochlear implants. Otol Neurotol. 2016 Sept 14. Epub ahead of print. PubMed PMID: 27631833

Moberly AC, Bhat J, Shahin AJ. Acoustic Cue Weighting by Adults with Cochlear Implants: A Mismatch Negativity Study. Ear Hear. 2016 Jul-Aug;37(4):465-72. PubMed PMID: 26655914

Harris MS, Capretta NR, Henning SC, Feeney L, Pitt MA, Moberly AC. Postoperative rehabilitation strategies used by adults with cochlear implants: a pilot study.  Laryngoscope Investigative Otolaryngology. 2016 Jun;3(1):42-48

Patel TR, Moberly AC. Revision Stapedectomy in a Female Patient with Inner Ear Malformation. Case Rep Otolaryngol. 2016. Epub 2016 Apr 6. PubMed PMID: 27144044

Capretta NR, Moberly AC. Does quality of life depend on speech recognition performance for adult cochlear implant users?. The Laryngoscope. 2016 Mar;126(3):699-706. PubMed PMID: 26256441

Moberly AC, Lowenstein JH, Nittrouer S. Early Bimodal Stimulation Benefits Language Acquisition for Children With Cochlear Implants. Otol Neurotol. 2016 Jan;37(1):24-30. PubMed PMID: 26571408

Moberly AC, Lowenstein JH, Nittrouer S. Word Recognition Variability with Cochlear Implants: “Perceptual Attention” Versus “Auditory Sensitivity”. Ear Hear. 2016 Jan-Feb;37(1):14-26. PubMed PMID: 26301844

N-Z

Matthew Old, MD

Kumar B., Yadav A., Brown V.N., Zhao S., Cipolla M.J., Wakely P.E., Yan F., Schmitt A.C., Baiocchi R.A., Teknos T.N., Old M., and Kumar P*. "High expression of PRMT5 and Cyclin D1 predicts poor outcome in oropharyngeal squamous cell carcinoma and is inversely associated with p16 status. 2017, Oncotarget, doi: 10.18632/oncotarget.14682

Kang SY, Old MO, Teknos TN. Contour and osteotomy of free fibula transplant using a ruler template. Laryngoscope. 2016 Oct;126(10):2288-90. PubMed PMID: 26972482

Kumar B, Brown N, Swanson B, Schmitt A, Old M, Ozer E, Agrawal A, Schuller D, Teknos T, Kumar P. High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status. Oncotarget. 2016 Apr 5; 7(14):18665-77. PMID: 26919244

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1794-802. PubMed PMID: 26694981

Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M. Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy. International journal of radiation oncology, biology, physics 94(4):888. Feb 2016

Bradley A. Otto, MD

Upadhyay S, Buohliqah L, Vieira Junior G, Otto BA, Prevedello DM, Carrau RL. First olfactory fiber as an anatomical landmark for frontal sinus surgery. Laryngoscope. 2016 May;126(5):1039-45. PubMed PMID 26490546

Soldatova L, Campbell R, Schmidt T, Pinto J, Prevedello D, ElKhatib A, Ditzel Filho L, Otto BA, Carrau RL. Role of Leukocyte Platelet Rich Fibrin in Endoscopic Endonasal Skull Base Surgery Defect Reconstruction. J Neurol Surg B, 2016 Mar

Upadhyay S, Dolci RL, Buohliqah L, Fiore ME, Ditzel Filho LF, Prevedello DM, Otto BA, Carrau RL. Effect of incremental endoscopic maxillectomy on surgical exposure of the pterygopalatine and infratemporal fossae. J Neurol Surg B Skull Base. 2016 Feb;77(1):66-74. PubMed PMID: 26949591

Beer-Furlan A, Otto BA, Carrau RL, Prevedello DM. Letter to the Editor: The endoscopic endonasal approach in the treatment of olfactory groove meningiomas. J Neurosurg. 2016 Feb 5:1-2. PubMed PMID: 26848918

Muto J, Prevedello DM, Ditzel Filho LF, Tang IP, Oyama K, Kerr EE, Otto BA, Kawase T, Yoshida K, Carrau RL. Comparative analysis of the anterior transpetrosal approach with the endoscopic endonasal approach to the petroclival region. J Neurosurg. 2016 Feb 5:1-16. PubMed PMID: 26848916

Soldatova L, Campbell R, Carrau RL, Prevedello D, Ditzel Filho L, Otto BA. Sinonasal Neuroendocrine Neoplasms: Histopathologic Differentiation and Treatment Outcomes. J Neurol Surg B 2016; 77 - A127

Goulart CR, Upadhyay S, Ditzel L, Otto BA, Carrau RL, Prevedello LM, Prevedello D. Newly Diagnosed Sellar Tumors in Patients with Cancer. Advantages of Surgical Intervention Over Empiric Radiotherapy. J Neurol Surg B 2016; 77 - A065 DOI: 10.1055/s-0036-1579853

Enver Ozer, MD

Leon ME, Santosh N, Agarwal A, Teknos TN, Ozer E, Iwenofu OH. Diagnostic Challenges in the Fine Needle Aspiration Biopsy of Chronic Sclerosing Sialadenitis (Küttner's Tumor) in the Context of Head and Neck Malignancy: A Series of 4 Cases. Head Neck Pathol. 2016 Sept;10(3):389-93. PubMed PMID: 26909791

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1794-802. PubMed PMID: 26694981

Kumar B, Brown N, Swanson B, Schmitt A, Old M, Ozer E, Agrawal A, Schuller D, Teknos T, Kumar P. High expression of myoferlin is associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with HPV-status. Oncotarget. 2016 Apr 5; 7(14):18665-77. PMID: 26919244

Gun R, Durmus K, Kucur C, Carrau RL, Ozer E. Transoral Surgical Anatomy and Clinical Considerations of Lateral Oropharyngeal Wall, Parapharyngeal Space, and Tongue Base. J Neurosurg. 2016 Feb 5:1-16. PMID: 26848916

Knobloch TJ, Uhrig LK, Pearl DK, Casto BC, Warner BM, Clinton SK, Sardo-Molmenti CL, Ferguson JM, Daly BT, Riedl K, Schwartz SJ, Vodovotz Y, Buchta AJ Sr, Schuller DE, Ozer E, Agrawal A, Weghorst CM. Suppression of Proinflammatory and Prosurvival Biomarkers in Oral Cancer Patients Consuming a Black Raspberry Phytochemical-Rich Troche. Cancer Prevention Research. 2016 Feb. PMID: 26701664

Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M. Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy. International journal of radiation oncology, biology, physics 94(4):888 · February 2016

Quintin Pan, PhD

Piao L, Mukherjee S, Chang Q, Xie X, Li H, Castellanos MR, Banerjee P, Iqbal H, Ivancic R, Wang X, and Pan Q (2016) TriCurin, a novel formulation of curcumin, resveratrol, and epicatechin gallate, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma. Oncotarget. 2016 Jul;16. PubMed PMID: 27437871

Iqbal H and Pan Q (2016) Role of capecitabine in treating head and neck cancer. Expert Opin. Investig. Drugs. Expert Opin Investig Drugs. 2016 Jul;25(7):851-9. PubMed PMID: 27144283

Iqbal H and Pan Q (2016) Image guided surgery in the management of head and neck cancer. Oral Oncol. 2016 Jun;57:32-9. PubMed PMID: 27206842

Datta J, Islam M, Dutta S, Roy S, Pan Q, and Teknos TN (2016) Suberoylanilide hydroxamic acid inhibits growth of head and neck cancer cell lines by reactivation of tumor suppressor microRNAs. Oral Oncol. 2016 May;56:32-39. PubMed PMID: 27086484

Kumar B, Cipolla M, Brown N, Kang SY, Dziegielewski PT, Durmus K, Ozer E, Old MO, Agrawal A, Carrau RL, Schuller DE, Leon M, Pan Q, Kumar P, Wood V, Burgers J, Wakely P, and Teknos TN. Surgical management of oropharyngeal squamous cell carcinoma: survival and functional outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1794-802. PubMed PMID: 26694981

Castellanos MR and Pan Q (2016) Drugs targeting p53 in head and neck cancers. World J. Otolaryngol. In Press

James Rocco, MD, PhD

Arogheh AH, Jakobiec FA, Hammon R, Grossniklaus HE, Rocco J, Lindeman NI,Sadow PM, Faquin WC. Evaluation for High-risk HPV in Squamous Cell Carcinomas and Precursor Lesions Arising in the Conjunctiva and Lacrimal Sac.  Am J Surg Pathol. 2016 Apr;40(4):519-28. PubMed PMID: 26735858

Ryan  J,  Rocco  J, Letai A.  iBH3: Simple, Fixable BH3 Profiling to Determine Apoptotic Priming in Primary Tissue by Flow Cytometry. Biol Chem. 2016 Jul 1;397(7):671-8. PubMed PMID: 26910743

Martin D, Kumar B, Brown N, Agrawal A, Ozer E, Kang S, Rocco JW, Carrau R, Schuller D, Grecula JC, Bhatt AD, Blakaj D, Teknos T, Diavolitsis VM, Old M. Survival Is Independent of Radiation Therapy Treatment Center Experience After Surgical Therapy. International journal of radiation oncology, biology, physics 94(4):888 · February 2016

James Ruda, MD

Olsen GH, Krishna SG, Jatana KR, Elmaraghy CA, Ruda JM, Tobias JD. Changes in intracuff pressure of cuffed endotracheal tubes while positioning for adenotonsillectomy in children. Paediatr Anesth. 2016 May;26(5):500-3. PubMed PMID 26956620

Miller KM. Ruda JM. Tobias JD.  Perioperative care of an adolescent with platelet storage pool disorder. Perioperative care of an adolescent with platelet storage pool disorder.  Ped Anesth Critical Care J. 2016; 13(2):140-144

Walia H. Ruda J. Tobias JD. Sevofluane and bradycardia in infants with trisomy 21:  a case report and review of the literature. Int J Pediatr Otorhinolaryngol. 2016 Jan; 80:5-7. PubMed PMID: 26746603

Patrick Walz, MD

Rastatter JC, Walz PC, Alden TD. Pediatric skull base reconstruction: case report of a tunneled temporoparietal fascia flap. J Neurosurg Pediatr. 2016 Mar;17(3):371-7. Epub 2015 Nov 6. PubMed PMID: 2654408

Gregory J. Wiet, MD

Wiet GJ, Stredeny D, Kerwin T, Kang R. Use of Simulation for Training in Resource Restricted Countries: A Case Study using a Scalable Temporal Bone Surgical Simulator. Int J Med Educ. 2016 Sept 8;7:293-4. PubMed PMID: 27611851

Wiet GJ, Stredney D, Powell K, Hittle B, Kerwin T. Integration of High-resolution Data for Temporal Bone Surgical Simulations. Int J Comput Assist Radiol Surg. 2016 Oct;11(10):1845-54. PubMed PMID: 26762105

Kai Zhao, PhD

Craig J., Zhao K., Doan N., Khalili S., John LYK, Adappa ND and Palmer J. Cadaveric validation study of computational fluid dynamics model of sinus irrigations before and after sinus surgery. Int Forum Allergy Rhinol. 2016 Apr;6(4):423-8. PubMed PMID: 26880742

Zhao K., Craig J., Cohen NA., Adappa ND, Khalili S. and Palmer J. Sinus irrigations before and after surgery – visualization through computational fluid dynamics simulations. Laryngoscope. 2016 Mar;126(3):E90-6. PubMed PMID: 26467934

Protocols and Funding

Protocols and Funding

Approved Institutional Review Board Protocols

Aaron Moberly
Active
12/22/2017
GENETIC ALTERATIONS IN VESTIBULAR SCHWANNOMAS: NEUROFIBROMATOSIS II AND SPONTANEOUS UNILATERAL VESTIBULAR SCHWANNOMAS

Aaron Moberly
Active
07/18/2017  
IN VITRO AND IN VIVO MOLECULAR-GENETIC ANALYSIS OF MENINGIOMAS

Edward Dodson
Active
07/01/2017  
PROTEOMICS STUDY OF THE STAPEDIAL FOOTPLATE IN OTOSCLEROSIS

Craig Hofmeister
Active
08/01/2017  
(OSU 09102) PHASE I STUDY OF AR-42 IN ADULTS WITH ADVANCED OR RECURRENT HEMATOLOGIC MALIGNANCIES AND SOLID TUMORS, FOR WHICH NO STANDARD THERAPY IS AVAILABLE

Gregory Wiet
Active
08/30/2017  
VIRTUAL TEMPORAL BONE SURGERY: DEFINING AND TRANSLATING STANDARDIZED METRICS TO AN AUTOMATED ASSESSMENT TOOL

Laura Matrka
Active
06/15/2017  
DOES TREATMENT OF VOCAL CORD DYSFUNCTION IN THE SETTING OF ASTHMA LEAD TO DECREASED MEDICATION USE?

Aaron Moberly
Active
03/28/2017
OTOLARYNGOLOGY RESEARCH DATABASE

Brad deSilva
Active
04/25/2017
VOICE OUTCOMES FOLLOWING TRANSCUTANEOUS STEROID INJECTION FOR VOCAL FOLD NODULES COMBINED WITH VOICE THERAPY COMPARED TO VOICE THERAPY ALONE

Laura Matrka
Active
03/14/2017
POTASSIUM TITANYL PHOSPHATE LASER TREATMENT OF VOCAL PROCESS GRANULOMAS

Brad deSilva
Active
09/19/2017
DEVELOPMENT OF AN ADULT LARYNGEAL PAPILLOMA TISSUE CELL LINE AND MOUSE MODEL

Aaron Moberly
Active
06/19/2017
OPTIMIZING PROGRAMMING FOR COCHLEAR IMPLANTS

Head and Neck Institutional Review Board Protocols

Ted Teknos
Active
02/10/2017
MULTI-INSTITUTIONAL, CASE-MATCHED STUDY COMPARING TRANSORAL SURGERY AND NON-SURGICAL TREATMENT OF HPV+OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Ted Teknos
Active
03/14/2017
A PHASE I TRIAL OF VORINOSTAT IN THE TREATMENT OF ADVANCED LARYNGEAL, HYPOPHARYNGEAL, NASSOPHARYNGEAL AND OROPHARYNGEAL SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

James Lang
Active
07/06/2017
TISSUE PROCUREMENT AND DATABASE FOR THE STUDY OF MOLECULAR EVENTS IN PRIMARY, RECURRENT, AND METASTIC SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK  

Ted Teknos
Active
10/11/2017
EVALUATION OF DIFFERENCES IN TUMOR BIOLOGY OF HEAD AND NECK CANCER  

James Rocco
Pending
HEAD AND NECK TUMOR HETEROGENITY  

James Rocco
Pending
HEAD AND NECK TUMOR BIOBANK 

Dukagjin Blakaj
Active
02/23/2017
A RETROSPECTIVE STUDY ANALYZING THE MOLECULAR ANALYSIS OF HEAD AND NECK TISSUE FROM PATIENTS WITH RECURRENT OR PERSISTENT MALIGNANCY: A STUDY OF RADIATION RESISTANCE

Dukagjin Blakaj
Active
06/06/2017
MOLECULAR ANALYSIS OF HEAD AND NECK TISSUE FROM PATIENTS WITH RECURRENT OR PERSISTENT MALIGNANCY: A STUDY OF RADIATION RESISTANCE

NIH Research Funding

Lauren Bakaletz, PhD
09/30/1999 - 07/31/2020
NIH/NIDCD
Determinants of H. Influenzae Virulence in Otitis Media
R01DC003915

Irina Castellanos, PhD
04/01/2017 - 03/31/2020
NIH/NIDCD
Psychosocial Outcomes on Deaf Children with Cochlear Implants
R21 DC016134

Tendy Chiang, MD
07/14/2017 - 06/30/2022
NIH/NHLBI
Mechanisms of Regeneration in Tissue Engineered Tracheal Grafts
K08 HL 138460-01

Derek Houston, PhD
12/1/2015 - 06/30/2020
NIH/NIDCD
Infant-Directed Speech and Language Development in Infants with Hearing Loss
R01DC008581

Aaron Moberly, MD
04/01/2017 - 03/31/2022
NIH/NIDCD
Variability in Speech Recognition for Adults with Cochlear Implants: Bottom-Up and Top-Down Factors
K23DC015539-01

Quintin Pan, PhD
04/08/2015 - 03/31/2020
NIH/NCI
Cancer Initiating Cells and Treatment Resistance
R01CA193590

Qunitin Pan, PhD
05/06/2015 - 04/30/2020
NIH/NIDCR
Role of P300 in HPV-Positive Head and Neck Cancer
R01DE023555

Quintin Pan, PhD
02/01/2016 - 01/31/2020
NIH/NIGMS
p53/Rb Reactivation Modulators for HPV-Positive Head and Neck Cancer
R01GM117921

Kai Zhao, PhD
12/1/2014 - 11/31/2018
NIH/NIDCD
Objective Evaluation of Conductive Olfactory Losses and Nasal Obstruction Symptoms
R01DC013626

Other Extramural Funding

Lauren Bakaletz, PhD
01/01/16 - 12/31/18
Australian Gov't National Health and Medical Research Council
Novel Epigenetic Regulatory Mechanisms in Moraxella Catarrhalis and Non-typeable Haemophilus Influenzae: Impact on Vaccine Development and Role in Pathobiology
APP1099279

Kris R. Jatana, MD
02/2015 - Present
Technology Development Fund Grant
Development of new surgical safety devices
Goal is to develop devices to improve surgical safety during otolaryngology surgery

Kris R. Jatana, MD
04/25/2011 - Present
Technology Development Fund Grant
Improving the Tracheostomy Tube Care
The goal of this study is to study is to develop improved tracheostomy tube care for both children and adults

Pawan Kumar, PhD (PI of Correlative Studies)
12/18/13 - 12/17/17
NCCN Clinical Trial
Phase I/II Clinical Trial of Sorafenib in Combination with Cisplatin and Docetaxel in Patients with Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Aaron Moberly, MD
2014 - Present
Triological Society Career Development Award, AAO-HNS CORE grant
Personalizing Aural Rehabilitation for Adults with Cochlear Implants
 
Matthew Old, MD
01/2013 - Present
OSUCCC Viral Oncology Program Research Award
Enhancement of Oncolytic Herpes Virus (34.5ENVE) Activity in Head and Neck Squamous Cell Carcinoma with Bortezomib