Research Associate Professor

Biomedical Research Tower, BRT 814
The Ohio State University Wexner Medical Center
460 W. 12th Ave.
Columbus, OH 43210

Edmund.Mroz@osumc.edu

Education:

BA: Chemistry, Yale University, Magna Cum Laude, 1970
AM: Physiology, Harvard University, 1971
PhD: Physiology, Harvard University, thesis adviser: Susan E. Leeman, PhD, 1978

View CV

Publications

Peer-reviewed publications in print or other media


Research investigations

Sullivan FJ, Mroz EA, Miller RE. Electronic calibration for indocyanine dye-dilution curves. Am Heart J 1973; 85: 506-510

Sullivan FJ, Mroz EA, Miller RE. The precision of a special-purpose analog computer for cardiac output determination.  Ann Surg 1975; 181: 232-238

Mroz EA, Brownstein MJ, Leeman SE. Evidence for substance P in the habenulo-interpeduncular tract.  Brain Research 1976; 113: 597-599

Brownstein MJ, Mroz EA, Kizer JS, Palkovits M, Leeman SE. Regional distribution of substance P in the brain of the rat.  Brain Research 1976; 116: 299-305

Schenker C, Mroz EA, Leeman SE. Release of substance P from isolated nerve endings.  Nature 1976; 264: 790-792

Mroz EA, Brownstein MJ, Leeman SE. Evidence for substance P in the striatonigral tract.  Brain Research 1977; 125: 305-311

Brownstein MJ, Mroz EA, Tappaz ML, Leeman SE. On the origin of substance P and glutamic acid decarboxylase in the substantia nigra. Brain Research 1977; 135: 315-323

Gamse R, Mroz EA, Leeman SE, Lembeck F. The intestine as source of immunoreactive substance P in plasma of the cat. Naunyn-Schmiedeberg’s Arch Pharmacol 1978; 305: 17-21

Palkovits M, Mroz EA, Brownstein MJ, Leeman SE. Descending substance P-containing pathway: a component of the ansa lenticularis.  Brain Research 1978; 156: 124-128

Guyenet PG, Mroz EA, Aghajanian GK, Leeman SE. Iontophoretic ejection of substance P from glass micropipets--correlation with time-course of neuronal excitation in vivo. Neuropharmacology 1979; 18: 553-558

Nutt JG, Mroz EA, Leeman SE, Williams AC, Engel WK, Chase TN. Substance P in human cerebrospinal fluid: reductions in peripheral neuropathy and autonomic dysfunction.  Neurology 1980; 30: 1280-1285

Mroz EA, Lechene C. Fluorescence analysis of picoliter samples. Analyt Biochem 1980; 102: 90-96

Graber ML, Bengele HH, Mroz E, Lechene C, Alexander EA. Acute metabolic acidosis augments collecting duct acidification rate in the rat.  Am J Physiol 1981; 241: F669-F676

Mroz EA, Roman RJ, Lechene C.  Fluorescence assay for picomole quantities of ammonia. Kidney International 1982; 21: 524-527

Mroz EA, Lechene, C. An NADH-coupled assay for femtogram or nanogram quantities of chymotrypsin. Analyt Biochem 1983; 128: 181-185

Leese, HJ, Biggers, JD, Mroz, EA, Lechene, C. Nucleotides in a single mammalian ovum or preimplantation embryo.  Analyt Biochem 1984; 140: 443-448

Mroz EA, Lechene C. Pancreatic zymogen granules differ markedly in protein composition. Science 1986; 232: 871-873

Adams JC, Mroz EA, Sewell WF. A possible neurotransmitter role for CGRP in a hair-cell sensory organ. Brain Research 1987; 419: 347-351

Sweeney TK, Mroz EA, Sewell WF. Isolation and culture of auditory cells from the goldfish (Carassius auratus). Hearing Research 1987; 28: 153-160

Sewell WF, Mroz EA. Neuroactive substances in inner ear extracts. J Neuroscience 1987; 7: 2465-2475

Mroz EA, Sewell WF. Pharmacological alterations of the activity of afferent fibers innervating hair cells. Hearing Research 1989; 38: 141-162

Sewell WF, Mroz EA. Purification of a low-molecular-weight excitatory substance from the inner ears of goldfish. Hearing Research 1990; 50:127-137

Mroz EA, Nissim KR, Lechene C. Electron-probe analysis of isolated goldfish hair cells: implications for preparing healthy cells. Hearing Research 1993; 70:9-21

Mroz EA, Nissim KR, Lechene C. Rapid resting ion fluxes in goldfish hair cells are balanced by (Na+,K+)-ATPase. Hearing Research 1993; 70:22-30

Sewell WF, Mroz EA. Flavin-adenine dinucleotide is a major endogenous fluorophore in hair cells of the inner ear. Hearing Research 1993; 70: 131-138

Mroz EA, Lechene C. Calcium and magnesium transport by isolated goldfish hair cells. Hearing Research 1993; 70: 139-145

Mroz EA, Lechene C. Extracellular N-methyl-d-glucamine leads to loss of hair-cell sodium, potassium, and chloride. Hearing Research 1993; 70: 146-150

Sewell WF, Mroz EA, Evans JE. Extracts of retina and brain that excite afferent fibers in nervating hair cells contain a compound related to hydroxyphenylglycine-N-carbamoyl. Synapse 2005; 58: 129-40

Mroz EA, Baird AH, Michaud WA, Rocco JW. COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells. Cancer Res 2008; 68: 6049-53

Michaud WA*, Nichols AC*, Mroz EA*, Faquin WC, Clark JR, Begum S, Westra WH, Wada H, Busse PM, Ellisen LW, Rocco JW. Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous-cell carcinoma. Clin Cancer Res 2009; 15: 1645-54. *co-first authors

Nichols AC, Faquin WC, Westra WH, Mroz EA, Begum S, Clark JR, Rocco JW. HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg 2009; 140: 228-34

Nichols AC, Finkelstein DM, Faquin WC, Westra WH, Mroz EA, Kneuertz P, Begum S, Michaud WA, Busse PM, Clark JR,  Rocco JW. Bcl2 and HPV16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Clin Cancer Res 2010; 16: 2138-2146

Mroz EA, Rocco JW. MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma. Oral Oncol 2013; 49: 211-5.

Mroz EA, Tward AD, Pickering CR, Myers JN, Ferris RL, Rocco JW. High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma. Cancer 2013; 119: 3034-42

Mroz EA, Tward AD, Hammon RJ, Ren Y, Rocco JW. Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas. PLOS Medicine Feb. 10, 2015; DOI: 10.1371/journal.pmed.1001786

Other peer-reviewed publications 

Leeman SE, Mroz EA. Substance P. Life Sci 1974; 15: 2033-2044

Mroz EA, Leeman SE. Substance P. Vitamins and Hormones 1977; 35: 209-281

Mroz, EA. Possible role of carbamates in neurotoxicity and neurotransmitter inactivation. Science 1989; 243: 1613

Mroz, EA, Rocco JW. RNA interference: natural, experimental, and clinical roles in cancer biology. Head Neck 2006; 28: 1132-41

Mroz EA, Rocco JW. Functional p53 status as a biomarker for chemotherapy response in oral-cavity cancer. J Clin Oncol 2010; 28: 715-7

Mroz EA, Forastiere AA, Rocco JW. Implications of the oropharyngeal cancer epidemic. J Clin Oncol. 2011; 29: 4222-3

Mroz EA, Rocco JW. Gene expression analysis as a tool in early-stage oral cancer management. J Clin Oncol. 2012; 30: 4053-5

Bonilla-Velez J, Mroz EA, Hammon RJ, Rocco JW. Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment. Otolaryngol Clin North Am. 2013; 46:521-43

Non-peer reviewed scientific or medical publications/materials in print or other media


Proceedings of meetings or other non-peer reviewed research publications

Mroz EA, Brownstein MJ, Leeman SE.  Distribution of substance P in the rat brain: evidence for the existence of substance P-containing tracts.  In: von Euler US, Pernow B, eds. Substance P.  New York: Raven, 1977: 147-154

Losay J, Mroz EA, Tregear GW, Leeman SE, Gamble WJ.  Action of substance P on the coronary blood flow in the isolated dog heart. In: von Euler US, Pernow B, eds. Substance P. New York: Raven, 1977: 287-293

Reviews, chapters, monographs and editorials

Leeman SE, Mroz EA, Carraway RE. Substance P and neurotensin. In: Gainer H, ed. Peptides in Neurobiology.  New York: Plenum, 1977: 99-144

Mroz EA, Leeman SE. Substance P. In: Jaffe BM, Behrman HR, eds. Methods of Hormone Radioimmunoassay, second edition. New York: Academic, 1978: 121-137

Professional Educational Materials

1975 - 1995: “Camel” for HMS first-year Medical Physiology course. Wrote discussion questions on respiratory physiology in 1975; reviewed and revised annually through 1995. Prepared and annually revised detailed lecture notes for my lectures (1982-1995); depending on year, topics included respiratory mechanics, respiratory gas exchange, control of ventilation, acid-base regulation, renal concentrating mechanisms, renal acid-base handling.

1984 - 2003: Handouts on selected topics covered in graduate physiology courses: units of measurement, forces and flows in physiology, equations commonly used in physiology, solute and ion transport, respiratory mechanics and flow limitation, acid-base chemistry in physiology

1984 - 2003: Problem sets/discussion questions (approximately biweekly during the semester) for graduate physiology courses

1996 - 2003: Notes and bibliography on “Cochlear homeostasis” for HMS/MEEI Basic Sciences course in Otolaryngology

1997 - 1998: Overview, “Getting started in physiology,” written for students in Markey/MBS program taking “Human physiology: classical and contemporary approaches”

1997 - 1998: Detailed notes to accompany assigned textbook readings, for students in Markey/MBS program taking “Human physiology: classical and contemporary approaches”

Abstracts, Poster Presentations and Exhibits

Mroz EA, Michaud W, Ryan J,  Deschler D, Emerick K, Lin D, Faquin W, Busse, P,  Chan A, Clark J, Rothenberg S, Wirth L, Letai A, Rocco JW.  BH3 profiling to predict outcome in oropharyngeal cancer. MGH Clinical Research Day, Boston MA, October 2011. (Named best abstract from the Department of Surgery)

Mroz EA, Michaud W, Ryan J, Letai A, Rocco JW. Directly measuring mitochondrial apoptotic priming in human oropharyngeal cancer. Cell Death Meeting, Cold Spring Harbor NY, October 2011

Mroz EA, Rocco JW. MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma.  MGH Clinical Research Day, Boston MA, October 2012

Mroz EA, Tward A, Pickering C, Myers J, Ferris R, Rocco JW. Higher intra-tumor genetic heterogeneity is related to worse outcome in head and neck squamous cell carcinoma. MGH Clinical Research Day, Boston MA, October 2013

Rocco JW, Tward AD, Ren Y, Hammon RJ, Mroz EA. Mutant-Allele Tumor Heterogeneity (MATH) Adds to Human Papillomavirus (HPV) Status in Predicting Outcome in Head and Neck Squamous Cell Carcinoma. Multidisciplinary Head and Neck Cancer Symposium. Scottsdale AZ, February 2014 (Featured in Meeting highlights and Meeting Press conference)