Department of Radiology’s advancements in imaging science


Imaging science is dedicated to exploring and advancing magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, single photon emission computed tomography (SPECT), positron emission tomography (PET) and X-ray. The main interests of the group are DCE-MRI of tumors, cardiovascular contrast agents, magnetic resonance angiography (MRA), angiogenesis and molecular imaging. In addition to research within the aforementioned areas, the imaging science team conducts web-based conferencing with a number of collaborators, including the Ohio Supercomputer Center (OARnet), NIH/Clinical Center and biomedical informatics.

Facilities and Equipment

Wright Center

Wright Center of Innovation in Biomedical Imaging

Wright Center of Innovation in Biomedical Imaging

Dr. Michael V. Knopp received a $9.1 million Third Frontier Grant from Ohio Governor Bob Taft and $8 million from BRTT (the Biomedical Research and Technology Transfer award) to create the Wright Center of Innovation in Biomedical Imaging. The project is also known as the Biomedical Structural, Functional and Molecular Imaging Enterprise.

In addition to The Ohio State University, project collaborators include Case Western Reserve University, Philips Medical Systems of Highland Heights and the Ohio Supercomputer Center.

Concourse Building Martha MorehouseOur Location
WCI-BMI: Concourse Building
Martha Morehouse Medical Plaza
2050 Kenny Road
Columbus, OH 43221

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Program Director:
Michael V. Knopp, MD, PhD


Goals of Funding

Goals of the funding include:
  • The creation of an ultra-high-field 7 Tesla MRI scanner, which will reduce the need for exploratory surgery and permit doctors to closely monitor the effects of medications. It will enable functional imaging research in cancer, neuroscience and cardiovascular care at Ohio State
  • Development of a new and more powerful PET scanner to help physicians better understand disease processes and treatment
  • Exploration into mobile imaging facilities and remote access systems that would facilitate advanced diagnostic and imaging capabilities in the field during quickly changing and demanding biohazard events
  • Organization of a powerful, extensive imaging and bioinformatics infrastructure that will integrate the state's scientific community into a virtual think tank for research and development
  • Provide startup funding in the amount of $1 million for support of innovative and promising imaging projects

Equipment at This Location

The Wright Center of Innovation in Biomedical Imaging is a state-of-the-art 26,000 square-foot outpatient and research facility adjacent to The Ohio State University Wexner Medical Center outpatient facility, Martha Morehouse Medical Plaza. Approximately one third of the facility is dedicated to animal preparation including two separate animal exam rooms and animal holding areas. The area has suitable air handling, animal exam tables, anesthesia machines and supplies for veterinary animal care.
  • One 3T clinical MRI (Achieva, Philips, Cleveland, Ohio)
  • One 7T human, preclinical MRI (Achieva, Philips, Cleveland, Ohio)
  • 64-slice Mobile PET/CT system (Philips, Cleveland, Ohio)

Animal Imaging

WCI-BMI: Animal Imaging

WCI-BMI: Animal Imaging

The 4.7T/40cm MRI facility was created as part of the Ohio Cellular and Molecular Imaging Consortium (OCMIC) with the goal to advance state-of-the-art technology for animal imaging at the molecular, cellular and system level, to serve as a resource for medical research, biotechnology advances and pharmaceutical development, and for probing in-vivo gene function, disease processes and therapeutic applications including drug delivery and trials. The goal of the consortium is to facilitate inter-institutional collaboration between academic institutions in Ohio and technology transfer to Industry.

Wiseman HallOur Location
Animal MRI Facility (4.7T)
N113 Wiseman Hall
400 W. 12th Ave.
Columbus, OH 43210

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Program Director:
Petra Schmalbrock, PhD 


Equipment at This Location

The facility houses a 4.7T/40 cm magnet that is controlled by a Bruker Avance Console allowing for MR imaging and spectroscopy of:
  • Medium sized animals (less than 20 cm) using the 260 mm inner diameter gradient coil (max. 100 mT/m, 280 microseconds rise time, diameter of spherical volume: 18.0 cm, shielded, water cooled) with a 200 mm inner diameter proton volume RF coil   
  • Small animals (less than seven cm) using the 120 mm inner diameter gradient coil (max. 400 mT/m, 170 microseconds rise time, diameter of spherical volume: 8.0 cm, shielded, water cooled) with a 72 mm inner diameter proton volume RF coil
The Bruker Avance console uses an HP LINUX ParaVision workstation, controls a 13-order room temperature shim coil, has dual RF transmit channels (6-220 MHz, one kWatt pulsed with 100 Watt CW; other nuclei, one kWatt pulsed with 100 Watt CW) with dual broad-band frequency synthesizers, quadrature detection receiving system with a sampling rate of two MHz and combined one H /19F and 13C/14N/23Na preamplifiers and 2D/31P and 3He exchangeable filters.

The system is equipped with the Bruker BioTrig monitoring unit for the display of physiological monitoring and for synchronization of MR acquisitions by using ECG or respiration triggering signals. The system is equipped with respiratory sensory pads, a temperature probe, a set of ECG electrodes and a laptop PC.

Instrument Access and Request for Usage

Cost for instrument access

Cost of operation and maintenance of the facility will be shared by the users. Based on initial estimates for the annual operating budget (personnel costs, instrument maintenance and supplies) and comparison with rates at comparable facilities the following rates have been established. Budget, costs and rates will be reviewed annually.

  • $320/hour for commercial and out-of-state users
  • $200/hour reduced rate for in-state academic users
  • $1200/day reduced daily rate for in-state academic users
One-time free access for 10 hours will be given to new start-up projects.

Additional charges (these charges will be assessed if not provided by user).
  • Animal handling including gas anesthesia (equipment loan from ULAR) and supplies, e.g. isoflurane (at cost)
  • Data analysis 
  • MRI contrast agent at cost
  • Usage of computer workstations

Imaging Core Lab

WCI-BMI: Imaging Core Laboratory

WCI-BMI: Imaging Core Laboratory

The Imaging Core Laboratory (ICL) through the Wright Center of Innovation at The Ohio State University performs visual reads, quantification, lesion tracking, perfusion and metabolic mapping, pharmacokinetic analysis, quantification of lesion heterogeneity, 3D segmentation and rendering in addition to conventional methodologies such as RECIST/WHO, volume tracking and morphologic characterization.

Imaging Core LabOur Location
Imaging Core Lab (ICL)
Wright Center of Innovation in Biomedical Imaging
395 W. 12th Ave., Room 414
Columbus, OH 43210

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Program Director:
Michael V. Knopp, MD, PhD



Imaging Modalities

The following are core modalities and services of the Imaging Core Laboratory that is staffed by a multi-disciplinary team:
  • PET and CT
  • CT
  • MRI
  • X-ray
  • Mammography
  • Nuclear medicine studies
  • Preclinical validation for translational studies including uCT, uPET/CT, uSPECT/CT

MRI and MRS

In final stages of development for core lab services:

  • SPECT and CT
  • MRS
  • Neurofunctional imaging

Additional generic imaging services are offered:

  • Imaging trial design and GCP compliance
  • Blinded read of diagnostic and therapy assessment studies with electronic tracking
  • Trial progress assessment and reporting
  • Site qualification
  • Site training and QA oversight
  • Compliance review
  • External trial review
  • Site visit services – virtual and on-site
  • Multi-language support for trial information and communications
  • Trial enrollment and performance tracking with automated reporting
  • DICOM consultation services
  • Database transfer
  • caBig connectivity and consulting services

Equipment at This Location

There are numerous PCs with Windows XP and Linux software. Image processing software is developed independently using Interactive Data Language (IDL, ITT Visual Information Solutions, Boulder, CO, USA). The image processing hardware includes high performance multi-core processing for computing purposes with a total storage capacity of more than 10 TB as well as data servers, PACS access points and FTP servers. In addition, there are five dedicated post processing workstations for volume data processing (Leonardo, Siemens, Erlangen, Germany), three dedicated post processing workstations for volume data processing (Advantage Windows, GE, Milwaukee, WI) and a client-based TeraRecon system.

Microimaging Lab

WCI-BMI: Microimaging Lab

WCI-BMI: Microimaging Lab

The Biomedical Research Tower (BRT) is a 10-story, 403,000-square-foot facility housing more than 180,000 square feet of lab space. The BRT is the largest research facility on The Ohio State University campus, nearly doubling the amount of biomedical research space on campus.

The Microimaging Laboratory is housed within the lower level of the BRT. It serves as part of the advanced structural, functional and molecular animal imaging infrastructure. The facility is part of the Wright Center of Innovation in Biomedical Imaging resources/services.

BRTOur Location
Microimaging Lab
Wright Center of Innovation in Biomedical Imaging
460 W. 12th Ave., 0080 BRT, Box #41
Columbus, OH 43210

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Program Director:
Michael V. Knopp, MD, PhD



Equipment at This Location

Micro PET-CT (Inveon, Siemens), which is used in small animal and specimen imaging.

Molecular Imaging Agent Laboratory

WCI-BMI: Molecular Imaging Agent Laboratory

WCI-BMI: Molecular Imaging Agent Laboratory

The Molecular Imaging Agent Laboratory is housed within the Biomedical Research Tower on the seventh floor. The facility is part of the Wright Center of Innovation in Biomedical Imaging Resources and Services.

The laboratory, led by Dr. Michael Tweedle, pursues problems in cancer diagnosis and therapy using biochemical in-vivo imaging. The goal is hyper-effective cancer therapy through biochemically personalized treatment.

BRTOur Location
Microimaging Lab
Wright Center of Innovation in Biomedical Imaging
460 W. 12th Ave., 0080 BRT, Box #41
Columbus, OH 43210

Get directions

Program Director:
Michael F. Tweedle, PhD

Mutation and selection makes human cancer heterogeneous with respect to specific protein expressions and biochemical pathways used for growth and metastasis. The heterogeneity in phenotype results in the eventual failure of treatments targeted at a specific proteins and pathways. Hence targeted therapeutics are only effective in subsets of patients, who themselves usually fail treatment eventually. Current research projects are aimed at this fundamental problem.

Theranostics

Theranostics are experimental injectables that combine the function of diagnostics and therapeutics. They can use whole body in vivo imaging to pre-select only receptor positive patients for treatment, then treat, monitor and modulate the treatment in progress. 177LuAMBA is a GRP+ targeted radiotheranostic from the group that can kill cancer cells within two millimeters of the targeted cell. Metal, organic and peptide chemistries were all important elements of its discovery.

Multivalent and Multifunctional Approaches

Multivalent and multifunctional approaches to cancer targeting usually create dose limiting kidney or liver toxicity during excretion of the drugs. A general solution is to place cleavable (e.g. enzyme substrates) linking groups between the targeting and toxic moieties of multifunctional drug molecules, chosen to react only in the natural environment of the liver or kidney. The problem encompasses biochemistry of the organ, chemical kinetics and medicinal chemistry. 

Intra-Operative Diagnostics

Intra-operative diagnostics are emerging technology that seek to use new imaging technologies, mainly based upon fluorescence light emitting pharmaceuticals or ultrasound, to guide surgical interventions. Projects will place the student into collaborations with surgeons and bioengineers.

Clinical Research

Clinical research problems are translated into biochemical targets and addressed through creation of new pharmaceuticals. Organic, inorganic and radiochemistry, cell and animal biology and in vivo micro-imaging are used as needed. The group has a broad intellectual history and provides opportunities to exercise creativity at the interface of chemistry, biology and medicine. We use a wide range of techniques to create and characterize new, usually complex multifunctional molecules, and take the solved chemical problems to testing in cells, animals and, in some cases, clinical testing.
Our Imaging Science Faculty

Our Imaging Science Faculty

Imaging Science Faculty

Michael V. Knopp, MD, PhD
Professor, Division Chief, Novartis Chair of Imaging Research
Director, Wright Center of Innovation in Biomedical Imaging
 
Krishan Kumar, PhD
Associate Professor, Ohio Molecular Imaging Scholar
Director, Laboratory for Translational Research in Imaging Pharmaceuticals
 
Petra Schmalbrock, PhD
Associate Professor
 
Michael Tweedle, PhD
Professor, Stefanie Spielman Chair in Cancer Imaging
 
Xiangyu Yang, PhD
Assistant Professor, Medical Physicist
 
Jun Zhang, PhD
Assistant Professor, Medical Physicist

Imaging Science Adjunct Faculty

Johannes Heverhagen, MD, PhD
Adjunct Assistant Professor
 
Guang Jia, PhD
Adjunct Assistant Professor
 
Robert R. McKenney, PhD, FAAMA
Adjunct Assistant Professor
 
Juergen Reichenbach, PhD
Adjunct Professor
 
Steffen Sammet, MD, PhD
Adjunct Assistant Professor
 
Hendrik von Tengg-Kobligk, MD
Adjunct Instructor
Imaging Science Staff

Imaging Science Staff

Melanie Hughes Administrative Director

Wright Center of Innovation
395 W. 12th Ave., Room 428
Columbus, OH 43210

Phone: 614-293-9998
Fax: 614-293-9275
hughes@wcibmi.org

Sarah Spaulding Office Associate

Wright Center of Innovation in Biomedical Imaging
395 W. 12th Ave., Room 428
Columbus, OH 43210

Phone: 614-293-9998
Fax: 614-293-9275
spaulding@wcibmi.org

Edivan Neves Systems Analyst

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1265C
Columbus, OH 43221
Phone: 614-366-4932

neves@wcibmi.org

Trung Vu, MS Research Data Analyst

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, 2nd floor
Columbus, OH 43221

vu@wcibmi.org
Nuclear Medicine Technologists

George Aliulis Nuclear Medicine Technologist

Wright Center of Innovation
2050 Kenny Road, Concourse Bldg.
Columbus, OH 43221

Phone: 614-293-8844
Fax: 614-366-1745
George.Aliulis@osumc.edu

Jim Ellis Nuclear Medicine Technologist

Wright Center of Innovation
2050 Kenny Road
Columbus, OH 43221

Phone: 614-293-8844
Fax: 614-366-1745
James.Ellis@osumc.edu
Research Scientists

Katherine Binzel, PhD Research Scientist

Wright Center of Innovation
Department of Radiology
2050 Kenny Road, Room 1233
Columbus, OH 43221

Phone: 614-293-7508
Fax: 614-293-9275
binzel@wcibmi.org

Karen Briley, PhD Research Scientist

Wright Center of Innovation in Biomedical Imaging
395 W. 12th Avenue, Room 414
Columbus, OH 43210
Phone: 614-293-2788

briley@wcibmi.org

Li Gong, PhD Research Scientist

Molecular Imaging Agent Laboratory
740 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210

Phone: 614-247-8684
Li.Gong@osumc.edu 

Yu-Lung (Ivan) Hsieh, PhD Research Scientist

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1255
Columbus, OH 43221
Phone: 614-293-2964

hsieh@wcibmi.org

Shankaran Kothandaraman, PhD Research Scientist

WCI - MIAL
712 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210

Phone: 614-247-4540
Shankaran.Kothandaraman@osumc.edu

More +

Maria (Isabel) Menendez, DVM, PhD Research Scientist

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1233
Columbus, OH 43221
Phone: 614-293-7508

menendez@wcibmi.org

Huyen Nguyen, PhD Research Scientist

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1255
Columbus, OH 43221
Phone: 614-293-2964

nguyen@wcibmi.org

Adam Pippin, PhD Research Scientist

Wright Center of Innovation in Biomedical Imaging
Laboratory for Translational Research in Imaging Pharmaceuticals
1216 Kinnear Road
Columbus, OH 43212

adam.pippin@osumc.edu
Research Associates

Rich Jacko Research Associate

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1265C
Columbus, OH 43221
Phone: 614-366-4932

jacko.1@osu.edu

Shivangi Vora, MS Research Associate

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Road, Concourse Bldg.
Room 1233
Columbus, OH 43221

Phone: 614-293-7508
vora@wcibmi.org

Karen Woolum Research Associate

Wright Center of Innovation in Biomedical Imaging
Laboratory for Translational Research in Imaging Pharmaceuticals
1216 Kinnear Road
Columbus, OH 43212

Karen.Woolum@osumc.edu
Research Assistants

Jeff Clark Research Assistant

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1233
Columbus, OH 43221

clark@wcibmi.org

Michael Friel Research Assistant

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd
Columbus, OH 43221

friel@wcibmi.org

Chris Markeson Research Assistant

Wright Center of Innovation in Biomedical Imaging
395 W. 12th Avenue, Room 414
Columbus, OH 43210
Phone: 614-293-2929

markeson@wcibmi.org

Mohamed Mohamed, MBBCh Research Assistant

Wright Center of Innovation in Biomedical Imaging
2050 Kenny Rd, Room 1204
Columbus, OH 43221

mohamed@wcibmi.org

Matt Orabella Research Assistant

Wright Center of Innovation in Biomedical Imaging
395 W. 12th Avenue, Room 414
Columbus, OH 43210
Phone: 614-293-2929

orabella@wcibmi.org