Assistant Professor of Surgery

565 Davis Heart and Lung Research Institute
473 W. 12th Ave.
Columbus, Ohio 43210-1252
614-247-7840

Research interests: Tissue injury and repair, neurodegeneration and stroke

Education:
BS: Meerut University, Meerut, Uttar Pradesh, India, 1984

MS: Meerut University, Meerut, Uttar Pradesh, India, 1986
MPh: Meerut University, Meerut, Uttar Pradesh, India, 1988
PhD: University of Kuopio, Kuopio, Finland, 2000

Specialty training: Research fellowship in molecular and cell biology, University of California, Berkeley

Appointment: 2009

Savita Khanna, PhD, is an assistant professor of surgery at The Ohio State University, Columbus, Ohio. She received her PhD in 2000 in physiology from the University of Kuopio, Finland and completed her postdoctoral training at the University of California, Berkeley and at The Ohio State University. Her research interests include the study of brain injury, neurodegeneration, nutrition and therapeutics. Her laboratory performs in vitro and in vivo studies related to mechanisms of neurodegeneration and interventional rescue. Dr. Khanna has over 95 peer-reviewed publications with an H-index of 43. She serves as the managing editor for the international peer-reviewed journal Antioxidants and Redox Signaling, which has an impact factor of 7.2, the highest ranking in the field. She has presented lectures at meetings and conferences both nationally and internationally. Dr. Khanna’s research is funded by the National Institute Neurological Disorders & Stroke (NINDS), the American Heart Association (AHA), industry and the NIH-funded OSU Center for Clinical and Translational Science (CCTS) to investigate brain injury, repair and the role of glutamate metabolism in stroke. In 2008, together with three other colleagues, Dr. Khanna co-founded a University Technology Commercialization Company called NutrimiR LLC.

Chapters in books

Sen, C.K., Roy, S., Khanna, S., and Packer, L. "Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection."." In Methods Enzymol.. Vol. 299. 239-246. San Diego, CA, US|USA: Elsevier, January 1999

Roy, S., Venojarvi, M., Khanna, S., and Sen, C.K.. "Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC coulometric electrode array." In Methods Enzymol.. Vol. 353. 326-332. San Diego, CT, US|USA: Elsevier, January 2002

Roy, S., Khanna, S., Bentley, K., Beffrey, P., and Sen CK.. "Functional genomics: high-density oligonucleotide arrays." In Methods Enzymol.. Vol. 353. 487-497. San Diego, CA, US|USA: Elsevier, January 2002

Khanna, S., Venojarvi, M., Roy, S., and Sen, C.K.. "Glutamate-induced c-Src activation in neuronal cells." In Methods Enzymol.. Vol. 352. 191-198. San Diego, CA, US|USA: Elsevier, January 2002

W.A. Wallace, A. J. Cardounel, S Khanna, C.K. Sen. "Survival surgery for coronary occlusion and reoxygenation in a rodent model." In Methods Enzymol. Vol. 381. 175-184. San Diego, US|USA: Elsevier, January 2004

A.K Tewari, S Roy, S Khanna, S, Sen C.K. "Proteomic analysis of the mammalian cell nucleus." In Methods Enzymol. Vol. 381. 192-201. San Diego, CA, US|USA: Elsevier, January 2004

S Roy, S Khanna and C.K. Sen.. "Perceived hyperoxia: oxygen-regulated signal transduction pathways in the heart." In Methods Enzymol. Vol. 381. 133-9. San Diego, CA, US|USA: Elsevier, February 2004

C.K. Sen, S Khanna, C Rink, S Roy.. "Tocotrienols: The Emerging Face of Natural Vitamin E." In Vitamin E. Vol. 76." In Vitamin E. Vol. 76. Edited by Gerald Witlack. -. San Diego: Academic Press, July 2007

H Park, S Roy, S Khanna, C.K. Sen. "Current Technologies in Single Cell Microinjection and Application to Study Signal Transduction." In Method in Redox Signaling. Edited by Dipak K Das. -. New Rochelle: Mary Ann Liebert, Inc, September 2009

D Larson, M Atalay, S Khanna, CK Sen. "Exercise and oxidative stress in diabetes mellitus." In Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention. Edited by J. T. Kumpulainen and J. T. Salonen. 22-26. [unspecified]: The Royal Society of Chemistry, January 2010

M Atalay, D Larson, S Khanna, O Hänninen, C.K. Sen. "Oxidative stress induced by physical exercise." In Natural Antioxidants and Food Qualityin Atherosclerosis and cancer Prevention. Edited by J. T. Kumpulainen and J. T. Salonen. 36-40. [unspecified]: The Royal Society of Chemistry, January 2010

C Rink, S Khanna, C.K. Sen. "Arachidonic Acid Metabolism and Lipid Peroxidation in Stroke: Alpha-Tocotrienol as a Unique Therapeutic Agent." In Studies on experimental models. Edited by Samar Basu and Lars Wiklund. -. New York: Humana Prss, April 2011

C Rink and S Khanna. "Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress." In Chronic Inflammation. Edited by Sashwati Roy , Debasis Bagchi , and Siba P . Raychaudhuri. -. Boca Raton: CRC Press, September 2012

Conferences

Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., Packer, L., Hänninen, O., and Sen, C.K.. "Tissue glutathione homeostasis in response to lipoate supplementation and exercise." Oxygen Club of California, World Congress. (February 1997). Abstract # 132-

Roy, S., Kobuchi, H., Sen, C.K., Gohil, K., Khanna, S., and Packer, L.. "Antioxidant properties and cell regulation." Oxygen Club of California, World Congress. (February 1998). Abstract # 52-

Khanna, S., Sen, C.K., Roy, S., Christen, M. O., and Packer, L.. "Anethole dithiolethione (Sulfarlem) protects against oxidative stress induced cytotoxicity in human Jurkat T cells." Oxygen Club of California, World Congress. (February 1998). Abstract # 123-

Khanna, S., Atalay, M., Laaksonen, D. E., Gul, M., Roy, S., Packer, L., Hänninen, O., and Sen, C.K.. "lipoate supplementation in exercise induced oxidative stress." Experimental Biology. (April 1998). Abstract # 6024-

Gohil, K., Sen, C.K., Roy, S., Khanna, S., and Packer, L.. "Differential regulation of tumor necrosis factor –alpha induced expression by alpha-lipoate." Experimental Biology. (April 1998). Abstract # 1866-

Vider, L., Atalay, M., Gul, M., Laaksonen, D. E., Khanna, S., Roy, S., Hänninen, O., and Sen, C.K.. "Effects of endurance training on tissue vitamin E and Ubiquinone levels." III International Congress of Pathophysiology. (June 1998). Abstract #118-

Gul, M., Laaksonen, D. E., Atalay, M., Khanna, S., Vider, L., Roy, S., Hänninen, O., and Sen, C.K.. "Endurance training may decrease oxidative stress in streptozotocin-induced diabetic rats." III International Congress of Pathophysiology. (June 1998). Abstract #115-

Khanna, S., Roy, S., Reznick, A. Z., Packer, L., and Sen, C.K.. "TNF induced NF-B activation in skeletal muscle L6 cells is regulated by cell glutathione status." III International Congress of Pathophysiology. (June 1998). Abstract #116-

Gohil, K., Roy, S., Khanna, S., Packer, L., and Sen, C.K.. "-lipoic acid alters gene expression in human Jurkat T lymphocytes." III International Congress of Pathophysiology. (June 1998). Abstract #77-

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in L6 skeletal myotubes and the role of R-lipoic acid." Oxygen Club of California, World Congress. (March 1999). Abstract # 155-

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in L6 skeletal myotubes and the role of R-lipoic acid." American Society of Biochemistry and Molecular and Cellular Biology. (May 1999). Abstract # 1002-

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Redox regulation of cytokine-induced glucose uptake in skeletal muscle." 46th Annual Meeting of the American College of Sports Medicine. (June 1999). Abstract #1523-

Atalay, M., Khanna, S., Laaksonen, D. E., Gul, M., Vider, L., Roy, S., Hänninen, O., and Sen, C.K.. "-Lipoic acid supplementation in exercise." 46th Annual Meeting of the American College of Sports Medicine. (June 1999). Abstract #394-

Sen,C,K; Khanna,S; Roy,S; Packer,L. "Vitamin E alpha-tocotrienol potently inhibits glutamate induced pp60c-Src kinase activation and death of HT4 neuronal cells." In FASEB JOURNAL. (March 2000). A554-A554

Sen, C.K., Khanna, S., Roy, S., and Packer, L.. "Vitamin E Alpha tocotrienol potently inhibits glutamate induced pp60-Src kinase activation and death of HT4 neuronal cells." Experimental Biology. (April 2000). Abstract # 398.9-

Roy, S., Khanna, S., Vider. J., and Sen, C.K.. "Redox control of wound angiogenesis." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #176-

Khanna, S., Roy, S., Alessio, H., Bagchi, D., Bagchi, M., and Sen, C.K.. "Anti-angiogenic property of berry extracts." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #75-

Sen, C.K., Khanna, S., Ryu. H., and Roy, S.. "Molecular basis of vitamin E neuroprotection." 8th Annual Meeting of the Oxygen Society. (November 2001). Abstract #178-

Sen,C,K; Khanna,S; Ellison,E,C; Hunt,T,K; Roy,S. "Redox control of wound repair." In FREE RADICAL BIOLOGY AND MEDICINE. (January 2002). S75-S76

Khanna, S., Roy, S., Ryu, H., and Sen, C.K.. "Revisting the neuroprotective properties of vitamin E." Oxygen Club of California, World Congress. (March 2002). Abstract # 68-

Sen, C.K., Khanna, S., Babior, B. M., Hunt, T.K., Ellison, E. C., and Roy, S.. "Redox control of wound repair." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 15-

Roy, S., Khanna, S., Bickerstaff, A.A., Atalay, M., Bierl, M., Levy, D., Subramanian, S.V., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C.G., and Sen C.K.. "Oxygen sensitive signaling in the heart." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 20-

Lappalainen, J., Atalay, M., Khanna, S., Roy, S., Nakao C., Oksala, N., Hanninen, O., and Sen C.K.. "Oxidative stress and heat shock proteins: protective role of physical exercise." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 50-

Khanna, S., Roy, S., Ryu, H., Ratan R.R., and Sen, C.K.. "Molecular basis of vitamin E neuroprotection." Wound Healing: Oxygen & Emerging Therapeutics. (September 2002). Abstract # 49-

Khanna, S., Roy, S., Chaki, S., and Sen, C.K.. "Tocotrienol: Nature’s Vitamin E for Neuroprotection?." Society for Neuroscience 34th Annual Meeting. (October 2004)

Khanna, S. Slivka, A., Roy, S., Rink, C., Notestine, M. and Sen, C.K.. "Protective effects of oral -tocotrienol in experimental stroke." 1st Mtg of the Japanese Society for Tocotrienol Research. (December 2004)

Rink, C.L., Khanna, S.,Roy, S., Slivka, A., Craft, T.K.S.; Notestine, M., DeVries, C., and Sen, C.K.. "Natural vitamin E -tocotrienol protects against glutamate-induced neurodegeneration and stroke." Society for Neuroscience 35th Annual Meeting. (November 2005)

Khanna, S., Roy, S., Maurer, M.R., Ratan.R.R., and Sen, C.K.. "Oxygen-sensitive reset of inducible hif transactivation response." Society for Neuroscience 35th Annual Meeting. (November 2005)

Khanna, S., Ojha, N., Rink, C.L.S., Roy. S., and Sen, C. K.. "-Tocotrienol: a potent form of natural vitamin E against stroke-related neurodegeneration." Society for Free Radical International XIII Congress. (August 2006)

Khanna, S., Park, H., Rink, C.L.S., Roy, S. and Sen, C.K.. "Potent neuroprotection by the natural vitamin e α-tocotrienol: beyond antioxidant mechanisms." Society for Neuroscience 36th Annual Meeting. (October 2006)

Rink, C.L.S., Khanna, S., Roy, S.; Park, H., Ghafourifar, P., and C.K.Sen. "The 12-lipoxygenase path of neurodegeneration: mitochondrial involvement and protection by the natural vitamin e α-tocotrienol." Society for Neuroscience 36th Annual Meeting. (October 2006)

Roy, S., Khanna, S., and Sen, C.K.. "Fra2 mediates oxygen-induced tgfbeta-1 mrna expression in adult cardiac fibroblasts: significance in myocardial fibrosis following ischemia-reperfusion injury." American Heart Association. (November 2007)

Rink, C.L.S., Khanna, S., Ojha, N., Roy, S., Radtke, J., and Sen, C.K.. "The oxygen-sensitive transcriptome in stroke-related injury of the brain: a therapeutic window of opportunity." Society for Neuroscience 37th Annual Meeting. (November 2007)

Khanna, S., Roy, S., Park, H., and Sen, C.K.. "Regulation of c-src activity in glutamate-induced neurodegeneration." Society for Neuroscience 37th Annual Meeting. (November 2007)

Khanna, S., N. Parinandi., Roy, S., Rink., Park, H., and Sen, C.K.. "Tocotrienol protects mature cortical neurons against arachidonic acid-induced cell death through modulation of lipoxygenase." Society for Neuroscience 38th Annual Meeting. (November 2008)

Khanna, S., Rink, C.L.S., Park, H., Roy, S., and Sen, C.K.. "Potent neuroprotection by the natural vitamin e α-tocotrienol: Beyond antioxidant mechanisms." International Conference on Free Radicals & Natural Products in Health and Seventh Annual Meeting of the Society of Free Radical Research India. (February 2008)

Rink, C. L., Christoforidis G. A., Kontzialis M., Bergdall V. K., Abduljalil, A., Roy, S., Khanna S., Knopp, M. V., and Sen, C. K.. "Novel pre-clinical model of acute ischemic stroke in canines: a minimally invasive neuroradiological approach of middle cerebral artery occlusion." Society for Neuroscience 38th Annual Meeting. (November 2008)

Khanna, S., N. Parinandi, Kotha, S.R., Roy, S., C. Rink., Bibus, D., and Sen, C.K. "Arachidonic acid pathway as a key target for neuroprotection by nanomolar -tocotrienol." Society for Neuroscience 39th Annual Meeting. (October 2009)

Rink, C. L.,Roy, S., Khan, M., Ananth, P., Kuppusamy, P., Sen, C.K and Khanna, S.. "Characterization of the therapeutic potential for supplemental oxygen therapy in acute ischemic stroke." International Conference on Advances in Free Radicals & Natural Products, Antioxidants and Radioprotectors in Health and 9th Annual Meeting of the Society of Free Radical Research India. (January 2010)

Khanna, S., N. Parinandi, Kotha, S.R., Roy, S., C. Rink., Bibus, D., and Sen, C.K. "Arachidonic acid pathway as a key target for neuroprotection by nanomolar -tocotrienol." Annual meeting of the Oxygen Club of California. (February 2010)

Inventions and patents

Sen, Chandan; Rink, Cameron; Roy, Sashwati; Khanna, Savita. "Antiplatelet Effects of Natural Viatmin E Alpha-Tocotrienol." Malaysian Palm Oil Board (MPOB).. filed 2012, (patent pending), and Application No. 61/673, 500

Sen, Chandan; Roy, Sashwati; Khanna, Savita. "Methods and compositions for the topical oxygenation of hypoxic tissue." filed 2007, (patent pending), and Application No. PCT/US07/78674

Chandan K Sen; Savita Khanna; Sashwati Roy; Sangly P Srinivas. "Apparatus, System and Method for Tissue Oximetry." filed 2006, (patent pending), and Application No. 13351850

Sen, Chandan; Roy, Sashwati; Khanna, Savita; Rink, Cameron. "Methods for Reducing the Occurance of Hot Flashes." Hovid LLC.. filed 2013, (patent pending), and Application No. 61/857, 087

Sen, Chandan; Roy, Sashwati; Rink, Cameron; Khanna, Savita. "Methods for Improving Liver Function." filed 2012, (patent pending), and Application No. 13/897, 704

Sen, Chandan; Roy, Sashwati; Khanna, Savita; Rink, Cameron. "Method of Ameliorating Clotting Pathologies and Related Materials and Methods." filed 2013, (patent pending), and Application No. 13/837, 021

Chadan Sen; Sashwati Roy; Savita Khanna. "Protective and therapeutic uses for tocotrienols." filed 2006, (patent pending), and Application No. 2006-53272

Sen, Chandan; Roy, Sashwati; Rink, Cameron; Khanna, Savita. "Methods for Treating Burn and Scar Injury Using Tocotrienol Compostitions." Hovid LLC.. filed 2012, (patent pending), and Application No. 61/657, 443

Honors

  • Junior Investigator Award. Wound Healing: Oxygen & Emerging Therapeutics, The Ohio State University, 2002 - present 
  • Poster winner, DHLRI Research Poster Competition. 3rd Annual Research Retreat, DHLRI, The Ohio State University, 2008 - present
  • Assistant Professor Award, Fifth Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care Conference, The Ohio State University, 2012 - present

Presentations

Presented at first Meeting of the Japanese Society for Tocotrienol Research, Hyogo, JP|JPN. (December 2004)

"Oxygen-Sensitive Reset of Inducible Hif Transactivation Response." Presented at Society for Neuroscience 35th Annual Meeting, Washington. (November 2005)

"�-Tocotrienol: A Potent form of Natural Vitamin E Against Stroke-Related Neurodegeneration." Presented at XIII International Congress of the Free Radical Society International, Davos, CH|CHE. (May 2006)

"Potent Neuroprotection by the Natural Vitamin E α-Tocotrienol: Beyond Antioxidant Mechanisms." Presented at Society for Neuroscience 36th Annual Meeting, Atlanta. (October 2006)

"Regulation of c-Src Activity in Glutamate-Induced Neurodegeneration." Presented at Society for Neuroscience 37th Annual Meeting, San Diego. (November 2007)

"Tocotrienol Protects Mature Cortical Neurons Against Arachidonic Acid-Induced Cell Death Through Modulation of Lipoxygenase." Presented at Society for Neuroscience 38th Annual Meeting, Washington. (November 2008)

"Regulation of c-Src Activity in Glutamate-Induced Neurodegeneration." Presented at International Conference on Free Radicals & Natural Products in Health and Seventh Annual Meeting of the Society of Free Radical Research India, Jaipur, IN|IND. (February 2008)

"Arachidonic Acid Pathway as a key Target for Neuroprotection by Nanomolar α-Tocotrienol." Presented at Society for Neuroscience 39th Annual Meeting, Chicago. (October 2009)

"Bioavailability of Orally Supplemented Tocotrienol in Human Tissues & Organs." Presented at 1st International Conference on Tocotrienols and Chronic Diseases, Las Vegas. (July 2010)

"Natural Vitamin E Tocotrienol Against Stroke." Presented at OSUN spring seminar series, . (May 2010)

"Characterization of the Therapeutic Potential for Supplemental Oxygen Therapy in Acute Ischemic Stroke." Presented at International Conference on Advances in Free Radicals & Natural Products, Antioxidants and Radioprotectors in Health and 9th Annual Meeting of the Society of Free Radical Research India, Hyderabad, IN|IND. (January 2010)

"Arachidonic Acid Pathway as a Key Target for Neuroprotection by Nanomolar α-Tocotrienol." Presented at Annual meeting of the Oxygen Club of California, Santa Barbara. (February 2010)

"MRP1: A Novel Tocotrienol Target against Stroke." Presented at 2nd International Conference on Tocotrienols and Chronic Diseases., Las Vegas, US|USA. (July 2011)

"Oxygen-Inducible Glutamate Oxaloacetate Transaminase as Protective Switch Transforming Neurotoxic Glutamate to Metabolic Fuel during Acute Ischemic Stroke." Presented at Society for Neuroscience 41st Annual Meeting, Washington. (November 2011)

"Natural Vitamin E Tocotrienol Against Stroke." Presented at International Conference on Recent Trends in Therapeutic Advancement of Free Radical Science and 10th Annual Meeting of the Society of Free Radical Research India, chennai, IN|IND. (January 2011)

"Vitamin E alpha-Tocotrienol Protects Against Acute Ischemic Stroke by Preventing Loss of miR-29b." Presented at 5th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care Conference, Columbus. (March 2012)

"Palm Vitamin E alpha-Tocotrienol Protects Against Acute Ischemic Stroke by Preventing Loss of miR-29b." Presented at FAV Health 2012, The Fifth International Symposium on Human Health Effects of Fruits and Vegetables, Dharwad & Goa, IN|IND. (January 2013)

"The microRNA Basis of Palm Tocotrienol Neuroprotection." Presented at PALM oil nutrition week, Pataling Jaya, MY|MYS. (May 2013)

"Loss of miR-29b Following Acute Ischemic Stroke Contributes to Neurodegeneration and Infarct Size." Presented at 6th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care, Columbus. (March 2013)

"Inducible Glutamate Oxaloacetate Tranaminase: A New Target for Stroke Therapy." Presented at 7th Annual Translational to Clinical (T2C) Regenerative Medicine Wound Care, Columbus. (March 2014)

"Inducible Glutamate Oxaloacetate Transaminase a New Target for Stroke Therapy." Presented at International Stroke Conference 2014, San Diego,. (February 2014)

Professional activities

  • Lipoprotein Metabolism, Kuopio, Finland, August 14-16, 1995
  • TULES-GS Course “Muscle cellular respiration, oxidative stress and damage in exercise” Kuopio, Finland, December 18-20, 1995
  • International symposium and practical course on Skeletal Muscle Research. Part II, Jyväskylä, Finland, November 6-11, 1995
  • Emerging Potential of Antioxidant Therapy, Goa, India, January 9-11, 1999
  • Annual meeting of the Oxygen Club of California, Santa Barbara, California, March 3-6, 1999
  • 46th Annual meeting of the American College of Sports Medicine, Seattle, Washington, June 1-5, 1999
  • 45th Annual meeting of the American college of sports medicine, Orlando, Florida, June 3-6, 1998
  • Gene Transfer “Strategies for in vivo gene transfer and techniques to monitor therapeutic effects” A.I.V Institute, Kuopio, Finland, September 2-7, 1996
  • Experimental Biology, New Orleans, Louisiana, April 20-24, 2000
  • Wound Healing: Oxygen & Emerging Therapeutics, Columbus, Ohio, September 12-15, 2002
  • Eighth annual meeting of the Oxygen Society, Research Triangle Park, North Carolina, November 15-19, 2001
  • Annual meeting of the Oxygen Club of California, Santa Barbara, California, February 3-5, 1998
  • Annual meeting of the Oxygen Club of California, Santa Barbara, California, Feb 27 - March 1, 1997
  • American Society of Biochemistry and Molecular and Cellular Biology, San Francisco, California, May 16-20, 1999
  • III International Congress of Pathophysiology, Lahti, Finland, June 28 - July 3, 1998
  • Experimental Biology 1998, San Francisco, California, April 18-22, 1998
  • Experimental Biology 2000, San Diego,California, April 15-18, 2000
  • Society for Neuroscience 34th Annual Meeting, San Diego, California, October 23-27, 2004

Edited books

Sen, Packer & Hanninen. "Handbook of Oxidants and Antioxidants in Exercise." Edited by Sen, Packer & Hanninen. Amsterdam: Elsevier Science Publishers, January 2000

Chandan K Sen and Lester Packer. "Methods in Enzymology." Edited by Chandan K Sen and Lester Packer. San Diego: Academic Press, June 2002

Chandan K Sen and Lester Packer. "Methods in Enzymology." Vol. 352. Edited by Chandan K Sen and Lester Packer. San Diego: Academic press, July 2002

Chandan K. Sen and Gregg L. Semenza. "Methods in Enzymolgy." Vol. Volume 381. Edited by Chandan K. Sen and Gregg L. Semenza. San Diego: Elsevier Academic Press, April 2004

Editorial activities

  • Antioxidants & Redox Signaling, 1999 - present 
  • Antioxidants & Redox Signaling, 1999 - present
  • Oxidative Medicine and Cellular Longevity, 2000 - present
  • Journal of Neuroscience, 2000 - present
  • Clinical Biochemistry, 2000 - present
  • Arteriosclerosis, Thrombosis and Vascular Biology, 2000 - present
  • Nutrition Research, 2000 - present
  • Journal of Internal Medicine , 2000 - present
  • Experimental Neurology, 2000 - present
  • Experimental Brain Research, 2000 - present
  • International Journal of Sports Medicine, 2001 - present
  • Methods in Enzymology, 2002
  • Methods in Enzymology, 2002
  • Methods in Enzymology, 2004
  • Life Sciences, 2005 - present
  • Free Radical Biology and Medicine, 2006 - present
  • European Journal of Physiology, 2006 - present
  • Journal of Agricultural and Food Chemistry, 2006 - present
  • Journal of the American Collage of Nutrition, 2009 - present
  • Lipids, 2010 - present
  • Biochimica et Biophysica Acta, 2010 - present
  • American Journal of Physiology, 2012 - present

Journal articles

Atalay, M., Khanna, S., Laaksonen, D. E., Hänninen, O., Seene, T., Vider, J Korho., and Sen, C. K.. "Glutathione dependent antioxidant protection in skeletal muscle: exercise and training." Acta Medica Baltica. Vol. 4, no. 1. (January 1997.): 10-14

Sen, C. K., Khanna S., Reznick, A. Z., Roy, S., and Packer, L.. "Glutathione regulation of tumor necrosis factor-alpha-induced NF-kappa B activation in skeletal muscle-derived L6 cells." Biochem Biophys Res Commun. Vol. 237, no. 3. (August 1997.): 645-649

Khanna, S., Sen, C. K., Roy, S.,Christen, M. O., and Packer, L.. "Protective effect of anethole dithiolethione against oxidative stress induced cytotoxicity in human Jurkat T cells." Biochem Pharmacol. Vol. 56, no. 1. (July 1998.): 61-69

Khanna, S., Atalay, M., Lodge J. K., Laaksonen, D., Roy, S., Hänninen, O., Packer, L., and Sen, C. K.. "Skeletal muscle and liver lipoyllysine content in response to exercise, training and dietary - lipoic acid supplementation." Biochem Mol Biol Int. Vol. 46, no. 2. (October 1998.): 297-306

Khanna, S., Atalay, M., Laaksonen, D., Gul, M., Roy, S and Sen, C. K.. "-Lipoate supplementation: tissue glutathione homeostasis at rest and following exercise." J. Appl. Phyiol. Vol. 86, no. 4. (April 1999.): 1191-1196

Sen, C.K., Roy, S., Khanna, S., and Packer, L.. "Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection." Methods Enzymol. Vol. 299, (January 1999.): 239-246

Khanna, S., Roy, S., Packer, L., and Sen, C.K.. "Cytokine-induced glucose uptake in skeletal muscle: redox regulation and the role of alpha-lipoic acid." Am. J. Physiol. Vol. 276, no. regulatory Integrative Comp. Physiol. 5 Pt 2. (May 1999.): R1327-R1333

Sen, C.K., Khanna, S., Roy, S., and Packer, L.. "Molecular basis of vitamin E action: Tocotrienol potently inhibits glutamate induced pp60c-Src kinase activation and death of HT4 neuronal cells." J Biol Chem. Vol. 275, no. 17. (April 2000.): 13049-13055

Atalay, M., Laaksonen, D. E., Khanna, S., Korhonen, E. K., Hänninen, O,. and Sen, C. K.. "Vitamin E regulates changes in tissue antioxidants induced by fish oil and accute exercise." Med Sci Sports Exerc. Vol. 32, no. 3. (March 2000.): 601-607

Khanna, S., Roy, S., Bagchi, D., Bagchi, M., and Sen, C.K.. "Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract." Free Radic Biol Med. Vol. 31, no. 1. (July 2001.): 38-42

Roy, S., Lado B.H., Khanna, S and Sen, C.K.. "Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarry analysis." FEBS Lett. Vol. 530, no. 1-3. (October 2002.): 17-

Khanna, S., Venojarvi, M., Roy, S., Sharma, S., Trikha, P., Bagchi, D., Bagchi, M and Sen, C. K.. "Dermal wound healing properties of redox-active grape seed proanthocyanidins." Free Radic Biol Med. Vol. 33, no. 8. (January 2002.): 1089-1096

Khanna, S., Venojarvi, M., Roy, S., and Sen, C.K.. "Glutamate-induced c-Src activation in neuronal cells." Methods Enzymol. Vol. 352, (January 2002.): 191-198

Roy, S., Venojarvi, M., Khanna, S., and Sen, C.K.. "Simultaneous detection of tocopherols and tocotrienols in biological samples using HPLC coulometric electrode array." Methods Enzymol. Vol. 352, (January 2002.): 326-332

Roy, S., Khanna, S., Bentley, K., Beffrey, P., and Sen CK. "Functional genomics: high-density oligonucleotide arrays." Methods Enzymol. Vol. 353, (January 2002.): 487-497

Sen, C.K., Khanna, S., Babior, B. M., Hunt, T.K., Ellison, E. C., and Roy, S. "Oxidant-induced vascular endothelial growth factor expression and wound healing." J Biol Chem. Vol. 277, no. 36. (September 2002.): 33284-33290

Sen, C.K., Khanna, S., Venojarvi, M., Trikha, P., Ellison, E. C., Hunt, T.K and Roy, S. "Copper induced vascular endothelial growth factor expression and wound healing." Am J Physiol Heart Circ Physiol. Vol. 282, no. 5. (May 2002.): H1821-H1827

Roy, S., Khanna, S., Alessio, H.M., Vider, J., Bagchi, D., Bagchi, M., and Sen, C.K.. "Anti-angiogenic property of edible berries." Free Radic Res. Vol. 36, no. 9. (January 2002.): 1023-1031

Sen, C.K., Khanna, S., Gordillo, G., Bagchi, D., Bagchi, M and Roy, S. "Oxygen, oxidants, and antioxidant in wound healing: an emerging paradigm- Review." Ann N Y Acad Sci. Vol. 957, (May 2002.): 239-249

McClelland, G.B., Khanna, S., Gonzalez, G.F., Butz, C.E., and Brooks, G.A.. "Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system?." Biochem Biophys Res Commun. Vol. 304, no. 1. (April 2003.): 130-135

Roy, S., Khanna, S., Wallace, W.A., Lappalainen, J., Rink, C., Cardounel, A.J., Zweier, J.L., and Sen, C.K.. "Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart." J Biol Chem. Vol. 278, no. 47. (November 2003.): 47129-47135

Roy,S; Khanna,S; Bickerstaff,A,A; Subramanian,S,V; Atalay,M; Bierl,M; Pendyala,S; Levy,D; Sharma,N; Venojarvi,M; Strauch,A; Orosz,C,G; Sen,C,K. "Oxygen sensing by primary cardiac fibroblasts - A key role of p21(Waf1/Cip1/Sdi1)." CIRCULATION RESEARCH. Vol. 92, no. 3. (February 2003.): 264-271

Roy, S., Khanna, S., Bickerstaff, A.A., Subramanian, S.V., Atalay, M., Bierl, M., Pendyala, S., Levy, D., Sharma, N., Venojarvi, M., Strauch, A., Orosz, C.G., and Sen C.K.. "Oxygen sensing by primary cardiac fibroblasts: akey role of p21waf1/Cip1/Sdi1 in signaling for perceived hyperoxia." Circ Res. Vol. 92, no. 3. (February 2003.): 264-271

Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P.W., Ratan, R.R., and Sen, C.K.. "Molecular basis of vitamin E action. Tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration." J Biol Chem. Vol. 278, no. 44. (October 2003.): 43508-43515

Sen, C.K., Khanna S, Roy S. "Tocotrienol: The natural vitamin E to defend the nervous system?." Ann NY Acad Sci. Vol. 1031, (January 2004.): 127-142

Tewari, A.K., Roy, S, Khanna, S., and Sen C.K.. "Proteomic analysis of the mammalian cell nucleus." Methods Enzymol. Vol. 381, (January 2004.): 192-201

Wallace, W. A., Cardounel, A. J., Khanna, S., and Sen, C.K.. "Survival surgery for coronary occlusion and reoxygenation in a rodent model." Methods Enzymol. Vol. 381, (January 2004.): 175-184

Roy,Sashwati; Rink,Cameron; Khanna,Savita; Phillips,Christina; Bagchi,Debasis; Bagchi,Manashi; Sen,Chandan,K. "Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement.." Gene expression. Vol. 11, no. 5-6. (January 2004.): 251-262

Atalay, M., Oksala, N.K., Laaksonen, D.E., Khanna, S., Nakao, C., Lappalainen, J., Roy, S., Hanninen, O.O., and Sen C.K.. "Exercise training modulates heat shock protein response in diabetic rats." J Appl Physiol. Vol. 97, no. 2. (August 2004.): 605-611

Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M, Sen CK. "Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement." Gene Expr. Vol. 11, no. 5-6. (January 2004.): 251-262

Atalay, M., Oksala, N.K., Laaksonen, D.E., Khanna, S., Nakao, C., Lappalainen, J., Roy, S., Hanninen, O.O., and Sen C.K. "Exercise training modulates heat shock protein response in diabetic rats." J Appl Physiol. Vol. 97, no. 2. (August 2004.): 605-611

Roy, S., Khanna, S and Sen, C.K.. "Perceived hyperoxia: oxygen-regulated signal transduction pathways in the heart." Methods Enzymol. Vol. 381, (January 2004.): 133-139

Patel V, Chivukula IV, Roy S, Khanna S, He G, Ojha N, Mehrotra A, Dias LM, Hunt TK, Sen CK. "Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress." Antioxid Redox Signal. Vol. 7, no. 9-10. (January 2005.): 1377-1387

Khanna S, Patel V, Rink C, Roy S, Sen CK. "Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice." Free Radic Biol Med. Vol. 39, no. 10. (November 2005.): 1310-1319

Roy S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, Subbaraju GV, Trimurtulu G, Krishnaraju AV, Bagchi M, Bagchi D, Sen CK. "Human genome screen to identify the genetic basis of the anti-inflammatory effects of boswellia in microvascular endothelial cells." DNA Cell Biol. Vol. 24, no. 4. (April 2005.): 244-255

Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C, Notestine MA, DeVries AC, Parinandi NL, Sen CK. "Neuroprotective properties of the natural vitamin E alpha-tocotrienol." Stroke. Vol. 36, no. 10. (October 2005.): 2258-2264

Khanna,Savita; Roy,Sashwati; Slivka,Andrew; Craft,Tara,KS; Chaki,Soma; Rink,Cameron; Notestine,Margaret,A; DeVries,A,Courtney; Parinandi,Narasimham,L; Sen,Chandan,K. "Neuroprotective properties of the natural vitamin E alpha-tocotrienol.." Stroke; a journal of cerebral circulation. Vol. 36, no. 10. (October 2005.): 2258-2264

Roy S, Khanna S, Yeh PE, Rink C, Malarkey WB, Kiecolt-Glaser J, Laskowski B, Glaser R, Sen CK. "Wound site neutrophil transcriptome in response to psychological stress in young men." Gene Expr. Vol. 12, no. 4-6. (January 2005.): 273-287

Sen CK, Khanna S, Roy S. "Tocotrienols: Vitamin E beyond tocopherols- Review." Life Sci. Vol. 78, no. 18. (March 2006.): 2088-2098

Khosla P, Patel V, Whinter JM, Khanna S, Rakhkovskaya M, Roy S, Sen CK. "Postprandial levels of the natural vitamin e tocotrienol in human circulation." Antioxid Redox Signal. Vol. 8, no. 5-6. (May 2006.): 1059-1068

Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK. "Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol." J Neurochem. Vol. 98, no. 5. (September 2006.): 1474-1486

Roy S, Khanna S, Kuhn DE, Rink C, Williams WT, Zweier JL, Sen CK. "Transcriptome analysis of the ischemia-reperfused remodeling myocardium: temporal changes in inflammation and extracellular matrix." Physiol Genomics. Vol. 25, no. 3. (May 2006.): 364-374

Khanna S, Roy S, Maurer M, Ratan RR, Sen CK. "Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point." Free Radic Biol Med. Vol. 40, no. 12. (June 2006.): 2147-2154

Rink C, Roy S, Khanna S, Rink T, Bagchi D, Sen CK. "Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type II Leprdb obese diabetic mice with niacin-bound chromium." Physiol Genomics. Vol. 27, no. 3. (November 2006.): 370-379

Roy S, Khanna S, Nallu K, Hunt TK, Sen CK. "Dermal wound healing is subject to redox control." Mol Ther. Vol. 13, no. 1. (January 2006.): 211-220

Oksala NK, Laaksonen DE, Lappalainen J, Khanna S, Nakao C, Hanninen O, Sen CK, Atalay M. "Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation." J Diabetes Complications. Vol. 20, no. 4. (July 2006.): 257-261

Patel V, Khanna S, Roy S, Ezziddin O, Sen CK. "Natural vitamin E alpha-tocotrienol: retention in vital organs in response to long-term oral supplementation and withdrawal." Free Radic Res. Vol. 40, no. 7. (July 2006.): 763-771

Sen CK, Khanna S, Roy S. "Perceived hyperoxia: Oxygen-induced remodeling of the reoxygenated heart- Review." Cardiovasc Res. Vol. 71, no. 2. (July 2006.): 280-288

Roy S, Khanna S, Krishnaraju AV, Subbaraju GV, Yasmin T, Bagchi D, Sen CK. "Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia." Antioxid Redox Signal. Vol. 8, no. 3-4. (March 2006.): 653-660

Bagchi D, Roy S, Patel V, He G, Khanna S, Ojha N, Phillips C, Ghosh S, Bagchi M, Sen CK. "Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries." Mol Cell Biochem. Vol. 281, no. 1-2. (January 2006.): 197-209

Khanna S, Roy S, Park HA, Sen CK. "Regulation of c-SRC activity in glutamate-induced neurodegeneration." J Biol Chem. Vol. 282, no. 32. (August 2007.): 23482-23490

Roy S, Shah H, Rink C, Khanna S, Bagchi D, Bagchi M, Sen CK. "Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement." DNA Cell Biol. Vol. 26, no. 9. (January 2007.): 627-639

Shilo S, Roy S, Khanna S, Sen CK. "MicroRNA in cutaneous wound healing: a new paradigm- Review." DNA Cell Biol. Vol. 26, no. 4. (April 2007.): 227-237

Oksala NK, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M. "Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney." Antioxid Redox Signal. Vol. 9, no. 4. (April 2007.): 497-506

Kuhn D, Roy S, Radtke J, Khanna S, Sen CK. "Laser microdissection and capture of pure cardiomyocytes and fibroblasts from infarcted heart regions: perceived hyperoxia induces p21 in peri-infarct myocytes." Am J Physiol Heart Circ Physiol. Vol. 292, no. 3. (March 2007.): H1245-H1253

Roy S, Khanna S, Rink T, Radtke J, Williams WT, Biswas S, Schnitt R, Strauch AR, Sen CK. "p21waf1/cip1/sdi1 as a Central Regulator of Inducible Smooth Muscle Actin Expression and Differentiation of Cardiac Fibroblasts to Myofibroblasts." Mol Biol Cell. Vol. 18, no. 12. (December 2007.): 4837-4846

Sen CK, Khanna S, Roy S. "Tocotrienols in health and disease: the other half of the natural vitamin E family- Review." Mol Aspects Med. Vol. 28, no. 5-6. (January 2007.): 692-728

Roy S, Patel D, Khanna S, Gordillo G, Biswas S, Friedman A, Sen CK. "Genome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue." Proc Natl Acad Sci U S A. Vol. 104, no. 36. (September 2007.): 14472-14477

Sen CK, Khanna S, Rink C, Roy S. "Tocotrienols: the emerging face of natural vitamin E- Review." Vitam Horm. Vol. 76, (January 2007.): 203-261

Lappalainen Z, Lappalainen J, Oksala NK, Laaksonen DE, Khanna S, Sen CK, Atalay M. "Exercise training and experimental diabetes modulate heat shock protein response in brain." Scand J Med Sci Sports. Vol. 20(1), (November 2008.): 83-9

Rink C, Christoforidis G, Abduljalil A, Kontzialis M, Bergdall V, Roy S, Khanna S, Slivka A, Knopp M, Sen CK. "Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines." Proc Natl Acad Sci U S A. Vol. 105, no. 37. (September 2008.): 14100-14105

Roy S, Khanna S, Sen CK. "Redox regulation of the VEGF signaling path and tissue vascularization: Hydrogen peroxide, the common link between physical exercise and cutaneous wound healing." Free Radic Biol Med. Vol. 44, no. 2. (January 2008.): 180-192

Khanna S, Park HA, Sen CK, Golakoti T, Sengupta K, Venkateswarlu S, Roy S. "Neuroprotective and anti-inflammatory properties of a novel demethylated curcuminoid." Antioxid Redox Signal. Vol. 20(1), (August 2008.): 83-9

Roy S, Khanna S, Rink C, Biswas S, Sen CK. "Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome." Physiol Genomics. Vol. 34, no. 2. (July 2008.): 162-184

Gordillo GM, Roy S, Khanna S, Schlanger R, Khandelwal S, Phillips G, Sen CK. "Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds." Clin Exp Pharmacol Physiol. Vol. 35, no. 8. (August 2008.): 957-964

Ojha N, Roy S, He G, Biswas S, Velayutham M, Khanna S, Kuppusamy P, Zweier JL, Sen CK. "Assessment of wound-site redox environment and the significance of Rac2 in cutaneous healing." Free Radic Biol Med. Vol. 44, no. 4. (February 2008.): 682-691

Terentyev D, Györke I, Belevych AE, Terentyeva R, Sridhar A, Nishijima Y, de Blanco EC, Khanna S, Sen CK, Cardounel AJ, Carnes CA, Györke S. "Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure." Circ Res. Vol. 103, no. 12. (December 2008.): 1466-1472

Shilo S, Roy S, Khanna S, Sen CK. "Evidence for the involvement of miRNA in redox regulated angiogenic response of human microvascular endothelial cells." Arterioscler Thromb Vasc Biol. Vol. 28, no. 3. (March 2008.): 471-477

Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK. "Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm." Antioxid Redox Signal. Vol. 11, no. 1. (January 2009.): 47-58

Sen CK, Gordillo GM, Khanna S, Roy S. "Micromanaging Vascular Biology: Tiny MicroRNAs Play Big Band." J Vasc Res. Vol. 46, no. 6. (June 2009.): 527-540

Lappalainen Z, Lappalainen J, Oksala NK, Laaksonen DE, Khanna S, Sen CK, Atalay M. "Diabetes impairs exercise training-associated thioredoxin response and glutathione status in rat brain." J Appl Physiol. Vol. 106, no. 2. (February 2009.): 461-467

Park HA, Khanna S, Rink C, Gnyawali S, Roy S, Sen CK. "Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway." Cell Death Differ. Vol. 16, no. 8. (August 2009.): 1167-1179

Roy S, Biswas S, Khanna S, Gordillo G, Bergdall V, Green J, Marsh CB, Gould LJ, Sen CK. "Characterization of a preclinical model of chronic ischemic wound." Physiol Genomics. Vol. 37, no. 3. (May 2009.): 211-224

Roy S, Khanna S, Hussain SR, Biswas S, Azad A, Rink C, Gnyawali S, Shilo S, Nuovo GJ, Sen CK. "MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue." Cardiovasc Res. Vol. 82, no. 1. (April 2009.): 21-29

Sen CK, Rink C, Khanna S.. "Palm oil-derived natural vitamin E alpha-tocotrienol in brain health and disease." J Am Coll Nutr. Vol. 29, no. 3 Suppl. (June 2010.): 314S-323S

Gnyawali SC, Roy S, Driggs J, Khanna S, Ryan T, Sen CK. "High-frequency high-resolution echocardiography: first evidence on non-invasive repeated measure of myocardial strain, contractility, and mitral regurgitation in the ischemia-reperfused murine heart." J Vis Exp. Vol. 41, (July 2010.): 1781-

Lappalainen J, Lappalainen Z, Oksala NK, Laaksonen DE, Khanna S, Sen CK. "Atalay M. Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain." Cell Biochem Funct. Vol. 28, no. 8. (October 2010.): 644–650-

Biswas S, Roy S, Banerjee J, Hussain SR, Khanna S, Meenakshisundaram G, Kuppusamy P, Friedman A, Sen CK. "Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds." Proc Natl Acad Sci U S A. Vol. 107, no. 15. (April 2010.): 6976-6981

Khanna S, Biswas S, Shang Y, Collard E, Azad A, Kauh C, Bhasker V, Gordillo GM, Sen CK, Roy S.. "Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice." PLoS One. Vol. 5, no. 3. (March 2010.): e9539-

Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen CK, Khanna S.. "Oxygen-sensitive outcomes and gene expression in acute ischemic stroke." Journal of Cerebral Blood Flow and Metabolism. Vol. 30(7), (February 2010.): 1275-87

Khanna S, Parinandi NL, Kotha SR, Roy S, Rink C, Bibus D, Sen CK. "Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A and causes neuroprotection." J Neurochem. Vol. 112, no. 5. (March 2010.): 1249-1260

Lappalainen Z, Lappalainen J, Laaksonen DE, Oksala KJ, Khanna S, Sen CK, Atalay M. "Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes." Int J Sport Nutr Exerc Metab. Vol. 20, no. 3. (June 2010.): 206-215

Roy S, Khanna S, Azad A, Schnitt R, He G, Weigert C, Ichijo H, Sen CK. "Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts." Cardiovasc Res. Vol. 87(4), no. Cardiovasc. (April 2010.): 647-55

Rink C, Khanna S.. "Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke." Antioxid Redox Signal. Vol. 14(10), (May 2011.): 1889-903

Roy,Sashwati; Dickerson,Ryan; Khanna,Savita; Collard,Eric; Gnyawali,Urmila; Gordillo,Gayle,M; Sen,Chandan,K. "Particulate beta-glucan induces TNF-alpha production in wound macrophages via a redox-sensitive NF-kappa beta-dependent pathway." WOUND REPAIR AND REGENERATION. Vol. 19, no. 3. (May 2011.): 411-419

Christoforidis GA, Rink C, Kontzialis MS, Mohammad Y, Koch RM, Abduljalil AM, Bergdall VK, Roy S, Khanna S, Slivka AP, Knopp MV, Sen CK. "An Endovascular Canine Middle Cerebral Artery Occlusion Model for the Study of Leptomeningeal Collateral Recruitment." Invest Radiol.. Vol. 46(1), (January 2011.): 34-40

Chan,Yuk,Cheung; Khanna,Savita; Roy,Sashwati; Sen,Chandan,K. "miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 3. (January 2011.): 2047-2056

Rink,Cameron; Gnyawali,Surya; Peterson,Laura; Khanna,Savita. "Oxygen-Inducible Glutamate Oxaloacetate Transaminase as Protective Switch Transforming Neurotoxic Glutamate to Metabolic Fuel During Acute Ischemic Stroke." ANTIOXIDANTS & REDOX SIGNALING. Vol. 14, no. 10. (May 2011.): 1777-1785

Park,Han-A; Kubicki,Natalia; Gnyawali,Surya; Chan,Yuk,Cheung; Roy,Sashwati; Khanna,Savita; Sen,Chandan,K. "Natural Vitamin E alpha-Tocotrienol Protects Against Ischemic Stroke by Induction of Multidrug Resistance-Associated Protein 1." STROKE. Vol. 42, no. 8. (August 2011.): 2308-U450

Rink,Cameron; Christoforidis,Greg; Khanna,Savita; Peterson,Laura; Patel,Yojan; Khanna,Suchin; Abduljalil,Amir; Irfanoglu,Okan; Machiraju,Raghu; Bergdall,Valerie,K; Sen,Chandan,K. "Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis." JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Vol. 31, no. 11. (November 2011.): 2218-2230

Rink,Cameron; Christoforidis,Greg; Khanna,Savita; Peterson,Laura; Patel,Yojan; Khanna,Suchin; Abduljalil,Amir; Irfanoglu,Okan; Machiraju,Raghu; Bergdall,Valerie,K; Sen,Chandan,K. "Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis." JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Vol. 31, no. 11. (November 2011.): 2218-2230

Patel,Viren; Rink,Cameron; Khanna,Savita; Sen,Chandan,K. "Tocotrienols: The lesser known form of natural vitamin E." INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY. Vol. 49, no. 10. (October 2011.): 732-738

Roy,Sashwati; Driggs,Jason; Elgharably,Haytham; Biswas,Sabyasachi; Findley,Muna; Khanna,Savita; Gnyawali,Urmila; Bergdall,Valerie,K; Sen,Chandan,K. "Platelet-rich fibrin matrix improves wound angiogenesis via inducing endothelial cell proliferation." WOUND REPAIR AND REGENERATION. Vol. 19, no. 6. (November 2011.): 753-766

Rink C, Khanna S.. "MicroRNA in Ischemic Stroke Etiology and Pathology." Physiol Genomics. Vol. 43(10), (May 2011.): 521-8

Patel,Viten; Rink,Cameron; Gordillo,Gayle,M; Khanna,Savita; Gnyawali,Urmila; Roy,Sashwati; Shneker,Bassel; Ganesh,Kasturi; Phillips,Gary; More,J,Layne; Sarkar,Atom; Kirkpatrick,Robert; Elkhammas,Elmahdi,A; Klatte,Emily; Miller,Michael; Firstenberg,Michael,S; Chiocca,E,Antonio; Nesaretnam,Kalanithi; Sen,Chandan,K. "Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients." JOURNAL OF NUTRITION. Vol. 142, no. 3. (March 2012.): 513-519

Ganesh,Kasturi; Das,Amitava; Dickerson,Ryan; Khanna,Savita; Parinandi,Narasimham,L; Gordillo,Gayle,M; Sen,Chandan,K; Roy,Sashwati. "Prostaglandin E-2 Induces Oncostatin M Expression in Human Chronic Wound Macrophages through Axl Receptor Tyrosine Kinase Pathway." JOURNAL OF IMMUNOLOGY. Vol. 189, no. 5. (September 2012.): 2563-2573

Chan,Yuk,Cheung; Roy,Sashwati; Khanna,Savita; Sen,Chandan,K. "Downregulation of Endothelial MicroRNA-200b Supports Cutaneous Wound Angiogenesis By Desilencing GATA Binding Protein 2 and Vascular Endothelial Growth Factor Receptor 2." ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Vol. 32, no. 6. (June 2012.): 1372-1382

Chan,Yuk,Cheung; Roy,Sashwati; Huang,Yue; Khanna,Savita; Sen,Chandan,K. "The MicroRNA miR-199a-5p Down-regulation Switches on Wound Angiogenesis by Derepressing the v-ets Erythroblastosis Virus E26 Oncogene Homolog 1-Matrix Metalloproteinase-1 Pathway." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 287, no. 49. (November 2012.): 41032-41043

Roy,Sashwati; Banerjee,Jaideep; Gnyawali,Surya,C; Khanna,Savita; He,Guanglong; Pfeiffer,Douglas; Zweier,Jay,L; Sen,Chandan,K. "Suppression of Induced microRNA-15b Prevents Rapid Loss of Cardiac Function in a Dicer Depleted Model of Cardiac Dysfunction." PLOS ONE. Vol. 8, no. 6. (June 2013.): e66789-

Elgharably,Haytham; Roy,Sashwati; Khanna,Savita; Abas,Motaz; Dasghatak,Piya; Das,Amitava; Mohammed,Kareem; Sen,Chandan,K. "A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds." WOUND REPAIR AND REGENERATION. Vol. 21, no. 3. (May 2013.): 473-481

Khanna,Savita; Rink,Cameron; Ghoorkhanian,Reza; Gnyawali,Surya; Heigel,Mallory; Wijesinghe,Dayanjan,S; Chalfant,Charles,E; Chan,Yuk,Cheung; Banerjee,Jaideep; Huang,Yue; Roy,Sashwati; Sen,Chandan,K. "Loss of miR-29b following acute ischemic stroke contributes to neural cell death and infarct size." JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. Vol. 33, no. 8. (August 2013.): 1197-1206

Gordillo,G,M; Biswas,A; Khanna,S; Pan,J; Sen,C,K. "MICRORNA IS REQUIRED FOR IN VIVO ANGIOGENESIS." WOUND REPAIR AND REGENERATION. Vol. 21, no. 2. (March 2013.): A24-A24

Banerjee,Jaideep; Das Ghatak,Piya; Roy,Sashwati; Khanna,Savita; Sequin,Emily,K; Bellman,Karen; Dickinson,Bryan,C; Suri,Prerna; Subramaniam,Vish,V; Chang,Christopher,J; Sen,Chandan,K. "Improvement of human keratinocyte migration by a redox active bioelectric dressing.." PloS one. Vol. 9, no. 3. (January 2014.): e89239-

1. Banerjee J, Das Ghatak P, Roy S, Khanna S, Sequin EK, Bellman K, Dickinson BC, Suri P, Subramaniam VV, Chang CJ, Sen CK.. "Improvement of human keratinocyte migration by a redox active bioelectric dressing." PLoS One. Vol. 9(3), (March 2014.): e89239-

Gordillo GM, Biswas A, Khanna S, Pan X, Sinha M, Roy S, Sen CK.. "Dicer Knockdown Inhibits Endothelial Cell Tumor Growth via MicroRNA 21a-3p Targeting of Nox-4.." J Biol Chem.. Vol. 289, no. 13. (March 2014.): 9027-38

Gordillo GM1, Biswas A, Khanna S, Pan X, Sinha M, Roy S, Sen CK.. "Dicer Knockdown Inhibits Endothelial Cell Tumor Growth via MicroRNA 21a-3p Targeting of Nox-4." J Biol Chem.. Vol. 289, (March 2014.): J 9027-38

Das,Amitava; Ganesh,Kasturi; Khanna,Savita; Sen,Chandan,K; Roy,Sashwati. "Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation." JOURNAL OF IMMUNOLOGY. Vol. 192, no. 3. (February 2014.): 1120-1129

Roy,Sashwati; Elgharably,Haytham; Sinha, Mithun; Ganesh,Kasturi; Chaney, Sommer; Mann, E; Miller, Cheryl; Khanna,Savita; Bergdall, Valerie K; Powell, Heather M; Cook, Charles H; Gordillo Gayle, Wozniak, Daniel; Sen, Chandan K.. "Mixed-species biofilm compromises wound healing by disrupting epidermal barrier function." J Pathol.. Vol. 233, no. 4. (August 2014.): 331-343

Banerjee,Jaideep; Das Ghatak,Piya; Roy,Sashwati; Khanna,Savita; Sequin,Emily,K; Bellman,Karen; Dickinson,Bryan,C; Suri,Prerna; Subramaniam,Vish,V; Chang,Christopher,J; Sen,Chandan,K. "Improvement of human keratinocyte migration by a redox active bioelectric dressing.." PloS one. Vol. 9, no. 3. (January 2014.): e89239-