Books, Articles and Published Papers
Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M (2009) Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and β cell proliferation during embryogenesis. Mol Endocrinol 23:324-36
Lawrenica C, Charrier A, Huang G and Brigstock DR (2009) Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells Growth Factors 27 91-99
Wang J, Leclercq, Brymore JM, Ramezani-Mogadam M, London RM, Brigstock DR, George J (2009). Kupffer cells mediate leptin-induced liver fibrosis Gastroenterology 137 713-723
Brigstock DR (2009) Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. J. Cell Comm Signal 3 5-18
Tong Z, Chen R, Kemper S, Perbal B, and Brigstock DR (2009) Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes Hepatology 50 939-947
Gao R and Brigstock DR (2009) Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function. World J Gastroenterology 15 3807-3813
Brigstock DR (2009) Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: Lessons from transgenic animals. J. Cell Comm. Signal http://dx.doi.org/1007/s12079-009-0071-5
Leask A, Chen S, Pala D, and Brigstock DR (2008) Regulation of CCN2 expression and promoter activity in activated hepatic stellate cells. J. Cell Comm. 2 49-56
Tong Z, Brigstock, D.R. (2006) Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor J. Endocrinol 188 R1-R8
Gao, R. and Brigstock, D.R. (2006) A novel integrin ?5?1–binding domain in module 4 of connective tissue growth factor promotes adhesion and migration of activated pancreatic stellate cells. Gut 55 856-862
Gao R and Brigstock DR (2005) Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin ?5?1 as a novel CCN2 receptor. Gastroenterology 129 2019-2030
Gao R, Ball DK, Perbal B, Brigstock DR (2004) Connective tissue growth factor (CCN2) induces c-fos gene activation and cell proliferation through p44/42 MAP kinase (ERK1/2) in primary rat hepatic stellate cells J. Hepatol 40 431-438
Gao R., Brigstock DR (2004) Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its carboxyl-terminal domain to integrin ?v?3 and heparan sulfate proteoglycans. J Biol Chem 279 8848-8855
Ball, D.K., Moussad, E.E-D.A., Rageh, M.A.E., Kemper, S.A, Brigstock, D.R. (2003) Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction 125 271-284
Wang JF, Olson ME, Ball DK, Brigstock DR, Wright JB, Hart DA (2003). Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression.Wound Repair Regen 11 220-229
Gao R, Brigstock DR (2003) Low-density lipoprotein receptor-related protein is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 27 214-220
Ball DK, Wilson AW, Kemper SA, Brigstock DR (2003). The heparin-binding 10kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol 176 R1-R7
di Mola FF, Friess H, Riesle E, Koliopanos A, Buchler P., Zhu Z, Brigstock DR, Korc M, Buchler MW (2002) Connective tissue growth factor (CTGF) is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Annals Surgery 235 60-67
Williams, E.J., Gaca, M.D.A., Brigstock, D.R., Arthur, M.J.P, and Benyon, R.C. (2000) Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J. Hepatology 32 754-761
Brigstock, D.R., Steffen, C.L. Kim, G.Y., Vegunta, R.K. Diehl, J.R. and Harding P.A. (1997) Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: Identification as heparin-regulated 10,000-Mr forms of connective tissue growth factor. J. Biol. Chem.272 20275-20282
Lawrenica C, Charrier A, Huang G and Brigstock DR (2009) Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells Growth Factors 27 91-99
Wang J, Leclercq, Brymore JM, Ramezani-Mogadam M, London RM, Brigstock DR, George J (2009). Kupffer cells mediate leptin-induced liver fibrosis Gastroenterology 137 713-723
Brigstock DR (2009) Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo. J. Cell Comm Signal 3 5-18
Tong Z, Chen R, Kemper S, Perbal B, and Brigstock DR (2009) Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes Hepatology 50 939-947
Gao R and Brigstock DR (2009) Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function. World J Gastroenterology 15 3807-3813
Brigstock DR (2009) Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: Lessons from transgenic animals. J. Cell Comm. Signal http://dx.doi.org/1007/s12079-009-0071-5
Leask A, Chen S, Pala D, and Brigstock DR (2008) Regulation of CCN2 expression and promoter activity in activated hepatic stellate cells. J. Cell Comm. 2 49-56
Tong Z, Brigstock, D.R. (2006) Intrinsic biological activity of the thrombospondin structural homology repeat in connective tissue growth factor J. Endocrinol 188 R1-R8
Gao, R. and Brigstock, D.R. (2006) A novel integrin ?5?1–binding domain in module 4 of connective tissue growth factor promotes adhesion and migration of activated pancreatic stellate cells. Gut 55 856-862
Gao R and Brigstock DR (2005) Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin ?5?1 as a novel CCN2 receptor. Gastroenterology 129 2019-2030
Gao R, Ball DK, Perbal B, Brigstock DR (2004) Connective tissue growth factor (CCN2) induces c-fos gene activation and cell proliferation through p44/42 MAP kinase (ERK1/2) in primary rat hepatic stellate cells J. Hepatol 40 431-438
Gao R., Brigstock DR (2004) Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its carboxyl-terminal domain to integrin ?v?3 and heparan sulfate proteoglycans. J Biol Chem 279 8848-8855
Ball, D.K., Moussad, E.E-D.A., Rageh, M.A.E., Kemper, S.A, Brigstock, D.R. (2003) Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction 125 271-284
Wang JF, Olson ME, Ball DK, Brigstock DR, Wright JB, Hart DA (2003). Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression.Wound Repair Regen 11 220-229
Gao R, Brigstock DR (2003) Low-density lipoprotein receptor-related protein is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 27 214-220
Ball DK, Wilson AW, Kemper SA, Brigstock DR (2003). The heparin-binding 10kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol 176 R1-R7
di Mola FF, Friess H, Riesle E, Koliopanos A, Buchler P., Zhu Z, Brigstock DR, Korc M, Buchler MW (2002) Connective tissue growth factor (CTGF) is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Annals Surgery 235 60-67
Williams, E.J., Gaca, M.D.A., Brigstock, D.R., Arthur, M.J.P, and Benyon, R.C. (2000) Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J. Hepatology 32 754-761
Brigstock, D.R., Steffen, C.L. Kim, G.Y., Vegunta, R.K. Diehl, J.R. and Harding P.A. (1997) Purification and characterization of novel heparin-binding growth factors in uterine secretory fluids: Identification as heparin-regulated 10,000-Mr forms of connective tissue growth factor. J. Biol. Chem.272 20275-20282