Associate Professor of Surgery
Division of Cardiac Surgery

ZhuHua Hua.Zhu@osumc.edu
614-212-2130

Assistant
Erin.Haggard@osumc.edu

Dr. Hua Zhu is an associate professor of Cardiac Surgery. Dr. Zhu investigates the factors that control normal structure and intracellular signaling in cardiac and skeletal muscle physiology and diseases. Specifically, he is interested in whether one can enhance transverse tubular structure and function in treatment of muscular dystrophy; how to fine tune balance among intracellular cell death pathways, such as necroptosis, apoptosis and autophagy for cardiac and skeletal muscle protection; and how to rejuvenate stem cell function to enhance tissue regeneration in the aging process.

Education
  • PhD: Institute of Biophysics, Chinese Academy of Sciences, Molecular and Cellular Biology
  • Fellowship: Cancer Institute of New Jersey, Rutgers University, Postdoctoral Cancer Research
  • Fellowship: University of Medicine and Dentistry of New Jersey (Rutgers Medical School), Postdoctoral Fellow in Physiology

Research Interests
  • Ischemic heart diseases
  • Muscular dystrophy
  • Sarcopenia
  • Corneal wound healing
  • Stem cells

Current Funding
  • NIH R01-AR067766
    Regulation of Mitsugumin 29 expression in muscle physiology and diseases
  • NIH R01-HL124122
    Oxidized Low-density Lipoprotein Impairs Bone Marrow Stem Cell Survival in Myocardial Infarction

View PubMed

Honors

2008  N. Ronald Morris Award for Excellent Research, UMDNJ

2011  Gallo Award for Outstanding Cancer Research, New Jersey.

Editorial Activities

  • 2009 - present Journal of Medical and Biological Sciences
  • 2009 - present Journal of Cell and Animal Biology
  • 2009 - present Journal of Biology, Biological Systems and Bioinformatics
  • 2009 - present Journal of Physical and Natural Sciences
  • 2009 - present Journal of Pharmacy, Pharmacology and Toxicology
  • 2009 - present Journal of Cell Biology and Genetics
  • 2010 - present Journal of Toxicology Research
  • 2010 - present IOMC conference
  • 2011 - present Journal of Nanomaterials
  • 2012 - present Acta Oto‐Laryngologica
  • 2012 - present Molecular Biology Reports
  • 2013 - present Current Vascular Pharmacology
  • 2013 - present Journal of Microbiology and Infectious Diseases
  • 2014 - present Journal of Cellular Physiology
  • 2014 - present Journal of Pharmacy and Pharmacology
  • 2014 - present World Journal of Surgical Oncology
  • 2014 - present Journal of Immunology Research
  • 2014 - present Cellular Physiology and Biochemistry
  • 2014 - present Oncotarget
  • 2015 - present Experimental Biology and Medicine
  • 2015 - present Scientific Reports
  • 2015 - present American Journal of Physiology - Heart and Circulatory Physiology

Journal Articles

Cai,C,X; Zhu,H; Chen,J,W. "Overexpression of caveolin-1 increases plasma membrane fluidity and reduces P-glycoprotein function in Hs578T/Dox." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 320, no. 3. (July 2004.): 868-874

Zhu,H; Cai,C,X; Chen,J,W. "Suppression of P-glycoprotein gene expression in Hs578T/Dox by the overexpression of caveolin-1." FEBS LETTERS. Vol. 576, no. 3. (October 2004.): 369-374

Pang,Y,H; Zhu,H; Wu,P; Chen,J,W. "The characterization of plasma membrane Ca2+-ATPase in rich sphingomyelin-cholesterol domains." FEBS LETTERS. Vol. 579, no. 11. (April 2005.): 2397-2403

Wu,Ping; Qi,Baoju; Zhu,Hua; Zheng,Yamin; Li,Fei; Chen,Jianwen. "Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1." CANCER LETTERS. Vol. 256, no. 1. (October 2007.): 64-72

Wu,Ping; Wang,Xiaohui; Li,Fei; Qi,Baoju; Zhu,Hua; Liu,Shuang; Cui,Yeqing; Chen,Jianwen. "Growth suppression of MCF-7 cancer cell-derived xenografts in nude mice by caveolin-1." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 376, no. 1. (November 2008.): 215-220

Zhu,Hua; Weisleder,Noah; Wu,Ping; Cai,Chuanxi; Chen,Jian-Wen. "Caveolae/Caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells." JOURNAL OF PHARMACOLOGICAL SCIENCES. Vol. 106, no. 2. (February 2008.): 287-294

Zhu,Hua; Wu,Hao; Liu,Xiuping; Euans,Brad,R; Medina,Daniel,J; Liu,Chang-gong; Yang,Jin-Ming. "Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells." BIOCHEMICAL PHARMACOLOGY. Vol. 76, no. 5. (September 2008.): 582-588

Zhu,Hua; Evans,Brad; O'Neill,Peter; Ren,Xingcong; Xu,Zude; Hait,William,N; Yang,Jin-Ming. "A role for p53 in the regulation of extracellular matrix metalloproteinase inducer in human cancer cells." CANCER BIOLOGY & THERAPY. Vol. 8, no. 18. (September 2009.): 1722-1728

Zhu,Hua; Wu,Hao; Liu,Xiuping; Li,Biao; Chen,Yun; Ren,Xingcong; Liu,Chang-gong; Yang,Jin-Ming. "Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells." AUTOPHAGY. Vol. 5, no. 6. (August 2009.): 816-823

Wu,Hao; Zhu,Hua; Liu,David,X; Niu,Ting-Kuang; Ren,Xingcong; Patel,Rajesh; Hait,William,N; Yang,Jin-Ming. "Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-D-Glucose against Human Glioma Cells through Blunting of Autophagy." CANCER RESEARCH. Vol. 69, no. 6. (March 2009.): 2453-2460

Zhang,Shi-Jin; Sandstrom,Marie; Ahlsen,Maria; Ivarsson,Niklas; Zhu,Hua; Ma,Jianjie; Ren,Jian-Ming; Westerblad,Hakan; Katz,Abram. "2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle." EXPERIMENTAL PHYSIOLOGY. Vol. 95, no. 8. (August 2010.): 892-898

Zhu,Hua; Yue,Jingyin; Pan,Zui; Wu,Hao; Cheng,Yan; Lu,Huimei; Ren,Xingcong; Yao,Ming; Shen,Zhiyuan; Yang,Jin-Ming. "Involvement of Caveolin-1 in Repair of DNA Damage through Both Homologous Recombination and Non-Homologous End Joining." PLOS ONE. Vol. 5, no. 8. (August 2010.): e12055-

Zhu,Hua; Lin,Peihui; De,Gejing; Choi,Kyoung-Han; Takeshima,Hiroshi; Weisleder,Noah; Ma,Jianjie. "Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 15. (April 2011.): 12820-12824

Jin,Wei; Liu,Yang; Chen,Li; Zhu,Hua; Di,Gen-Hong; Ling,Hong; Wu,Jiong; Shao,Zhi-ming. "Involvement of MyoD and c-myb in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene." BREAST CANCER RESEARCH AND TREATMENT. Vol. 125, no. 3. (February 2011.): 699-713

Gu,Shengmei; Chen,Li; Hong,Qi; Yan,Tingting; Zhuang,Zhigang; Wang,Qiaoqiao; Jin,Wei; Zhu,Hua; Wu,Jiong. "PEA3 activates CXCR4 transcription in MDA-MB-231 and MCF7 breast cancer cells." ACTA BIOCHIMICA ET BIOPHYSICA SINICA. Vol. 43, no. 10. (October 2011.): 771-778

Weisleder,Noah; Lin,Peihui; Zhao,Xiaoli; Orange,Matthew; Zhu,Hua; Ma,Jianjie. "Visualization of MG53-mediated cell membrane repair using in vivo and in vitro systems.." Journal of visualized experiments : JoVE. Vol. doi: 10.3791/2717, no. 52. (January 2011.): 2717-

Lin,Peihui; Zhu,Hua; Cai,Chuanxi; Wang,Xianhua; Cao,Chunmei; Xiao,Ruiping; Pan,Zui; Weisleder,Noah; Takeshima,Hiroshi; Ma,Jianjie. "Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair." FASEB JOURNAL. Vol. 26, no. 5. (May 2012.): 1875-1883

He,Bo; Tang,Ru-Hang; Weisleder,Noah; Xiao,Bin; Yuan,Zhenhua; Cai,Chuanxi; Zhu,Hua; Lin,Peihui; Qiao,Chunping; Li,Jianbin; Mayer,Christina; Li,Juan; Ma,Jianjie; Xiao,Xiao. "Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in delta-Sarcoglycan-deficient Hamsters." MOLECULAR THERAPY. Vol. 20, no. 4. (April 2012.): 727-735

Weisleder,Noah; Takizawa,Norio; Lin,Peihui; Wang,Xianhua; Cao,Chunmei; Zhang,Yan; Tan,Tao; Ferrante,Christopher; Zhu,Hua; Chen,Pin-Jung; Yan,Rosalie; Sterling,Matthew; Zhao,Xiaoli; Hwang,Moonsun; Takeshima,Miyuki; Cai,Chuanxi; Cheng,Heping; Takeshima,Hiroshi; Xiao,Rui-Ping; Ma,Jianjie. "Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy." SCIENCE TRANSLATIONAL MEDICINE. Vol. 4, no. 139. (June 2012.): 139ra85-

Jin,Wei; Chen,Bo-bin; Li,Ji-Yu; Zhu,Hua; Huang,Mark; Gu,Sheng-Mei; Wang,Qiao-Qiao; Chen,Jia-Ying; Yu,Sanjian; Wu,Jiong; Shao,Zhi-Ming. "TIEG1 Inhibits Breast Cancer Invasion and Metastasis by Inhibition of Epidermal Growth Factor Receptor (EGFR) Transcription and the EGFR Signaling Pathway." MOLECULAR AND CELLULAR BIOLOGY. Vol. 32, no. 1. (January 2012.): 50-63

Nishi,Miyuki; Aoyama,Fumiyo; Kisa,Fumihiko; Zhu,Hua; Sun,Mingzhai; Lin,Peihui; Ohta,Hiroya; Van,Bo; Yamamoto,Shinichiro; Kakizawa,Sho; Sakai,Hideki; Ma,Jianjie; Sawaguchi,Akira; Takeshima,Hiroshi. "TRIM50 Protein Regulates Vesicular Trafficking for Acid Secretion in Gastric Parietal Cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 287, no. 40. (September 2012.): 33523-33532

Yi,Jae-Sung; Park,Jun,Sub; Ham,Young-Mi; Nguyen,Nga; Lee,Na-Rae; Hong,Jin; Kim,Bong-Woo; Lee,Hyun; Lee,Chang-Seok; Jeong,Byung-Cheon; Kyu Song,Hyun; Cho,Hana; Kim,Yoon,Ki; Lee,Jae-Seon; Park,Kyong,Soo; Shin,Haksub; Choi,Inho; Lee,Seung,Hee; Park,Woo,Jin; Park,Shi-Young; Choi,Cheol,Soo; Lin,Peihui; Karunasiri,Malith; Tan,Tao; Duann,Pu; Zhu,Hua; Ma,Jianjie; Ko,Young-Gyu. "MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.." Nature communications. Vol. 4, (August 2013.): 2354-?

Corona,Benjamin,T; Garg,Koyal; Roe,Janet,L; Zhu,Hua; Park,Ki,Ho; Ma,Jianjie; Walters,Thomas,J. "EFFECT OF RECOMBINANT HUMAN MG53 PROTEIN ON TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN RAT MUSCLE." MUSCLE & NERVE. Vol. 49, no. 6. (June 2014.): 919-921

Zhu,Hua; Roe,Janet,L; Park,Ki,Ho; Tan,Tao; Lin,Pei-Hui; Ma,Jianjie; Walters,Thomas,J. "Amelioration of Ischemia-Reperfusion Induced Muscle Injury by the Recombinant Human MG53 Protein." BIOPHYSICAL JOURNAL. Vol. 106, no. 2. (January 2014.): 728A-729A

Zhang, B., Zhang, J., Tan, T., Zhang, H., Zhu, H.. "Biological roles of CD39 in translational medicine." Translational Medicine Journal. Vol. 3, no. 3. (July 2014.): 180-183

Jia,Yanlin; Chen,Ken; Lin,Peihui; Lieber,Gissela; Nishi,Miyuki; Yan,Rosalie; Wang,Zhen; Yao,Yonggang; Li,Yu; Whitson,Bryan,A; Duann,Pu; Li,Haichang; Zhou,Xinyu; Zhu,Hua; Takeshima,Hiroshi; Hunter,John,C; McLeod,Robbie,L; Weisleder,Noah; Zeng,Chunyu; Ma,Jianjie. "Treatment of acute lung injury by targeting MG53-mediated cell membrane repair." NATURE COMMUNICATIONS. Vol. 5, (July 2014.): 4387-

Liu,Xin-Yu; Zhou,Xin-Yu; Hou,Jin-cai; Zhu,Hua; Wang,Zhong; Liu,Jian-xun; Zheng,Yong-Qiu. "Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway." ACTA PHARMACOLOGICA SINICA. Vol. 36, no. 4. (April 2015.): 421-428

Ma,Hanley; Liu,Jason; Bian,Zehua; Cui,Yuqi; Zhou,Xinyu; Zhou,Xuefeng; Zhang,Bo; Adesanya,T,MAyodele; Yi,Frank; Park,Ki,Ho; Tan,Tao; Chen,Zhishui; Zhu,Hua. "Effect of Metabolic Syndrome on Mitsugumin 53 Expression and Function." PLOS ONE. Vol. 10, no. 5. (May 2015.): e0124128-

Duann,Pu; Li,Haichang; Lin,Peihui; Tan,Tao; Wang,Zhen; Chen,Ken; Zhou,Xinyu; Gumpper,Kristyn; Zhu,Hua; Ludwig,Thomas; Mohler,Peter,J; Rovin,Brad; Abraham,William,T; Zeng,Chunyu; Ma,Jianjie. "MG53-mediated cell membrane repair protects against acute kidney injury." SCIENCE TRANSLATIONAL MEDICINE. Vol. 7, no. 279. (March 2015.): 279ra36-

Cai,Chuanxi; Lin,Peihui; Zhu,Hua; Ko,Jae-Kyun; Hwang,Moonsun; Tan,Tao; Pan,Zui; Korichneva,Irina; Ma,Jianjie. "Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 290, no. 22. (May 2015.): 13830-13839

Cui,Yuqi; Jia,Fengpeng; He,Jianfeng; Xie,Xiaoyun; Li,Zhihong; Fu,Minghuan; Hao,Hong; Liu,Ying; Liu,Dylan,Z; Cowan,Peter,J; Zhu,Hua; Sun,Qinghua; Liu,Zhenguo. "Ambient Fine Particulate Matter Suppresses In Vivo Proliferation of Bone Marrow Stem Cells through Reactive Oxygen Species Formation." PLOS ONE. Vol. 10, no. 6. (June 2015.): e0127309-

Guo,Weixin; Li,Zhihong; Xie,Xiaoyun; Qin,Tiehe; Wu,Yan; Li,Zhou; Chai,Jing; Yi,Frank; Tan,Tao; Zhu,Hua; Wang,Shouhong. "Urinary Trypsin Inhibitor Attenuates Acute Lung Injury by Improving Endothelial Progenitor Cells Functions." CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. Vol. 36, no. 3. (January 2015.): 1059-1068

Huang,Yujian; Wang,Yi-Jun; Wang,Yongzhong; Yi,Sijia; Fan,Zhen; Sun,Leming; Lin,Derrick; Anreddy,Nagaraju; Zhu,Hua; Schmidt,Michael; Chen,Zhe-Sheng; Zhang,Mingjun. "Exploring naturally occurring ivy nanoparticles as an alternative biomaterial.." Acta biomaterialia. Vol. 25, (October 2015.): 268-283

Laganà,Alessandro; Veneziano,Dario; Spata,Tyler; Tang,Richard; Zhu,Hua; Mohler,Peter,J; Kilic,Ahmet. "Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).." PloS one. Vol. 10, no. 11. (January 2015.): e0143313-

Li,Haichang; Duann,Pu; Lin,Pei-Hui; Zhao,Li; Fan,Zhaobo; Tan,Tao; Zhou,Xinyu; Sun,Mingzhai; Fu,Minghuan; Orange,Matthew; Sermersheim,Matthew; Ma,Hanley; He,Duofen; Steinberg,Steven,M; Higgins,Robert; Zhu,Hua; John,Elizabeth; Zeng,Chunyu; Guan,Jianjun; Ma,Jianjie. "Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair.." journal of biological chemistry. Vol. 290, no. 40. (October 2015.): 24592-24603

Zhang,Bo; Cowden,Daniel; Zhang,Fan; Yuan,Jue; Siedlak,Sandra; Abouelsaad,Mai; Zeng,Liang; Zhou,Xuefeng; O'Toole,John; Das,Alvin,S; Kofskey,Diane; Warren,Miriam; Bian,Zehua; Cui,Yuqi; Tan,Tao; Kresak,Adam; Wyza,Robert,E; Petersen,Robert,B; Wang,Gong-Xian; Kong,Qingzhong; Wang,Xinglong; Sedor,John; Zhu,Xiongwei; Zhu,Hua; Zou,Wen-Quan. "Prion Protein Protects against Renal Ischemia/Reperfusion Injury." PLOS ONE. Vol. 10, no. 9. (September 2015.): e0136923-

Yang,Ze-Tian; Li,Zhihong; Wang,Xian-Guo; Tan,Tao; Yi,Frank; Zhu,Hua; Zhao,Jin-Ping; Zhou,Xue-Feng. "Overexpression of Long Non-Coding RNA ZXF2 Promotes Lung Adenocarcinoma Progression Through c-Myc Pathway.." Cellular physiology and biochemistry. Vol. 35, no. 6. (January 2015.): 2360-2370

Cui,Yuqi; Narasimhulu,Chandrakala,A; Liu,Lingjuan; Li,Xin; Xiao,Yuan; Zhang,Jia; Xie,Xiaoyun; Hao,Hong; Liu,Jason,Z; He,Guanglong; Cowan,Peter,J; Cui,Lianqun; Zhu,Hua; Parthasarathy,Sampath; Liu,Zhenguo. "Oxidized low-density lipoprotein alters endothelial progenitor cell populations." FRONTIERS IN BIOSCIENCE-LANDMARK. Vol. 20, (June 2015.): 975-988

zhu. "mg53." molecular therapy. 

Zhu, H., Hou, J., Roe, JL, Park, KH., Tan, T., Zheng, Y., Li, L., Zhang, C., Liu, J., Liu, Z., Ma, J., Walters, TJ.. "Amelioration of ischemia-reperfusion induced muscle injury by the recombinant human MG53 protein.." Muscle and Nerve. 

Huang, Y., Wang, Y., Wang, Y., Yi, S., Fan, Z., Sun, L., Lin, D., Anreddy, N., Zhu, H., Schmidt, M., Chen, Z., Zhang, M.. "Exploring naturally occurring ivy nanoparticles as an alternative biomaterial.." Acta Biomaterialia. 

Li, H., Duann, P., Lin, PH., Zhao, L., Fan, Z., Tan, T., Zhou, X., Sun, M., Fu, M., Orange, M., Sermerseim, M., Ma, H., He, D., Steinberg, S., Higgins, R., Zhu, H., John, E., Zeng, C., Guan, J., Ma, J.. "Modulation of wound healing and scar formation by MG53-mediated cell membrane repair." Journal of Biological Chemistry. 

Presentations

  • Modulation of transverse tubular structure in skeletal muscle physiology and diseases
  • Metabolic disorders reduce Mitsugumin 53 level in blood circulation
  • The role of calcium signaling in progression of esophageal squamous cell carcinoma
  • The roles of MG53: plasma membrane repair and beyond
  • Serum MicroRNA-378 as a novel diagnostic biomarker for myocardial infarction

Academic Advising

  • 2012 Xinyu Zhou, The Ohio State University.
  • 2012 Timothy M., The Ohio State University. 
  • 2013 - 2015 Frank Yi, The Ohio State University. Graduated 2015.
  • 2016 Qiang Wang The Ohio State University, Graduated 2015
  • 2015 - 2016 Jialong Guo, The Ohio State University. Graduated 2005.
  • 2015 - 2016 Xiaomeng Shi, The Ohio State University. Graduated 2016​.
  • 2015 Yanmei Ji, The Ohio State University. Graduated 2006.
  • 2016 Chunlin Yang, The Ohio State University. Graduated 2015.
  • 2013 - 2015 Li Zhang, The Ohio State University. Graduated 2015.
  • 2012 - 2014 Malith Karunasiri, The Ohio State University. Graduated 2014.
  • 2012 - 2015 Yuan Xiao, The Ohio State University. Graduated 2015.
  • 2012 - 2015 Xin Li, The Ohio State University. Graduated 2015.
  • 2012 - 2015 Yuqi Cui, The Ohio State University. Graduated 2015.
  • 2013 - 2015 Bo Zhang, The Ohio State University. Graduated 2015.
  • 2013 - 2015 Jianfeng He, The Ohio State University. Graduated 2015.
  • 2014 - 2015 Yanhong Luo, The Ohio State University. Graduated 2015.
  • 2014 - 2015 Yongqiu Zheng, The Ohio State University. Graduated 2015.
  • 2014 - 2015 Xuefeng Zhou, The Ohio State University.
  • 2014 - 2015 Xiaoyun Xie, The Ohio State University. Graduated 2015.