Innovations in trauma, critical care and burn surgery at Ohio State


The division has broadened the scope of its research activities to include representatives from anesthesiology, dietary, pain and palliative medicine, nursing and pharmacy. Dr. Charles Cook, associate professor of surgery, continues NIH-funded research examining cytomegalovirus (CMV) reactivation during critical illness and following transplantation. His laboratory recently published a notable article in the American Journal of Transplantation suggesting that cytomegalovirus reactivation can disrupt development of tolerance after heart transplantation.

The Division has a diverse research portfolio spanning basic science to clinical outcomes research in its mission areas of Trauma, Critical Care, Emergency General Surgery and Burn Care.  Faculty members in the division published over 46 scholarly articles in FY 2017. Division members had seven podium presentations at national meetings and numerous other presentations at international and national meetings. Funding comes from a variety of mechanisms including NIH, academic societies, industry and internal sources.

Health Services Research

  • Heena Santry, MD, MS, FACS - Director, Health Services Research Outcomes Center
  • Amy Rushing, MD- Foundation of Acute Care Surgery Registry, Acute Care Surgery in Cancer Patients
  • Daniel Eiferman, MD- Patient Safety and Healthcare Quality
  • David Evans, MD- Quality in Trauma Care
  • Daniel Vazquez, MD- Department of Surgery Innovations Collaborative
    Structured program in innovation in collaboration with the Colleges of Engineering and Business- partnering with industry and entrepreneurs to accelerate development and deployment of innovations in a variety of technological arenas relevant to surgery and critical care.
  • J. Kevin Bailey, MD- Laser Treatment for Burn Scar Hypertrophy
    Collaboration with College of Engineering
  • David Lindsey, MD, Ihab El-Hassan, MD and David C. Evans, MD- Educational Methods and Innovation

Research Programs

  • Sepsis Research Lab
    Jon Wisler, MD, PI- Epigenetic Regulation and DNA Methylation in Circulating Microvesicles during Sepsis
    Can “Helen” Hou, MD- Post-Doctoral Researcher, Chinese Scholarship Council
  • Neurotrauma Research Laboratory Collaboration- Daniel Eiferman, MD
Clinical Trials

Clinical Trials

Burn clinical trials

  • A phase 2A randomized double blind, placebo controlled, single center study to access amnion derived cellular cytokines solution spray in diabetic subjects with deep burns managed with meshed skin grafts (Sponsor, STEMNION ). PI: Dr. Larry Jones

Trauma clinical trials

  • GM-CSF for immunomodulation following trauma (GIFT) study (Sponsor NIH). CO PI: Dr. David Evans
  • A phase 3, randomized double-blind, double-dummy, multicenter, prospective study to assess the efficacy and safety of Eravacycline compared with Ertapenem in complicated intra-abdominal infections (Sponsor Tetraphase Pharmaceuticals, Inc.). PI: Dr. David Evans
  • A multicenter, open-label, randomized study to compare the safety and efficacy of intravenous Ceftolozane/Tazobactam with that of Pipercillin/Tazobactam in ventilator associated pneumonia (sponsor, Cubist Pharmaceutical). PI: Dr. Daniel Eiferman, Co PI: Dr. David Evans
  • A randomized trial of supplemental parenteral nutrition in under and overweight critically ill patients: The Top UP Trial (sponsor, Health Canada). PI: Dr. David Evans

Clinical trials group

David C. Evans, MD, FACS, Lead Investigator
Karina Woodling, MD, CCRP, Clinical Research Coordinator
Zoe Peters, BA, CCRP, Clinical Research Coordinator
Erika, Williams, BS, Clinical Research Assistant

Regulatory, Business and Administrative Support provided by OSU’s Clinical Trials Management Organization (CTMO)

Selected clinical trial areas by investigator

  • Evans et. al.- Gastric emptying drugs, parenteral nutrition, and anti-infectives for pneumonia, abdominal and bloodstream infections
  • Evans, Wisler, et al.- Necrotizing Soft Tissue Infection and Immunomodulation
  • Evans, Vazquez, Wisler, et. al.- Non-invasive sepsis detection devices
  • Lindsey, Evans et. al.- Factor replacement for anticoagulation reversal
  • Jones et. al.- Nutrition therapy for burns, novel wound care, pain control strategies
  • Evans, Yeager, et al.- Post-Traumatic Stress Disorder in hospitalized patients immediately after trauma
  • Hart, Evans, et al.- Nutrition supplementation before pancreatic surgery
  • Vazquez et. al.- Mobility technology and assessment in the ICU
  • Vazquez et al.- Physiologic monitoring and communication technology innovation in critical illness and injury