• Research Interests

  • Nicole Bernal, MD, FACS – Diagnosis and treatment of burns, burn health outcomes
  • Julia Coleman, MD MPH - Trauma-induced coagulopathy, resuscitation practices, sex dimorphisms in coagulation
  • Anahita Jalilvand, MD PhD – Sepsis, emergency general surgery, obesity, adipose tissue inflammation
  • Jennifer Knight Davis, MD – Clinical outcomes in emergency general surgery, robotics in acute care surgery, leadership
  • Daniel Eiferman, MD- Healthcare quality, spinal cord injury, opioid inpatient management, abdominal wall reconstruction, lymphedema
  • John Loftus, MD – Skin substitutes in the management of burns, utilization of plating (open reduction and internal fixation) of traumatic rib fractures , evaluation and management of frostbite
  • Carrie Sims, MD – Novel resuscitative strategies, geriatric trauma, sepsis, NADH biology, domestic and intimate partner violence, gun violence
  • Brett Tracy, MD – Neurological outcomes research, gun violence, resident education, biostatistical programs, frailty, multicenter trials
  • Carrie Valdez, MD - Reducing opioid use in trauma patients, improving outcomes in rib fractured patients, intimate partner violence in trauma patients
  • Wendy Wahl, MD – Complications and outcomes in the ICU, geriatric trauma patients, sepsis, anticoagulation
  • Jon Wisler, MD – Sepsis, clinical trials, immune dysregulation, necrotizing soft tissue infections, health outcomes
  • Andrew Young, MD – Machine learning, predictive analysis, geriatric falls, blood cerebral vascular injuries, failure to rescue, trauma data systems

  If you are interested in collaborating with a faculty member, please reach out to Holly Baselice at Holly.Baselice@osumc.edu.

• Research Programs

  • Epigenetic Regulation and DNA Methylation in Circulating Microvesicles during Sepsis PI: Wisler
  • Role of Toll-like Receptor 9 in Fibroblastic Reticular Cell-based Therapy for Intraabdominal Sepsis PI: Deng

Clinical Trials

• Trauma/Hemorrhagic Shock

  Ohio State University TRACK SCI Registry PI: Farhadi/Eiferman

  What is the ideal dose of whole blood in massively bleeding trauma patients? PI: Valdez

  Evaluation of a Ketogenic Diet for Improvement of Neurological Recovery in Individuals with Acute Spinal Cord Injury PI: Yarar-Fisher

• Coagulation

  A Phase 3, Prospective, Randomized, Open-label, Adaptive Group Sequential, Multicenter Trial with Blinded Endpoint Assessment to Evaluate the Efficacy and Safety of TAK-330 for the Reversal of Direct Oral Factor Xa Inhibitor-induced Anticoagulation in Patients Requiring Urgent Surgery/Invasive Procedure PI: Wisler

• Antimicrobials

  • A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Single Dose of Exebacase in Adult Patients Receiving Standard-of-Care Antibiotics for the Treatment of Staphylococcus aureus Bloodstream Infections (Bacteremia), Including Right-Sided Infective Endocarditis PI: Wisler

• Burn/Skin Grafting

  The VICToRY Pilot Study – VItamin C in Thermal injuRY PI: Wisler

  A Pivotal Study to Assess the Safety and Effectiveness of NovoSorb Biodegradable Temporizing Matrix (BTM) in the Treatment of Severe Burn Skin Injuries PI: Bernal

• Wound Healing

  Registry of Myriad Utilization in Soft Tissue Reconstruction Procedures PI: Loftus

• Traumatic Brain Injury (TBI)

  Biomarker Response to Amantadine Improves Neurorecovery: The BRAIN Study PI: Tracy

  Brain Oxygen Optimiization in Severe Traumatic Brain Injury - Phase 3): A multicenter, randomized, blinded-endpoint, comparative effectiveness study of goal-directed critical care based upon monitoring of brain tissue oxygen and intracranial pressure versus monitoring of intracranial pressure along in patients with severe traumatic brain injury. PI: Mainali/Wisler

• Critical Care/Rehab

  Analyzing the long-term impact of epigenetic immunomodulation following sepsis PI: Wisler

• Clinical trials group

  Jonathan Wisler, MD, Lead Investigator
  Adara McCarty, Clinical Research Coordinator
  George Abboud II, Clinical Research Coordinator
  Maya Daoud, Clinical Research Assistant

  Regulatory, Business and Administrative Support provided by OSU’s Clinical Trials Management Organization (CTMO)