Our goal is to improve people's lives through innovation in research, education and patient care.

The Dardinger Microneurosurgery Skull Base Lab is a neurosurgical, educational and research facility that is part of the Department of Neurological Surgery in The Ohio State University College of Medicine. The lab was established in 2006 by Mario Ammirati, MD, MBA, a professor of Neurological Surgery who also directs the lab and serves as director of skull base neurosurgery at Ohio State.

Our vision is to train neurosurgeons in mastering approaches to the skull base by integrating sound anatomical knowledge of the skull base with cutting-edge intraoperative technology. This vision is implemented by providing a research environment where, by dissecting anatomical specimens and using equipment similar to that found in the operating room, the neurosurgeon becomes conversant with established skull-base approaches and is stimulated to think of new ways of operating on skull-base lesions.

The “What if?” question is at the core of laboratory philosophy. What if I would use a different approach or different technology to reach an area of the skull base? Would that solve some of the clinical problems encountered in the operating room? Would it help decrease morbidity? These questions are studied and answered in the laboratory. If laboratory results are satisfactory, they are taken back to the operating room to be evaluated in a clinical setting, completing the translational research cycle.

The laboratory thrives on cross-collaboration among neurosurgeons, radiologists, ear nose and throat (ENT) surgeons, and basic biotechnologist scientists, and also on interactions among undergraduates, medical students and neurosurgeons in a diverse cultural environment.

The laboratory encourages cooperation with industry by sharing knowledge, thus creating an interactive platform where ideas may be generated, discussed and implemented.

Our Team

Our leaders

AmmiratiMario

Mario Ammirati, MD, MBA

Director, Dardinger Microneurosurgical Skull Base Laboratory

Dr. Ammirati's clinical interests include skull-base surgery, benign and malignant brain tumors, and degenerative spine disease. His research focuses on microneurosurgical anatomy of the skull base and brain-drug delivery systems. He earned his MD at the University of Naples in 1977 and completed residencies in neurological surgery at the University of Naples (1980) and Northwestern University (1987).

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Staff

Tariq Lamki, MD

Clinical & Research Fellow, Spartan Health Sciences University, Oman

David Mette, BS

The Ohio State University College of Medicine

Omar Mostafa

Undergraduate Student

Hongyang Pi

Undergraduate Student

Mohamad Ragaee, MD

Visiting Research Fellow, Egypt

mohamed.aly@osumc.edu

Chi-Tun Tang, MD

Visiting Research Fellow, Tri-Service General Hospital/National Defense Medical Center, Taipei, Taiwan

omeprazon8@hotmail.com

Current Projects

Current Projects

Current Projects

  1. Endoscopic analysis of the roof of the fourth ventricle: a qualitative and quantitative anatomical study
  2. Qualitative and quantitative radio-anatomical variation of the posterior clinoid process
  3. Endoscopic-assisted microvascular decompression: a cadaveric study
  4. Intradural endoscope-assisted anterior clinoidectomy: a cadaveric study
  5. Endoscopic subfrontal infrachiasmatic approach to third ventricle floor: a cadaveric study
  6. Assisted endoscopic technique in sublabial transsphenoidal approach to assess the working area in the sellar and suprasellar space with the use of computed tomography frameless-based stereotaxy: a cadaveric study
  7. Anterior occipito-axial fixation device following anterior spinal cord decompression
Recent Publications

Recent Publications

Recent Publications

Salma A, Wang S, Ammirati M. Extradural endoscope-assisted subtemporal posterior clinoidectomy: a cadaver investigation study. Neurosurgery 67:ons43-48, 2010 (Editor’s Choice for September 2010).

Salma A, Lubow M, Scheffer A, Ammirati M. Endoscopic orbital roof fenestration as an alternative treatment option for idiopathic intracranial hypertension: a cadaveric anatomical study. Journal of Neuro-Ophthalmology 31:25-28, 2010.

Makiese O, Pillai P, Sammet S, Ammirati M. Accuracy validation in a cadaver model of cranial neuronavigation using a surface autoregistration mask. Neurosurgery 67:ons85-90, 2010.

Wang S, Salma A, Ammirati M. Posterior interhemispheric transfalx transprecuneus approach to the atrium of the lateral ventricle: a cadaver study. Journal of Neurosurgery 113:949-954, 2010.

Filipce V, Pillai P, Makiese O, Zarzour H, Pigott M, Ammirati M. Quantitative and qualitative analysis of the working area obtained by endoscope and microscope in various approaches to the anterior communication artery complex using computer tomography-based frameless stereotaxy: a cadaver study. Neurosurgery 5:1147-1152, 2009.

Pillai P, Baig MN, Karas CS, Ammirati M. Endoscopic image-guided transoral approach to the craniovertebral junction: an anatomic study comparing surgical exposure and surgical freedom obtained with the endoscope and the operating microscope. Neurosurgery 64:437-442, 2009.

Pillai P, Sammet S, Ammirati M. Image-guided, endoscopic-assisted drilling and exposure of the whole length of the internal auditory canal and its fundus with preservation of the integrity of the labyrinth using a retrosigmoid approach: a laboratory investigation. Neurosurgery 65-53-59, 2009.

Pillai P, Lubow M, Ortega A, Ammirati M. Endoscopic transconjunctival surgical approach to the optic nerve and medial intraconal space: a cadaver study. Neurosurgery 63:204-208, 2008.

Pillai P, Sammet S, Ammirati M. Application accuracy of computed tomography-based, image-guided navigation of temporal bone. Neurosurgery 63:326-332, 2008.

Salma A. Alkandari A, Sammet S, Ammirati M. Laterial supraorbital approach versus pterional approach: an anatomical qualitative and quantitative evaluation. Neurosurgery 2011 68:364-372.

Salma A. Chow A, Ammirati M. Setting up a microneurosurgical skull base lab: technical and operational considerations. Neurosurgical Review 2011 34(3):317-326.

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