Contact

Phone: 614-292-5878

Address:

Dreese Labs Address

The Ohio State University 
Building 279 
2015 Neil Ave
Columbus, OH 43210

Biomedical Research Tower

The Ohio State University
Building 112 
460 W 12th Ave
Columbus, OH 43210

For information about how you can support Ohio State biotronic engineering research: Leigh Briggs, Director of Development – Neurosciences, 614-293-4584

For information about career or postdoctoral training opportunities in this lab, contact Liang Guo, PhD Guo.725@osu.edu.

GuoLabImageRTFThe Laboratory for Biotronic Engineering designs and builds electronic circuits that can be integrated with biological tissue.

The lab, which is part of the Ohio State Neurological Institute, is working to develop these so-called integrated cellular circuits as implantable medical devices for treatment, restoration, and augmentation to body functions. The lab also uses these circuits as biomedical research tools to study biological principles, systems, and functions.

Our Team

Our leaders

GuoLiang

Liang Guo, PhD

Assistant Professor, Electrical and Computer Engineering and SBS-Neuroscience

Dr. Guo integrates advances in tissue engineering, synthetic biology, stem cell technology, drug delivery, biomaterials, electronics, microelectromechanical systems, nanoelectromechanical and neural engineering.

View Full Bio

Staff

Nick Chehade

Undergraduate Student

Forest Kunecke

Undergraduate Student

Mary C. Lenk

Undergraduate Student

Jordan Prox, BS

Graduate Student

Farhan S. Quadri

Undergraduate Student

Qinwan Rabbani

Undergraduate Student

Yongchen Wang, MA

Graduate Student

Yu Wu, BE

Graduate Student

Xiao Xie, PhD, CAS

Research Associate

Bingxi Yan, MS

Graduate Student

David Youssef

Undergraduate Student

Alumni

Our leaders

Staff

Daniel Beyer, (2014)

Undergraduate Student, Ohio State University

Daniel Gomez, (2014)

Undergraduate Student, Ohio State University

Michael Kunchal, (2014)

Undergraduate Student, Ohio State University

Boyi Li, (2014-2015)

Undergraduate Student, Ohio State University

Carlos Mendez, (2014)

Undergraduate Student, Ohio State University

Seth Ringel, BS (2013-2015)

Graduate Student, University of Michigan

Emily R. Watson, (2014)

Undergraduate Student, Ohio State University

Current Projects

Current Projects

Current Projects

Current projects at the Laboratory for Biotronic Engineering focus on integrated cellular circuits (ICC)—the biological implementation of circuits, devices and systems using cells from multicellular organisms, including animals and plants. We are looking to apply these circuits to a variety of applications, including implantable medical devices, scientific tools, and biological models. Fundamental approaches for building the biological circuits include microfabrication, tissue engineering, biomaterials, stem cell biology, and synthetic biology. We are pioneering the science and engineering of ICC with a focus on three goals:

  1. Develop ICC as implantable medical devices for treatment, restoration, and augmentation to body functions
  2. Develop ICC as scientific tools to facilitate novel biomedical research
  3. Study biological principles, systems, and functions through the engineering of ICC models
  4. Integration of neural prosthetics and tissue engineering
  5. Exploring fabrication methods and circuit designs for creating biological cybertronics
  6. Developing cybertronics to study plant compenents
Recent Publications

Recent Publications

Recent Publications

L. Guo, Conducting Polymers as Smart Materials for Tissue Engineering, Fundamental Principles of Smart Materials for Tissue Engineering (RSC Smart Materials Series), Royal Society of Chemistry, in preparation.

Y. Wang and L. Guo, Nanoparticle-Enabled Neural Stimulation, in preparation.

G. S. Guvanasen, L. Guo, R. J. Aguilar, A. L. Cheek, C. S. Shafor, S. Rajaraman, T. R. Nichols, and S. P. DeWeerth, A Stretchable Microneedle Electrode Array for Stimulating and Measuring Intramuscular Electromyographic Activity, in preparation.

Y. Gao, A. Wilford, L. Guo, Self-correcting Multi-atlas Segmentation, SPIE Medical Imaging 2016, San Diego, California, February 27-March 3, 2016, submitted.

B. Yan, B. Li, F. Kunecke, Z. Gu, and L. Guo, Polypyrrole-Based Implantable Electroactive Pump for Controlled Drug Microinjection, ACS Applied Materials & Interfaces, vol. 7, no. 27, pp. 14563–14568, July 2015.

L. Guo, Stretchable Polymeric Neural Electrode Array: Toward a Reliable Neural Interface, Materials Research Society 2015 Spring Meeting, San Francisco, California, April 6–10, 2015.

L. Guo, M. Ma, N. Zhang, R. Langer, and D. G. Anderson, Stretchable Polymeric Multielectrode Array for Conformal Neural Interfacing, Advanced Materials, vol. 26, no. 9, pp. 1427–1433, March 2014.

G. S. Guvanasen, R. J. Aguilar, L. Guo, C. Karnati, S. Rajaraman, T. R. Nichols, and S. P. DeWeerth, Development of a Stretchable, Penetrating Electrode Array for Measuring Intramuscular Electromyographic Activity, The 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Freiburg, Germany, October 27-31, 2013.

L. Guo, G. S. Guvanasen, X. Liu, C. Tuthill, T. R. Nichols, and S. P. DeWeerth, A PDMS-Based Integrated Stretchable Microelectrode Array (isMEA) for Neural and Muscular Surface Interfacing, IEEE Transactions on Biomedical Circuits and Systems, vol. 7, no. 1, pp. 1–10, February 2013.

M. Ma, L. Guo, D. G. Anderson, and R. Langer, Bio-Inspired Polymer Composite Actuator and Generator Driven by Water Gradients, Science, vol. 339, no. 6116, pp. 186–189, January 2013.

Movies associated with this publication:

http://video.mit.edu/watch/artificial-muscles-at-mit-13539/ 

https://www.youtube.com/watch?v=R6SxMqh9530 

A. Srinivasan, L. Guo, and R. V. Bellamkonda, Regenerative Microchannel Electrode Array for Peripheral Nerve Interfacing, The 5th International IEEE EMBS Conference on Neural Engineering, Cancun, Mexico, April 27-May 1, 2011.

L. Guo, G. S. Guvanasen, C. Tuthill, T. R. Nichols, and S. P. DeWeerth, A Low-Cost, Easy-Fabricating Stretchable Microneedle-Electrode Array for Intramuscular Recording and Stimulation, The 5th International IEEE EMBS Conference on Neural Engineering, Cancun, Mexico, April 27-May 1, 2011.

L. Guo, G. S. Guvanasen, C. Tuthill, T. R. Nichols, and S. P. DeWeerth, Characterization of a Stretchable Multielectrode Array for Epimysial Recording, talk, The 5th International IEEE EMBS Conference on Neural Engineering, Cancun, Mexico, April 27-May 1, 2011.

K. W. Meacham, L. Guo, S. P. DeWeerth, and S. Hochman, Selective Stimulation of the Spinal Cord Surface Using a Stretchable Microelectrode Array, Frontiers in Neuroengineering, vol. 4, article 5, April 2011.

L. Guo and S. P. DeWeerth, An Effective Lift-Off Method for Patterning High-Density Gold Interconnects on an Elastomeric Substrate, Small, vol. 6, no. 24, pp. 2847–2852, December 2010.

L. Guo, I. P. Clements, R. V. Bellamkonda, and S. P. DeWeerth, A Conformable Microelectrode Array (cMEA) with Integrated Electronics for Interfacing to a Regenerated Peripheral Nerve, IEEE Biomedical Circuits and Systems Conference 2010, Paphos, Cyprus, November 3-5, 2010.

L. Guo, K. W. Meacham, S. Hochman, and S. P. DeWeerth, A PDMS-Based Conical-Well Microelectrode Array for Surface Stimulation and Recording of Neural Tissues, IEEE Transactions on Biomedical Engineering, vol. 57, no. 10, pp. 2485–2494, October 2010.

S. P. DeWeerth, A. C. Hughes, K. Sundar, L. Guo, and L. H. Ting, A Hybrid Muscle-in-the-Loop Robot System for Studying the Neuromechanical Properties of Movement, talk, The 3rd IEEE RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics, Tokyo, Japan, September 26-29, 2010.

L. Guo and S. P. DeWeerth, High-Density Stretchable Electronics: Toward an Integrated Multilayer Composite, Advanced Materials, vol. 22, no. 36, pp. 4030–4033, September 2010.

A. C. Hughes, L. Guo, and S. P. DeWeerth, Interleaved Multichannel Epimysial Stimulation for Eliciting Smooth Contraction of Muscle with Reduced Fatigue, talk, The 32st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Buenos Aires, Argentina, August 31-September 4, 2010.

S. A. Desai, J. D. Rolston, L. Guo, and S. M. Potter, Improving Impedance of Implantable Microwire Multi-Electrode Arrays by Ultrasonic Electroplating of Durable Platinum Black, Frontiers in Neuroengineering, vol. 3, article 5, May 2010.

L. Guo, L. J. Kitashima, C. R. Villari, A. M. Klein, and S. P. DeWeerth, Muscle Surface Recording and Stimulation Using Integrated PDMS-Based Microelectrode Arrays: Recording-Triggered Stimulation for Prosthetic Purposes, IEEE Biomedical Circuits and Systems Conference 2009, Beijing, China, November 26-28, 2009.

L. Guo and S. P. DeWeerth, Implementation of Integratable PDMS-Based Conformable Microelectrode Arrays Using a Multilayer Wiring Interconnect Technology, The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, Minnesota, September 2-6, 2009.

L. Guo and S. P. DeWeerth, PDMS-Based Conformable Microelectrode Arrays with Selectable Novel 3-D Microelectrode Geometries for Surface Stimulation and Recording, The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, Minnesota, September 2-6, 2009.

K. W. Meacham, R. J. Giuly, L. Guo, S. Hochman, and S. P. DeWeerth, A Lithographically-Patterned, Elastic Multi-Electrode Array for Surface Stimulation of the Spinal Cord, Biomedical Microdevices, vol. 10, no. 2, pp. 259–269, April 2008.

W. Jia, X. Liu, X. Gao, L. Guo, Y. Lei, Y. Ku, and S. Gao, The Detection of Seizure Vulnerable Period from Epidural EEG Recordings of Epilepsy Rat, The 2nd International IEEE EMBS Conference on Neural Engineering, Washington D.C., March 16-19, 2005.

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