Brain and Spine Tumor Center

ElderJames

Director, Neurosurgical Oncology
Associate Professor, Department of Neurological Surgery

300 West 10th Avenue
Columbus, OH 43210

Research Interests: Research largely involves collaborative efforts with a neuro-oncology research team at Ohio State that includes neuro-oncologists, neuro-pathologists and basic science researchers. Contributions include the development of surgical techniques in animal models that facilitate delivery of therapeutic agents in glioma and brain metastasis models, such as convection-enhanced delivery and intra-arterial drug-delivery methods.

Current Research: Focus on clinical trials and translational research related to collaborative efforts at The Ohio State University Wexner Medical Center and at Ohio State’s Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC –James). Principal investigator (PI) on multiple clinical trials, including a newly opened clinical trial that aims to determine the maximum tolerated dose of carboplatin delivered by convection-enhanced delivery into the brain of patients with recurrent glioblastoma. PI or co-PI on multiple gene therapy studies and oncolytic (cancer-killing) virus studies in humans that involve application of viral vectors into brain tumors during surgery for resection or biopsy for recurrent glioblastoma.

Background: Throughout his neurosurgical training, Dr. Elder maintained an interest in neurosurgical oncology. He dedicated a year during residency to work at California Institute of Technology developing artificial extracellular matrix proteins with the goal of characterizing the extracellular matrix cues important for brain tumor stem cell differentiation. After residency, he spent a clinical year at Memorial Sloan-Kettering Cancer Center as a neurosurgical oncology fellow. During this time, Dr. Elder participated in the interdepartmental review process for proposed clinical trials and was involved in the enrollment and evaluation of clinical trial participants.

Education: M.D., Columbia University College of Physicians & Surgeons

Postgraduate Education/Training: Neurological Surgery, LA County - USC Medical Center

Fellowship: Neurological Surgery, Memorial Sloan-Kettering Cancer Center

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