The Research Institute at Nationwide Children's Hospital

KasperBrianPrincipal Investigator in the Center for Gene Therapy, Associate Professor in the Department of Pediatrics and Department of Neuroscience

College of Medicine
Department of Pediatrics, Department of Neuroscience

PubMed articles

The Research Institute at Nationwide Children's Hospital
700 Children’s Drive
Columbus, OH 43205
Phone: 614-722-2700
Fax: 614-355-5247
Email: Brian.Kaspar@nationwidechildrens.org

Areas of Interest: Our laboratory focuses on basic and translational studies related to neurological and neuromuscular disorders, particularly the mechanism(s) of neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Using rodent models of this disease, we investigate the involvement of various cell types in disease onset and progression. Furthermore, we are developing novel methods to deliver genes and therapies more efficiently to the nervous system and testing novel targets to combat this debilitating, lethal disease.

We are also investigating the biological control of embryonic and adult derived stem cells to evaluate cell cycle regulation and to develop methods to control cell differentiation to defined phenotypes, such as complex motor neurons.

Finally, we are developing muscle-enhancing strategies designed to combat musculoskeletal disorders. Follistatin is a potent antagonist of myostatin and enhances muscle size and mass when introduced to skeletal muscle by a one-time gene. Interestingly, we have shown that follistatin reduces the inflammatory environment in dystrophic muscles and induces improvements in functional strength in rodent models of Duchene Muscular Dystrophy. We are currently developing a human clinical trial for Inclusion Body Myositis with Dr. Jerry Mendell.

Research Techniques: Animal models of neurodegenerative and neuromuscular disease, gene delivery, stem cell biology.

Education:
Postdoctoral Research, University of California, San Diego
Postdoctoral Research, Salk Institute for Biological Studies, 2003-2004

Honors/News:
In 2013, Dr. Kaspar was named a Fellow of the American Association for the Advancement of Science (AAAS)

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