Department of Molecular Virology, Immunology and Medical Genetics

WitwerCarolineVice President for Research, Professor of Microbial Infection and Immunity, Department of Molecular Virology, Immunology and Medical Genetics

College of Medicine
Department of Microbial Infection and Immunity

208 Bricker Hall
190 North Oval Mall
Columbus OH 43210
Phone: 614-247-8356
Fax: 614-292-6602
whitacre.3@osu.edu

Research Interests:
• Immune tolerance
• CNS autoimmune disease
• Multiple sclerosis
• Animal models for the study of multiple sclerosis
• Gender differences in autoimmune disease
• Neuroendocrine-immune interactions
• Immune effects in spinal cord injury

Current Research: The primary focus of research is to understand the mechanisms underlying gender differences in autoimmune diseases, specifically differences in the immune response to explain why women tend to get autoimmune diseases more often than men, yet men often exhibit a more rapidly progressive course of disease. The lab also studies the effect of pregnancy on disease progression in MS. A recent area of investigation is the role of microRNA in the pathogenesis and treatment of MS and experimental autoimmune encephalomyelitis.

Research Techniques: The laboratory uses cellular and molecular approaches to devise therapeutic regimens for multiple sclerosis focusing on the animal model, experimental autoimmune encephalomyelitis.

PubMed articles

Education:
PhD: The Ohio State University
Postdoctoral Fellowship: Northwestern University Medical School

Honors:
Ohio State Distinguished Scholar Award (2008)
Fellow of the American Association for the Advancement of Science (2004)
Ohio State Faculty Award for Distinguished University Service (2001)

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