Department of Physical Medicine and Rehabilitation

GauthierLynneAssistant Professor, Department of Physical Medicine and Rehabilitation

Director, Neurorecovery and Brain Imaging Laboratory

Department of Physical Medicine and Rehabilitation
Wexner Medical Center

480 Medical Center Drive
2145 Dodd Hall
Columbus, OH 43210
614-293-3830
Lynne.Gauthier@osumc.edu

Research Goals: The mission of the Neurorecovery and Brain Imaging Lab is to improve the quality of life for individuals who have experienced stroke or other neurological injury. They strive to achieve this objective in two ways: 

  1. They study how rehabilitation interventions promote structural and functional changes in the brain. It is their hope that by identifying the mechanisms of brain change through therapy, they can enhance the effectiveness of existing interventions. 
  2. They aim to make the most effective therapies more fun, cost-effective, and accessible through use of technology, such as video games. Their research relies heavily on the input and volunteer efforts of the local stroke community.

Research Interests

  • Neuroplasticity
  • Motor rehabilitation
  • Hemispatial neglect rehabilitation
  • Virtual reality, constraint-induced movement therapy
  • Stroke
  • Multiple sclerosis
  • Brain injury

Research Techniques: Neurorehabilitation, including constraint-induced movement therapy and behavioral techniques to promote carry-over, structural MRI analysis (e.g., voxel-based morphometry, diffusion tensor imaging, myelin mapping), continuous data capture during rehabilitation

Current Research

  1. Examining the mechanisms of neuroplasticity following mother rehabilitation in stroke: Our laboratory is using new magnetic resonance funded research, imaging techniques to better understand the time-course and cellular/molecular nature of brain changes during constraint-induced movement therapy (CI therapy), a highly efficacious treatment for residual motor disability in chronic stroke. Its effectiveness is believed to be due, at least in part, to the therapy’s ability to aid the brain in “rewiring itself.” We are hopeful that by better understanding how CI therapy can change the brain, the effectiveness of rehabilitation can be improved upon. 
  2. Virtual reality gaming for motor rehabilitation: CI therapy is the current “gold standard” intervention for arm hemiparesis but is unavailable to most patients due to cost, travel/scheduling demands, and dearth of trained providers. We are developing a home-based, computer-gaming version of CI therapy that will provide equal access to high-quality rehabilitation regardless of a patient’s resources. We are currently conducting a multi-site randomized clinical trial to compare the in-home game-based therapy to in-clinic CI therapy and standard care. We are also conducting a pilot trial of the system for improving upper extremity weakness in Multiple Sclerosis. 
  3. The laboratory is performing data analytics on our large database of cognitive, sensorimotor and kinematic recordings (collected through rehab gaming) for personalized prediction of rehabilitation response.

Active Funding:

The Patient-Centered Outcomes Research Institute 
Rudi Schulte Foundation

Past Funding:

American Heart Association - Scientist Development Grant
Jeffrey Thomas Stroke Shield Foundation
National Multiple Sclerosis Society

PubMed articles

Staff/Lab Members/Collaborators: 
Petra Schmalbrock, PhD, Radiology
Stephen Page, PhD, Health and Rehabilitation Sciences
Roger Crawfis, PhD, Computer Science
Ryan McPherson, PhD, Electrical Engineering
Linda Lowes, PT, PhD, Physical Therapy (NCH)
Marcia Bockbrader, MD, PhD
Hojjat Adeli, PhD, Neuroscience

Education and Training:
PhD: Health/Medical Psychology University of Alabama 
MA: Health/Medical Psychology University of Alabama

Residency: Clinical Internship: Behavioral Medicine, Brown University

Editorial Activities:
2014 – Present Reviewer, Journal of NeuroEngineering and Rehabilitation
2014 – Present Reviewer, The International Journal of Neuroscience
2014 – Present Ad hoc reviewer, Restorative Neurology and Neuroscience
2013 – Present Grant Reviewer, Grant reviewer, American Heart Association
2012 – Present Reviewer, American Journal of Physical Medicine & Rehabilitation
2012 – Present Reviewer, BMC Neuroscience
2012 – Present Reviewer, Brain
2012 – Present Reviewer, Human Brain Mapping
2012 – Present Grant Reviewer, Grant Reviewer, PCORI
2009 – 2010 Grant Reviewer, UK Multiple Sclerosis Society

Society/Memberships: 

2015 - Present Co-Chair, American Congress of Rehabilitation Medicine, Neuroplasticity
2012 - Present Member, American Heart Association
2011 - Present Member, American Congress of Rehabilitation Medicine
2011 - Present Member, Organization for Human Brain Mapping
2010 - Present Member, American Psychological Association, Division 22

Honors/News:
Researchers Develop At-Home 3D Video Game for Stroke Patients
2012, Faculty Spotlight, Center for Faculty Advancement, The Ohio State University

My Clinical Bio

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