Department of Biological Chemistry and Pharmacology

Associate Professor in the Department of Biological Chemistry and Pharmacology

College of Medicine
Division of Molecular and Cellular Biochemistry

Department of Biological Chemistry and Pharmacology
184 Rightmire Hall
1060 Carmack Road
Columbus, OH 43210
Phone: 614-292-8542
Fax: 614-292-5379

Research Interests:
1. Drug discovery for neurodegenerative diseases and spinal cord injury
2. Role of metabolic dysfunction in Alzheimer’s disease
3. Regulatory mechanisms for myelination during development and after injury

Current Research:
1. Drug discovery for Alzheimer’s disease with JNK3-selective small molecule(s) that are orally available and also cross the blood-brain-barrier
2. Understanding the role of metabolic dysfunction in Alzheimer’s disease pathology
A) Role of hypothalamic p75 in leptin-mediated action
B) Role of hypothalamic p75 in Alzheimer’s disease pathology in regard to its action on leptin signaling
3. Understanding the mechanisms of neurotrophin action during development and under pathological conditions
A) Role of p75 in non-myelinating Schwann cells
B) Role of p75-proNGF in the spinal cord and the bladder for spinal cord injury-mediated bladder dysfunction

NIH-NINDS-UH2/UH3 (Role: MPI, Contact PI: Philip LoGrasso) 
“Discovery and preclinical development of isoform selective JNK inhibitors for Alzheimer's disease.”
The goal of this project is to develop JNK3-selective inhibitor with brain bioavailability.

Alzheimer’s Drug Discovery Foundation (Role: PI)
“Attenuating AD pathology with novel JNK inhibitors”
The goal of this proposal is to test whether a novel JNK inhibitor that crosses the BBB will attenuate Alzheimer’s symptoms.

PubMed articles  

Ph.D., Tufts University Medical School, 1993
Post-doctoral Training: Cornell University, 1997
Medical College: Columbia University, 1998

1. An award from School of Biomedical Science Excellence in Research and Teaching, Ohio State University (2008)
2. Whitehall Foundation Research Award (1999-2002)
3. Career Development Award from American Cancer Society (2000-2003)
4. Young Investigator Award from the National Alliance for Research on Schizophrenia and Depression (1999-2000)
5. Postdoctoral Fellowship, the National Multiple Sclerosis Society (1994-1997)
6. First Prize, Charlton Fund Student Research Scientist Poster Competition, Tufts Univ. School of Medicine
7. Committee on Grants-in-Aid of Research, Sigma Xi

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