Department of Biological Chemistry and Pharmacology

Associate Professor in the Department of Biological Chemistry and Pharmacology

College of Medicine
Division of Molecular and Cellular Biochemistry

184 Rightmire Hall
1060 Carmack Road
Columbus, OH 43210
Phone: 614-292-8542
Fax: 614-292-5379
sung.yoon@osumc.edu

Research Interests:
  • Drug discovery for neurodegenerative diseases and spinal cord injury
  • Role of metabolic dysfunction in Alzheimer’s disease
  • Regulatory mechanisms for myelination during development and after injury

Current Research:
1.     Drug discovery for Alzheimer’s disease with JNK3-selective, brain penetrating small molecule(s) that are orally bioavailable 
2.     Understanding the role of metabolic dysfunction in Alzheimer’s disease pathology 
   a)   Role of hypothalamic and sympathetic p75 in leptin-mediated action in Alzheimer’s disease and type 2 diabetes 
   b)   Metabolomic profiling to identify biomarkers for Alzheimer’s disease
3.     Understanding the mechanisms of neurotrophin action during development and under pathological conditions
   a)   Role of p75 in peripheral and central myelination during development and after injury
   b)   Role of p75-proNGF in the peripheral and central pathways involved in bladder control after spinal cord injury 


Ongoing Funded Projects:

1R01AG055059, Yoon (contact PI), 4/01/2017 - 3/31/2022
“Preclinical drug development of isoform selective JNK3 inhibitors for Alzheimer's disease”
The goal of the project is to develop an orally bioavailable JNK3-selective inhibitor that improves cognition in Alzheimer’s disease mouse models.
Yangbo Feng, MPI

R21 NS098362, Yoon (contact PI), 05/15/2016 - 04/30/2018
“A novel role for the p75 neurotrophin receptor in regulating nociception”
The goal of the project is to determine the mechanism by which p75 influences nociception in Schwann cells.
Bruce Carter, MPI

Alzheimer’s Drug Discovery Foundation, Yoon (PI), 1/1/2016-7/31/2017
“Attenuating Alzheimer’s disease pathology with JNK inhibitors”
The goal of the project is to test whether a pan-JNK inhibitor is effective in curtailing Ab42 production in mouse models of Alzheimer’s disease.

PubMed articles  

Background/Education:
PhD: Tufts University Medical School
Postdoctoral Training: Cornell University 
MD: Columbia University

Honors/Awards:

  • School of Biomedical Science Excellence in Research and Teaching, Ohio State University (2008)
  • Whitehall Foundation Research Award (1999-2002)
  • Career Development Award from American Cancer Society (2000-2003)
  • Young Investigator Award from the National Alliance for Research on Schizophrenia and Depression (1999-2000)
  • Postdoctoral Fellowship, the National Multiple Sclerosis Society (1994-1997)
  • First Prize, Charlton Fund Student Research Scientist Poster Competition, Tufts Univ. School of Medicine
  • Committee on Grants-in-Aid of Research, Sigma Xi

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