Center for Cognitive and Memory Disorders

WolfgangSadeeFelts Mercer Professor of Medicine and Pharmacology, Director, Center for Pharmacogenomics

College of Medicine
Department of Molecular Immunology, Virology, and Medical Genetics
Center for Pharmacogenomics

5078 Graves Hall
333 W. 10th Avenue
Columbus OH 43210-1239
Phone: 614-292-5593
Fax: 614-292-7232
Email: wolfgang.sadee@osumc.edu

Research Interests: Pharmacogenomics, Personalized/Genomic Medicine

Research Lab Goals: The Center for Pharmacogenomics pursues the discovery of genetic variants that can serve as biomarkers guiding successful drug therapy in individual patients. Researchers at the Center have developed new approaches for the discovery of genetic variants, with a focus on gene regulation, including innovative genome-scale technologies, such as massively parallel sequencing, and data integration using large-scale data repositories.

Current Research: Regulatory variants in genes involved in cardiovascular and central nervous system disorders, innate immunity, and drug metabolism; systems biology using transcriptomes; and clinical relevance

Research Techniques: Molecular genetics methodologies, next-generation sequencing, bioinformatics, mathematical modeling, large-scale data analytics

Active Funding:

  • 2010-2016, Expression Genetics of Drug Therapy, NIH, $9.1 million
  • 2010-2015, Pharmacogenomic Evaluation of Antihypertensive Responses, NIH, ~$400,000
  • 2011-2015, Pharmacogenomics Implementation, NIH, ~$180,000
  • 2011-2015, Next-generation Sequencing for CNS, NIH, ~$480,000
  • 2012, Genomic studies on Dementia with Lewy Bodies
  • Mangurian Foundation, $100,000
  • 2012, Clinical pharmacogenomics studies, Sub-contract from the OSUMC CTSA, grant from the National Center for Research Resources, $50,000
  • 2012-2015, Genomic studies on autism spectrum disorders, Department of Defense subcontract from Nationwide Children's Hospital, $450,000
  • 2014-2015, Molecular genetics and genomics of vortioxetine (Brintellix), Takeda Pharmaceuticals, $92,700
  • 2015, Molecular genetics and genomics of vortioxetine (Brintellix), Takeda Pharmaceuticals, $105,000
  • 2015-2017, Alveolar macrophage immunobiology and functional genomics: Unlocking human to human variation in host response to M. tuberculosis,
  • Gates Foundation, $599,000

PubMed articles

Education:
N/A, Pharmacy, ETH Zurich, 1963
Apotheker, Pharmacy, Free University of Berlin, 1966
Dr. rer. nat., Pharmaceutical Chemistry, Free University of Berlin, 1968

Fellowships:
Postdoctoral Fellow (NATO), 1968-‘69
Department of Pharmaceutical Chemistry, University of California San Francisco
1970-71 Research Associate, Fellowship (Deutsche Forschungs Gemeinschaft)
School of Pharmacy and Clinical Pharmacology, Freie Universität Berlin, Germany

Honors/News:
1981 Fellow, Humboldt Foundation, Germany
1991 Research Achievement Award in Biotechnology (first recipient), American Association of Pharmaceutical Scientists
1994 Distinguished Service Award, American Association of Pharmaceutical Scientists
Fellow, American Association of Pharmaceutical Scientists
Certificate of Appreciation as Founding Editor, Pharmaceutical Research, American Association of Pharmaceutical Scientists
Paul Dawson Award in Biotechnology, American Association of Colleges of Pharmacy
1996 Certificate of Appreciation, University of California Health Sciences Committee
1999 Phoenix Wissenschaftspreis 1999 for outstanding scientific research paper with pharmaceutical relevance (coauthor in Biochem. 37, 16582-16590 (1998)
2001 Avis Distinguished Visiting Professor, University of Tennessee
The Nagai Foundation Tokyo, Distinguished Lectureship 2001
Distinguished Pharmaceutical Scientist Award, American Association of Pharmaceutical Scientists
2002 Honorary Lecturer, 22nd Annual Graduate Student Symposium in the Pharmacological Sciences and Bio-related Chemistry. University of Michigan
Opening Plenary Speaker, First AAPS National Biotechnology Conference, San Diego
Distinguished Lecturer, Frontiers in Chemistry, Case Western Reserve University
2003 47th Annual Julius A. Koch Lecture, University of Pittsburgh
Fellow, American Association for the Advancement of Science
2004 Presidential Citation, AAPS
2005 Plenary Lecturer, 34th Ann. Meeting, New England Pharmacologists
U.S. Food and Drug Administration. Advisory Committee Service Award
2007 Keynote Speaker. University of Texas at Austin, College of Pharmacy “Celebrating Research Achievements”. April.
2011 College of Medicine nominee for The Ohio State Innovator of the Year Award
2013 Distinguished Scholar Award at The Ohio State University
2013 David Chu Lecturership, University of New York in Buffalo

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