The use of allograft tissue in anterior cruciate ligament (ACL) reconstruction has been associated with increased failure rates, the cause of which is unclear and likely multifactorial; it is believed that different patterns of revascularization and ligamentization may contribute. Positron emission tomography (PET) scans have the capacity to demonstrate revascularization as well as metabolic activity of tissues. Chemical exchange saturation transfer (proteinCEST) imaging can also assess the intra-articular environment. This study is being done to explore this new method of imaging.

This multi-year study gathers data on the knee before, during and after ACL reconstruction in order to determine what factors may help or hinder the success of an ACL reconstruction. If you have been diagnosed with an ACL tear and are planning on having an ACL reconstruction, you may be eligible to participate.

Quadriceps (thigh) weakness is common following anterior cruciate ligament (ACL) injury and reconstruction. This decrease in volume and strength of the quad muscles can cause athletes to get more injuries, have asymmetry in strength, or not get cleared for return to sport. This prospective cohort testing of DJO eStim devices: Compex Rehab(R) and Compex Wireless® study is testing the effectiveness of neuromuscular electrical stimulation (NMES) in restoring strength, function and movement patterns of the quadriceps muscles after anterior cruciate ligament (ACL) injury.

Athletes who participate in pivoting, cutting, and jumping sports have a greater chance of suffering an ACL injury compared to most other athletes. The purpose of this study is to develop new, low-cost strategies for identifying athletes at risk of anterior cruciate ligament (ACL) injury. Healthy participants will undergo 3D motion analysis using skin-mounted muscle activity monitoring known as electromyography (EMG) and magnetic resonance imaging (MRI) of the knee and leg. By creating a computer model of participant's knees, we will be able to more accurately describe the effect of the way the participant moves during athletic tasks on their risk of injury. 

The Modeling Study: ACL Injury Risk in Active Individuals 14-35 

Injury to the cartilage in the knee, called focal chondral defects, may impact function, muscle strength and the way you move. The outcomes of individuals with focal chondral defects are unknown. Findings from this study will provide information regarding the function, muscle strength, movement and muscle activation patterns, and potential for progressive damage on the cartilage of individuals with focal chondral defects in the knee.

Novocart® 3D is a cellular implant system where small amount of knee cartilage is removed in a an initial surgery, cleaned and "grown" on a 3-dimensional sponge-like scaffold and then implanted into the damaged area in a second surgery approximately 3 weeks later. This Phase 3 prospective, randomized, partially blinded multi-center study measures the safety and efficacy of Novocart compared to the current Microfracture standard of care in repairing articular cartilage defects of the knee.

Novocart®3D for Treatment of Articular Cartilage of the Knee

This study compares the efficacy and safety of the Agili-C implant to the surgical standard of care treatment in patients suffering from joint surface lesions of the knee. Agili-C™ is a cell-free, off-the-shelf implant for use in cartilage and osteochondral defects in traumatic and osteoarthritic joints. The implant is a porous, biocompatible, and resorbable bi-phasic scaffold, consisting of interconnected natural inorganic calcium carbonate.

A Treatment Study of Joint Surface Lesions of the Knee - Agili-C™ vs. Surgical Standard of Care

This is a prospective, randomized trial designed to compare two treatments for articular cartilage defect legions: microfracture and Hyalofast® scaffold. Hyalofast is made from a synthetic form of a substance called hyaluronic acid that is found naturally in the knee joint and other places throughout the body. It is combined with autologous bone marrow aspirate concentrate and surgically implanted into the cartilage defect. It is believed that the bone marrow cells eventually will grow into new cartilage and fill the defect while the Hyalofast® eventually dissolves away with time.

A Treatment Study for Damaged Knee Cartilage Requiring Repair--Hyalofast with BMAC

This study is testing the effectiveness of "dry needling" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.

The Effects of Dry Needling on Knee Pain

This observational cohort follow-up study seeks to understand the post-operative outcomes of subjects choosing to undergo the Subchondroplasty™ (SCP™) procedure, a minimally invasive procedure to treat bone defects in the knee associated with bone marrow lesions (BMLs). BMLs are subchondral defects in the bone, also called insufficiency fractures. This follow-up study will collect information on the short- and long-term safety and effectiveness of the SCP procedure.

Follow-up Study for Those Who Have Undergone (or Will Undergo) the Subchondroplasty (SCP) Knee Procedure

Degenerative disease of the knee joint is an increasingly common condition. Cases of advanced joint degeneration lead to significant disability and often require invasive, expensive treatments. This study evaluates normal and injured knees of patients in different age groups and sexes to determine the value of certain pictures taken by a Magnetic Resonance Image (MRI) machine.

Patellar dislocations are debilitating injuries that frequently affect young, active patients. In spite of the relatively high incidence of this condition, significant controversy remains regarding the ideal treatment protocol. This study evaluates patients following their treatment for patellar dislocation to help in future treatments for those with the same condition.

The purpose of this study is to evaluate the ability of neuromuscular training and knee braces to reduce the risk of suffering a knee injury. Neuromuscular training typically involves controlled movement tasks such as side-stepping, jumping, and plyometrics under the supervision of a trained clinical specialist. Knee braces may also have the potential to help ‘train’ the knee by providing feedback to an athlete when their knee is moving in a way that could cause it to get injured.