‚ÄčThe Ohio State Human Tissue Resource Network (HTRN) facilitates research biospecimen access for funded, IRB approved or reviewed for non-human subject status (basic and translational investigators). HTRN is the organizational umbrella for National Cancer Institute (NCI) funded programs to advance bench to bedside research. Investigator biospecimen access is for investigators from The Ohio State University, as well as for basic and translational researchers throughout the United States and Canada. These NCI funded groups join to improve resource utilization and thereby reduce the researcher fees for samples. Services include biospecimen and biofluid procurement by the Department of Pathology Tissue Procurement Services and processing, transient storage, biobanking and virtual microscopy with and without digital image analysis as requested.

Home Building


Office, Research and Biorepository Space

The Human Tissue Resource Network Investigator Management Service (IMS) has administrative office space to accommodate a pathologist microscopy area for quality review of biospecimens prior to shipment, and investigator and IT managers. HTRN research space at the Polaris Innovation Centre includes a common biorepository areas totaling 3,000 square feet with electric (-80C, -20C) and LN2 (-196C) freezers, emergency generator backup power, 24/7 Rees Scientific Unit Monitoring System and an emergency response team. This site is locked 24/7 with authorized entry to individuals via key card access.

Investigator Services

Human Tissue Resource Network (HTRN) Investigator Services

  1. Accept and process investigator applications for biospecimens
  2. Review application and determine if biospecimen request and research needs can be met
  3. Provide consultation with investigator if requested or needed
  4. Notify investigator of research protocol acceptance or approval
  5. Post investigator approved biospecimen requests in the Tissue Quest Investigator Management (TQIM) software for service by Tissue Procurement Services (TPS)
  6. Follow the biospecimen procurement process in Tissue Quest
  7. Provide a Biospecimen Management Service (BMS) to assure proper transport and management during transient storage prior to shipping or delivery to the investigator
  8. Provide tissue pathology review (QC) for TPS prospectively collected samples requested by CCC and Cooperative Human Tissue Network (CHTN) investigators
  9. Ship samples using temperature controlled and monitored packages
  10. Provide serviced investigator with quality biospecimens, demographic subject data, QC report, pathology report and monitored shipping

Biospecimen Management Service (BMS)

The Human Tissue Resource Network Biospecimen Management Service (BMS) receives fresh, frozen and fixed biospecimens locally from the Tissue Procurement Service at The Ohio State University Wexner Medical Center, which are collected from consenting patients from the James Cancer Hospital and Wexner Medical Center. These tissues are for the approved CHTN and CCC investigators. For the Alliance group, samples come nationally from more than 250 hospitals associated with Alliance. Alliance clinical trials process whole blood, plasma, serum, white blood cells, urine, frozen and paraffin-embedded tissue and their derivatives to isolate DNA/RNA. Fresh samples may be shipped directly from the Tissue Procurement Service (TPS) at The Ohio State University Wexner Medical Center or may from shipped from the BMS located at Polaris Centre.

Federally funded research programs under HTRN

Three federally funded research programs are maintained under the HTRN umbrella including the Cooperative (AKA Collaborative) Human Tissue Network (CHTN), the Alliance Biorepository at OSU (ABOSU) and The Ohio State University Comprehensive Cancer Center Total Cancer Care Program (TCCP). HTRN receives support from the Department of Pathology Tissue Procurement Service (TPS), digital imaging, laser capture microscopy and biorepository.

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