The Cancer Diagnosis Program of the National Cancer Institute (NCI) initiated the Collaborative (AKA Cooperative) Human Tissue Network (CHTN) grant in 1987. The Ohio State University was an original NCI grantee for this program and 2016 was our 30th year of CHTN funding. The major goal of the Collaborative Human Tissue Network is to facilitate the use of human tissues in biomedical research for basic and applied scientists from academia, industry and government to accelerate the advancement of scientific discoveries, as well as progress in cancer diagnosis and treatment. The Collaborative Human Tissue Network uses a prospective biospecimen procurement model rather than a biobanking model and works directly with investigators to determine the appropriate tissue sources (e.g. surgery, autopsy and transplant) in order to tailor tissue-processing methods to meet the research needs of the specific investigator. The Collaborative Human Tissue Network obtains human tissues and fluids from remnant materials removed from medically indicated surgical resections, autopsies and other procedures.
The Tissue Procurement Service (TPS) is a supporting service of the Collaborative Human Tissue Network.
The CHTN is comprised of five adult divisions based on geographical regions and one pediatric division that manages all investigator requests for pediatric specimens. The Midwestern Division, based at The Ohio State University and directed by Leona W. Ayers, MD, a professor in the Department of Pathology, includes Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, West Virginia and Wisconsin, as well as Canada.
The CHTN divisions work both independently with individual investigators and together as a seamless operation to fulfill requests that are difficult to serve by any single division. The CHTN's unique informatics system allows each division to effectively communicate and network the needs of its investigators to all CHTN divisions. This tissue procurement network can collaboratively facilitate and fulfill an investigator's biospecimen request.