Digital pathology is the future of the field of pathology. Virtual microscopy is one of the tools that makes this future possible. The Digital Pathology Core (DPC) provides a variety of services to researchers and their collaborators, both locally and around the world, to ensure that research and education are conducted faster, better and at a lower cost.

Digital slide images are ideal for collaboration between researchers, offering those down the hall, in different buildings or on opposite sides of the globe the ability to instantly view, assess and annotate slide images. Hosted digital slide images optimize busy researcher time by allowing viewing, assessing and annotating slide images from any location at any time. Multiple researchers can work on a set of slide images at the same time. Digital slide images protect tissue resources by minimizing cuttings and guarding against loss or damage in transportation. Another benefit of digital slide images is the ability to provide a permanent record of tissue specimens, stains and annotations for archival purposes. Digital slide images are the first step to unlocking tissue data through digital image analysis.

Digital Pathology Core Request Form (DOC)

Fees

Fees

Costs

20x magnification
$14
40x magnification
$40 
Whole mount (2x3) scans
$40 
Slide analysis (20x/40x)
$10 
1-100 Core TMA image analysis    
$100 
100+ Core TMA image analysis
$150 
DVD w/ image analysis results
TBD 
Analysis algorithm development
$100 
Additional slide prep
$20 

Payments through the Digital Pathology Core are by check.

The client must complete a Digital Pathology Core Request Form for billing purposes. An invoice will be generated and sent to the client once the work request has been completed. Checks are the only form of payment accepted.

Billing Contact

Billing contact:

614-293-5368

The administrative offices of the Human Tissue Resource Network are located at the Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240.
Equipment

Equipment

Aperio Scanscope XT

The DPC provides affordable, high-quality digital imaging of tissue sections using the Aperio Scanscope XT scanner by Leica. Slides can be scanned at 5x, 20x and 40x magnification with the ability to scan standard one inch by three inch slides as well as two inch by three inch slides. A single slide takes about six minutes to scan. Scanned image files are in the svs format, but can be converted to other formats if needed. Scanned image file size varies but 250 MB is average. Image files can be viewed using Aperio's ImageScope software or ePathViewer for tablets.


Image files hosted on The Ohio State University Wexner Medical Center server can be accessed worldwide using Aperio's eSlide Manager web application. Researchers can view, annotate and analyze slide images, import and export statistical data and access pathology reports. eSlide manager's data elements are fully customizable to fit needed research specifications.


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HE of malignant uterine tissue, scanned by the AperioXT

Definiens Tissue Studio 3.6

The DPC provides image analysis services using Definiens Tissue Studio software. Powerful and customizable algorithms can be applied to digital slide images to extract precise and detailed information. The software can easily:

  • Detect and measure tissues, tumors or other desired morphologies
  • Count and measure nucleic and nuclear staining and grade as high, medium and low staining
  • Measure cytoplasmic staining and grade as high, medium or low staining
  • Measure, assess and quantify membrane staining and grade on staining intensity, completeness, etc.
  • Count and measure cells
  • Count and measure vessels

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Morphologic segmentation of a breast carcinoma by Definiens Tissue Studio 3.6


In collaboration with researchers, the image analysis team can also devise custom algorithms to measure features of special interest. Analysis can also be limited to standardized sections or particular morphologies of the tissue.

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