Our Tissue Procurement Service in the Department of Pathology


The Tissue Procurement Service (TPS) serves the Human Tissue Resource Network member groups but is not a member itself. TPS is a service laboratory of the Division of Surgical Pathology and the Department of Pathology, and operates under the supervision of medical director, Dr. Scott Scrape. Researchers do not interact directly with TPS to secure samples for research, but place requests through the Midwestern Division of the Collaborative Human Tissue Network (CHTN) and The Ohio State University Comprehensive Cancer Center Total Cancer Care Program (TCCP). The TPS procures and distributes the requested biospecimens to the HTRN while fluids and benign, normal, malignant and diseased tissues go to research investigators.

The TPS maintains adequate space in The Ohio State University Wexner Medical Center for procurement and is supervised by the technical and professional staff serving clinical diagnostic specimens and diagnostic archival formalin-fixed paraffin embedded tissues and hematoxylin and eosin (HE) stained slides, retained briefly on Ohio State's main campus prior to shipment to the Polaris or Kinnear research facilities.

The TPS procures samples for the CCC biorepository program. IRB approval with yearly review is held by each member. When an investigator is funded, approved by the IRB and vetted by the appropriate HTRN member group, the requests for tissue and/or fluids are posted in a Tissue Quest software management program managed out of Vanderbilt University.

CHTN Application (DOC)

CCC Request Form (PDF) - published on OneSource and available only to Ohio State personnel


Samples

Samples

Specimen Collection

Tissues and fluids are collected prospectively, as per the investigator’s protocol, or through patient consent for Ohio State protocol specific clinical trials. Banking can be provided to the researcher in various preparations including fresh, frozen, frozen OCT, frozen RNAlater, formalin-fixed paraffin-embedded tissue, unstained frozen section slide, unstained paraffin section slide, HE-stained paraffin section slide and frozen serum, plasma and urine.

All specimens are subject to an immediate gross examination. The diagnosis is then verified through frozen section, touch preparations or subsequent evaluation of permanent formalin-fixed, paraffin-embedded histopathology slide preparations. With the exception of fresh shipments, the diagnosis of each sample is confirmed before the specimen is released to the investigator. Fresh specimens are provided to the investigator with a preliminary diagnosis, and the investigator is informed of the final diagnosis as soon as this information is available.

Demographics

All samples are annotated with patient demographics including age, sex and race. If available, a de-identified pathology report is also provided for each sample. Additional patient information may be requested, but if a chart review is necessary, an additional charge is assessed.

Anatomic Sites

Anatomic sites include but are not limited to the following:
  • Breast, uterus and ovary
  • Colon, stomach and esophagus
  • Kidney, bladder and prostate
  • Liver, pancreas and spleen
  • Lung, pharynx and oral cavity
  • Brain, spinal cord and peripheral nerves
  • Muscle, skin and soft tissue

Available Biospecimen Types

Avalable biospecimen types include:
  • Malignant
  • Benign
  • Diseased
  • Normal, adjacent or distant adjacent
  • Biofluids (urine or blood serum, plasma, buffy coat)

Access to specimens vary according to the surgical schedules and autopsy rates and is thus unpredictable. Therefore, investigators requesting fresh specimens should make every effort to use these specimens when they are made available.

Processing

The processing of biospecimens varies according to the protocol of each individual investigator. Specimen processing categories include:
  • Snap-frozen or frozen in cryo-embedding media such as OCT are stored in liquid nitrogen or -80° C temperatures
  • Provided as fresh tissue, which can be minced or intact, placed in transport media of choice or saline, and shipped for next day arrival
  • Provided in a fixative of choice or as paraffin-embedded blocks. Stained or unstained slides can also be provided from either paraffin blocks or as frozen sections
  • Provided in RNAlater or other investigator-specified preservative, fresh or subsequently frozen
  • Tissue microarray slides are also available
Fees for CHTN investigators

Fees for CHTN investigators

Payment Information

Payment options
  1. Purchase orders
  2. Checks 
  3. Credit cards 

Once the client receives an electronic notification that a specimen has been procured for a given request, a processing fee payment can be provided by one of the following three options:

  1. Purchase order (PO): Contact your institution and obtain a purchase order at the time the electronic notification is received for the tissue specimen that has been procured and provide the PO number to the Tissue Procurement Distribution Office staff via fax (614-293-5851 or 614-293-7013) in order to include on the invoice for payment processing.
  2. Check: Client will receive an invoice (either electronically or by mail). Please submit invoice to your institution’s accounts payable department for payment processing.
  3. Credit card: Client will receive the invoice electronically with notification that the charge is ready for payment. Please contact the Tissue Procurement Service billing coordinator at 614-293-5368 and provide your credit card number. A receipt for the transaction will be emailed to you for record keeping and all credit card information will be shredded for security purposes. No credit card information is kept on file.

Billing contact


614-293-5493

The administrative offices of the Human Tissue Resource Network are located at the Innovation Centre, 2001 Polaris Parkway, Columbus, OH 43240.

Processing Fees

Because the Collaborative Human Tissue Network is an NCI supported resource, investigators are only charged a low processing fee for each sample to offset the costs of collecting, handling and preparing the specimens in accordance with the detailed requirements of the investigator. A sample is defined as one processed piece of a specimen, regardless of the sample size or type of processing. Each investigator is also responsible for all shipping costs.


Effective Oct. 1, 2015, the processing fees are as follows:

  • $50 processing fee per sample for investigators located at academic and government lab sites
  • $180 processing fee per tissue sample for investigators located at commercial organizations
  • $180 processing fee for prospectively-collected fluid sample for investigators located at commercial organizations
  • $75 processing fee for reassigned ("banked") fluid sample for investigators located at commerical organizations

Additional Service Fees

Additional services can be provided to investigators upon request. These fees are applicable to both academic and commercial investigators.

HE slide (from paraffin-embedded block)   $9 
Repeat HE slide (from paraffin-embedded block)
$5
Unstained slide (from paraffin-embedded block) 
$8
Repeat unstained slide (from paraffin-embedded block)
$5
Cryostat-cut, stained slide (from frozen block)
$14
Repeat cryostat-cut, stained slide (from frozen block)
$10
First cut, cryostat-cut, unstained slide (from frozen block)
$12 
Each additional cryostat-cut, unstained slide (from frozen block)
$8
20 micron section
$20
Ribbons and scrolls
$15
Touch preps 
$6

Investigators may request chart reviews for a minimal fee starting at $60. Other special handling or processing may available for $25 per hour (minimum of $25).

Shipping charges are the responsibility of the investigator and are determined by the courier that is used. This charge will vary according to the weight and priority status of the shipment.


Fees for OSUCCC – James members

Fees for OSUCCC – James members

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