Our Injury Core supports innovative neurological research here at Ohio State.

CNS/PNS Nerve Injury Core

The CNS (central nervous system)/PNS (peripheral nervous system) Injury Core provides technical support to generate animal models of injury and to characterize their behavioral impairment after injury. 

The services available in this Central Nervous System/Peripheral Nervous System Core provide unique and valuable services to investigators funded by the National Institute of Neurological Disorders and Stroke (NINDS). These services provide an array of surgical and behavioral techniques that are not typically located together in a single laboratory.

This core provides standardized peripheral nerve injuries, spinal contusion injuries and a variety of intraspinal or intracranial microlesions induced by microinjection of specific toxins or demyelinating agents. This core also provides behavioral tools commonly used in spinal cord injury (SCI) studies, which differ from those offered in the Behavioral Core. These core services provide an opportunity for investigators wishing to test the response of transgenic animals to CNS/PNS injury or to test the efficacy of therapeutic agents.

The primary service of this core is induced standardized peripheral nerve injuries or spinal cord injuries in small animals. The core also provides behavioral tools commonly used in spinal cord injury studies. Although this support covers costs of the behavioral technician, it does not cover equipment or animal per diem charges.

Services available: 
  • Sciatic nerve transection
  • Spinal contusion injury
  • Focal spinal injury via microinjection of specific toxins (e.g., LPS and zymosan)
  • Focal spinal demyelination via microinjection of lysolecithin or ethidium bromide

Please see our Terms of Service and User Fee Structure






Chronic oligodendrogenesis and remyelination after spinal cord injury in mice and rats. 

Hesp ZC, Goldstein EZ, Miranda CJ, Kaspar BK, McTigue DM.

J Neurosci. 2015 Jan 21;35(3):1274-90. doi: 10.1523/JNEUROSCI.2568-14.2015.

PMID: 25609641  


Stress exacerbates neuron loss and microglia proliferation in a rat model of excitotoxic lower motor neuron injury.

Puga DA, Tovar CA, Guan Z, Gensel JC, Lyman MS, McTigue DM, Popovich PG.

Brain Behav Immun. 2015 Oct;49:246-54. doi: 10.1016/j.bbi.2015.06.006. Epub 2015 Jun 19.

PMID: 26100488


Traumatic spinal cord injury in mice with human immune systems.

Carpenter RS, Kigerl KA, Marbourg JM, Gaudet AD, Huey D, Niewiesk S, Popovich PG.

Exp Neurol. 2015 Sep;271:432-44. doi: 10.1016/j.expneurol.2015.07.011.

Epub 2015 Jul 17.

PMID: 26193167  


Development of a database for translational spinal cord injury research.

Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR.

J Neurotrauma. 2014 Nov 1;31(21):1789-99. doi: 10.1089/neu.2014.3399. Epub 2014 Jul 31.

PMID: 25077610


Changes in NG2 cells and oligodendrocytes in a new model of intraspinal hemorrhage.

Sahinkaya FR, Milich L, McTigue DM.

Exp Neurol. 2014 May;255:113-26. doi: 10.1016/j.expneurol.2014.02.025.

Epub 2014 Mar 11.

PMID: 24631375


IL-4 signaling drives a unique Arginase+/IL-1b+ microglia phenotype and recruits macrophages to the inflammatory CNS: consequences of age-related deficits in IL-4Ra after traumatic spinal cord injury.

Fenn AM, Hall JC, Gensel JC, Popovich PG, and Godbout JP.

J Neurosci. 2014 Jun 25;34(26):8904-17. doi: 10.1523/JNEUROSCI.1146-14.2014.

PMID: 24966389


Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. 

Fenn AM, Skendelas JP, Moussa DN, Muccigrosso MM, Popovich PG, Lifshitz J, Eiferman DS, Godbout JP.

J Neurotrauma. 2015 Jan 15;32(2):127-38. doi: 10.1089/neu.2014.3514.

Epub 2014 Nov 13.

PMID: 25070744


Spinal cord injury causes chronic liver pathology in rats.

Sauerbeck AD, Laws JL, Bandaru VV, Popovich PG, Haughey NJ, McTigue DM.

J Neurotrauma. 2015 Feb 1;32(3):159-69. doi: 10.1089/neu.2014.3497. Epub 2014 Oct 21.

PMID: 25036371


Independent evaluation of the anatomical and behavioral effects of Taxol in rat models of spinal cord injury.

Popovich PG, Tovar CA, Lemeshow S, Yin Q, Jakeman LB.

Exp Neurol. 2014 Nov;261:97-108. doi: 10.1016/j.expneurol.2014.06.020. Epub 2014 Jul 3.

PMID: 24999028


Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia.

Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, and Godbout JP.

Exp Neurol. 2014 Nov;261:97-108. doi: 10.1016/j.expneurol.2014.06.020. Epub 2014 Jul 3.

PMID: 24999028


Spinal cord injury causes chronic liver pathology in rats.

Sauerbeck AD, Laws JL, Bandaru VV, Popovich PG, Haughey NJ, McTigue DM.

J Neurotrauma. 2015 Feb 1;32(3):159-69. doi: 10.1089/neu.2014.3497. Epub 2014 Oct 21.

PMID: 25036371


Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.

J Neurosci. 2013 Jan 9;33(2):397-410. doi: 10.1523/JNEUROSCI.0399-12.2013.

PMID: 23303920


Macrophage migration inhibitory factor potentiates autoimmune-mediated neuroinflammation.

Cox GM, Kithcart AP, Pitt D, Guan Z, Alexander J, Williams JL, Shawler T, Dagia NM, Popovich PG, Satoskar AR, Whitacre CC.

J Immunol. 2013 Aug 1;191(3):1043-54. doi: 10.4049/jimmunol.1200485. Epub 2013 Jun 24.

PMID: 23797673


The impact of myelination on axon sparing and locomotor function recovery in spinal cord injury assessed using diffusion tensor imaging.

Tu TW, Kim JH, Yin FQ, Jakeman LB, Song SK.

NMR Biomed. 2013 Nov;26(11):1484-95. doi: 10.1002/nbm.2981. Epub 2013 Jun 18.

PMID: 23775778


Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain.

Wang Y, Nowicki MO, Wang X, Arnold WD, Fernandez SA, Mo X, Wechuk J, Krisky D, Goss J, Wolfe D, Popovich PG, Lawler S, Chiocca EA.

Gene Ther. 2013 Jul;20(7):742-50. doi: 10.1038/gt.2012.90. Epub 2012 Dec 13.

PMID: 23235561


Autonomic Dysreflexia Causes Chronic Immune Suppression after Spinal Cord Injury.

Zhang Y, Guan Z, Reader B, Shawler T, Mandrekar-Colucci S, Huang K, Weil Z, Bratasz A, Wells J, Powell ND, Sheridan JF, Whitacre CC, Rabchevsky AG, Nash MS, Popovich PG.

J Neurosci. 2013 Aug 7;33(32):12970-81. doi: 10.1523/JNEUROSCI.1974-13.2013.

PMID: 23926252


Systemic iron chelation results in limited functional recovery and histological recovery after traumatic spinal cord injury in rats.

Sauerbeck A, Schonberg DL, Law L, McTigue DM.

Exp Neurol. 2013 Oct;248:53-61. doi: 10.1016/j.expneurol.2013.05.011. Epub 2013 May 24.

PMID: 23712107


Elevated mmp-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice.

Hansen CN, Fisher LC, Deibert RJ, Jakeman LB, Zhang H, Noble-Haeusslein L, White S, Basso DM.

J Neurosci. 2013 Aug 7;33(32):13101-11. doi: 10.1523/JNEUROSCI.1576-13.2013.

PMID: 23926264


Neonatal E.Coli infection causes neuro-behavioral deficits associated with hypomyelination and neuronal sequestration of iron.

Leiblein-Boff JC, Shea DT, Wei P, Deng Z, Quan N, Bilbo SB, Bailey MT, McTigue DM, and Godbout JP.

J Neurosci. 2013 Oct 9;33(41):16334-45. doi: 10.1523/JNEUROSCI.0708-13.2013.

PMID: 24107964


Macrophage migration inhibitory factor (MIF) is essential for inflammatory and neuropathic pain and enhances pain in response to stress.


Alexander JK, Cox GM, Tian JB, Zha AM, Wei P, Kigerl KA, Reddy MK, Dagia NM, Sielecki T, Zhu MX, Satoskar AR, McTigue DM, Whitacre CC, Popovich PG.

Exp Neurol. 2012 Aug;236(2):351-62. doi: 10.1016/j.expneurol.2012.04.018.

Epub 2012 May 1.

PMID: 22575600


Ferritin stimulates oligodendrocyte genesis in the adult spinal cord and can be transferred from macrophages to NG2 cells in vivo.

Schonberg DL, Goldstein EZ, Sahinkaya FR, Wei P, Popovich PG, McTigue DM.

J Neurosci. 2012 Apr 18;32(16):5374-84. doi: 10.1523/JNEUROSCI.3517-11.2012.

PMID: 22514302


System xc- regulates microglia and macrophage glutamate excitotoxicity in vivo.

Kigerl KA, Ankeny DP, Garg SK, Wei P, Guan Z, Lai W, McTigue DM, Banerjee R, Popovich PG.

Exp Neurol. 2012 Jan;233(1):333-41. doi: 10.1016/j.expneurol.2011.10.025.

Epub 2011 Nov 4.

PMID: 22079587


JNK3 perpetuates Metabolic Stress Induced by Aβ Peptides.

Yoon S, Park D, Ryu J, Ozer H, Tep C, Shin Y, Lim TH, Pastorino L, Kunwar AJ, Walton JC, Nagahara AH, Lu KP, Nelson RJ, Tuszynski MH, Huang K. 2012.

Neuron. 2012 Sep 6;75(5):824-37. doi: 10.1016/j.neuron.2012.06.024.

PMID: 22958823


Injured mice at the gym: review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury.

Jakeman LB, Hoschouer EL, Basso DM.

Brain Res Bull. 2011 Mar 10;84(4-5):317-26. doi: 10.1016/j.brainresbull.2010.06.002.

Epub 2010 Jun 15.

PMID: 20558254


Transforming growth factor α transforms astrocytes to a growth-supportive phenotype after spinal cord injury.

White RE, Rao M, Gensel JC, McTigue DM, Kaspar BK, Jakeman LB.

J Neurosci. 2011 Oct 19;31(42):15173-87. doi: 10.1523/JNEUROSCI.3441-11.2011.

PMID: 22016551


Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages.

Donnelly DJ, Longbrake EE, Shawler TM, Kigerl KA, Lai W, Tovar CA, Ransohoff RM, Popovich PG.

J Neurosci. 2011 Jul 6;31(27):9910-22. doi: 10.1523/JNEUROSCI.2114-11.2011.

PMID: 21734283


Progranulin expression is upregulated after spinal contusion in mice.

Naphade SB, Kigerl KA, Jakeman LB, Kostyk SK, Popovich PG, Kuret J.

Acta Neuropathol. 2010 Jan;119(1):123-33. doi: 10.1007/s00401-009-0616-y.

Epub 2009 Nov 28.

PMID: 19946692


Aberrant sensory responses are dependent on lesion severity after spinal cord contusion injury in mice.

Hoschouer EL, Basso DM, Jakeman LB.

Pain. 2010 Feb;148(2):328-42. doi: 10.1016/j.pain.2009.11.023. Epub 2009 Dec 22.

PMID: 20022699


Chronic expression of PPAR-delta by oligodendrocyte lineage cells in the injured rat spinal cord.

Almad A, McTigue DM.

J Comp Neurol. 2010 Mar 15;518(6):785-99. doi: 10.1002/cne.22242.

PMID: 20058304


Validity of acute and chronic tactile sensory testing after spinal cord injury in rats.

Detloff MR, Clark LM, Hutchinson KJ, Kloos AD, Fisher LC, Basso DM.

Exp Neurol. 2010 Oct;225(2):366-76. doi: 10.1016/j.expneurol.2010.07.009.

Epub 2010 Jul 17.

PMID: 20643128


A mouse model of ischemic spinal cord injury with delayed paralysis caused by aortic cross-clamping.

Awad H, Ankeny DP, Guan Z, Wei P, McTigue DM, Popovich PG.

Anesthesiology. 2010 Oct;113(4):880-91. doi: 10.1097/ALN.0b013e3181ec61ee.

PMID: 20808212


Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury.

Ankeny DP, Popovich PG.

Neuroscience. 2009 Feb 6;158(3):1112-21. doi: 10.1016/j.neuroscience.2008.07.001.

Epub 2008 Jul 4.

PMID: 18674593


L1 cell adhesion molecule is essential for the maintenance of hyperalgesia after spinal cord injury.

Hoschouer EL, Yin FQ, Jakeman LB.

Exp Neurol. 2009 Mar;216(1):22-34. doi: 10.1016/j.expneurol.2008.10.025.

 Epub 2008 Nov 13.

PMID: 19059398


Iron is essential for oligodendrocyte genesis following intraspinal macrophage activation.

Schonberg DL, McTigue DM.

Exp Neurol. 2009 Jul;218(1):64-74. doi: 10.1016/j.expneurol.2009.04.005.

Epub 2009 Apr 15.

PMID: 19374902


B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice.

Ankeny DP, Guan Z, Popovich PG.

J Clin Invest. 2009 Oct;119(10):2990-9. doi: 10.1172/JCI39780. Epub 2009 Sep 21.

PMID: 19770513


Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline.

Neigh GN, Karelina K, Glasper ER, Bowers SL, Zhang N, Popovich PG, DeVries AC.

Stroke. 2009 Nov;40(11):3601-7. doi: 10.1161/STROKEAHA.109.564146.

Epub 2009 Sep 17.

PMID: 19762688

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