Research Programs

Research Programs

Behavior and Biological Rhythms

Areas of study within Ohio State’s Behavior and Biological Rhythms program include:

Circadian Modulation of Retinal Function, Professor Stuart Mangel, PhD
Associate Professor Jonathan Godbout, PhD
Photoperiod Effects on Behavior, Professor and Chair Randy Nelson, PhD
Signaling and Circadian Timing, Professor Karl Obrietan, PhD
Seasonal and Circadian Effects on Physiology, Research Assistant Professor Zachary Weil, PhD

Channels and Receptors

Areas of study within our Channels and Receptors program include:

Acid Sensing Ion Channels, Associate Professor Candice Askwith, PhD
Neuronal Nicotinic Acetylcholine Receptors, Associate Professor R. Thomas Boyd, PhD
Ion Channels in Neuroendocrine Cells, Professor John Enyeart, PhD
Function of Neurotransmitter Receptors in Neural Circuits, Professor Stuart Mangel, PhD
Astrocyte Potassium, Gap Junction Channels and Receptors, Assistant Professor Min Zhou, MD, PhD

Development and Plasticity

This program encompasses these areas of study:
Motor Neuron Development and Motor Neuron Diseases
Synaptic Plasticity in Cerebellar Circuits, Professor Georgia Bishop, PhD

Retinal Development and Regeneration, Associate Professor Andy Fischer, PhD
Synaptogenesis and Neuronal Morphogenesis, Associate Professor James Jontes, PhD
Circadian and Adaptive Regulation of Synaptic Plasticity, Professor Stuart Mangel, PhD
Signaling and Circadian Timing, Professor Karl Obrietan, PhD

Disease Injury and Repair

This program encompasses these areas of study: 
Motor Neuron Development and Motor Neuron Diseases
Retinal Development and Regeneration, Associate Professor Andy Fischer, PhD
Associate Professor Jonathan Godbout, PhD
Assistant Research Professor Jessica Lerch, PhD
Glutamate Transport and RNA Processing in Motor Neuron Disease, Associate Professor C. Glenn Lin, PhD
Oligodendrocyte Genesis and Remyelination after Spinal Cord Injury, Associate Professor Dana McTigue, PhD
Epilepsy and Mechanisms of Excitotoxic Cell Death, Professor Karl Obrietan, PhD
Neuroimmunology of Spinal Cord Injury, Professor Phillip Popovich, PhD
Spinal Cord Injury and Alzheimer’s Disease, Assistant Professor Yingjie Shen, PhD
Social and Temporal Effects on Central Nervous System Injury, Research Assistant Professor Zachary Weil, PhD
Glial Involvement in Stroke Pathology, Assistant Professor Min Zhou, MD, PhD

Signaling Trafficking and Transport

This program encompasses these areas of study: 

Cytoskeleton and Axonal Transport, Professor Anthony Brown, PhD
Synaptogenesis and Neuronal Morphogenesis, Associate Professor James Jontes, PhD
Research Centers and Labs

Research Centers and Labs

Featured Publications

Featured Publications


Intraspinal TLR4 activation promotes iron storage but does not protect neurons or oligodendrocytes from progressive iron-mediated damage.

Goldstein EZ, Church JS, Pukos N, Gottipati MK, Popovich PG, McTigue DM.

Exp Neurol. 2017 Dec;298(Pt A):42-56. doi: 10.1016/j.expneurol.2017.08.015. Epub 2017 Aug 26.



Gut Microbiota Are Disease-Modifying Factors After Traumatic Spinal Cord Injury.

Kigerl KA, Mostacada K, Popovich PG.

Neurotherapeutics. 2017 Nov 3. doi: 10.1007/s13311-017-0583-2.

[Epub ahead of print] Review.



PRMT5 as a druggable target for glioblastoma therapy.

Banasavadi-Siddegowda YK, Welker AM, An M, Yang X, Zhou W, Shi G, Imitola J, Li C, Hsu S, Wang J, Phelps M, Zhang J, Beattie CE, Baiocchi R, Kaur B.

Neuro Oncol. 2017 Nov 2. doi: 10.1093/neuonc/nox206. [Epub ahead of print]



Traumatic brain injuries during development disrupt dopaminergic signaling.

Karelina K, Gaier KR, Weil ZM.

Exp Neurol. 2017 Nov;297:110-117. doi: 10.1016/j.expneurol.2017.08.003. Epub 2017 Aug 9.



Traumatic Brain Injury in hTau Model Mice: Enhanced Acute Macrophage Response and Altered Long-Term Recovery.

Kokiko-Cochran ON, Saber M, Puntambekar S, Bemiller SM, Katsumoto A, Lee YS, Bhaskar K, Ransohoff RM, Lamb BT.

J Neurotrauma. 2017 Nov 1. doi: 10.1089/neu.2017.5203. [Epub ahead of print]



Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex.

Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM.

Nat Neurosci. 2017 Nov;20(11):1549-1559. doi: 10.1038/nn.4643. Epub 2017 Sep 18.



The chick eye in vision research: An excellent model for the study of ocular disease.

Wisely CE, Sayed JA, Tamez H, Zelinka C, Abdel-Rahman MH, Fischer AJ, Cebulla CM.

Prog Retin Eye Res. 2017 Nov;61:72-97. doi: 10.1016/j.preteyeres.2017.06.004. Epub 2017 Jun 28. Review.



MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment.

Kim B, Kusibati R, Heisler-Taylor T, Mantopoulos D, Ding J, Abdel-Rahman MH, Satoskar AR, Godbout JP, Bhattacharya SK, Cebulla CM.

Sci Rep. 2017 Oct 30;7(1):14336. doi: 10.1038/s41598-017-14298-9.


HuD and the Survival Motor Neuron protein interact in motoneurons and are essential for motoneuron development, function and mRNA regulation.

Hao LT, Duy PQ, An M, Talbot J, Iyer CC, Wolman M, Beattie CE.

J Neurosci. 2017 Oct 23. pii: 1528-17. doi: 10.1523/JNEUROSCI.1528-17.2017.

[Epub ahead of print]


Social interaction modulates the neuroinflammatory response to global cerebral ischemia in male mice.

Gaudier-Diaz MM, Zhang N, Haines AH, Surbhi, Zhou M, DeVries AC.

Brain Res. 2017 Oct 15;1673:86-94. doi: 10.1016/j.brainres.2017.08.008. Epub 2017 Aug 12.


Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas.

Canella A, Welker AM, Yoo JY, Xu J, Abas FS, Kesanakurti D, Nagarajan P, Beattie CE, Sulman EP, Liu J, Gumin J, Lang FF, Gurcan MN, Kaur B, Sampath D, Puduvalli VK.

Clin Cancer Res. 2017 Oct 15;23(20):6215-6226. doi: 10.1158/1078-0432.CCR-16-3151. Epub 2017 Jul 5.



Systemic gene delivery transduces the enteric nervous system of guinea pigs and cynomolgus macaques.

Gombash SE, Cowley CJ, Fitzgerald JA, Lepak CA, Neides MG, Hook K, Todd LJ, Wang GD, Mueller C, Kaspar BK, Bielefeld EC, Fischer AJ, Wood JD, Foust KD.

Gene Ther. 2017 Oct;24(10):640-648. doi: 10.1038/gt.2017.72. Epub 2017 Aug 3.


BMP- and TGFβ-signaling regulate the formation of Müller glia-derived progenitor cells in the avian retina.

Todd L, Palazzo I, Squires N, Mendonca N, Fischer AJ.

Glia. 2017 Oct;65(10):1640-1655. doi: 10.1002/glia.23185. Epub 2017 Jul 13.



Kymograph analysis with high temporal resolution reveals new features of neurofilament transport kinetics.

Fenn JD, Johnson CM, Peng J, Jung P, Brown A.

Cytoskeleton (Hoboken). 2017 Sep 19. doi: 10.1002/cm.21411. [Epub ahead of print]


Dopamine Regulation of GABAA Receptors Contributes to Light/Dark Modulation of the ON-Cone Bipolar Cell Receptive Field Surround in the Retina.

Chaffiol A, Ishii M, Cao Y, Mangel SC.

Curr Biol. 2017 Sep 11;27(17):2600-2609.e4. doi: 10.1016/j.cub.2017.07.063. Epub 2017 Aug 24.



Molecular determinants of acidic pH-dependent transport of human equilibrative nucleoside transporter 3.

Rahman MF, Askwith C, Govindarajan R.

J Biol Chem. 2017 Sep 8;292(36):14775-14785. doi: 10.1074/jbc.M117.787952. Epub 2017 Jul 20.



Light at night as an environmental endocrine disruptor.

Russart KLG, Nelson RJ.

Physiol Behav. 2017 Sep 6. pii: S0031-9384(17)30274-3. doi: 10.1016/j.physbeh.2017.08.029. [Epub ahead of print] Review.


Enduring effects of perinatal nicotine exposure on murine sleep in adulthood.

Borniger JC, Don RF, Zhang N, Boyd RT, Nelson RJ.

Am J Physiol Regul Integr Comp Physiol. 2017 Sep 1;313(3):R280-R289. doi: 10.1152/ajpregu.00156.2017. Epub 2017Jun 21.



Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus.

Choi YS, Horning P, Aten S, Karelina K, Alzate-Correa D, Arthur JSC, Hoyt KR, Obrietan K.

ASN Neuro. 2017 Sep-Oct;9(5):1759091417726607. doi: 10.1177/1759091417726607.


Developing a data sharing community for spinal cord injury research.

Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP; FAIR Share Workshop Participants.

Exp Neurol. 2017 Sep;295:135-143. doi: 10.1016/j.expneurol.2017.05.012. Epub 2017 May 30. Review.


Depressive-like behavior is elevated among offspring of parents exposed to dim light at night prior to mating.

Cissé YM, Russart KLG, Nelson RJ.

Psychoneuroendocrinology. 2017 Sep;83:182-186. doi: 10.1016/j.psyneuen.2017.06.004. Epub 2017 Jun 12.


δ-Protocadherins: Organizers of neural circuit assembly.

Light SEW, Jontes JD.

Semin Cell Dev Biol. 2017 Sep;69:83-90. doi: 10.1016/j.semcdb.2017.07.037. Epub 2017 Jul 24. Review.


Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs.

Lerch JK, Alexander JK, Madalena KM, Motti D, Quach T, Dhamija A, Zha A, Gensel JC, Webster Marketon J, Lemmon VP, Bixby JL, Popovich PG.

eNeuro. 2017 Aug 21;4(4). pii: ENEURO.0246-17.2017. doi: 10.1523/ENEURO.0246-17.2017. eCollection 2017 Jul-Aug.


Mammary Tumors Induce Central Pro-inflammatory Cytokine Expression, but Not Behavioral Deficits in Balb/C Mice.

Walker Ii WH, Borniger JC, Surbhi, Zalenski AA, Muscarella SL, Fitzgerald JA, Zhang N, Gaudier-Diaz MM, DeVries AC.

Sci Rep. 2017 Aug 15;7(1):8152. doi: 10.1038/s41598-017-07596-9.



Identification of miRNAs involved in DRG neurite outgrowth and their putative targets.

Motti D, Lerch JK, Danzi MC, Gans JH, Kuo F, Slepak TI, Bixby JL, Lemmon VP.

FEBS Lett. 2017 Jul;591(14):2091-2105. doi: 10.1002/1873-3468.12718.

Epub 2017 Jul 2.



MicroRNAs: Roles in Regulating Neuroinflammation.

Gaudet AD, Fonken LK, Watkins LR, Nelson RJ, Popovich PG.

Neuroscientist. 2017 Jul 1:1073858417721150. doi: 10.1177/1073858417721150.

[Epub ahead of print]


E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord.

Church JS, Milich LM, Lerch JK, Popovich PG, McTigue DM.

Glia. 2017 Jun;65(6):883-899. doi: 10.1002/glia.23132. Epub 2017 Mar 2.



Cellular responses to recurrent pentylenetetrazole-induced seizures in the adult zebrafish brain.

Duy PQ, Berberoglu MA, Beattie CE, Hall CW.

Neuroscience. 2017 May 4;349:118-127. doi: 10.1016/j.neuroscience.2017.02.032. Epub 2017 Feb 24.



Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety.

McKim DB, Weber MD, Niraula A, Sawicki CM, Liu X, Jarrett BL, Ramirez-Chan K, Wang Y, Roeth RM, Sucaldito AD, Sobol CG, Quan N, Sheridan JF, Godbout JP.

Mol Psychiatry. 2017 Apr 4. doi: 10.1038/mp.2017.64. [Epub ahead of print]



BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy.

Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongkul P, Pichiorri F, Zhang J, Old M, Zhu D, Van Meir EG, Godbout JP, Caligiuri MA, Yu J, Kaur B.

Clin Cancer Res. 2017 Apr 1;23(7):1809-1819. doi: 10.1158/1078-0432.CCR-16-1818. Epub 2016 Nov 9.



Magnetic mapping of iron in rodent spleen.

Blissett AR, Ollander B, Penn B, McTigue DM, Agarwal G.

Nanomedicine. 2017 Apr;13(3):977-986. doi: 10.1016/j.nano.2016.11.011.

Epub 2016 Nov 25.



Parental Exposure to Dim Light at Night Prior to Mating Alters Offspring Adaptive Immunity.

Cissé YM, Russart KL, Nelson RJ.

Sci Rep. 2017 Mar 31;7:45497. doi: 10.1038/srep45497.


Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice.

Freria CM, Hall JC, Wei P, Guan Z, McTigue DM, Popovich PG.

J Neurosci. 2017 Mar 29;37(13):3568-3587. doi: 10.1523/JNEUROSCI.2841-16.2017. Epub 2017 Mar 6.


Spinal Cord Injury Suppresses Cutaneous Inflammation: Implications for Peripheral Wound Healing.

Marbourg JM, Bratasz A, Mo X, Popovich PG.

J Neurotrauma. 2017 Mar 15;34(6):1149-1155. doi: 10.1089/neu.2016.4611. Epub 2016 Oct 17.


Binge ethanol in adulthood exacerbates negative outcomes following juvenile traumatic brain injury.

Karelina K, Gaier KR, Prabhu M, Wenger V, Corrigan TE, Weil ZM.

Brain Behav Immun. 2017 Feb;60:304-311. doi: 10.1016/j.bbi.2016.11.009.

Epub 2016 Nov 12.



Timing of light exposure affects mood and brain circuits.

Bedrosian TA, Nelson RJ.

Transl Psychiatry. 2017 Jan 31;7(1):e1017. doi: 10.1038/tp.2016.262. Review.


Time-of-Day Dictates Transcriptional Inflammatory Responses to Cytotoxic Chemotherapy.

Borniger JC, Walker Ii WH, Gaudier-Diaz MM, Stegman CJ, Zhang N, Hollyfield JL, Nelson RJ, DeVries AC.

Sci Rep. 2017 Jan 24;7:41220. doi: 10.1038/srep41220.



Can Sustained Glia-Mediated Brain Inflammation After Repeated Concussive Brain Injury Be Detected In Vivo?

Witcher KG, Godbout JP.

JAMA Neurol. 2017 Jan 1;74(1):23-25. doi: 10.1001/jamaneurol.2016.4539.

No abstract available. 


Microglia Priming with Aging and Stress.

Niraula A, Sheridan JF, Godbout JP.

Neuropsychopharmacology. 2017 Jan;42(1):318-333. doi: 10.1038/npp.2016.185. Epub 2016 Sep 8.



Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal.

Weber MD, Godbout JP, Sheridan JF.

Neuropsychopharmacology. 2017 Jan;42(1):46-61. doi: 10.1038/npp.2016.102.

Epub 2016 Jun 20.



Photoperiodic regulation of behavior: Peromyscus as a model system.

Borniger JC, Nelson RJ.

Semin Cell Dev Biol. 2017 Jan;61:82-91. doi: 10.1016/j.semcdb.2016.06.015.

Epub 2016 Jun 23. Review.




miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-ExtrinsicBarriers to Spinal Cord Repair.
Gaudet AD, Mandrekar-Colucci S, Hall JC, Sweet DR, Schmitt PJ, Xu X, Guan Z, Mo X, Guerau-de-Arellano M, Popovich PG.
J Neurosci. 2016 Aug 10;36(32):8516-32. doi: 10.1523/JNEUROSCI.0735-16.2016.
PMID: 27511021

Photoperiodicregulation of behavior: Peromyscus as a model system.
Borniger JC, Nelson RJ.
Semin Cell Dev Biol. 2016 Jun 23. pii: S1084-9521(16)30177-X. doi: 10.1016/j.semcdb.2016.06.015. [Epub ahead of print] Review.
PMID: 27346738

Insensitivity ofastrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.
Norden DM, Trojanowski PJ, Walker FR, Godbout JP.
Neurobiol Aging. 2016 Aug;44:22-41. doi: 10.1016/j.neurobiolaging.2016.04.014. Epub 2016 Apr 27.
PMID: 27318131

Repeated Social Defeat,Neuroinflammation, and Behavior: Monocytes Carry the Signal.
Weber MD, Godbout JP, Sheridan JF.
Neuropsychopharmacology. 2016 Jul 20. doi: 10.1038/npp.2016.102. [Epub ahead of print] Review.
PMID: 27319971

TLR4 Deficiency ImpairsOligodendrocyte Formation in the Injured Spinal Cord.
Church JS, Kigerl KA, Lerch JK, Popovich PG, McTigue DM.
J Neurosci. 2016 Jun 8;36(23):6352-64. doi: 10.1523/JNEUROSCI.0353-16.2016.
PMID: 27277810

Breast cancer andsocial environment: getting by with a little help from our friends.
Hinzey A, Gaudier-Diaz MM, Lustberg MB, DeVries AC.
Breast Cancer Res. 2016 May 26;18(1):54. doi: 10.1186/s13058-016-0700-x. Review.
PMID: 27225892 

Lumbar Myeloid CellTrafficking into Locomotor Networks after Thoracic Spinal Cord Injury.
Hansen CN, Norden DM, Faw TD, Deibert R, Wohleb ES, Sheridan JF, Godbout JP, Basso DM.
Exp Neurol. 2016 Aug;282:86-98. doi: 10.1016/j.expneurol.2016.05.019. Epub 2016 May 16.
PMID: 27191729

Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
Ueno M, Ueno-Nakamura Y, Niehaus J, Popovich PG, Yoshida Y.
Nat Neurosci. 2016 Jun;19(6):784-7. doi: 10.1038/nn.4289. Epub 2016 Apr 18.
PMID: 27089020

mTor signaling isrequired for the formation of proliferating Müller glia-derived progenitorcells in the chick retina.
Zelinka CP, Volkov L, Goodman ZA, Todd L, Palazzo I, Bishop WA, Fischer AJ.
Development. 2016 Jun 1;143(11):1859-73. doi: 10.1242/dev.133215. Epub 2016 Apr 11.
PMID: 27068108

Neuroinflammation: TheDevil is in the Details.
DiSabato D, Quan N, Godbout JP.
J Neurochem. 2016 Mar 15. doi: 10.1111/jnc.13607. [Epub ahead of print] Review.
PMID: 26990767

miR-155 Deletion inFemale Mice Prevents Diet-Induced Obesity.
Gaudet AD, Fonken LK, Gushchina LV, Aubrecht TG, Maurya SK, Periasamy M, Nelson RJ, Popovich PG.
Sci Rep. 2016 Mar 8;6:22862. doi: 10.1038/srep22862.
PMID: 26953132 

NeuroinflammatoryDynamics Underlie Memory Impairments after Repeated Social Defeat.
McKim DB, Niraula A, Tarr AJ, Wohleb ES, Sheridan JF, Godbout JP.
J Neurosci. 2016 Mar 2;36(9):2590-604. doi: 10.1523/JNEUROSCI.2394-15.2016.
PMID: 26937001

MicroRNA-155 deletionreduces anxiety- and depressive-like behaviors in mice.
Fonken LK, Gaudet AD, Gaier KR, Nelson RJ, Popovich PG.
Psychoneuroendocrinology. 2016 Jan;63:362-9. doi: 10.1016/j.psyneuen.2015.10.019. Epub 2015 Nov 2.
PMID: 26555429

Sequential activationof microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAPimmunoreactivity following systemic immune challenge.
Norden DM, Trojanowski PJ, Villanueva E, Navarro E, Godbout JP.
Glia. 2016 Feb;64(2):300-16. doi: 10.1002/glia.22930. Epub 2015 Oct 15.
PMID: 26470014

Gap junction coupling confersisopotentiality on astrocyte syncytium.
Ma B, Buckalew R, Du Y, Kiyoshi CM, Alford CC, Wang W, McTigue DM, Enyeart JJ, Terman D, Zhou M.
Glia. 2016 Feb;64(2):214-26. doi: 10.1002/glia.22924. Epub 2015 Oct 5.
PMID: 26435164

Sympathetic Release ofSplenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.
McKim DB, Patterson JM, Wohleb ES, Jarrett BL, Reader BF, Godbout JP, Sheridan JF.
Biol Psychiatry. 2016 May 15;79(10):803-13. doi: 10.1016/j.biopsych.2015.07.010. Epub 2015 Jul 26.
PMID: 26281717

Endocrine Effects of Circadian Disruption.
Bedrosian TA, Fonken LK, Nelson RJ.
Annu Rev Physiol. 2016;78:109-31. doi: 10.1146/annurev-physiol-021115-105102. Epub 2015 Jul 22.
PMID: 26208951




Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat 

McKim DB, Patterson JM, Wohleb ES, Jarrett BL, Reader BF, Godbout JP, Sheridan JF.

Biol Psychiatry 2015 Jul 26. pii: S0006-3223(15)00598-3. doi: 10.1016/j.biopsych.2015.07.010. [Epub ahead of print] 

PMID: 26281717 


Hedgehog Signaling Stimulates the Formation tf Proliferating Müller Glia-Derived Progenitor Cells in the Chick Retina 

Todd L, Fischer AJ.

Development 2015 Aug 1;142(15):2610-22. doi: 10.1242/dev.121616. Epub 2015 Jun 26. 

PMID: 26116667 


Monocyte Trafficking to the Brain With Stress and Inflammation: A Novel Axis of Immune-to-Brain Communication That Influences Mood and Behavior

Wohleb ES, McKim DB, Sheridan JF, Godbout JP.

Front Neurosci 2015 Jan 21;8:447. doi: 10.3389/fnins.2014.00447. eCollection 2014. Review.  

PMID: 25653581 


Reactive Retinal Microglia, Neuronal Survival, and the Formation of Retinal Folds and Detachments 

Fischer AJ, Zelinka C, Milani-Nejad N. Glia.

2015 Feb;63(2):313-27. doi: 10.1002/glia.22752. Epub 2014 Sep 18.

PMID: 25231952


SMN Expression Is Required in Motor Neurons to Rescue Electrophysiological Deficits in the SMNΔ7 Mouse Model of SMA 

McGovern VL, Iyer CC, Arnold WD, Gombash SE, Zaworski PG, Blatnik AJ 3rd, Foust KD, Burghes AH.

Hum Mol Genet. 2015 Jul 23. pii: ddv283. [Epub ahead of print]

PMID: 26206889 


SMN Deficiency Disrupts Gastrointestinal and Enteric Nervous System Function in Mice 

Gombash SE, Cowley CJ, Fitzgerald JA, Iyer CC, Fried D, McGovern VL, Williams KC, Burghes AH, Christofi FL, Gulbransen BD, Foust KD.

Hum Mol Genet. 2015 Jul 1;24(13):3847-60. doi: 10.1093/hmg/ddv127. Epub 2015 Apr 9. 

PMID: 25859009 


Motoneuron Development Influences Dorsal Root Ganglia Survival and Schwann Cell Development in a Vertebrate Model of Spinal Muscular Atrophy 

Hao le T, Duy PQ, Jontes JD, Beattie CE.

Hum Mol Genet 2015 Jan 15;24(2):346-60. doi: 10.1093/hmg/ddu447. Epub 2014 Sep 1.

PMID: 25180019 


Low Levels of Survival Motor Neuron Protein Are Sufficient for Normal Muscle Function in the SMNΔ7 Mouse Model of SMA 

Iyer CC, McGovern VL, Murray JD, Gombash SE, Zaworski PG, Foust KD, Janssen PM, Burghes AH.

Hum Mol Genet 2015 Aug 13. pii: ddv332. [Epub ahead of print] 

PMID: 26276812 


Restored Glial Glutamate Transporter EAAT2 Function as a Potential Therapeutic Approach for Alzheimer’s Disease 

Takahashi K, Kong Q, Lin Y, Stouffer N, Schulte DA, Lai L, Liu Q, Chang LC, Dominguez S, Xing X, Cuny GD, Hodgetts KJ, Glicksman MA, Lin CL.

J Exp Med 2015 Mar 9;212(3):319-32. doi: 10.1084/jem.20140413. Epub 2015 Feb 23. 

PMID: 25711212


Toll-Like Receptors and Dectin-1, a C-Type Lectin Receptor, Trigger Divergent Functions in CNS Macrophages 

Gensel JC, Wang Y, Guan Z, Beckwith KA, Braun KJ, Wei P, McTigue DM, Popovich PG.

J Neurosci 2015 Jul 8;35(27):9966-76. doi: 10.1523/JNEUROSCI.0337-15.2015. 

PMID: 26156997


Chronic Oligodendrogenesis and Remyelination After Spinal Cord Injury in Mice and Rats

Hesp ZC, Goldstein EZ, Miranda CJ, Kaspar BK, McTigue DM.

J Neurosci 2015 Jan 21;35(3):1274-90. doi: 10.1523/JNEUROSCI.2568-14.2015. Erratum in: J Neurosci. 2015 May 6;35(18):7313. Goldstein, Evan A [Corrected to Goldstein, Evan Z] and Kaspar, Brain K [Corrected to Kaspar, Brian K]. 

PMID: 25609641


Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types 

Liu X, Yamashita T, Chen Q, Belevych N, Mckim DB, Tarr AJ, Coppola V, Nath N, Nemeth DP, Syed ZW, Sheridan JF, Godbout JP, Zuo J, Quan N.

J Neurosci 2015 Feb 18;35(7):2860-70. doi: 10.1523/JNEUROSCI.3199-14.2015. 

PMID: 25698726


Improving Single Injection CSF Delivery of AAV9-Mediated Gene Therapy for SMA: A Dose-Response Study in Mice and Nonhuman Primates 

Meyer K, Ferraiuolo L, Schmelzer L, Braun L, McGovern V, Likhite S, Michels O, Govoni A, Fitzgerald J, Morales P, Foust KD, Mendell JR, Burghes AH, Kaspar BK.

Mol Ther 2015 Mar;23(3):477-87. doi: 10.1038/mt.2014.210. Epub 2014 Oct 31. 

PMID: 25358252


Modulation of the Proteoglycan Receptor Ptpσ Promotes Recovery After Spinal Cord Injury 

Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, Madalena KM, Brown BP, Weng YL, Li S, Karimi-Abdolrezaee S, Busch SA, Shen Y, Silver J.

Nature 2015 Feb 19;518(7539):404-8. doi: 10.1038/nature13974. Epub 2014 Dec 3. 

PMID: 25470046 


Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice

Xie Y, Zhou B, Lin MY, Wang S, Foust KD, Sheng ZH.

Neuron 2015 Jul 15;87(2):355-70. doi: 10.1016/j.neuron.2015.06.026.

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A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases 

Xue C, Shtylla B, Brown A.

PLoS Comput Biol 2015 Aug 18;11(8):e1004406. doi: 10.1371/journal.pcbi.1004406. eCollection 2015 Aug. 

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Melatonin Treatment During Early Life Interacts With Restraint to Alter Neuronal Morphology and Provoke Depressive-Like Responses

Aubrecht TG, Weil ZM, Nelson RJ.

Behav Brain Res. 2014 Apr 15;263:90-7. doi: 10.1016/j.bbr.2014.01.025. Epub 2014 Jan 29.

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Is No Evidence of Disease Activity a Realistic Goal for Patients With Multiple Sclerosis?

Imitola J, Racke MK. JAMA Neurol 2014.

JAMA Neurol. 2015 Feb;72(2):145-7. doi: 10.1001/jamaneurol.2014.3860.

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Modulation of the Proteoglycan Receptor Ptpσ Promotes Recovery After Spinal Cord Injury

Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, Madalena KM, Brown BP, Weng YL, Li S, Karimi-Abdolrezaee S, Busch SA, Shen Y, Silver J.

Nature 2014. doi: 10.1038/nature13974.

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Social Overcrowding as a Chronic Stress Model That Increases Adiposity in Mice 

Lin EJ, Sun M, Choi EY, Magee D, Stets CW, During MJ.

Psychoneuroendocrinology 2015;51:318-30. doi: 10.1016/j.psyneuen.2014.10.007.

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Regulation of Neurovascular Coupling in Autoimmunity to Water and Ion Channels

Jukkola P, Gu C.

Autoimmun Rev 2014. 2015 (3):258-267. doi:10.1016/j.autrev.2014.11.010.

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Neuroendocrine Control of Photoperiodic Changes in Immune Function 

Weil ZM, Borniger JC, Cisse YM, Abi Salloum BA, Nelson RJ.

Front Neuroendocrinol 2014. pii: S0091-3022(14)00098-3. doi: 10.1016/j.yfrne.2014.10.001.

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Profiling status epilepticus-induced changes in hippocampal RNA expression using high-throughput RNA sequencing

Hansen KF, Sakamoto K, Pelz C, Impey S, Obrietan K.

Sci Rep 2014;4:6930. doi: 10.1038/srep06930.

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Improving Single Injection CSF Delivery of AAV9-mediated Gene Therapy for SMA: A Dose-response Study in Mice and Nonhuman Primates 

Meyer K, Ferraiuolo L, Schmelzer L, Braun L, McGovern V, Likhite S, Michels O, Govoni A, Fitzgerald J, Morales P, Foust KD, Mendell JR, Burghes AH, Kaspar BK.

Mol Ther 2014. doi:10.1038/mt.2014.210.

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Motoneuron Development Influences Dorsal Root Ganglia Survival and Schwann Cell Development in a Vertebrate Model of Spinal Muscular Atrophy 

Hao le T, Duy PQ, Jontes JD, Beattie CE.

Hum Mol Genet 2015;24(2):346-60. doi: 10.1093/hmg/ddu447.

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Glucocorticoid Receptors in the Retina, Müller Glia and the Formation of Müller Glia-Derived Progenitors 

Gallina D, Zelinka C, Fischer AJ.

Development 2014;141(17):3340-51. doi: 10.1242/dev.109835.

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Primary Cilia Enhance Kisspeptin Receptor Signaling on Gonadotropin-Releasing Hormone Neurons 

Koemeter-Cox AI, Sherwood TW, Green JA, Steiner RA, Berbari NF, Yoder BK, Kauffman AS, Monsma PC, Brown A, Askwith CC, Mykytyn K.

Proc Natl Acad Sci USA 2014;111(28):10335-40. doi: 10.1073/pnas.1403286111.

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IL-4 Signaling Drives a Unique Arginase+/IL-1β+ Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4Rα After Traumatic Spinal Cord Injury.

Fenn AM, Hall JC, Gensel JC, Popovich PG, Godbout JP.

J Neurosci 2014;34(26):8904-17. doi: 10.1523/JNEUROSCI.1146-14.

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Reactive Microglia and Macrophage Facilitate the Formation of Müller Glia-Derived Retinal Progenitors

Fischer AJ, Zelinka C, Gallina D, Scott MA, Todd L.

Glia 2014;62(10):1608-28. doi: 10.1002/glia.22703. 

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Tgfβ Produced by IL-10 Redirected Astrocytes Attenuates Microglial Activation

Norden DM, Fenn AM, Dugan A, Godbout JP.

Glia 2014;62(6):881-95. doi: 10.1002/glia.22647.

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Microglia Induce Motor Neuron Death via the Classical NF-Κb Pathway in Amyotrophic Lateral Sclerosis

Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BK.

Neuron 2014; 81(5):1009-23. doi: 10.1016/j.neuron.2014.01.013.

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Local Regulation of Neurofilament Transport by Myelinating Cells 

Monsma PC, Li Y, Fenn JD, Jung P, Brown A.

J Neurosci 2014;34(8):2979-88. doi: 10.1523/JNEUROSCI.4502-13.

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Physiological and Pathological Functions of Mechanosensitive Ion Channels 

Gu Y, Gu C.

Mol Neurobiol 2014;50(2):339-47. doi: 10.1007/s12035-014-8654-4.

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Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior 

Wohleb ES, Patterson JM, Sharma V, Quan N, Godbout JP, Sheridan JF.

J Neurosci 2014;34(7):2583-91. doi: 10.1523/JNEUROSCI.3723-13.

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Re-Establishment of Anxiety in Stress-Sensitized Mice Is Caused By Monocyte Trafficking from the Spleen to the Brain

Wohleb ES, McKim DB, Shea DT, Powell ND, Tarr AJ, Sheridan JF, Godbout JP.

Biol Psychiatry 2014;75(12):970-81. doi: 10.1016/j.biopsych.2013.11.029.

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Ankyrin-G Directly Binds to Kinesin-1 to Transport Voltage-Gated Na+ Channels Into Axons 

Barry J, Gu Y, Jukkola P, O'Neill B, Gu H, Mohler PJ, Rajamani KT, Gu C.

Dev Cell 2014;28(2):117-31. doi: 10.1016/j.devcel.2013.11.023.

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Protocadherin-18b Interacts With Nap1 to Control Motor Axon Growth and Arborization in Zebrafish 

Biswas S, Emond MR, Duy PQ, Hao le T, Beattie CE, Jontes JD.

Mol Biol Cell 2014;25(5):633-42. doi: 10.1091/mbc.E13-08-0475.

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Immune Activation Promotes Depression 1 Month After Diffuse Brain Injury: A Role for Primed Microglia 

Fenn AM, Gensel JC, Huang Y, Popovich PG, Lifshitz J, Godbout JP.

Biol Psychiatry 2014;76(7):575-84. doi: 10.1016/j.biopsych.2013.10.014.

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Calcium Binding Is Essential for Plastin 3 Function in Smn-Deficient Motoneurons

Lyon AN, Pineda RH, Hao le T, Kudryashova E, Kudryashov DS, Beattie CE.

Hum Mol Genet 2014;23(8)0:1990-2004. doi: 10.1093/hmg/ddt595.

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Autonomic Dysreflexia Causes Chronic Immune Suppression After Spinal Cord Injury

Zhang Y, Guan Z, Reader B, Shawler T, Mandrekar-Colucci S, Huang K, Weil ZM, Bratasz A, Wells J, Powell ND, Sheridan JF, Whitacre CC, Rabchevsky AG, Nash MS, Popovich PP.

J Neurosci. 2013 Aug 7;33(32):12970-81. doi: 10.1523/JNEUROSCI.1974-13.2013.

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Elevated MMP-9 in the Lumbar Cord Early After Thoracic Spinal Cord Injury Impedes Motor Relearning in Mice

Hansen CN, Fisher LC, Deibert RJ, Jakeman LB, Zhang H, Noble-Haeusslein L, White S, Basso DM.

J Neurosci. 2013 Aug 7;33(32):13101-11. doi: 10.1523/JNEUROSCI.1576-13.2013.

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Nocturnal Light Exposure Impairs Affective Responses in a Wavelength-Dependent Manner 

Bedrosian TA, Vaughn CA, Galan A, Daye G, Weil ZM, Nelson RJ.

J Neurosci. 2013 Aug 7;33(32):13081-7. doi: 10.1523/JNEUROSCI.5734-12.2013.

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Temporal Requirement for SMN in Motoneuron Development

Hao LT, Duy PQ, Jontes JD, Wolman M, Granato M, Beattie CE.

Hum Mol Genet. 2013 Jul 1;22(13):2612-25. doi: 10.1093/hmg/ddt110. Epub 2013 Mar 3.

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Chronic Dim Light at Night Provokes Reversible Depression-like Phenotype: Possible Role for TNF

Bedrosian TA, Weil ZM, Nelson RJ.

Molecular Psychiatry 2013;18(8):930-6. 

Mol Psychiatry. 2013 Aug;18(8):930-6. doi: 10.1038/mp.2012.96. Epub 2012 Jul 24.

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Clock and Light Regulation of the CREB Coactivator CRTC1 in the Suprachiasmatic Circadian Clock

Sakamoto K, Norona FE, Alzate-Correa D, Scarberry D, Hoyt KR, Obrietan K.

J Neurosci. 2013 May 22;33(21):9021-7. doi: 10.1523/JNEUROSCI.4202-12.2013.

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Early Interneuron Dysfunction in ALS: Insights from a Mutant Sod1 Zebrafish Model

McGown A, McDearmid JR, Panagiotaki N, Tong H, Al Mashhadi S, Redhead N, Lyon AN, Beattie CE, Shaw PJ, Ramesh TM.

Annals of Neurology 2013 Feb;73:246-258.


Severing and End-to-End Annealing of Neurofilaments in Neurons 

Uchida A, Colakoglu G, Wang L, Monsma PC, Brown A.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2696-705. doi: 10.1073/pnas.1221835110. Epub 2013 Jul 2.

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Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome 

Garg SK, Lioy DT, Cheval H, McGann JC, Bissonnette JM, Murtha MJ, Foust KD, Kaspar BK, Bird A, Mandel G.

J Neurosci. 2013 Aug 21;33(34):13612-20. doi: 10.1523/JNEUROSCI.1854-13.2013.

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Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-like Behavior

Wohleb ES, Powell ND, Godbout JP, Sheridan JF.

J Neurosci. 2013 Aug 21;33(34):13820-33. doi: 10.1523/JNEUROSCI.1671-13.2013.

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Activation of Conventional Kinesin Motors in Clusters by Shaw Voltage-Gated Potassium Channels

Barry J, Xu M, Gu Y, Dangel AW, Jukkola P, Shrestha C, Gu C.

J Cell Sci. 2013 May 1;126(Pt 9):2027-41. doi: 10.1242/jcs.122234. Epub 2013 Mar 13.

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Kv3 Channel Assembly, Trafficking and Activity are Regulated by Zinc Through Different Binding Sites. 

Gu Y, Barry J, Gu C.

J Physiol 2013 May 15;591(Pt 10):2491-507. doi: 10.1113/jphysiol.2013.251983. Epub 2013 Feb 18.

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Influence of the Modern Light Environment on Mood

Bedrosian TA, Nelson RJ.

Mol Psychiatry 2013 Jul;18(7):751-7. doi: 10.1038/mp.2013.70. Epub 2013 May 28.

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Neonatal e. Coli Infection Causes Neuro-Behavioral Deficits Associated With Hypomyelination and Neuronal Sequestration of Iron

Lieblein-Boff JC, McKim DB, Shea DT, Wei P, Deng Z, Sawicki C, Quan N, Bilbo SD, Bailey MT, McTigue DM, Godbout JP.

J Neurosci 2013 Oct 9;33(41):16334-45. doi: 10.1523/JNEUROSCI.0708-13.2013.

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Therapeutic AAV9-mediated Suppression of Mutant SOD1 Slows Disease Progression and Extends Survival in Models of Inherited ALS 

Foust KD, Salazar DL, Likhite S, Ferraiuolo L, Ditsworth D, Illieva H, Meyer K, Schmelzer L, Braun L, Cleveland DW, Kaspar BK.

MOL Ther 2013 Sep 6. doi: 10.1038/mt.2013.211 [Epub ahead of print]

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Increased micro-RNA 29b in the Aged Brain Correlates With the Reduction of Insulin-Like Growth Factor-1 and Fractalkine Ligand 

Fenn AM, Smith KM, Lovett-Racke AE, Guerau-de-Arellano M, Whitacre CC, Godbout JP.

Neurobiol Aging 2013 Dec;34(12):2748-58. doi: 10.1016/j.neurobiolaging.2013.06.007. Epub 2013 Jul 21.

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Chronic Dim Light at Night Provokes Reversible Depression-Like Phenotype: Possible Role for TNF 

Bedrosian TA, Weil ZM, Nelson RJ.

Mol Psychiatry 2013 Aug;18(8):930-6. doi: 10.1038/mp.2012.96. Epub 2012 Jul 24.

PMID: 22824811 


Lessons Learned from Fatal Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis Treated With Natalizumab

Boster AL, Nicholas JA, Topalli I, Kisanuki YY, Pei W, Morgan-Followell B, Kirsch CF, Racke MK, Pitt D.

JAMA Neurol. 2013 Mar 1;70(3):398-402. doi: 10.1001/jamaneurol.2013.1960.

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Reintroducing Laboratory Mice to Sociality Induces Adaptive Transgenerational Regulation of MUP Expression

Nelson AC, Cauceglia AW, Merkley SD, Youngson NA, Oler AJ, Nelson RJ, Cairns BR, Whitelaw E, Potts WK.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19848-53. doi: 10.1073/pnas.1310427110. Epub 2013 Nov 18.

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Chronic Citalopram Treatment Ameliorates Depressive Behavior Associated With Light at Night

Bedrosian TA, Weil ZM, Nelson RJ.

Behav Neurosci. 2012 Oct;126(5):654-8. doi: 10.1037/a0029699. Epub 2012 Aug 13.

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p53 Regulates the Neuronal Intrinsic and Extrinsic Responses Affecting the Recovery of Motor Function Following Spinal Cord Injury 

Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, Kigerl KA, Popovich PG, Di Giovanni S.

J Neurosci. 2012 Oct 3;32(40):13956-70. doi: 10.1523/JNEUROSCI.1925-12.2012.

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Building Bridges for Spinal Cord Repair

Popovich PG.

Cell. 2012 Sep 14;150(6):1105-6. doi: 10.1016/j.cell.2012.08.025.PubMed

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Toward an efficient and integrative analysis of limited-choice behavioral experiments 

Schilling K, Oberdick J, Schilling RL.

J Neurosci. 2012 Sep 12;32(37):12651-6. doi: 10.1523/JNEUROSCI.1452-12.2012.

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Myelination of rodent hippocampal neurons in culture 

Gardner A, Jukkola P, Gu C.

Nat Protoc. 2012 Oct;7(10):1774-82. doi: 10.1038/nprot.2012.100. Epub 2012 Sep 6.

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Bicarbonate Efflux Via GABA(A) Receptors Depolarizes Membrane Potential and Inhibits Two-Pore Domain Potassium Channels of Astrocytes in Rat Hippocampal Slices 

Ma BF, Xie MJ, Zhou M.

Glia. 2012 Nov;60(11):1761-72. doi: 10.1002/glia.22395. Epub 2012 Jul 31.

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Chronic Dim Light at Night Provokes Reversible Depression-Like Phenotype: Possible Role for TNF 

Bedrosian TA, Weil ZM, Nelson RJ.

Mol Psychiatry. 2013 Aug;18(8):930-6. doi: 10.1038/mp.2012.96. Epub 2012 Jul 24.

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Dimethyl Fumarate Inhibits Dendritic Cell Maturation Via Nuclear Factor Κb (NF-Κb) and Extracellular Signal-Regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-Activated Kinase 1 (MSK1) Signaling 

Peng H, Guerau-de-Arellano M, Mehta VB, Yang Y, Huss DJ, Papenfuss TL, Lovett-Racke AE, Racke MK.

Mol Psychiatry. 2013 Aug;18(8):930-6. doi: 10.1038/mp.2012.96. Epub 2012 Jul 24.

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Survival Motor Neuron Affects Plastin 3 Protein Levels Leading to Motor Defects 

Hao le T, Wolman M, Granato M, Beattie CE.

J Neurosci. 2012 Apr 11;32(15):5074-84. doi: 10.1523/JNEUROSCI.5808-11.2012.

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GABA-Mediated Spatial and Temporal Asymmetries That Contribute to the Directionally Selective Light Responses of Starburst Amacrine Cells in Retina 

Dmitriev AV, Gavrikov KE, Mangel SC.

J Physiol. 2012 Apr 1;590(7):1699-720. doi: 10.1113/jphysiol.2011.225482. Epub 2012 Jan 30.

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Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency

Gu Y, Barry J, McDougel R, Terman D, Gu C.

J Biol Chem. 2012 Jan 13;287(3):1755-69. doi: 10.1074/jbc.M111.299305. Epub 2011 Nov 21.

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Axonal Transport of Neurofilaments: A Single Population of Intermittently Moving Polymers 

Li Y, Jung P, Brown A.

J Neurosci. 2012 Jan 11;32(2):746-58. doi: 10.1523/JNEUROSCI.4926-11.2012.

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A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouse 

Porensky PN, Mitrpant C, McGovern VL, Bevan AK, Foust KD, Kaspar BK, Wilton SD, Burghes AH.

Hum Mol Genet. 2012 Apr 1;21(7):1625-38. doi: 10.1093/hmg/ddr600. Epub 2011 Dec 20.

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Ferritin stimulates oligodendrocyte genesis in the adult spinal cord and can be transferred from macrophages to NG2 cells in vivo

Schonberg DL, Goldstein EZ, Sahinkaya FR, Wei P, Popovich PG, McTigue DM. J Neurosci. 2012 Apr 18;32(16):5374-84. doi: 10.1523/JNEUROSCI.3517-11.2012.

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Peripheral Innate Immune Challenge Exaggerated Microglia Activation, Increased the Number of Inflammatory CNS Macrophages, and Prolonged Social Withdrawal in Socially Defeated Mice

Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP. Psychoneuroendocrinology. 2012 Sep;37(9):1491-505. doi: 10.1016/j.psyneuen.2012.02.003. Epub 2012 Mar 2.

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Altered Temporal Patterns of Anxiety in Aged and Amyloid Precursor Protein (APP) Transgenic Mice 

Bedrosian TA, Herring KL, Weil ZM, Nelson RJ.

Proc Natl Acad Sci U S A 2011 Jul 12;108(28):11686-91. Epub 2011 Jun 27. 2011

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Circadian Regulation of Intracellular G-Protein Signaling Mediates Intercellular Synchrony and Rhythmicity in the Suprachiasmatic Nucleus

Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H.

Nat Commun. 2011;2:327. doi: 10.1038/ncomms1316.

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Deficient CX3CR1 signaling promotes recovery after mouse spinal cord injury by limiting the recruitment and activation of Ly6Clo/iNOS+ macrophages 

Donnelly DJ, Longbrake EE, Shawler TM, Kigerl KA, Lai W, Tovar CA, Ransohoff RM, Popovich PG. J.

J Neurosci. 2011 Jul 6;31(27):9910-22. doi: 10.1523/JNEUROSCI.2114-11.2011.

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A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion

Emond MR, Biswas S, Blevins CJ, Jontes JD.

J Cell Biol. 2011 Dec 26;195(7):1115-21. doi: 10.1083/jcb.201108115. Epub 2011 Dec 19.

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Sustained Melatonin Treatment Blocks Body Mass, Pelage, Reproductive and Fever Responses to Short Day Lengths in Female Siberian Hamsters 

Fenn A, Fonken LK, Nelson RJ.

J Pineal Res. 2011 Sep;51(2):180-6. doi: 10.1111/j.1600-079X.2011.00874.x. Epub 2011 Apr 12.

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Air Pollution Impairs Cognition, Provokes Depressive-Like Behaviors and Alters Hippocampal Cytokine Expression and Morphology 

Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, Nelson RJ.

Mol Psychiatry. 2011 Oct;16(10):987-95, 973. doi: 10.1038/mp.2011.76. Epub 2011 Jul 5.

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Function and mechanism of axonal targeting of voltage-sensitive potassium channels 

Prog Neurobiol. 2011 Jul;94(2):115-32. doi: 10.1016/j.pneurobio.2011.04.009. Epub 2011 Apr 22.

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Clustering and Activity Tuning of Kv1 Channels in Myelinated Hippocampal Axons 

Gu C, Gu Y. J Biol Chem 2011 Jul 22;286(29):25835-47.

J Biol Chem. 2011 Jul 22;286(29):25835-47. doi: 10.1074/jbc.M111.219113. Epub 2011 May 20.

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The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity 

Janich P, Pascual G, Merlos-Suárez A, Batlle E, Ripperger J, Albrecht U, Cheng HY, Obrietan K, Di Croce L, Benitah SA.

Nature. 2011 Nov 9;480(7376):209-14. doi: 10.1038/nature10649.

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Oxytocin Mediates Social Neuroprotection After Cerebral Ischemia 

Karelina K, Stuller KA, Jarrett B, Zhang N, Wells J, Norman GJ, DeVries AC.

Stroke. 2011 Dec;42(12):3606-11. doi: 10.1161/STROKEAHA.111.628008. Epub 2011 Sep 29.

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Cardiopulmonary Arrest and Resuscitation Disrupts Cholinergic Anti-Inflammatory Processes: A Role for Cholinergic α7 Nicotinic Receptors 

Norman G, Morris J, Karelina K, Weil Z, Zhang N, Al-Abed Y, Brothers H, Wenk G, Pavlov V, Tracey K, DeVries A.

J Neurosci. 2011 Mar 2;31(9):3446-52. doi: 10.1523/JNEUROSCI.4558-10.2011.

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Heteromeric Acid-Sensing Ion Channels (Asics) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death 

Sherwood TW, Lee KG, Gormley MG, Askwith CC. J Neurosci 2011 Jun 29;31(26):9723-34.

J Neurosci. 2011 Jun 29;31(26):9723-34. doi: 10.1523/JNEUROSCI.1665-11.2011.

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Transforming Growth Factor α Transforms Astrocytes to a Growth-Supportive Phenotype after Spinal Cord Injury

White RE, Rao M, Gensel JC, McTigue DM, Kaspar BK, Jakeman LB.

J Neurosci. 2011 Oct 19;31(42):15173-87. doi: 10.1523/JNEUROSCI.3441-11.2011.

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