Department of Neuroscience
The Ohio State University
190 Rightmire Hall
1060 Carmack Rd.
Columbus, OH 43210
Office phone: 614-292-5113
Lab phone: 614-292-6757
Fax: (614) 292-5379
The Beattie Lab investigates the biological basis of motoneuron diseases with a focus on spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
Lab members are also interested in the genetic and molecular mechanisms that promote motoneuron development, such as the cues that guide motor axons to their target muscles and the formation of the connections between motoneurons and muscle. The lab has also recently started a project modeling glioblastoma to characterize the mechanism of tumor cell migration in the brain and to generate an animal model for efficient drug screening. Zebrafish is the vertebrate model organism used in this lab, due to their well-characterized nervous system and relatively simple neuromuscular organization. Moreover, by modeling diseases in zebrafish, researchers in the Beattie Lab are able to develop new approaches, such as genetic and drug screens, to identify targets that may alleviate the disease process.
Christine Beattie, PhD
Associate Professor, Department of Neuroscience
Dr. Beattie received her PhD from Case Western Reserve University and completed postdoctoral training with Dr. Judith Eisen at the University of Oregon. Dr. Beattie is using zebrafish as a vertebrate model system to study the genetic and molecular underpinnings of motoneuron development in the context of motoneuron diseases.
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Tessa Carrel, PhD
Adjunct Professor of Anatomy, Columbus College of Art and Design
Anil Challa, PhD
Research Instructor, University of Alabama, Genetics Research Division
Michelle Gray, PhD
Assistant Professor, University of Alabama Dept of Neurology
Alison Lyon, PhD
Navicore Group LLC, Medical writer
Michelle McWhorter, PhD
Associate Professor, Wittenberg University Dept of Biology
Tennore Ramesh, PhD
Lecturer, Academic Neurology, University of Sheffield
Louise Rodino-Klapac, PhD
Assistant Professor, Center for Gene Therapy, Nationwide Children's Hospital
Biological basis of the motoneuron disease Spinal Muscular Atrophy (SMA) and ALS
Using zebrafish to study brain cancer