Contact

The Ohio State University
Harding Hospital
1670 Upham Drive Suite 460
Columbus, OH 43210-1250

Phone: 614-293-9197
Fax: 614-293-4949

For general inquiries about the lab, please contact:

Sarah Black
Email: sarah.black@osumc.edu

Hannah Wolfson
Email: hannah.wolfson@osumc.edu

FristadLabImageRTFOur mission is to design and implement high-quality research, which can be translated into effective clinical assessment tools and interventions to improve the lives of children with mood disorders and their families.

 

Our Team

Our leaders

FristadMary

Mary Fristad, PhD, ABPP

Principal Investigator

Dr. Fristad is a professor of Psychiatry and Behavioral Health. The main focus of her research is to improve the diagnosis and treatment of mood disorders (depression and bipolar disorder) in children.


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ArnoldEugene

L. Eugene Arnold, MEd, MD

Principal Investigator

Dr. Arnold is Professor Emeritus of Psychiatry, formerly director of the Division of Child and Adolescent Psychiatry and vice-chair of Psychiatry. His research includes aromatic essential oil therapy for autism spectrum disorder, omega-3 fatty acids for mood disorders, and neurofeedback for ADHD.


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Staff

Sarah Black, PhD

Post-doctoral fellow

sarah.black@osumc.edu

Ilana Seager, MA

Graduate Researcher

seager.12@osu.edu

Current Projects

Current Projects

ARETAEUS: An Observational Longitudinal Study in Offspring of Parents with Bipolar Disorder

This is a multi-site study of 208 individuals aged 15-25 to determine the relationship of impairment in psychosocial functioning with the manifestation of mood symptoms over 24 months.

Individual-Family PsychoEducational Psychotherapy (IF-PEP) and Omega 3 for Children with Depression: OATS (Omega 3 And Therapy Study)

We completed the treatment portion of an RCT for 72 children (ages 7-14) with major depressive disorder and/or dysthymic disorder and are now completing a post-study follow-up assessment. In this 12-week trial participants received omega 3 fatty acids or placebo and IF-PEP or active monitoring. Acute study-NIMH funded; Follow-up-Foundation funded.

IF-PEP and Omega 3 for Children with Bipolar Disorder-Not Otherwise Specified (BP-NOS)

We completed the treatment portion of an RCT for 23 children (ages 7-14) with BP-NOS or cyclothymic disorder and are now completing a post-study follow-up assessment. In this 12-week trial subjects received omega 3 fatty acids or placebo and IF-PEP or active monitoring. Acute study-NIMH funded; Follow-up-Foundation funded.

Longitudinal Assessment of Manic Symptoms (LAMS)

We are in the second five-years of an NIMH funded study, in which over 700 children from four sites (Case Western Reserve University-Cleveland; University of Pittsburgh Western Psychiatric Institutes & Clinics; Cincinnati Children’s Hospital and OSU) were assessed every six months. Assessments included extensive clinical interviews, neurocognitive batteries and neuroimaging.

Recent Publications

Recent Publications

Recent Publications

Jones L, Black SR, Arnold LE, Fristad MA. (in press). Not all masks are created equal: Masking success in clinical trials of children and adolescents. Journal of Clinical Child and Adolescent Psychology.

Bell Z, Seager I, Shader T, Fristad MA. (in press). Updating the textbook: A novel approach to training graduate students in evidence-based youth practices. Cognitive & Behavioral Practice.

Christian L, Young A, Mitchell A, Belury M, Gracious B, Arnold LE, Fristad MA. (in press). Body weight affects Ω3 polyunsaturated fatty acid (PUFA) accumulation in youth following supplementation in post-hoc analyses of a randomized controlled trial. PLOS ONE.  PMID: 28379964

Salcedo S, Chen YL, Youngstrom E A, Fristad MA, Gadow KD, Horwitz SM, Frazier TW, Arnold LE, Phillips ML, Birmaher B, Kowatch RA, Findling RL. (in press). Diagnostic efficiency of the Child and Adolescent Symptom Inventory depression subscales for youth mood disorders. Journal of Clinical Child and Adolescent Psychology.  PMID: 28278596

Steinberg B, Bartimole L, Habash D, Fristad MA. (in press). Tai Chi for Workplace Wellness: Pilot Feasibility Study. Explore: The Journal of Science and Healing.

Versace A, Sharma V, Bertocci MA, Bebko G, Iyengar S, Dwojak A, Bonar L, Perlman SB, Schirda C, Travis M, Gill MK, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Frazier TW, Arnold LE, Fristad MA, Youngstrom EA, Horwitz SM, Findling RL, Phillips ML. Using machine learning and surface reconstruction to accurately differentiate different trajectories of mood and energy dysregulation in youth. PLoS One. 2017 Jul 6;12(7):e0180221. doi: 10.1371/journal.pone.0180221. PMID: 28683115

Bartimole L, Fristad MA. (in press). Taiji (Tai Chi) for fall prevention in the elderly: Training the trainers evaluation project.  Explore: The Journal of Science and Healing.  PMID:28342686

Bartimole L, Fristad MA. (2017). Taiji Train the Trainers Curriculum: Increasing the work force to decrease falls in the elderly. Explore: The Journal of Science and Healing. 13(2): 132.  PMID: 28089440

Jo B, Findling RL, Hastie TJ, Youngstrom EA, Wang CP, Arnold LE, Fristad MA, Birmaher B, Gill MK, Horwitz SM. (in press). Construction of longitudinal prediction targets using semi-supervised learning. Statistical Methods in Medical Research. PMID: 28067113

Bertocci MA, Bebko G, Versace A, Iyengar S, Bonar L, Forbes EE, Almeida JR, Perlman SB, Schirda C, Travis M, Gill MK, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Frazier TW, Arnold LE, Fristad MA, Youngstrom EA, Horwitz SM, Findling RL, Phillips ML (in press) Reward-related neural activity and structure predict future substance use in dysregulated youth. Psychological Medicine. PMID: 27998326

Arnold LE, Young A, Belury MA, Cole RM, Gracious B, Seidenfeld A, Wolfson H, Fristad MA. (in press). Omega-3 fatty acid plasma levels before and after supplementation: Correlations with mood and clinical outcomes in the Omega 3 and Therapy Studies (OATS). Journal of Child & Adolescent Psychopharmacology. PMID: 28157380

Fristad MA. (2016). Autobiography. Journal of Clinical Psychology in Medical Settings. 23: 323. doi:10.1007/s10880-016-9469-4. PMID: 27704233

Hopkins LC, Fristad MA, Goodway JD, Eneli I, Holloman C, Kennel J, Melnyk B, Gunther CW. (in press). Camp NERF: Methods of a theory-based nutrition education recreation and fitness program aimed at preventing unhealthy weight gain in underserved elementary children during summer months. BMC Public Health. PMID: 27784290

Jo B, Findling RL, Wang CP, Hastie TJ, Youngstrom EA, Arnold LE, Fristad MA, Horwitz SM. (in press). Targeted use of growth mixture modeling: a learning perspective. Statistics in Medicine.; PMID: 27804177

Young ME, Bell ZE, Fristad MA. (2016). Validation of a brief structured interview: The Children’s Interview for Psychiatric Syndromes. Journal of Clinical Psychology in Medical Settings, 23: 327. doi:10.1007/s10880-016-9474-7. PMID: 27761777

Bertocci MA, Bebko G, Dwojak A, Iyengar S, Lacouceur CD, Fournier J, Versace A, Perlman SB, Almeida JR, Travis M, Gill MK, Bonar L, Schirda C, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Frazier TW, Arnold LE, Fristad MA, Youngstrom EA, Findling RL, Phillips ML. (in press). Longitudinal relationships among activity in neural circuitry underlying redirection of attention during emotional regulation and symptom severity in youth, Biological Psychiatry: CNNI. PMID: 28480336

Fristad MA, Vesco AT, Young AS, Nader ES, Healy KZ, Seidenfeld A, Gardner W, Wolfson HL,  Arnold LE. (in press). Pilot RCT of omega-3 and Individual-Family Psychoeducational Psychotherapy for children and adolescents with depression. Journal of Clinical Child and Adolescent Psychology. PMID: 27604240

Hafeman DM, Bebko G, Bertocci MA, Chase H, Fournier JC, Bonar L, Perlman SB, Travis M, Gill MK, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Arnold LE, Fristad MA, Frazier TW, Youngstrom EA, Findling RL, Phillips ML. (in press). Amygdala-prefrontal cortical functional connectivity during implicit emotion processing differentiates youth with bipolar spectrum from youth with externalizing disorders. Journal of Affective Disorders. PMID: 27756046

Van Meter AR, You DS, Halverson T, Youngstrom EA, Birmaher B, Fristad MA, Kowatch RA, Storfer-Isser A, Horwitz SM, Frazier TW, Arnold LE, Findling RL, the LAMS Group. (in press). Diagnostic efficiency of caregiver report on the SCARED for identifying youth anxiety disorders in outpatient settings. Journal of Clinical Child & Adolescent Psychology. PMID: 27485325

Young AS, Arnold LE, Wolfson HL, Fristad MA. Psychoeducational Psychotherapy and Omega-3 supplementation improve co-occurring behavioral problems in youth with depression: Results from a pilot RCT. (in press) Journal of Abnormal Child Psychology. PMID: 27604240

Fristad MA. (2016). Evidence-based psychotherapies and nutritional interventions for children with bipolar spectrum disorders and their families. The Journal of Clinical Psychiatry, 77(suppl 3):e04. PMID: 27570930

Ong M, Youngstrom EA, Chua JJX, Halverson TF, Horwitz SM, Storfer-Isser A, Frazier TW, Fristad MA, Arnold LE, Phillips ML, Kowatch RA, Findling RL. (in press). Comparing the CASI-4R and the PGBI-10M for differentiating bipolar spectrum disorders from other outpatient diagnoses in youth. Journal of Abnormal Child Psychology.  PMID: 27364346

Arnold LE, Fristad MA, Gracious BL, Johnstone JM, Kaplan BJ, Popper CW, Rucklidge JJ. (in press). Psychosis resulting from herbs rather than nutrients: The importance of truth in labelling. Primary Care Companion: CNS Disorders. PMID: 27486549

Bartimole L, Fristad MA. (in press). Taiji Train the Trainers Curriculum: Increasing the Work Force to Decrease Falls in the Elderly. Explore: The Journal of Science and Healing. PMID: 28089440

Grants

Grants

Grants

Janssen

Davis Family Funds

Fristad Mood Disorder Research Funds

Career Opportunities

We have approximately 10 students every quarter who assist with our various research projects and attend a weekly seminar and are overseen by our post-doctoral study coordinator. For information about this opportunity, please visit http://www.psy.ohio-state.edu/4998/ or e-mail Dr. Sarah Black at Sarah.Black@osumc.edu.

Summer Interns - We take a variable number of qualified students every summer who commit to a 20-hour per week unpaid internship. These slots are usually filled by individuals whose homes are in the greater Columbus area and return from college for the summer. For information about this opportunity, please e-mail Dr. Sarah Black at Sarah.Black@osumc.edu.

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