The Ohio State University
Harding Hospital
1670 Upham Drive Suite 460
Columbus, OH 43210-1250

Phone: 614-293-9197
Fax: 614-293-4949

For general inquiries about the lab, please contact:

Sarah Black

Hannah Wolfson

FristadLabImageRTFOur mission is to design and implement high-quality research, which can be translated into effective clinical assessment tools and interventions to improve the lives of children with mood disorders and their families.


Our Team

Our leaders


Mary Fristad, PhD, ABPP

Principal Investigator

Dr. Fristad is a professor of Psychiatry and Behavioral Health. The main focus of her research is to improve the diagnosis and treatment of mood disorders (depression and bipolar disorder) in children.

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L. Eugene Arnold, MEd, MD

Principal Investigator

Dr. Arnold is Professor Emeritus of Psychiatry, formerly director of the Division of Child and Adolescent Psychiatry and vice-chair of Psychiatry. His research includes aromatic essential oil therapy for autism spectrum disorder, omega-3 fatty acids for mood disorders, and neurofeedback for ADHD.

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Sarah Black, PhD

Post-doctoral fellow

Ilana Seager, BA

Graduate Student Interviewer

Adina Seidenfeld, PhD

Post-doctoral Fellow

Hannah Wolfson, BA

Lab Coordinator

Current Projects

Current Projects

Individual-Family PsychoEducational Psychotherapy (IF-PEP) and Omega 3 for Children with Depression: OATS (Omega 3 And Therapy Study)

We completed the treatment portion of an RCT for 72 children (ages 7-14) with major depressive disorder and/or dysthymic disorder and are now completing a post-study follow-up assessment. In this 12-week trial participants received omega 3 fatty acids or placebo and IF-PEP or active monitoring. Funded by NIMH.

IF-PEP and Omega 3 for Children with Bipolar Disorder-Not Otherwise Specified (BP-NOS)

We completed the treatment portion of an RCT for 23 children (ages 7-14) with BP-NOS or cyclothymic disorder and are now completing a post-study follow-up assessment. In this 12-week trial subjects received omega 3 fatty acids or placebo and IF-PEP or active monitoring. Funded by NIMH.

Longitudinal Assessment of Manic Symptoms (LAMS)

We are in the second five-years of an NIMH funded study, in which over 700 children from four sites (Case Western Reserve University-Cleveland; University of Pittsburgh Western Psychiatric Institutes & Clinics; Cincinnati Children’s Hospital and OSU) are assessed every six months. In LAMS2, the current 5-year study, we are completing neurocognitive and neuroimaging assessments of the participants, in addition to extensive clinical interviews every six months.

Recent Publications

Recent Publications

Recent Publications

Bertocci, M.A., Bebko, G., Olino, T., Fournier, J., Hinze, A. K., Bonar, L., Almeida, J. R. C., Perlman, S. B., Versace, A., Travis, M., Gill, M. K., Demeter, C., Diwadkar, V. A., White, R., Schirda, C., Sunshine, J. L., Arnold, L. E., Holland, S. K., Kowatch, R. A., Birmaher, B., Axelson, D., Youngstrom, E. A.,  Findling, R. L., Horwitz, S. M., Fristad, M. A., and Phillips, M. L. (in press). Behavioral and emotional dysregulation trajectories marked by prefrontal-amygdala function in symptomatic youth. Psychological Medicine. doi:10.1017/S0033291714000087

Bertocci MA, Bebko G, Versace A, Fournier J, Iyengar S, Olino T, Bonar L, Almeida JR, Perlman SB, Schirda C, Travis M, Gill MK, Diwadkar VA, Forbes E, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Frazier TW, Arnold LE, Fristad MA, Youngstrom EA, Findling RL, Phillips ML. (in press). Predicting clinical outcome from reward circuitry function and white matter structure in youth. Molecular Psychiatry.

Dickstein,  D.P., Axelson, D., Weissman, A.B., Yen, S., Hunt, J.I., Goldstein, B.I., Goldstein, T.R., Liao, F., Gill, M.K., Hower, H., Frazier, T.W., Diler, R.S., Youngstrom, E.A., Fristad, M.A., Arnold, L.E., Findling, R.L., Horwitz, S.M., Kowatch, R.A., Ryan, N.D., Strober, M., Birmaher, B., Keller, M.B. (in press).  Cognitive flexibility and performance in children and adolescents with threshold and sub-threshold bipolar disorder.  European Child & Adolescent Psychiatry.

Fristad, M.A. & Arnold, L.E. (in press). Psychosocial and nutritional interventions for childhood mood disorders. Alternative and Complementary Therapies.

Fristad MA, Wolfson H, Algorta GP, Youngstrom EA, Arnold LE, Birmaher B, Horwitz S, Axelson D, Kowatch RA, Findling RL, Frazier T, Holland S, Phillips M, Taylor HG. (in press). Disruptive Mood Dysregulation Disorder and Bipolar Disorder Non-Specified: Identical or Fraternal Twins? Journal of Child and Adolescent Psychopharmacology.

Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Perlman SB, Travis M, Gill MK, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Arnold LE, Fristad MA, Frazier TW, Youngstrom EA, Findling RL, Drevets W, Phillips ML.  (in press). Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: attenuated by medication. Journal of Psychiatric Research.

Klaus, N.M., Perez Algorta, G., Young, A.S., Fristad, M.A. (in press). Validity of the Expressed Emotion Adjective Checklist (EEAC) in caregivers of children with mood disorders. Couple and Family Psychology: Research and Practice.

Persch, A., Lamb, A., Metzler, C. & Fristad, M.A. (in press). Health policy perspectives: Health habits for children—leveraging existing evidence to demonstrate value. The American Journal of Occupational Therapy, 69(4).

Young AS, Horwitz S, Findling RL, Youngstrom EA, Arnold LE, Fristad MA, LAMS Group. (in press). Parents' perceived treatment match and treatment retention over 12 months among youth in the LAMS study. Psychiatric Services.

Vallarino, M., Henry, C., Etain, B., Gehue, L.J., NacNeil, C., Scott, E.M., Barbato, A., Conus, P., Hlastala, S.A., Fristad, M.A., Miklowtiz, D.J. & Scott, J. (in press). An evidence map of psychosocial interventions for the earliest stages of bipolar disorder. The Lancet: Psychiatry.

Vesco, A.T., Lehmann, J., Gracious, B.L., Arnold, L.E., & Fristad, M.A. (in press). Omega-3 supplementation for psychotic mania and comorbid anxiety in children: Review and case presentation. Journal of Child & Adolescent Psychopharmacology.

Yee, A., Algorta, G.P., Youngstrom, E.A., Findling, R.L., Birmaher, B., Fristad, M.A. & the LAMS Group (in press). Unfiltered administration of the YMRS and CDRS-R in a clinical sample of children. Journal of Clinical Child and Adolescent Psychology. ID: 915548 DOI: 10.1080/15374416.2014.915548

Fristad, MA, Young, AS, Vesco, AT, Nader, ES, Healy, KZ, Gardner, W, Wolfson, HL, & Arnold, LE (2015). A randomized controlled trial of Individual Family Psychoeducational Psychotherapy & omega-3 fatty acids in youth with subsyndromal bipolar disorder. J Child Adolesc Psychopharmacol, 25(10), 764-774. doi:10.1089/cap.2015.0132





Career Opportunities

We have approximately 10 students every quarter who assist with our various research projects and attend a weekly seminar and are overseen by our post-doctoral study coordinator. For information about this opportunity, please visit or e-mail Dr. Sarah Black at

Summer Interns - We take a variable number of qualified students every summer who commit to a 20-hour per week unpaid internship. These slots are usually filled by individuals whose homes are in the greater Columbus area and return from college for the summer. For information about this opportunity, please e-mail Dr. Sarah Black at

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