Stephen J. Kolb, MD, PhD
Director, OSU Wexner Medical Center's ALS/MND Multidisciplinary Clinic and Translational Research Program

The Ohio State University Wexner Medical Center
Rightmire Hall, Rm 226A
1060 Carmack Road
Columbus, OH 43210

For patient-related phone calls, please call 614-293-4969.

For information about clinical trials in the Department of Neurology, contact either:
Amy Bartlett, Clinical Research Coordinator: 614-366-9050

For information about supporting motor neuron disease research at OSU please contact Jen Lamb, Director of Development, Neurological Institute at 614-366-2380.

Kolb1ImageRTFThe Kolb Lab is devoted to an understanding of molecular pathways that, when altered, result in diseases of the motor neuron.

The overall goal is to understand motor neuron biology to develop effective treatments for motor neuron diseases such as spinal muscular atrophy, amyotrophic lateral sclerosis and a group of motor neuron diseases called hereditary motor neuropathies.

The Kolb Lab is interested in the molecular determinants of the entire life cycle of the motor neuron. In collaboration with other laboratories in the Center for Muscle Health and Neuromuscular Disorders at Ohio State and Nationwide Children’s Hospital, the Kolb Lab has translational and basic science components that are focused on optimizing the way motor neuron diseases can be modeled, studied and targeted in the lab, leading the way to improvements in therapeutic development and clinical trial design.

Our Team

Our leaders


Stephen J. Kolb, MD, PhD

Director, ALS/MND Multidisciplinary Clinic and Translational Research Program

Dr. Kolb is an associate professor in the Departments of Neurology and Molecular & Celluar Biochemistry. His clinical interests include neuromuscular disorders, motor neuron diseases and hereditary neuropathies.

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Patrick Heilman

Graduate Student

Amy Knapp

Research Technician

Christopher Weir

Graduate Student


Our leaders


Nicole Naiman


Samantha Renusch


Amit Srivastava


Scott Sutton


Shirly Wang


Current Projects

Current Projects

Current Projects

Our laboratory combines three areas of study to understand the molecular pathogenesis of motor neuron diseases and the hereditary neuropathies:

  1. Biochemical and biophysical measurements allow us to dissect and understand specific molecular pathways involved in motor neuron diseases and hereditary neuropathies.
  2. Animal models of motor neuron diseases and hereditary neuropathies provide us with essential tools to study and develop treatment strategies.
  3. Clinical and translational studies bridge the basic science investigations to the neuromuscular clinic and provide opportunities to discover new and effective therapies.
Recent Publications

Recent Publications

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