Davis Heart and Lung Research Institute

John H. and Mildred C. Lumley Chair in Medicine
Professor and Vice Chair of Research, Department of Surgery
Associate Dean of Translational Research, College of Medicine
Director, Center for Regenerative Medicine and Cell-Based Therapies
Executive Director, Ohio State Comprehensive Wound Center

Davis Heart and Lung Research Institute
473 W. 12th Ave., Suite 513
Columbus, OH 43210
Phone: 614-247-7658
Fax: 614-247-7818
Chandan.Sen@osumc.edu
 
Research Interests:
  • Regenerative medicine and cell-based therapies
  • Stroke 
  • Tissue injury and repair 
  • miRNA in injury and repair
  • Cell and tissue reprogramming
  • Redox signaling
  • Tissue oxygenation
  • Wound epigenetics

Current Research: Dr. Sen’s program is interested in tissue injury and repair. His group works across small animals, large animal model to human and patient-based research.

In the brain, specific focus is directed towards stroke biology and related neurodegeneration. In a 2017 publication in Nature Nanotechnology, the Sen Group reported successful tissue reprogramming in vivo and use of skin-derived reprogrammed neural cells to rescue the stroke-affected brain. Dr. Sen’s laboratory has concluded Phase I and Phase II stroke clinical trials and is currently planning a Phase III stroke trial testing the tocotrienol form of natural vitamin E.

Almost two decades ago, Dr. Sen reported that the tocotrienol form of natural vitamin E is orders of magnitude better than the widely known tocopherol form of vitamin E in protecting neural cells and the brain tissue. This line of work progressed from rodent stroke to canine stroke to clinical trial. Dr. Sen’s work is cited 25,000+ times in the literature. At present, he is cited more than 2,000 times annually and has an H-index of 83.   

PubMed articles
 

Google Scholar

Active Funding: Dr. Sen is the PI on five active NIH R01 awards and two Department of Defense awards

Education:
PhD: University of Eastern Finland
Post-Doc: University of California, Berkeley

Honors:
  • 2017 Mark and Mildred Maurer Lecture , University of Louisiana
  • 2016 Gerritsen Award, The Microcirculatory Society, Inc.
  • John H and Mildred C. Lumley Chair in Medical Research, The Ohio State University
  • 2014 Bieber Award, America College of Nutrition, San Antonio
  • 2014 Science and Humanity Prize, University of California at Davis
  • Past Chair (2013), NIH Study Section on Surgery Anesthesia & Trauma 
  • Ohio State University College of Engineering 2012 "Building Bridges" Excellence Award
  • 2011 Distinguished Service Award, American Association of Physicians of Indian Origin
  • 2009 Health Sciences E. J. Van Liere Convocation and Annual Research Day Guest Plenary Speaker, West Virginia University
  • Columbus TopCAT award finalist (Technology Commercialization in Ohio)
 

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