Department of Neuroscience

LerchJessicaAssistant Professor
College of Medicine
Department of Neuroscience
The Center for Brain and Spinal Cord Repair

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696 Biomedical Research Tower
460 W. 12th Ave.
Columbus, OH 43210
614-688-1599
lerch.27@osu.edu

Research Lab: Lerch Lab

Research Interests: Transcriptional regulation of gene expression in axon regeneration and neuropathic pain models, stress-induced changes in sensory neuron plasticity and gene expression

Current Research: Dr. Lerch's laboratory focuses on gene expression regulation in the context of axon regeneration and neuropathic pain development. They use RNA-Seq to examine gene expression in sensory neurons after injury to identify the underlying molecular genetic mechanisms of axon regeneration, plasticity, and neuropathic pain development. Using RNA-Seq enables the team to unbiasedly identify novel RNA isoforms and non-coding RNAs. They then examine the function of these novel isoforms and non-coding RNAs in axon growth and the development of neuropathic pain.

Research Techniques:
Microscopy: Cellomics ArrayScanXTI High Content Microscope for cellular morphology determination and light-sheet microscopy for 3D image analysis of axon regeneration and plasticity
Molecular biology: Plasmid cloning and neuronal transfection to overexpress or knockdown isoforms/RNAs of interest, in vivo viral transduction
Injury models: Spinal cord contusion, sciatic nerve crush and spared nerve injury
Behavior: BMS, von Frey filament test, plantar heat test, acetone test, open field and activity box

Education:
Degree: Case Western Reserve University
Postdoctoral Associate: The Miami Project to Cure Paralysis

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