Department of Neuroscience

Gao 840Assistant Professor, Department of Neuroscience

PubMed Articles

614 Biomedical Research Tower
460 W. 12th Ave, Columbus, OH, 43210
Tel: (614) 293-8915
Jie.Gao@osumc.edu

Research Interests: Mammalian brain is a highly lipid-rich organ, and lipid homeostasis is essential for normal neural development, maintenance of proper synaptic function, and recovery from brain injury. On the other hand, dysregulated lipid signaling in brain has been implicated in many neurodegenerative disorders, especially Alzheimer's disease (AD). The risk of developing AD is strongly influenced by genetic variations of genes, such as ApoE, ABCA7, and TREM2, which are involved in brain lipid transport, sensing and cellular uptake. 
The goal of Dr. Gao’s lab is to study the fundamental changes in the brain lipid composition, distribution, and signaling associated with aging and Alzheimer's disease; and the mechanisms by which these changes affect cellular function in the process of aging and the pathogenesis of AD. To achieve the goal, they take advantage of a multidisciplinary approach that combines biochemistry, molecular and cell biology, lipidomic analysis, transgenic animal models, next-generation sequencing and data analysis. 

Grant support:
Principle investigator, K99/R00 AG054736, NIH/NIA 
7/15/2017- 06/30/2022
The Idol-ApoE receptor pathway in Alzheimer's disease

 

 

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