Department of Physical Medicine and Rehabilitation

GauthierLynneAssistant Professor, Department of Physical Medicine and Rehabilitation

Director, Neurorecovery and Brain Imaging Laboratory

Department of Physical Medicine and Rehabilitation
Wexner Medical Center

480 Medical Center Drive
2145 Dodd Hall
Columbus, OH 43210

Research Goals: The mission of the Neurorecovery and Brain Imaging Lab is to improve the quality of life for individuals who have experienced stroke or other neurological injury. We strive to achieve this objective in two ways. 

  1. We study how rehabilitation interventions promote structural and functional changes in the brain. It is our hope that by identifying the mechanisms of brain change through therapy, we can enhance the effectiveness of existing interventions. 
  2. We aim to make the most effective therapies more fun, cost-effective, and accessible through use of technology, such as video games. Our research relies heavily on the input and volunteer efforts of the local stroke community.

Research Interests: Neuroplasticity, motor rehabilitation, hemispatial neglect rehabilitation, virtual reality, constraint-induced Movement therapy, stroke, multiple sclerosis, brain injury

Research Techniques: Neurorehabilitation, including constraint-induced movement therapy and behavioral techniques to promote carry-over, structural MRI analysis (e.g., voxel-based morphometry, diffusion tensor imaging, myelin mapping), continuous data capture during rehabilitation

Current Research

  1. Examining the mechanisms of neuroplasticity following mother rehabilitation in stroke: Our laboratory is using new magnetic resonance funded research, imaging techniques to better understand the time-course and cellular/molecular nature of brain changes during constraint-induced movement therapy (CI therapy), a highly efficacious treatment for residual motor disability in chronic stroke. Its effectiveness is believed to be due, at least in part, to the therapy’s ability to aid the brain in “rewiring itself.” We are hopeful that by better understanding how CI therapy can change the brain, the effectiveness of rehabilitation can be improved upon. 
  2. Virtual reality gaming for motor rehabilitation: CI therapy is the current “gold standard” intervention for arm hemiparesis but is unavailable to most patients due to cost, travel/scheduling demands, and dearth of trained providers. We are developing a home-based, computer-gaming version of CI therapy that will provide equal access to high-quality rehabilitation regardless of a patient’s resources. We are currently conducting a multi-site randomized clinical trial to compare the in-home game-based therapy to in-clinic CI therapy and standard care. We are also conducting a pilot trial of the system for improving upper extremity weakness in Multiple Sclerosis. 
  3. A new game based treatment for hemispatial neglect: We are applying the critical principles of CI therapy to rehabilitation of spatial inattention post-stroke. The intervention includes high-intensity cognitive training delivered through a video game that is played by looking with the eyes. Established behavioral techniques emphasize carry-over of therapeutic gains to daily activities. We have developed the gaming system in conjunction with the stroke community and are now in the process of completing initial efficacy testing.

Active Funding:
The Patient-Centered Outcomes Research Institute 
American Heart Association - Scientist Development Grant
Jeffrey Thomas Stroke Shield Foundation National Multiple Sclerosis Society
Rudi Schulte Foundation

PubMed articles

Staff/Lab Members/Collaborators: 
Dr. Petra Schmalbrock, Associate Professor of Radiology
Dr. Stephen Page, Associate Professor of Health and Rehabilitation Sciences
Dr. Roger Crawfis, Computer Science
Dr. Ryan McPherson, Electrical Engineering
Dr. Linda Lowes, Physical Therapy
Ms. Lise Worthen-Chaudhari, Biomechanics.

Education and Training:
PhD: Health/Medical Psychology University of Alabama 
MA: Health/Medical Psychology University of Alabama

Residency: Clinical Internship - Behavioral Medicine, Brown University

Editorial Activities:
2014 – Present Reviewer Journal of NeuroEngineering and Rehabilitation
2014 – Present Reviewer The International Journal of Neuroscience
2014 – Present Ad hoc reviewer Restorative Neurology and Neuroscience
2013 – Present Grant Reviewer, Grant reviewer, American Heart Association
2012 – Present Reviewer American Journal of Physical Medicine & Rehabilitation
2012 – Present Reviewer BMC Neuroscience
2012 – Present Reviewer Brain
2012 – Present Reviewer Human Brain Mapping
2012 – Present Grant Reviewer, Grant Reviewer, PCORI
2009 – 2010 Grant Reviewer, UK Multiple Sclerosis Society


2015 - Present Co-Chair. American Congress of Rehabilitation Medicine, Neuroplasticity
2012 - Present Member. American Heart Association
2011 - Present Member. American Congress of Rehabilitation Medicine
2011 - Present Member. Organization for Human Brain Mapping
2010 - Present Member. American Psychological Association, Division 22

Researchers Develop At-Home 3D Video Game for Stroke Patients
2012, Faculty Spotlight, Center for Faculty Advancement, The Ohio State University

Clinical Services:
Licensed Clinical Psychologist
Rehabilitation Psychologist
Rehabilitation Psychology

My Clinical Bio

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