ArnoldWDavidAssociate Professor - Clinical

Department of Neurology
Division of Neuromuscular

395 W. 12th Avenue, 7th Floor
Columbus, Ohio 43210
Phone: 614-293-8434
Fax: 614-293-4688
William.Arnold@osumc.edu

Research Interests

  • Sarcopenia
  • Age-related loss of physical function
  • Genetic neuromuscular disorders (spinal muscular atrophy, myotonic dystrophy, etc.)

Current Research

Dr. Arnold’s research program is primarily focused on translational neuromuscular physiology in health and disease. His prior work helped define the natural history of motor unit loss in spinal muscular atrophy (SMA) and defined the effects of genetic therapies in preclinical models of SMA.

As part of a multidisciplinary team at the Ohio State University and Nationwide Children’s Hospital, he was involved in the first-in-human clinical gene therapy trial in infants with SMA. His team is currently investigating the role of motor neuron degeneration in age-related loss of physical function and testing survival motor neuron protein, the protein that is deficient in SMA, as a potential therapeutic strategy in sarcopenia. Dr. Arnold is also interested in developing biomarkers and therapies for other genetic forms neuromuscular disorders, in particular, nondystrophic myotonic disorders and myotonic dystrophy.

Education

  • MD: University of Louisville School of Medicine

Postgraduate Training

  • Residency: Frazier Rehabilitation Institute at the University of Louisville
  • Fellowship: Ohio State University

Honors

  • 2018 Alumni Award, University of Louisville Physical Medicine and Rehabilitation
  • 2018 Teaching Award, Department of Physical Medicine and Rehabilitation, The Ohio State University

My lab website
PubMED articles

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