Senior Research Associate, Division of Transplant Surgery

ReaderBrenda2Division of Transplantation Surgery
395 W. 12th. Ave.
Columbus OH 43210
614-293-8021
Brenda.Reader@osumc.edu

Research Interests:
  • Immunology
  • Innate immune cells
  • Sympathetic nervous system
  • Basic mechanisms of lung innate immune host defense
  • Innate immune system in transplantation
  • Organ preservation and repair in transplantation

Research Lab Goals: As the core manager of the Comprehensive Transplant Center (CTC) Biorepository, my mission is to provide high quality, clinically annotated biological specimens from normal and diseased tissues for current and future Ohio State University researchers in order to stimulate scientific discovery. Along with our IRB approved Total Transplant Care Program (TTCP), we hope that the biorepository will significantly impact basic science researchers, physicians, and the patients themselves. Through the TTCP, OSU investigators can obtain biospecimens and clinical data to facilitate research that will further allow us understand the functional and molecular underpinnings of human physiology and pathology of disease leading to the need for surgery or transplantation and our capacity to predict survival while awaiting transplantation, prognosis in the perioperative and postoperative period, short and long term outcomes and complications, and response to therapy. Additionally, the TTCP will promote increased collaborations between physicians and investigators that are necessary to bridge specific areas of research and expertise. Finally, the CTC Biorepository will create the rare opportunity for these transplant patients, many of whom want to be involved in the research process, to directly contribute to the research efforts at Ohio State.

Research Techniques: 

  • Cell Isolation and Culture
  • Molecular Biology
  • Histology/Immunohistochemistry

PubMed

Background: My graduate training was in neuroscience and immunology, and I focused my research on how stress affects asthmatic inflammation. In my postdoctoral years, I focused on the pathophysiology of idiopathic pulmonary fibrosis (IPF), which is a disease that can lead to a need for transplantation. Aside from my current role as core manager of the Comprehensive Transplant Biorepository, my research projects still focus on IPF with the addition of liver and lung organ preservation and repair during transplantation.

Education:

  • Undergraduate: The Ohio State University, Psychology/Biochemistry
  • PhD: The Ohio State University, Integrated Biomedical Science
  • Postdoctoral fellowship: T32 NHLBI Mechanisms of Lung Inflammation

Honors/News:

  • 2017: Awarded Postdoctoral Scholar of the Year by the OSU Postdoctoral Association and the OSU Postdoctoral Advisory Council
  • 2016-2017: Appointed Ad Hoc member of the President and Provost’s Council of Women’s (PPCW)

  • 2016-2017: Elected Co-Chair of the OSU Postdoctoral Association

  • 2015-2016: Appointed Chair of the OSU Postdoctoral Association Policy and Advocacy Committee

  • 2014: Awarded T32 NHLBI Fellowship

  • 2014: Honorable Mention for Best Talk at IBMR Research Day

  • 2011: Awarded F31 NIDCR NRSA Fellowship 

  • 2011: Nominated for Denman Outstanding Research Mentor Award

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