Assistant Professor, Clinical

KellerBrianDepartment of Internal Medicine
Division of Pulmonary, Critical Care and Sleep Medicine

201 Davis Heart and Lung Research Institute
473 W. 12th Ave.
Columbus, OH 43210
Phone: 614-293-5822
Fax: 614-293-9820
Brian.Keller2@osumc.edu

Research interests: 

  • Lung virome and microbiome
  • Lung transplantation
  • Biobanking

Current research: Different regions of the human body possess distinct microbiomes, and recently the lungs were proposed to harbor a microbiome as well. While most studies have focused on the bacterial microbiome, or bacteriome, I am interested in using omics technologies, in particular metagenomics, to study the lung virome and its interaction with other microbes and the host in the setting of pulmonary health and disease. 

Currently, we are working on four projects: 

  1. The role of the lung virome in lung transplantation outcomes
  2. Effects of smoking on the lung microenvironment
  3. A murine model of pulmonary inflammation and its impact on the lung microbiome
  4. Development of the OSU lung transplant biorepository and clinical database

Research techniques:

  • Biobanking
  • Research bronchoscopy
  • Next-generation sequencing
  • Bioinformatics

PubMed
ResearchGate

Education:

  • Medical Degree: University of Texas Southwestern Medical School
  • PhD: Molecular microbiology, University of Texas Southwestern Graduate School of Biomedical Sciences
  • Residency: Internal Medicine Residency, Washington University School of Medicine
  • Fellowship: Pulmonary and Critical Care Medicine Fellowship, Washington University School of Medicine
  • Fellowship: Postdoctoral Research Scholar, Metagenomics, Washington University School of Medicine

Chapters in Books: Keller BC, Brody SL. “Viral pulmonary infections.” In: The Washington Manual Pulmonary Medicine Subspecialty Consult. Second edition. Edited by Shifren A, Byers DE, Witt CA. Philadelphia:Wolters Kluwer, 2017

Honors and news:

  • NIH Loan Repayment Program Renewal Grantee, 2016
  • American Thoracic Society Abstract Scholarship, Assembly on Allergy, Immunology and Inflammation, 2016
  • Fellows Track Symposium, American Thoracic Society International Conference, 2015
  • NIH Loan Repayment Program Grantee, 2014

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