Professor, Cardiovascular Medicine

Professor, SBS-Biology, Chemistry and Pharmacology

460 W. 12th Ave.
Columbus, OH 43210


614-292-5709
Yong.Xia@osumc.edu

Education:

MS: Tongji Medical University, 1992
MD: Tongji Medical University, 1989

Honors:

  • Mentored Clinical Scientist Award, National Institute on Aging, 1998 - present
  • The Pharmacia and Upjohn Award for Young Investigators, International Society for Heart Research, 1997 - present
  • Trainee Investigator Certificate of Achievement for Outstanding Abstract, Biomedicine Meeting, AAP, ASCI and AFMR, 1997 - present
  • Research Fellowship Award, Researcher for Harry and Jane W. Alburger Trust, 1997 - present
  • Student Research Merit Prize, Tongji Medical University, 1986 - present
  • Caroline tum Suden/Frances A. Hellenbrandt Professional Award, American Physiological Society, 1996 - present
  • Trainee Investigator Award for Excellence in Research, Association of American Physicians, 1996 - present
  • Young Investigator Award for Excellence in Research, Chinese Society of Pathophysiology, 1994 - present
  • Young Investigator Award for Excellence in Research, Chinese Society of Pharmacology, 1991 - present

Professional activities:

  • Director of Protein Expression Core Laboratory, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, 2003 - 2005

Chapters in Books

Xia, Y., and Zweier, J.L. "Superoxide anion release from inducible nitric oxide synthase." In Progress in Inflammation Research: Nitric Oxide and Inflammation. Edited by D. Salvemini, T.R. Billiar, and Y. Vodovotz. -. Basel, CH|CHE: Birkhauser Publishing, January 2002

Forbes, S.P., Xia, Y., and Cardounel, A.J. "Endogenous regulation of nitric oxide synthase activity and free radical generation." In The Oxidative Stress: Clinical and Biomedical Implications. Edited by B.M. Matata. 203-226. New York, NY, US|USA: NOVA Scientific Publishers, January 2007

Editorial Activities

Present Activities
  • Biotechniques
  • American Journal of Physiology - Cell Physiology
  • Neuroscience Letter
  • Circulation Research
  • Atherosclerosis
  • Circulation
  • British Journal of Pharmacology
  • Journal of Biological Chemistry
  • Thrombosis and Vascular Biology
  • Pharmacology Biochemistry and Behavior
  • Journal of Cellular and Molecular Medicine
  • Antioxidants and Redox Signaling
  • Journal of Pharmacology and Experimental Therapeutics

Journal Articles

Xia, Y., Zhang, J., Qian, J.Q., and Zeng, G.Y. "Antihypertensive effect of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on conscious renal hypertensive canines.." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 16-20

Xia, Y., Qian, J.Q., and Wang, X.L. "Effects of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on membrane currents of single ventricular myocyte of rats." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 47-52

Xia, Y., and Qian, J.Q.. "Effect of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on the heart conductive system in anesthetized rabbits.." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 53-58

Xia, Y., and Qian, J.Q. "Effects of 1-(2,6-dimethyphenoxy)-2-(3,4-dimethylphenlethlamino) propane hydrochloride on the action potential of isolated sinoatrial node cells of rabbits." Bulletin of New Drug Res. Foundation. Vol. 3, (January 1993.): 59-62

Xia, Y., and Han, C.. "ATP-sensitive potassium channels in cardiovascular system.." Pharmacol. Bulletin. Vol. 9, (January 1993.): 410-413

Xia, Y., and Han, C.. "Role of K+ channels in neuropeptide Y-induced vasoconstriction in rabbit cerebral basilar artery.." Eur. J. Pharmacol.. Vol. 255, (January 1994.): 67-72

Xia, Y., and Zweier, J.L.. "Substrate control of free radical generation from xanthine oxidase in the postischemic heart.." J. Biol. Chem.. Vol. 270, (January 1995.): 18797-18803

Xia, Y., Khatchikian, G., and Zweier, J.L.. "Adenosine deaminase inhibition prevents free radical mediated injury in the postischemic heart.." J. Biol. Chem.. Vol. 271, (January 1996.): 10096-10102

Xia, Y., Dawson, V.L., Dawson, T.M., Snyder, S.H., and Zweier, J.L.. "Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite mediated cellular injury.." Proc. Natl. Acad. Sci. USA. Vol. 93, (January 1996.): 6770-6774

Polyak K, Xia, Y., Zweier J.L., Kinzler, K.W., and Vogelstein B.. "A model for p53-induced apoptosis.." Nature. Vol. 389, (January 1997.): 300-305

Xia, Y., and Zweier, J.L.. "Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages.." Proc. Natl. Acad. Sci. USA. Vol. 94, (January 1997.): 6954-6958

Xia, Y., and Zweier, J.L.. "Measurement of myeloperoxidase in leukocyte-containing tissues.." Anal. Biochem.. Vol. 245, (January 1997.): 93-96

Xia, Y., and Zweier, J.L.. "Direct measurement of nitric oxide generation from nitric oxide synthase.." Proc. Natl. Acad. Sci. USA. Vol. 94, (January 1997.): 12705-12710

Giraldez, R.R., Panda, A., Xia, Y., Saunders, S.P., and Zweier, J.L.. "Decreased nitric oxide synthase activity causes impaired endothelium-dependent relaxation in the postischemic heart.." J. Biol. Chem.. Vol. 272, (January 1997.): 21420-21426

Irani, K., Xia, Y., Zweier, J.L., Sollott, S.J., Der C.J., Fearon, E.R., Sundaresan M., Finkel, T., and Goldschmidt-Clermont, P.J.. "Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.." Science. Vol. 275, (January 1997.): 1649-1652

Hu, Q., Xia Y., Corda, S., Zweier, J.L., and Ziegelstein, R.C.. "Hydrogen peroxide decreases pHi in human aortic endothelial cells by inhibiting Na+/H+ exchange.." Circ. Res.. Vol. 83, (January 1998.): 644-651

Xia, Y., Tsai, A.L., Berka, V., and Zweier, J.L.. "Superoxide generation from endothelial nitric oxide synthase: a Ca2+/calmodulin dependent and tetrahydrobiopterin regulatory process.." J. Biol. Chem.. Vol. 273, (January 1998.): 25804-25808

Xia, Y., Roman L.J., Masters B.S.S., and Zweier, J.L.. "Inducible nitric oxide synthase generates superoxide from the reductase domain.." J. Biol. Chem.. Vol. 273, (January 1998.): 22635-22639

Xia, Y., Cardounel, A.J., Vanin, A.F., and Zweier, J.L.. "Electron paramagnetic resonance spectroscopy with N-methyl-D-glucamine dithiocarbamate iron distinguishes nitric oxide and nitroxyl in a redox dependent manner: applications in identifying nitrogen monoxide products from nitric oxide synthase.." Free Radic. Biol. Med.. Vol. 29, (January 2000.): 793-797

Paolocci N, Biondi, R., Bettini M, Berlowitz, C.O., Rossi R, Xia Y, Ambrosio G, Labbate A, Kass D, Zweier JL.. "Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart.." J Mol Cell Cardiol. Vol. 33, (January 2001.): 671-679

Song, Y., Zweier, J.L., and Xia, Y.. "Determination of the enhancing action of Hsp90 on neuronal nitric oxide synthase by EPR spectroscopy.." American J. Physiology-Cell Physiology. Vol. 281, (January 2001.): C1819-C1824

Song, Y., Zweier, J.L., and Xia, Y. "Heat shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding.." Biochem. J.. Vol. 355, (January 2001.): 357-360

Biondi, R., Xia, Y., Rossi, R., Paolocci N, Ambrosio G, and Zweier JL.. "Detection of hydroxyl radicals by D-phenylalanine hydroxylation: a specific assay of hydroxyl radical generation in biological systems.." Anal. Biochem. Vol. 290, (January 2001.): 138-145

Song, Y., Cardounel, A.J., Zweier, J.L., and Xia Y.. "Heat shock protein 90 prevents superoxide generation from neuronal nitric oxide synthase: implications in NOS regulation.." Biochemistry. Vol. 41, (January 2002.): 10616-10622

Yoshida, M., and Xia, Y.. "Heat shock protein 90 as an endogenous protein enhancer of inducible nitric oxide synthase.." J. Biol. Chem.. Vol. 278, (January 2003.): 36953-36958

Cardounel, A.J., Xia Y., and Zweier, J.L.. "Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.." J. Biol. Chem.. Vol. 280, (January 2005.): 7540-7549

Wei, Q., and Xia, Y.. "Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric oxide synthase phosphorylation and function by heat shock protein 90.." J. Biol. Chem.. Vol. 280, (January 2005.): 18081-18086

Joshi, M.S., Julian, M.W., Huff, J.E., Bauer, J.A., Xia, Y., and Crouser, E.D.. "Calcineurin regulates myocardial function during acute endotoxemia.." Am. J. Respir. Crit. Care Med.. Vol. 173, (January 2006.): 999-1007

Wei, Q., and Xia, Y.. "Proteasome inhibition down-regulates endothelial nitric oxide synthase phosphorylation and function.." J. Biol. Chem.. Vol. 281, (January 2006.): 21652-21659

Xia, Y, Berlowitz, C.O.. "PIN inhibits nitric oxide and superoxide production from purified neuronal nitric oxide synthase.." Biochimica et Biophysica Acta. Vol. 1760, (January 2006.): 1445-1449

Jiang, J.G., Chen, R.J., Xiao, B., Yang, S., Wang, J.N., Wang, Y., Cowart, L.A., Xiao, X., Wang, D.W., and Xia, Y.. "Regulation of endothelial nitric-oxide synthase activity through phosphorylation in response to expoyeicosatrienoic acids.." Prostaglandins Other Lipid Mediat.. Vol. 82, (January 2007.): 162-174

Xia Y. "Superoxide generation from nitric oxide synthases." Antioxid Redox Signal. Vol. 9, no. 10. (October 2007.): 1773-8

Xia, Y. "Superoxide generation from nitric oxide synthase." Vol. 9, (January 2007.): 1771-1778

Dumitrescu C, Biondi R, Xia Y, Cardounel AJ, Druhan LJ, Ambrosio G, Zweier JL. "Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4.." Proc Natl Acad Sci USA. Vol. 104, no. 38. (January 2007.): -

Pope AJ, Druhan L, Guzman JE, Forbes SP, Murugesan V, Lu D, Xia Y, Chicoine LG, Parinandi NL, Cardounel AJ. "Role of DDAH-1 in lipid peroxidation product-mediated inhibition of endothelial NO generation.." Am J Physiol Cell Physiol. Vol. 293, no. 5. (November 2007.): C1679-86

Chu L, Jiang Y, Hao H, Xia Y, Xu J, Liu Z, Verfaillie CM, Liu Z. "Nitric oxide enhances Oct-4 expression in bone marrow stem cells and promotes endothelial differentiation." Eur. J. Pharmacol. Vol. 591, (January 2008.): 59-65

Hu Z, Chen J, Wei Q, Xia Y. "Bidirectional actions of hydrogen peroxide on endothelial nitric oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK." J. Biol. Chem. Vol. 283, (January 2008.): 25256-25263

Yong Xia. "How does Viagra protect the ischemic heart? Focus on “ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice�." Am J Physiol Heart Circ Physiol. Vol. 296, (January 2009.): H1209-H1210

Pope, A.J., Karuppiah, K., Kearns, P.N., Xia, Y., and Cardounel, A.J. "Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production." J. Biol. Chem.. Vol. 284, (January 2009.): 35338-35347

Li, X., Wang, P., Xu, X., Wang, Y., Xia, Y., and Wang D.W. "Simvastatin Increases the Activity of Endothelial Nitric Oxide Synthase via Enhancing Phosphorylation." J. Huazhong Univ. Sci. Technol.-Med. Sci. Vol. 29, (January 2009.): 286-290

Moens. A.L., Arkenbout, E.K., Yang, H., Bedja, D., Gabrielson, K.; Chen, J., Xia, Y., Champion, H.C., Halushka, M., Barker, N., Wuyts, F.L., Kaminski, P.S., Wolin, M.S., Kass, D.A., Barouch, L.A. "Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.." J. Mol. Cell Cardiol. Vol. 47, (January 2009.): 576-585

Reference Works

January 2007:

Chen, J., Qin, H., Chiang, P.Y., Lu, D., and Xia, Y. "Loss of Endothelial NO Synthase Serine 1179 Phosphorylation and Function in ER stress." : 308

Unpublished Works

Luo S., Wang T., and Xia Y. Hsp90 regulation of inducible nitric oxide synthase expressions. January 2009

Lu D., Qin H., and Xia Y. Regulation of endothelial nitric oxide synthase function by protein phosphatase 1. January 2009

Wei, Q. and Xia, Y. Nitric Oxide Regulates Endothelial Nitric Oxide Synthase Phosphorylation and Function via Modulating Akt and AMPK. January 2009

Chen, J. and Xia, Y.. Roles of Dynamic Associations with Hsp70 and Hsp90 inAkt Activation in Cell Stresses. January 2009