campbell395 W. 12th Ave.
Columbus, Ohio 43210
Courtney.Campbell@osumc.edu

I was born and raised in Dallas, Texas. My first research experience was in high school. I worked in Dr. Eric Olsen’s laboratory at UT Southwestern where I studied genetic muscular development in mice and became hooked on laboratory research. For college, I moved up to north to Boston. I graduated from Harvard University in 2006 with an BA in history and science and an MA in history of science. In addition to spending my time in the stacks writing about medical history and volunteering in the hospital, most of my free time was in the lab. While at Harvard, I investigated zebrafish heart regeneration with Mark Keating, MD and worked on chemical screening to induce the directed differentiation of stem cells with Doug Melton, PhD. I also spent a summer at the Roslin Institute in Edinburgh, Scotland studying human embryonic stem cells. I took a year out of academia after college. I lived in Costa Rica working at the Hospital Nacional de Ninos becoming proficient in medical Spanish. Next, I worked at Aestus Therapeutics, a biotech start-up, identifying candidate drugs for neuropathic pain and ALS through microarray screens and pathway analysis in addition to writing and editing grant and patent applications.

I then attended Vanderbilt University School of Medicine as part of their Medical Scientist Training Program (MSTP). I defended my PhD in 2013 in the laboratory of Alfred George, MD with my dissertation: Pharmacological Targeting of Gain of Function KCNQ1 Mutations Predisposing to Atrial Fibrillation. In addition to first author publications and presentations at national meetings, I received pre-doctoral fellowships from the American Heart Association and National Heart, Lung and Blood Institute. I graduated from Vanderbilt in 2015 with my husband, Richard Samade, MD, PhD.

At the end of the MSTP, I knew I still wanted to purse a physician-scientist career in cardiology. I looked for physician scientist training programs that supported the internal medicine to cardiology ABIM pathway. I wanted to train in an outstanding and growing research program in cardiac arrhythmias in addition to a high-volume, clinically excellent internal medicine residency and cardiology fellowship. I was thrilled to match with my husband at The Ohio State University Wexner Medical Center, which met all of our criteria. Peter Mohler, PhD, Director of the Davis Heart and Lung Research Institute (DHLRI), is a leading researcher in cardiac arrhythmias and has recruited an excellent team of cardiac researchers, especially in arrhythmias. Further, DHLRI has developed a strong translational science and medicine program with the OSU cardiology clinical faculty. OSUWMC uniquely has the Ross Heart Hospital, a stand-alone hospital dedicated to cardiac and vascular medicine. Individual patient rooms can be upgraded from floor to ICU level care without changing care teams. Furthermore, Dr. Baiocchi has developed a PSTP with an intensive mentoring program to support the development and transition to independent faculty. Lastly, my husband, an OSU orthopedic surgery resident in the research track, and I love Columbus – an affordable, young, fun city for when we do get time away from the hospital.

View CV

Education:

Clinical instructor house staff, resident physician, The Ohio State University Wexner Medical Center, Physician Scientist Training Program, present

MD: Vanderbilt University School of Medicine, Medical Scientist Training Program (MSTP), 2015 

PhD: Vanderbilt University School of Medicine, Department of Pharmacology, 2013

MS: Harvard University, history of science, 2006

BA: Harvard University, history and science, cum laude, 2006


Publications

  • Yang Z, Chopra N, Knollmann BC, George AL, Campbell CM, Pickett RA, Shaffer CM, Roden DM, and Murray KT. Azithromycin Causes a Novel Proarrhythmic Syndrome, submitted 2016
  • Bersell K, Montgomery JA, Kanagasundram AN, Campbell CM, Chung WK, Macaya D, Konecki D, Venter E, Shoemaker MB, and Roden DM. Partial duplication and Poly(A) insertion in KCNQ1 Not Detected by Next-Generation Sequencing in Jervell and Lange-Nielsen Syndrome, Circ Arrhythm Electrophysiol. 2016 Jun;9(6). PMCID: 27286732
  • Campbell CM, Campbell JD, Thompson CH, Vanoye CV, George AL. Selective Targeting of a Gain-offunction KCNQ1 Mutations Predisposing to Atrial Fibrillation. Circ Arrhythm Electrophyiol. 2013. Oct;6(5):960-6. PMCID: 3892565
  • Potet F, Lorinc AN, Chaigne S, Hopkins CR, Venkataraman R, Stepanovic SZ, Lewis LM, Days E,  Sidorov VY, Engers DW, Zou B, Afshartous D, George AL, Campbell CM, Balser JR, Li M, Baudenbacher FJ, Lindsley CW, Weaver CD, Kupershmidt S. (2012) Identification and characterization of a compound that protects cardiac tissue from human ether-a-go-go-related gene (hERG)-related, drug-induced Arrhythmias. J Biol Chem. 2012 Oct 2. PMCID: 23033485
  • Ungvari Z, Csiszar A, Sosnowska D, Philipp EE, Campbell CM, McQuary PR, Chow TT, Coelho M,  Didier ES, Gelino S, Holmbeck MA, Kim I, Levy E, Sonntag WE, Whitby PW, Austad SN, Ridgway I. Testing Predictions of the Oxidative Stress Hypothesis of Aging Using a Novel Invertebrate Model of Longevity: The Giant Clam (Tridacna Derasa). J Gerontol A Biol Sci Med Sci. 2012 Aug 17 PMCID: 22904097
  • Ungvari Z.,* Ridgway I.,* Philipp E.E.,* Campbell C.M., McQuary P., Chow T., Coelho M., Didier E.S., Gelino S., Holmbeck M.A., Kim I., Levy E., Sosnowska D., Sonntag W.E., Austad S.N., and Csiszar A. (2011) Extreme Longevity Is Associated With Increased Resistance to Oxidative Stress in Arctica islandica, the Longest-Living Non-Colonial Animal. J Gerontol A Biol Sci Med Sci, 66(7):741-50
  • Jorge B.S.,* Campbell C.M.,* Miller A.R., Rutter E.D., Gurnett C.A., Vanoye C.G., George A.L., Jr., and Kearney, J.A. (2011) Voltage-gated potassium channel KCNV2 (KV8.2) contributes to epilepsy susceptibility. Proc Natl Acad Sci USA, 108:5443-5448. [*equal contribution]
  • De Sousa P., Fletcher J, Campbell C.M., Harkness L., Ferrier T., and Gardner J. (2004) Human embryo stem cells: defining their attributes, cell culture requirements, and relevance to large animals. Anim Sci Pap Rep 22:107-118

Oral Presentations

  • Campbell C.M., Kearney J.A., and George A.L. Electrophysiological Characterization of Kv8.2, a Candidate Genetic Modifier of Seizure Severity in the Scn2aQ54 Epilepsy Model. Vanderbilt Emphasis Forum, Nashville, TN; May 2009

Poster Presentations

  • Campbell C.M., Thompson C.H., Welch R.C., Vanoye C.G., and George A.L. Selective Block of a Gainof-Function KCNQ1 Mutation Associated with Familial Atrial Fibrillation. Gordon Conference on Cardiac Arrhythmia Mechanisms; Ventura, CA. Feb 2013
  • Yang Z., Chopra N., Knollmann B.C., George A.L., Campbell C.M., Roden D.M., and Murray K.T. Electrophysiologic Effects of Azithromycin in Cardiomyocytes. Biophysical Society, Philadelphia, PA; Feb 2013
  • Campbell C.M. and George A.L. (2012) Selective Block of a Gain-of-function KCNQ1 Mutation Associated with Familial Atrial Fibrillation. National MD, PhD Student Conference, Keystone, CO; July 2012
  • Campbell C.M. and George A.L. Familial Atrial Fibrillation Mutation KCNQ1-S140G Exhibits Enhanced Sensitivity to Block by the IKs Selective Inhibitor HMR-1556. Cardiac Electrophysiological Society, Orlando, FL; Nov 2011
  • Campbell C.M., Darbar D., Roden D.M., and George A.L. Electrophysiology of KCNE3 mutation linked to lone atrial fibrillation. Gordon Conference on Cardiac Arrhythmia Mechanisms; Galveston, TX. Feb 2011
  • Campbell C.M., Kearney J.A., and George A.L. Electrophysiological Characterization of Kv8.2, a Candidate Genetic Modifier of Seizure Severity in the Scn2aQ54 Epilepsy Model. Vanderbilt Emphasis Forum, Nashville, TN; May 2009
  • Keramari M., Fletcher J., Campbell C.M., Gardner J., and De Sousa P. Expression of variant exons for CD44, the predominant receptor for hyaluronan in human embryonic stem cells. Scottish Stem Cell Network, Edinburgh, Scotland, UK; May 2005 and International Society for Stem Cell Research, San Francisco, CA; June 2005
Scholarships and fellowships

Scholarships and fellowships

Ruth L. Kirschstein National Research Service Award Individual Pre-doctoral MD/PhD Fellowship

National Heart Lung and Blood Institute
  • Awarded to highly promising pre-doctoral students in a combined MD/PhD degree training program for support during their mentored dissertation research training and clinical training under the guidance of outstanding faculty sponsor

Greater Southeast Affiliate Predoctoral Fellowship

American Heart Association
  • Awarded to full-time predoctoral students with superior scientific proposals and with excellent potential research careers in cardiovascular and stroke research

Vanderbilt Dissertation Enhancement Grant

Vanderbilt Graduate School of Arts and Sciences
  • Awarded to graduate students to enhance already outstanding dissertation projects by permitting the addition of a new dimension, additional breadth or other worthwhile extensions

Meade Haven MD/PhD Scholarship

Vanderbilt University School of Medicine
  • Awarded to support fully an outstanding Vanderbilt MD/PhD candidate

Harvard Stem Cell Institute Summer Internship

Harvard University
  • Awarded to support undergraduate students with a focused and challenging summer research experience in a cutting-edge stem cell science laboratory

Senator Robert C. Byrd Honors Scholarship

U.S. Department of Education
  • Awarded to support and recognize exceptionally able high school seniors who show promise of continued excellence in postsecondary education
Grants and awards

Grants and awards

Vanderbilt MSTP Travel Grant

Awarded to MSTP students presenting at a national scientific meeting

Vanderbilt Graduate Student Travel Grant

Awarded to select graduate students presenting at a national conference

Vanderbilt MSTP Keystone Grant

Full support to represent Vanderbilt at the National MD/PhD Keystone Symposia awarded to an MSTP student with excellent scientific quality

Ellison Medical Foundation Grant

Awarded to fully support students admitted to the Marine Biological Laboratory's Molecular Biology of Aging course in Woods Hole, MA

Adams House Arms

Awarded to graduating seniors for outstanding service and citizenship to the Harvard Adams House community

Harvard Pre-Medical Institute Award

Awarded to women in science to participate in the pilot year of summer pre-medical institute designed to engender medical literacy and inspire the next generation of medical scientist
Research Experience

Research Experience

Alfred L. George, Jr. MD Laboratory

Vanderbilt University School of Medicine, Nashville, TN
Dissertation: Pharmacological Targeting of Gain of Function KCNQ1 Mutations Predisposing to Atrial Fibrillation
Dan M. Roden, MD, Dissertation Committee Chair
  • Utilized current and voltage patch-clamp technique and electrophysiological analysis, identified novel pharmacological susceptibility of AF mutations, created rabbit and guinea pig four chamber myocyte isolation and culture method, developed potassium channel adenoviral gene delivery technique, plus mastery of fundamental gene cloning, transfection and cell culture methods
  • Elucidated voltage-gated potassium channels contribution to epilepsy susceptibility, assessed oxidative stress impact on AF susceptibility on potassium channels, collaborated on pharmacological targeting of hERG channels
  • Provided isolated rabbit myocytes and experimental training for five Vanderbilt laboratories

Michael J. Fowler, MD, Co-Director of Shade Tree Clinic

Vanderbilt University School of Medicine, Nashville, TN
  • Evaluating the efficacy of implementing the systematic use of comprehensive glucometer reports at Shade Tree Clinic, a medical student run free clinic

  • Focusing on medical decision making and medical student education in addition to patient comprehension and type 2 diabetes mellitus control

Molecular Biology of Aging - Special Topics Course

Marine Biological Laboratory, Woods Hole, MA
  • Course encompassed model systems, mitochondrial defects and oxidative stress, DNA mutations and repair, telomeres and cellular senescence, mammalian aging and evolutionary considerations

  • Experiments assessed mechanisms of oxidative stress damage and resistance in short and long lived bivalve species resulting in two publications

  • Mentors: Steve Austad, PhD, Gary Ruvkun, PhD and Zoltan Ungari, PhD

Heidi E. Hamm, PhD Laboratory May 2008 - June 2008

Vanderbilt University School of Medicine, Nashville, TN
  • Conducted platelet aggregation studies to determine differences in the downstream pathways involved in platelet function in both normal human subjects and patients with a continuum of type IIdiabetes from insulin resistance to full-blown disease

Dan M. Roden, MD Laboratory

Vanderbilt University School of Medicine, Nashville, TN
Co-Mentor: Sameer Chopra, MD, PhD
  • Optimized a genotyping assay for early zebrafish somitogenesis and analyzed in sit hybridization to investigate the role of sodium-channel related signaling in zebrafish cardiac development

Aestus Therapeutics

Research Analyst, North Brunswick, NJ 

Mentors: CSO Lillian Chang, PhD and CEO Tage Honore, PhD

  • Identified candidate drugs for neuropathic pain and amyotrophic lateral sclerosis (ALS) through microarray screens and pathway analysis; wrote and edited grant and patent applications 

Douglas A. Melton, PhD laboratory

Harvard University, Boston, MA

Co-Mentor: David A. Shaywitz, MD, PhD

  • Examined the directed differentiation of human and mouse embryonic stem cells towards endoderm and ideally pancreatic beta islet cells through media augmentation, growth factor screening and high throughput chemical screening methods

  • Utilized florescence activated cell sorting (FACS), immunohistochemistry and immunofluorescence, taught embryonic cell culture technique

Mark T. Keating, MD Laboratory

Children’s Hospital Boston, Boston, MA

Co-Mentor: Ellen Lien, PhD

  • Analysis of mouse cardiomyocyte regeneration after injury with Myo1 overexpression and investigation of zebrafish cardiomyocyte regeneration via in situ hybridization and gene chip analysis

Paul De Sousa, PhD Laboratory

Roslin Institute, Edinburgh, Scotland, UK
  • Using immunocytochemistry and high-resolution fluorescence microscopy, investigated human embryonic stem cell extracellular matrix to enable the development of a completely defined environment for hES cell culture and maintenance

Eric N. Olson, PhD Laboratory

University of Texas Southwestern Medical School, Dallas, TX 
Co-Mentor: M. Renee Valdez, MD, PhD
  • Investigated genetic muscular development in mice, looking specifically at myogenic bHLH transcription factors in the regulation of MEF2C in vertebrate myogenesis