LapoThe Ohio State University, James Comprehensive Cancer Center
410 W. 12th Ave., Room 464

Columbus, OH, 43210
Phone: 614-685-9256
Fax: 614-293-4890
Lapo.Alinari@osumc.edu

I was born in Florence, Italy, I graduated from Liceo Scientifico “Gobetti”, (high school) Florence, in July 1991. I started medical school at the University of Florence in October 1991 and received my medical degree with honors in 1998 after defending my dissertation on the biology of hepatocellular carcinoma.

In 1999, I started clinical training in medical oncology at the Oncology Department, Malpighi Hospital, Bologna. I spent the first two years working primarily with patients with solid tumors. At the end of my second year, I joined the Hematologic Malignancies Program at the “Seràgnoli” Institute of Hematology of the University of Bologna. This was a time when my interest in translational research began to develop and subsequently focused my efforts on B-cell non-Hodgkin’s lymphoma, Hodgkin’s disease and chronic lymphocytic leukemia.

In April 2003, I presented my research dissertation entitled "Identification of outcome predictors in diffuse large B-cell lymphoma. Immunohistochemical profiling of homogeneously treated de novo tumors with nodal presentation on tissue micro-arrays,” and became board certified in medical oncology. I then started a hematology fellowship program at the “Seràgnoli” Institute of Hematology and Medical Oncology, University of Bologna.

I was enthusiastic and flattered by the invitation (November 2005) offered by Dr. John Byrd to join the outstanding group of scientists he leads at The Ohio State University. My primary focus dealt with discovery and characterization of novel therapeutic targets for B-cell lymphoma. In Dr. Baiocchi’s laboratory, I went on to develop a project focused on the role of protein arginine methyltransferase-5 (PRMT5) overexpression in B-cell lymphomagenesis. I completed training in hematology in November 2007.

Given this strong introduction to basic and translational research, I decided to enroll in a PhD program in clinical and experimental hematology and hematopathology, which I completed in May 2011. The highly collaborative scientific atmosphere at Ohio State allowed me multiple opportunities to become involved in several basic, preclinical research projects. I have spent the last ten years of my life training as a cancer research scientist and I decided that The Ohio State University was the best place for me to continue growing as a physician scientist. I subsequently applied and was accepted in the Physician Scientist Training Program, I completed two years of internal medicine and three years of training as a hematology fellow in June 2016. Over the years I focused my research on the preclinical and early clinical development of novel experimental therapeutic strategies for B-cell lymphomas, particularly mantle cell lymphoma. I found that witnessing my preclinical research translated to therapies that may offer patients superior care over standard (and ultimately ineffective) treatments to be a rewarding and noble career path to follow.

Over the past 12 years I have produced a substantial amount of work that has resulted in the publication of more than 60 papers in peer-reviewed journals including Blood, Journal of Clinical Oncology, Clinical Cancer Research, many invited oral presentations at national and international conferences, the receipt of multiple competitive awards, as well as funding for myself and my former mentors. Perhaps more importantly, I have come to the realization that my skills are best suited in a collaborative scientific environment that will promote the translation of my research to meaningful therapies that benefit patients with cancer.

I joined the OSU Division of Hematology as an assistant professor on the tenure track in July 2016. I currently have an independent laboratory and our research focuses on identification of novel therapeutic targets and drugs development to treat patient with aggressive B-cell lymphomas and Hodgkin’s disease. I currently spend 75% of my time and effort conducting translational research in lymphoid malignancies, the remaining 25% of his time is devoted to patient care (eight weeks of inpatient service per year).

View CV

Education:

PhD: Clinical and experimental hematology and hematopathology, University of Bologna, Italy, May 2011
MD: University of Florence, Italy, April 1998

Honors:

  • Davis Bremer Award, The Ohio State University, February 2017
  • James V. Warren Internal Medicine Fellow Research Award, The Ohio State University, June 2016
  • American Society of Clinical Oncology Conquer Cancer Foundation Young Investigator Award, April 2016
  • Lymphoma Research Foundation Clinical Research Mentoring Program Award, November 2015
  • 2015 Excellence in Hematology and Oncology Research Award, Division of Hematology and Medical Oncology, The Ohio State University, June 2015
  • 2014 AACR Basic Cancer Research Fellowship, July 2014
  • 2013 Celgene Award for Future Leaders in Hematology, November 2013
  • Clara D. Bloomfield Excellence in Hematology and Oncology Research Award, June 2013
  • Chairman’s Award for Scholarly Achievement by a Senior Internal Medicine Resident, College of Medicine, The Ohio State University, June 2013
  • American Society of Hematology Abstract Achievement Award, October 2012
  • American Society of Hematology Abstract Achievement Award, October 2011
  • American Society of Hematology-European Hematology Association International Award, July 2008
  • 2007 Italian Society of Experimental Haematology Award, December 2006
Professional activities:
  • American Society of Clinical Oncology (ASCO), 2013 - present
  • American Association for Cancer Research (AACR), 2013 - present
  • American Society of Hematology (ASH), 2008 - present
  • European Hematology Association (EHA), 2007 - present
Certifications:
  • Board certification: Internal Medicine, American Board of Internal Medicine, 2014 - present
  • Board certification: Hematology, American Board of Internal Medicine, 2016 - present
Licensures:
  • Medical license: State Medical Board of Ohio (active)
  • DEA license: Drug Enforcement Agency (active)
Patents:
  • US Patent. No. 8,591,892 issued on Nov 26, 2013. Expiration date: 07/18/2032: FTY720 Increases CD74 Expression and Sensitizes Cancer Cells to Anti-CD74 Antibody-Mediated Cell Death. First named inventor: Lapo Alinari

Contributions to National, Institutional and Professional Organizations

  • Co-Chair, 2016 American Society of Hematology Meeting, Session: Aggressive Lymphomas (diffuse large B cell and other aggressive B cell non-Hodgkin lymphomas)- Results from prospective clinical trials: CNS and HIV lymphoma trials
  • Invited abstract reviewer, 2016 American Society of Hematology Meeting, Category: Aggressive Lymphomas (diffuse large B cell and other aggressive B cell non-Hodgkin lymphomas)-Results from prospective clinical trials
  • Co-Chair, 2014 American Society of Hematology Meeting, Session: Non-Hodgkin Lymphoma: Biology, excluding Therapy: Molecular Pathogenesis and Prognostic Factors
  • Co-Chair, 2013 American Society of Hematology Meeting, Session: Non-Hodgkin Lymphoma: Biology, excluding Therapy: Novel Prognostic Factors in Non-Hodgkin's Lymphomas
  • Co-Chair, 2013 American Society of Hematology Meeting, Session: Non-Hodgkin Lymphoma: Biology, excluding Therapy: Genetic Signature in Non-Hodgkin's Lymphomas
  • Invited coordinating abstract reviewer, 2013 American Society of Hematology Meeting, Category: Non-Hodgkin Lymphoma: Biology, excluding Therapy
  • Co-Chair, 2012 American Society of Hematology Meeting, Session: Lymphoma: Pre Clinical Chemotherapy and Biologic Agents
  • Invited abstract reviewer, 2012 American Society of Hematology Meeting, Category: Lymphoma: Pre Clinical – Chemotherapy and Biologic Agents
  • Co-Chair, 2010 American Society of Hematology Meeting, Session: Lymphoma: Pre Clinical Chemotherapy and Biologic Agents
  • Invited abstract reviewer, 2010 American Society of Hematology Meeting, Category: Lymphoma: Pre Clinical – Chemotherapy and Biologic Agents

Postdoctoral Training

  • 2013-6/2016: Fellowship in Hematology and Bone Marrow Transplantation, The Ohio State University College of Medicine, Columbus, Ohio. Participating in the ABIM Research Pathway.
  • 2011-2013: Internship and Residency, Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio. Participated in the ABIM Research Pathway
  • 2008-2011: Ph.D. in Clinical and Experimental Haematology and Haematopathology, University of Bologna, Italy
  • 2006-2008: Visiting Scholar, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. Laboratory of Robert Baiocchi, MD, PhD
  • 2003-2007: Fellowship in Hematology, Hematology and Medical Oncology Institute “L. e A. Seràgnoli,” University of Bologna, Italy
  • 1999-2003: Fellowship in Medical Oncology, Hematology and Medical Oncology Institute “L. e A. Seràgnoli,” S. Orsola Hospital, Bologna, Italy

Presentations

International

  • Fourth International Conference Translational Research in Oncology
    Forli’, Italy, November 9-11, 2016
    Targeting BTK in lymphoid malignancies.
  • 53rd Annual Meeting of American Society of Hematology
    San Diego, CA, USA, December 10-13, 2011
    FTY720 Increases CD74 Expression and Sensitizes Mantle Cell Lymphoma Cells to Milatuzumab-Mediated Cell Death
  • 50th Annual Meeting of American Society of Hematology
    San Francisco, CA, USA, December 6-9, 2008
    Combination anti-CD74 (Milatuzumab) and CD20 (Rituximab) Monoclonal Antibody Therapy has In Vitro and In Vivo Activity in Mantle Cell Lymphoma
  • New Drugs in Hematology
    Bologna, Italy, October 9-11, 2005
    Gemcitabine (Gemzar): from solid tumors to hematologic malignancies
  • Fifth International Symposium on Special Aspects of Radiotherapy.
    Berlin, Germany, May 9-11, 2000
    Neoadjuvant Hormonotherapy (NHT) and Radiotherapy (RT) in Prostatic Cancer

National

  • Association of Professors of Medicine, Winter Meeting, Charleston, South Carolina, February 26th, 2016
    Research-Based Schools “Physician Scientists Needed: Focus on PSTP – New Pathways and New Programs”
  • Successful Research Panel, The Ohio State University, Medical Student Research Orientation. Columbus, Ohio, May 13th, 2015
  • Cancer patients and fertility. Ravenna, Italy, November 11th, 2005
    Lymphoma treatment options in young patients
  • Observations in Hematology. Mestre, Italy, June 24th, 2005
    Monoclonal antibodies in the treatment of B-cell Chronic Lymphocytic Leukemia: “Campath-Rituximab-Zevalin”
  • Neuro-oncology - 2° Symposium. Turin, Italy, May 23-27, 2005
    Non-Hodgkin’s lymphomas with central nervous system (CNS) involvement
  • Non-Hodgkin’s lymphomas and minimal residual disease: diagnosis and treatment. Naples, Italy, December 13-14, 2004
    Role of Monoclonal Antibodies in the treatment of minimal residual disease.
  • Cutaneous Lymphomas: Dermatology or Hematology? Cervia, (Ravenna), Italy, October 2, 2004
    New drugs development for the treatment of Cutaneous Lymphomas: an update
  • Future Directions in Onco-Hematology. Palermo, Italy, June 18-19, 2004
    Gastrointestinal non-Hodgkin’s lymphomas
  • 79° National Meeting of the Italian Society of Dermatology and Sexually Transmitted Diseases (SIDeMaST). Castellaneta Marina (Taranto), Italy, May 26-29, 2004
    Cutaneous Lymphomas: old and new drugs
  • Neuro-oncology - 1° Symposium. Turin, Italy, May 20th, 2004
    Primary central nervous system (CNS) lymphomas. Radiotherapy and chemotherapy
  • Italian Association of Radiation Oncology (AIRO). Palermo, Italy, November 29, 2003
    Immunotherapy with naked and radio-conjugated monoclonal antibodies in Non Hodgkin’s Lymphomas
  • Italian Society of Hematology (SIE). Rome, Italy, October 27, 2003
    Front-line treatment of hairy cell leukemia with 2-chlorodeoxiadenosine: long-term outcome
  • Non-Hodgkin’s lymphomas in elderly patients. Milan, Italy, November 12th, 2002
    High-grade non-Hodgkin’s lymphomas in elderly patients
  • Annual Meeting of Oncology. Bentivoglio, (Bologna), Italy, October 9-11, 2000
    Role of radiotherapy in relapsed breast cancer patients
  • Annual Meeting of Oncology. Bentivoglio, (Bologna), Italy, October 9-11, 2000
    Thromboembolism in cancer patients: preliminary results of a retrospective multicenter national study