grieselhuberI grew up in Hamilton, OH, a small town about 30 miles north of Cincinnati. I earned a BS in biology at Case Western Reserve University in Cleveland, OH in 2003. I then enrolled in the Medical Scientist Training Program at Washington University in St. Louis, where I did my thesis work with Dr. Timothy Ley in the Division of Hematology. This research resulted in three peer reviewed publications and multiple abstracts at national meetings. I successfully defended my thesis entitled “The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia” in 2010 and then returned to medical school to finish my clinical rotations. During this time, I tried to keep an open mind regarding my future specialty, but truthfully nothing else seemed as interesting as hematology!

By the end of medical school, I knew that I wanted to pursue a career in academic hematology, combining patient care with basic or translational research in myeloid malignancies. To do this, I knew that I needed to do my residency and fellowship at an institution with rigorous clinical training, strong established research programs and a commitment to training future physician scientists. Ohio State definitely fulfilled all the criteria.

Following my graduation from the MSTP in 2012, I began residency training in internal medicine at Ohio State. I pursued the ABIM research track and am very happy with this decision. I really appreciated the opportunity to streamline my training and have additional time during fellowship to devote to research pursuits. I am now in my second year of hematology and oncology fellowship. Following the completion of my clinical rotations, I joined the laboratory of Dr. John Byrd, in the Division of Hematololgy, to pursue research on AML. My current research interests include molecular mechanisms of leukemogenesis, pharmacology of targeted inhibitors and the application of genomic technologies to patient care.

Columbus is an enjoyable city in which to live and work. The cost of living here is very reasonable and there are many interesting outdoor and cultural activities. When I’m not in the hospital or the lab, you can find me riding my horse, exercising, cooking or spending time with friends.

Publications

Nicole R. Grieselhuber, Jeffrey M. Klco, Angela M. Verdoni, Tamara Lamprecht, Shawn M. Sarkaria, Lukas D. Wartman and Timothy J. Ley.  Notch signaling in acute promyelocytic leukemia.  Leukemia.  2013. 27: 1548-1557
 
Geoff L. Uy, Andrew A. Lane, John S. Welch, Nicole R. Grieselhuber, Jacqueline E. Payton, and Timothy J. Ley.  A protease-resistant PML-RARa has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.  Blood. 2010. 116: 3604-3610
 
Jacqueline E. Payton, Nicole R. Grieselhuber*, Li-Wei Chang, Mark A. Murakami, Gary K. Geiss, Daniel C. Link, Rakesh Nagarajan, Mark A. Watson and Timothy J. Ley.  High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. Journal of Clinical Investigation. 2009. 119: 1714-26. * denotes co-first authorship

Awards

  • Best Plenary Abstract Award, Hematopoietic Malignancy and Development Program Annual Retreat, St. Louis, MO, 2010
  • Second place, graduate student poster, National DNA Day Symposium, St. Louis, MO, 2008
  • Travel award for outstanding poster or talk, Seventh International Workshop of Molecular Aspects of Myeloid Stem Cell Development and Leukemia, Annapolis, MD, 2007
  • Honors in Biology, Case Western Reserve University, 2003
  • Francis Hobart Herrick Prize for outstanding biological research and academic excellence in biology, 2003
  • John Schoff Millis Award to the senior with the best academic record, 2003
  • Delta Phi Upsilon Prize in Arts and Sciences to a junior woman with the best academic record, 2002
  • Phi Beta Kappa Prize to the sophomore with the best academic record, 2001
  • Case Western Reserve University Trustees’ Scholarship, 1999 - 2003
  • National Merit Scholarship semi-finalist, 1999
  • Robert C. Byrd Honors Scholarship, 1999

Invited Presentations

Genetics of AML. Clinical Trials Office Education Channel lecture, The Ohio State University, October 7, 2015.
 
Residency 101, American Physician Scientists Association Annual Meeting, Chicago, IL, April 27, 2013. 
 
Nicole R. Grieselhuber, Jacqueline E. Payton and Timothy J. Ley.  Dysregulation of the Notch ligand Jagged-1 leads to activation of Notch signaling in Acute Promyelocytic Leukemia (APL).  Oral presentation at the Hematopoietic Development and Malignancy Program Retreat, St. Louis, MO, June 2010.