Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine

Anasuya Sarkar
Assistant Professor, SBS-Physiology and Cell Biology

473 W. 12th Ave.
Columbus, OH 43210

614-292-1351 
Anasuya.Sarkar@osumc.edu

Education:

PhD: Jadavpur University, Kolkata, India, 2004

Honors:

  • ARDS Scholar Award, (2010 - 2011)
  • American Thoracic Society (ATS) Travel Award, ATS 2008, Toronto, Canada, (2008)
  • Best Poster Award, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, (2008)
  • Best Oral Presentation Award, Dorothy M. Davis Heart and Lung Research Institute, (2007)
  • Distinguished Post Doctoral Award, Dorothy M. Davis Heart and Lung Research Institute, (2006 - 2007)
  • Best Poster Award, fifth annual OSUWMC Graduate and Postgraduate Research Day, The Ohio State University, (2006)
  • Best Poster Award, Dorothy M. Davis Heart and Lung Research Institute, (2006)
  • NIH Post Doctoral Travel Scholarship, NIH Post Doctoral Travel Scholarship and Keystone Symposium, (2005)
  • Best Poster Award, International Conference on Natural Antioxidants and Free Radicals in Human Health and Radiation Biology NFHR, (2001)
  • Senior research fellow, Center of Scientific and Industrial Research (CSIR), (2000 - 2002)
  • Best Poster Award, Society of Biological Chemists (India), (1999)
  • Junior Research Fellowship, Council of Scientific and Industrial Research (CSIR), (1998 - 2000)
  • Gold medal, University of Calcutta, (1998)
  • Outstanding student, University of Calcutta, (1996)
  • National level merit award, University of Calcutta, (1993)

Professional activities:

  • Judge, The Ohio State University, (2011 - present)
  • Leukemia and Lymphoma Society - Capital City Half Marathon, (2009 - present)

Chapters in Books

    Sarkar A and Wewers MD. "Toll-like Receptors: Pathogen sensors that revolutionized innate immunity.." In Regulation of Innate Immune Function. Columbus: Research Signpost, January 2010

Journal Articles

Sarkar A; Bhaduri A. "Black tea is a powerful chemopreventor of reactive oxygen and nitrogen species: comparison with its individual catechin constituents and green tea.." Biochemical And Biophysical Research Communications. Vol. 284, no. 1. (June 2001.): 173-

Sarkar A; Duncan M; Hart J; Hertlein E; Guttridge DC; Wewers MD. "ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions.." Journal Of Immunology (Baltimore, Md.: 1950). Vol. 176, no. 8. (April 2006.): 4979-

Sarkar A; Hall MW; Exline M; Hart J; Knatz N; Gatson NT; Wewers MD. "Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.." American Journal Of Respiratory And Critical Care Medicine. Vol. 174, no. 9. (November 2006.): 1003-

Fahy RJ, Exline MC, Gavrilin MA, Bhatt NY, Besecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD. "Inflammasome mRNA expression in human monocytes during early septic shock.." Am J Respir Crit Care Med.. Vol. 9, no. 177. (May 2008.): 983-988

Swaan PW, Bensman T, Bahadduri PM, Hall MW, Sarkar A, Bao S, Khantwal CM, Ekins S and Knoell DL. "Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.." Am. J Respir. Cell Mol. Biol.. Vol. 5, no. 39. (November 2008.): 536-542

Raices RM, Kannan Y, Sarkar A, Bellamkonda-Athmaram V, Wewers MD. "A synergistic role for IL-1beta and TNFalpha in monocyte derived IFNgamma inducing activity.." Cytokine. Vol. 2, no. 44. (November 2008.): 234-241

Schmittgen TD, Lee FJ, Jiang J, Sarkar A, Yang L, Elton TS and Chen C. "Real-time PCR quantification of precursor and mature microRNA,." Methods. Vol. 1, no. 44. (January 2008.): 31-38

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.." PLoS Pathog.. Vol. 4, no. 5. (April 2009.): e1000361-

Sarkar A, Mitra S, Mehta S, Raices R, Wewers MD. "Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1." PLoS One. Vol. 9, no. 4. (September 2009.): e7140-

Wewers MD and Sarkar A. "P2X7 receptor and macrophage function.." Purinergic Signal.. Vol. 2, no. 5. (June 2009.): 189-195

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.." PLoS Pathogen. no. Apr;5(4):e1000361. (January 2009.): -

Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, Tracey KJ, Kanneganti TD, Dixit VM. "Inflammasome dependent release of the Alarmin HMGB1 in endotoxemia.." Journal of Immunology. no. 185(7):4385-92. (January 2010.): -

Miao EA, Leaf IA, Treuting P, Mao DP, Dors M, Sarkar A, Wewers M, Aderem A. "Caspase-1 induced pyroptosis clears intracellular bacteria independent of IL-1β/IL-18 in vivo.." Nat Immunol.. no. 11(12):1136-42.. (January 2010.): -

Sarkar A, Exline M, Berhe F, Hollyfield J, Beesecker B and Wewers M. "Circulatory Microvesicular Caspase-1 and Lymphocyte Death in Sepsis." AJRCCM. no. manuscript in preparation. (January 2011.): -

Reference Works

January 2011:
  • A Sarkar, F Berhe, S Mitra and M.D. Wewers."IL-1b Release Rrom Intact Microvesicles Is Regulated Extracellularly By ATP Ion Channels"
January 2010: 
  • M.C. Exline, A. Sarkar, B.Y. Besecker, J.L. Hollyfield, S. Mitra, M.D. Wewers. "Inflammasome Constituents Released Via Microvesicles During Sepsis"
January 2009:
  • A Sarkar, S Mitra and M.D. Wewers."Release of caspase-1 and IL-1beta in microvesicles regulated by ATP ion channels"
January 2008:
  • Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Microvesicular caspase-1 as death messenger to vascular smooth muscle cells."
  • Sarkar A, Mitra S, Mehta S, Raices R and Wewers MD."Monocyte derived microvesicles containing caspase-1 mediate smooth muscle cell apoptosis."
January 2007:
  • Raices R, Sarkar A and Wewers MD."Interleukin-1β, not Interleukin-18, is the primary product of LPS-stimulated human monocytes required for IFN-γ release by KG-1 cells."
  • Sarkar A, Raices R, Hall MW, Mitra S and Wewers MD."Role of tyrosine kinase in regulating LPS priming associated with caspase1 activation and sepsis response."
January 2006: 
  • Raices R, Sarkar A and Wewers MD."Identification of a monocyte-derived, IL-18-like, IFN-γ inducing factor"
  • Raices R, Sarkar A, Bao S, Bensman T, Hart J, Knoell D and Wewers MD."Relative Ability of Lung Epithelial Cells and Monocytes to Sense TLR Ligands."
  • Sarkar A, Bao S, Raices R, Bensman T, Wewers MD and Knoell D."NOD like receptor proteins coordinate the inflammasome response in human lung epithelial cells."
  • Sarkar A, Duncan M, Hart J, Hertlein E, Guttridge D and Wewers M."ASC direct NF-kappaB activation by regulating RIP2/caspase-1 interactions."
  • Sarkar A, Hall M, Exline M, Hart J, Knatz N, Gatso N and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality and splenic cell apoptosis unlike IL-1b knockout and IL-1b/IL-18 double knockout"
January 2005:
  • Sarkar A, Hall M, Hart J and Wewers MD."Caspase-1 knockout prevents E.coli induced mortality."
  • Sarkar A, Hart J, Hertlein E, Guttridge D and Wewers M."ASC is a dual regulator in caspase-1 mediated inflammation and NF-B activation."
January 2001:
  • Sarkar A and Bhaduri A."Black tea and flavonoids."
January 1999:
  • Sarkar A and Bhaduri A."Theaflavin in black tea as a powerful chemopreventor."

Presentations

"Inflammasome Constituents Released Via Microvesicles During Sepsis." Presented at ATS 2010, (May 2010)

"Microvesicular Death Messages." Presented at ATS 2011 minisymposium-SENSORS, DANGER SIGNALS, PEPTIDES AND CELL SUICIDE: NEW CONCEPTS OF HOST INFECTION CONTROL, (January 2011)

"IL-1B Release From Intact Microvesicles Is Regulated Extracellularly By ATP Ion Channels." Presented at ATS 2011- PATHOGENESIS OF ACUTE LUNG INJURY, (January 2011)

Contact

Division of Pulmonary, Critical Care and Sleep Medicine

Natalie Clum
Division Administrator
Natalie.Clum@osumc.edu
Phone: 614-247-7719
Fax: 614-293-4799

Division’s office:
201L Dorothy M. Davis Heart & Lung Research Institute
473 W. 12th Avenue
Columbus, OH 43210

Schedule an appointment: 614-293-4925