Professor and Vice Chair of Research in the Department of Neuroscience and in the Center for Brain and Spinal Cord Repair
College of Medicine
Department of Neuroscience, Center for Brain and Spinal Cord Repair
Faculty Affiliate, Chronic Brain Injury
692 Biomedical Research Tower
460 W. 12th Ave.
- Spinal cord injury and recovery of function
- Adult progenitor cell function
- Demyelination and remyelination of the CNS
Current Research: Dr. McTigue's laboratory focuses on the role of adult progenitor cells after CNS injury or disease. These cells have been shown to form new oligodendrocytes in vivo after demyelination, and to form oligodendrocytes, astrocytes and neurons in vitro. In recent studies, they determined that these cells spontaneously form a large number of new oligodendrocytes and remyelinate axons for several months after spinal cord injury. This work has relevance not only to traumatic injury but also conditions such as multiple sclerosis and even normal aging.
In ongoing studies, they are examining: 1) What molecules present after spinal cord injury promote this robust endogenous reparative response; 2) What effect inflammation has on the this spontaneous repair; 3) What type of intercellular communications are involved in gliogenesis after CNS injury, including interactions between progenitors, astrocytes, oligodendrocytes, microglia and macrophages.
The long-term goal of these studies is to determine how the formation of new cells in the adult CNS is regulated and whether this process can be manipulated to promote greater anatomical and functional recovery from spinal cord injury and other CNS disorders.
Research Techniques: Surgical techniques, behavioral analysis, intraspinal microinjection, cell culture, laser capture microdissection, real-time PCR, Western blots, light and confocal microscopy, image analysis of CNS tissue, immunohistochemistry.Active Funding:
Restoring iron homeostasis to promote recovery from SCI
PI: 8/1/2013 – 7/31/2018
Axons and the extracellular matrix after spinal cord injury
PI: McTigue 7/1/2012 – 6/30/2017
Spinal Cord Injury Training Program
PI: 1/1/2014 – 12/31/2018
Agency: The Craig Neilsen Foundation
Degree: PhD, The Ohio State University
Postdoctoral Training: Ohio State University
Research Scientist: Ohio State University
2013 James M. Siddens Award for Distinguished Faculty Advising, Ohio State University Council of Graduate Students