Jan Schwab, MD, PhD

Department of Neurology

Schwab_Jan_460x460Professor
William E. Hunt, MD & Charlotte M. Curtis Chair in Neuroscience

College of Medicine
Department of Neurology, Department of Physical Medicine and Rehabilitation, Department of Neuroscience

Faculty, Chronic Brain Injury

Biomedical Research Tower
460 W. 12th Ave. 6th Floor
Columbus, OH 43210
Phone: 614-685-9278
Fax: 614-293-9020
jan.schwab@osumc.edu

Research Interests

  • Protection of the intrinsic recovery potential after spinal cord injury
  • Resolution of inflammation in the lesioned central nervous system (CNS)
  • Control of the CNS on the immune system
  • Improving the predictive value of animal models for clinical translation

Current Research

Dr. Schwab's research aims to better understand and treat the maladaptive immune response after spinal cord injury (SCI). This is composed of the systemic SCI-induced immune deficiency syndrome (SCI-IDS) and the developing post-traumatic autoimmunity. Both maladaptive neuro-immunological syndromes are associated with inferior repair and a target to improve neurological recovery.

Schwab Lab  PubMed articles

Research Techniques

Clinical trials

  • Design and conduction of diagnostic and interventional mono-/and multicentric randomized trials in patients following spinal cord injury

Preclinical trials

  • Statistical analytical approaches to detect inflated effect size and confounding bias (Meta-analysis, Egger Regression, Trim and Fill Imputation)

Experimental models

  • SCI-models (contusion, transection)
  • Pneumonia model (Streptococcus pneumoniae)
  • Peritonitis model
Cell and molecular biology
  • Gene expression analysis (qPCR, Western blot)
  • FACS analysis

Immunohistochemistry

  • Single and double labeling

Education

MD: Eberhard-Karls-University Tubingen, Germany
PhD: Max-Planck Graduate Research School Tubingen, Germany

Postgraduate Training

Postdoctoral Fellowship: Developmental Neurobiology, Dr. Alain Chédotal, CNRS Paris, France;
Basic Immunology, Dr. Charles Serhan, Harvard Medical School
Group Leadership Training: Experimental Neurology, Charité – School of Medicine, Berlin, Germany
Clinical Training: Neurology, Charité – School of Medicine, Berlin, Germany;
Department of Spinal Cord Injury, Trauma Hospital Berlin

Dr. Schwab is partially funded by the Chronic Brain Injury program, a part of Ohio State’s Discovery Themes Initiative.

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