Research Assistant Professor, Lung Transplant Program

BallingerMegan

Research Assistant Professor
College of Medicine
Department of Internal Medicine
Division of Pulmonary, Critical Care and Sleep Medicine
305A Dorothy M. Davis Heart and Lung Research Institute
473 W. 12th Ave.
Columbus OH 43210
614-292-6578
Megan.Ballinger@osumc.edu

Research Interests:
  • Macrophages
  • Mechanisms of pulmonary fibrosis
  • Toll-like receptor signaling pathways
  • Basic mechanisms of lung innate immune host defense
  • Infectious and non-infectious lung injury models
  • Oxidative stress and regulation of antioxidant generation

Current Research:
My lab is interested in investigating the mechanisms by which innate immunity protects the lung against infectious and non-infectious injury and inflammation. Currently, I am investigating the role of macrophage in regulating the initiation and propagation of pulmonary fibrosis. 

Research Techniques:
I use both murine models of pulmonary fibrosis as well as primary tissue collected from patients with idiopathic pulmonary fibrosis to investigate the role of macrophages in regulating the initiation, propagation and resolution of excess extracellular matrix deposition in the lung. We examine macrophage functionality using in vitro and in vivo model systems, identify specific macrophage subpopulations within the lung using flow cytometry, and measure gene expression using molecular biological methods.    

Active Funding:

  • ATS Foundation/Genentech Research Grant in IPF
    American Thoracic Society/Genentech partnership grant
    1/1/2017-12/31/2018 ($100,000 for 2 years)
    Role: Principal Investigator (30% effort)
  • Scientist Development Grant
    American Heart Association
    07/01/2016-06/30/2019 ($231,000 for 3 years)
    Role: Principal Investigator (30% effort)
  • NIH/NIEHS R01 ES020350-06
    Extracellular Matrix, Innate Immunity, and Ozone-Induce Airway Disease
    PI: Mark Wewers
    06/01/2014-03/07/2018
    Role: Co-Investigator (30% effort)

PubMed: http://www.ncbi.nlm.nih.gov/pubmed?term=Ballinger%20MN[Author]

Education

  • Doctorate degree: Immunology: University of Michigan
  • Postdoctoral Research Fellowship: University of Michigan

Honors/News

  • American Thoracic Society, Members In Transition and Training (MITT) Committee
  • Awarded the Jo Rae Wright Award for Outstanding Science by the American Thoracic Society, May 2016
  • Parker B. Francis Fellow, 2012-2015

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