Licensed Genetic Counselor

SweetKevinAssistant Professor - Clinical, Human Genetics

Comprehensive Cancer Center
2012 Kenny Road
Columbus, OH 43221


614-293-6694
Kevin.Sweet@osumc.edu


Licenses:
  • Licensed genetic counselor: Ohio Board of Medical Examiners, 2013 - present
Specialty interests:
  • Clinical cancer genetics
  • Family history tools and risk assessment

Clinical interests: 

Mr. Sweet’s clinical duties include providing comprehensive cancer genetic consultations to individuals and families with a history of cancer. Cancer genetic consultation requires documentation of cancers in the family, risk assessment, screening recommendations and incorporation of genetic testing as necessary. To schedule an appointment, call 614-293-6694 or toll free at 1-888-329-1654. 

Education:

MS: Human genetics, Sarah Lawrence College, 1994
BS: Microbiology, University of Wisconsin, 1988

Biography

Over the course of 16 years of clinical research at The Ohio State University, my focus of study has been gene discovery and clinical translation for hereditary cancer syndromes, clinical implementation of automated online family history risk assessment tools and development of genetic and genomic service delivery models. As summarized in the grant and publications sections of my dossier, I have directed and published a number of original investigations (29 since my last promotion) in each of these areas. My work in hereditary cancer syndromes includes a 14-year collaboration with investigators at the University of Toronto on hereditary breast-ovarian cancer syndrome. Given the lack of study on the condition of hyperplastic (serrated) polyposis, upon professional travel to the University of Brisbane, I was fortunate to make inroads with local investigators which have since become the largest international collaboration on this rare condition. Through work on development of automated family history tools, The Ohio State University Division of Human Genetics has obtained a national reputation and informing public policy. In 2008, I launched the online public access version of Family HealthLink® an automated cancer and coronary heart disease family history triage tool. In 2012, I directed the implementation of Family HealthLink® at The Ohio State University Stefanie Spielman Comprehensive Breast Center, and recently published our findings on clinical utility (i.e. public and patient cohorts) in Genetics in Medicine. Family HealthLink® is listed as a general public resource on the NHGRI website, and the U.S. Department of Health and Human Services. It was promoted through a Wall Street Journal article, "The Life-Saving Secrets in Your Family Tree'' and has been advertised on WOSU radio and other local and national media outlets.

As a researcher in the newer field of genomic medicine, I am deeply committed to advancing our understanding of innovative genetic and genomic counseling service delivery models. In 2010, following establishment of an OSU research partnership with the Coriell Personalized Medicine Collaborative, I was asked to lead the design and implementation of a longitudinal study to investigate the impact of in-person genomic counseling in the return of actionable genomic information for complex disease and pharmacogenomics. Specifically, OSU patients with chronic disease managed in an academic medical center receive genomic results through a web portal, and are randomized to additional in-person post-test genomic counseling versus only the web-based return of results. Through the years, this partnership has evolved into a coordinated effort that takes advantage of the diversity and strengths of each institution. Significant infrastructure was developed that allows confidential sharing of data between institutions, including direct release of study results for uploading to the OSU EHR, extraction of clinical data from the EHR and transfer of the genomic datasets for research purposes. Study findings led to an NIH/NHGRI R21 award, for which I’m the principal investigator on a qualitative research study to assess and develop new genomic counseling service delivery models. In this regard, in the last year we have performed qualitative interviews of OSU-Coriell study participants, and incorporated genomic counseling experts from four academic institutions (University of Michigan; Stanford University; UNC-Chapel Hill; University of Pennsylvania) into the process. I will have a number of first-author publications from this work. This ongoing collaborative and multi-institutional effort will also allow for submission for RO1 level funding. Lastly, this work also ties into development of the clinical pharmacogenomics program at Ohio State, and has allowed for my involvement as co-investigator (10% FTE) on the funded Translational Pharmacogenomics Program as part of the NIH/NIGMS Pharmacogenomics Regional Network. 

These research accomplishments have resulted in accolades such as invited speaking engagements at international, national and local levels, nominations on four separate committees of the National Society of Genetic Counselors – Jane Engelberg Memorial Fellowship (JEMF), Practice Guidelines Committee, Efficient Delivery of Genetic Services Task Force and the Personalized Medicine Special Interest Group – and reviewer on numerous outstanding journals. Having now trained and performed research in multiple divergent areas of genetic and genomics, I have gained a unique perspective that is allowing me to forge a novel upward trajectory towards innovative, collaborative and ultimately translational health-related science. 

As my teaching has been evaluated by fixed-response surveys with opportunity for open comments, I consistently use this feedback to alter my teaching methodology. I have reflected on and responded to student feedback and have remained motivated to improve the teaching-learning environment through varied instructional approaches. For example, for a new 2015 graduate level course, Pharmacogenomics 5700, I had the opportunity to use online instruction to a larger degree. As effective teaching also involves assessment of student potential for future pursuits in the form of recommendation letters, I’ve had ample opportunity to advise Ohio State undergraduate and graduate students, with most performing a one to two year internship. These students are evaluated in terms of their academic, clinical and research capabilities, as well as their general character. I have written letters of recommendation for 12 undergraduate and graduate students pursuing advanced degrees, and all have successfully advanced to the next level. As chair of JEMF, the primary grant funding agency for the National Society of Genetic Counselors (NSGC), I was involved with the development of the "JEMF Graduate Student Award," which supports ongoing work for graduate thesis projects of genetic counseling students in training. Applicants submit a formal research proposal, which is reviewed and ranked by the JEMF Advisory Committee. During my tenure as chair, we provided awards to 36 graduate students, of which 32 subsequently published thesis work. I was active advisor and mentor for a number of these students. I am also faculty adviser for graduate students in The Ohio State University Genetic Counselor Graduate Training Program and currently a mentor of two graduate students. I provide classroom and clinical instruction for the training program. Lastly, in recent years, I authored two peer-reviewed books on genomic medicine – one for medical professionals, "The Busy Physician's Guide to Genetics, Genomics and Personalized Health Care" and the second for the lay public, "Your Genes, Your Health and Personalized Medicine." Each are used in graduate and professional education.

My accomplishments in service include both university and professional and national service. I provide service to The Ohio State University Division of Human Genetics as a licensed and certified genetic counselor. I serve as graduate student adviser and faculty member for The Ohio StateUniversity Genetic Counselor Graduate Training Program. I'm an active member of Ohio State's Personalized Genomic Medicine Working Group, the OSU Translational Pharmacogenomics Project and the OSU Bioinformatics Research Group. I served a two-year term on the OSU Cancer Institutional Review Board and multiple years on the OSU Clinical Implementation Working Group, the OSU Personalized Health Assessment Working Group, the OSU E-Tablet Initiative and the OSU Personalized Healthcare Virtual Genomics Working Group. 

At the professional and national level, through invited presentations locally, nationally and internationally, I strive to bring recognition to the tremendous merits of The Ohio State University. I was a founding member and chair of the NSGC Personalized Medicine-Special Interest Group, a core driver for genomics education and development of applications and tools to support our profession. I was an invited abstract reviewer and Program Moderator for the 2014 American Society of Human Genetics conference. I'm currently involved (3-year service commitment) as elected advisor to the NSGC Practice Guidelines Committee and, more recently was asked to join a new NSGC Efficient Delivery of Genetic Services task force. I will continue such service accepting more opportunities as presented as my research continues to attract prominence in multiple disciplines, whilst forging lucrative contacts with colleagues across the world.

Books

Sweet K, Phelan M, Tarleton J, Crawford E, Christensen B, Schroer R, Taylor H. Counseling Aids for Geneticists. Greenwood: Greenwood Genetic Center, January 1995

Saul RA, Phelan MC, Geer JS, Seaver LH, Sweet KM. Growth References: Third Trimester to Adulthood. Greenwood: Greenwood Genetic Center, January 1998

Sweet, Kevin M; Michaelis, Ron C. The Busy Physician's Guide to Genetics, Genomics and Personalized Medicine. Dordrecht; New York: Springer, January 2011. Review in Journal of Medical Genetics

Michaelis, R. and Sweet, K. Your Genes, Your Health and Personalized Medicine. Oxford, GB|GBR: Nottingham University Press, August 2012. Review in Society of Teachers of Family Medicine


Chapters in Books

Allain, DC, Gilligan MA, Redlich P. "Genetic Counseling and Testing for Breast Cancer." In Cancer of the Breast. 5 ed. Edited by William Donegan. 249-268. St. Louis, MO, US|USA: Saunders, January 2002

Allain, DC. "Testing Children for Adult-Onset Disorders." In Ethical Dilemmas in Genetics and Genetic Counseling: Principles Through Case Scenarios. 1 ed. Edited by Berliner, Janice L.. 96-116. New York, NY, US|USA: Oxford University Press, November 2014

Allain DC and Ormond KE. "Ethical Issues in Genetic and Genomic Research." In Ethical Dilemmas in Genetics and Genetic Counseling Principles Through Case Scenarios. 1 ed. Edited by Berliner, Janice L. 186-208. New York, NY, US|USA: Oxford University, November 2014

Clinical Services

Clinical services

  • OSUWMC Center for Personalized Health Care, McCampbell Hall, 2011 - 2013
  • Division of Human Genetics, Stefanie Spielman Comprehensive Breast Center, 2011
  • Director, Family HealthLink Cancer and Coronary Heart Disease Risk Assessment Program, 2007
  • Division of Human Genetics, OSUWMC clinic locations, 1999

Civic Engagement

Team leader and 100-mile Pelotonia rider, 2009-2014
Stefanie's Team of Hope, the largest non-corporate Peloton

Editorial Activities

Present Activities
  • Journal of Genetic Counseling
  • Genetics in Medicine
  • Clinical Genetics

Past Activities

  • Personalized Medicine, 2012
  • Obstetrics and Gynecology, 2004

Journal Articles

Fagerberg,W,R; Allain,D. "A quantitative study of tissue dynamics during closure in the traps of venus flytrap dionaea-muscipula ellis." AMERICAN JOURNAL OF BOTANY. Vol. 78, no. 5. (May 1991.): 647-657

Allain D, Niendorf KB, Leopold B. "Opportunity Knocks." Perspectives in Genetic Counseling. Vol. 3, no. 23. (January 2001.): 3-3

Allain, D.. "Genetic Counseling and Testing for Hereditary Breast and Colorectal Cancer Syndromes: An Overview." Contemporary Oncology. Vol. 1, no. 18. (January 2003.)

Allain DC. "Presidential address 2003: NSGC living life forward.." JOURNAL OF GENETIC COUNSELING. Vol. 13, no. 1. (February 2004.): 1-7

Allain D.. "Hereditary Cancer Syndromes: Nurses can enhance identification of at-risk clients and influence medical outcomes." Advance for Nurses. Vol. 4, no. 7. (January 2004.): 22-23

Allain, D.. "Presidential Address 2003: NSGC Living Life Forward." Journal of Genetic Counseling. Vol. 1, no. 13. (January 2004.): 1-7

Allain D, Sweet K, and Agnese D.. "Management options after prophylactic surgeries in women with BRCA mutations: a review." CANCER CONTROL: JOURNAL OF THE MOFFIT CANCER CENTER. Vol. 14, no. 4. (January 2007.): 330-337

Allain DC. "Genetic Counseling and Testing for Common Hereditary Breast Cancer Syndromes." Journal of Molecular Diagnostics. Vol. 10, no. 5. (September 2008.): 383-395

Allain DC. "Genetic counseling and testing for common hereditary breast cancer syndromes - A paper from the 2007 William Beaumont Hospital symposium on molecular pathology." JOURNAL OF MOLECULAR DIAGNOSTICS. Vol. 10, no. 5. (September 2008.): 383-395

Allain,Dawn,C. "Genetic counseling and testing for common hereditary breast cancer syndromes - A paper from the 2007 William Beaumont Hospital symposium on molecular pathology." JOURNAL OF MOLECULAR DIAGNOSTICS. Vol. 10, no. 5. (September 2008.): 383-395

Dworkin,Amy,M; Tseng,Stephanie,Y; Allain,Dawn,C; Iwenofu,O,Hans; Peters,Sara,B; Toland,Amanda,E. "Merkel Cell Polyomavirus in Cutaneous Squamous Cell Carcinoma of Immunocompetent Individuals." JOURNAL OF INVESTIGATIVE DERMATOLOGY. Vol. 129, no. 12. (December 2009.): 2868-2874

Dworkin, AM, Tseng SY, Allain DC, Iwenfofu OH, Peters SB, Toland AE.. "Merkel cell polyomavirus in cutanous squamous cell carcinoma of immunocompetent individuals.." JOURNAL OF INVESTIGTIVE DERMATOLOGY. Vol. 12, no. 129. (December 2009.): 2868-2874

Dworkin AM, Ridd K, Bautista D, Allain DC, Iwenofu OH, et al.. "Germline Variation Controls Architecture of Somatic Alterations in Tumors." PLoS Genet. Vol. 9, no. 6. (September 2010.): e1001136. doi:10.371/journal.pgen.1001136

Dworkin,Amy,M; Ridd,Katie; Bautista,Dianne; Allain,Dawn,C; Iwenofu,O,Hans; Roy,Ritu; Bastian,Boris,C; Toland,Amanda,Ewart. "Germline Variation Controls the Architecture of Somatic Alterations in Tumors." PLOS GENETICS. Vol. 6, no. 9. (September 2010.): e1001136

Allain D, Baker M, Blazer K, Cohen S, Copeland K, Djurdjinovic L, Faucett A, Lambert N, Manley S, Nagy R, Nazareth S, Rosenthal E, Solomon C, Trepanier A.. "Evolving Models of Cancer Risk Counseling." Perspectives in Genetic Counseling. Vol. 1, no. 32. (January 2010.): 13-16

Dworkin AM, Tseng SY, Allain DC, Iwenfofu OH, Peters SB, Toland AE. "Germline variation controls the architecture of somatic alterations in tumors." PLOS GENETICS. Vol. 6, no. 9. (September 2010.): e1001136

Stuenkel AJ, Campion M, Allain D, Hampel H. "Transition to the clinical doctorate: Attitudes of the genetic counseling training program directors in North America." JOURNAL OF GENETIC COUNSELING. Vol. 1, no. 21. (September 2011.): 136-149

Havercamp,S,M; Tasse,M,J; Benson,B,A; Manikam,M; Allain,Dawn; Grover,M. "Health and access to healthcare for Ohioans with Down syndrome." JOURNAL OF INTELLECTUAL DISABILITY RESEARCH. Vol. 56, no. 7-8. (July 2012.): 760-760

Havercamp,S,M; Tasse,M,J; Benson,B,A; Manikam,M; Allain,Dawn; Grover,M. "Health and access to healthcare for Ohioans with Down syndrome." JOURNAL OF INTELLECTUAL DISABILITY RESEARCH. Vol. 56, no. 7-8. (July 2012.): 760-760

Allain DC, Friedman S, Senter L. "Consumer awareness and attitudes about insurance discrimination post enactment of the Genetic Information Nondiscrimination Act." FAMILIAL CANCER. Vol. 11, no. 4. (December 2012.): 637-644

Hershberger,Ray,E; Hedges,Dale,J; Morales,Ana. "Dilated cardiomyopathy: the complexity of a diverse genetic architecture." NATURE REVIEWS CARDIOLOGY. Vol. 10, no. 9. (September 2013.): 531-547

Fleming, JL, Dworkin AM, Allain DC, Fernandez S, Wei,L, Peters SB; Iwenofu OH, Ridd K, Bastian BC, Toland AE. "Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma." INTERNATIONAL JOURNAL OF CANCER. Vol. 134, no. 1. (January 2014.): 244-248

Trepanier AM, Allain DC. "Models of service delivery for cancer genetic risk assessment and counseling." JOURNAL OF GENETIC COUNSELING. Vol. 23, no. 2. (April 2014.): 239-253

Trepanier AM, Cohen SA, Allain DC. "Thinking differently about genetic service delivery." CURRENT GENETIC MEDICINE REPORTS. Vol. 3, no. 2. (April 2015.): 1-8

Douma KFL, Smets EMA, Allain DC.. "Non-genetic health professionals’ attitude towards, knowledge of and skills in discussing and ordering genetic testing for hereditary cancer." Familial Cancer. Vol. Open Access, (November 2015.): 1-10

Tasse MJ, Navas Macho P, Havercamp SP, Benson BA, Allain DC, Manickam K, Davis S.. "Psychiatric Conditions Prevalent Among Adults with Down Syndrome." Journal of Policy and Practice in Intellectual Disabilities. Vol. 0, (May 2016.): 00-00

Gillespie J, Skeeles LE, Allain DC, Kent MN, Peters SB, et al.. "MicroRNA expression profiling in metastatic cutaneous squamous cell carcinoma." JOURNAL OF EURPOEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. Vol. 30, no. 6. (June 2016.): 1043-45

Douma,Kirsten,FL; Smets,Ellen,MA; Allain,Dawn,C. "Non-genetic health professionals' attitude towards, knowledge of and skills in discussing and ordering genetic testing for hereditary cancer.." Familial cancer. Vol. 15, no. 2. (April 2016.): 341-350

Reference Works

March 2011:
Trepanier A, Allain D, Cohen S. "Genetic Counseling" Vancouver

April 2010:
Manickam K, Allain D, "Genomic Practice" Bethesda

Presentations

"Professional Position Statements and Practice Guidelines the NSGC Perspective." Presented at American Society of Human Genetics, Los Angeles, CA, US|USA. (November 2003)

"National Society Genetic Counselor Report on Genetic Education and Training." Presented at Secretary's Advsiory Committee on Genetics, Health, and Society (SACGHS), Washington, DC, US|USA. (June 2004)

"Genetic Counseling and Testing for Breast Cancer." Presented at William Beaumont Hospital Symposium on Molecular Pathology, Troy, MI, US|USA. (September 2006)

"Work Life Balance." Presented at National Society of Genetic Counselors, Kansas City, MO, US|USA. (October 2007)

"Incorporating genome-wide association studies (GWAS) into Genetic Risk Assessment: Current Practices, Challenges, and Future Directions." Presented at National Society of Genetic Counselors 27th Annual Education Conference, Los Angeles, CA, US|USA. (October 2008)

"Student Transitions." Presented at National Society of Genetic Counselors Annual Education Conference, Atlanta, GA, US|USA. (November 2009)

"GINA: The Process and Implications.." Presented at National Society of Genetic Counselors 29th Annual Education Conference, Dallas, TX, US|USA. (November 2010)

"The Evolution and Drafting of the NSGC Gene Patenting Position Statement." Presented at National Society of Genetic Counselors 29th Annual Education Conference, Dallas, TX, US|USA. (November 2010)

"The Value of Genetic Counselors in Genetic Testing for Hereditary Breast-Ovarian Cancer." Presented at The National Society of Genetic Counselors 29th Annual Education Conference, San Diego, CA, US|USA. (October 2010)

"Copy Number Variant Genomics Clinic at The Ohio State University Medical Center." Presented at 4th National Conference on Genomics and Public Health, Bethesda, MD, US|USA. (October 2010)

"Assessing the Use of Various Service Delivery Models in Cancer Genetics." Presented at American College of Medical Genetics Annual Clinical Genetics Meeting, Vancouver, BC, CA|CAN. (March 2011)

"Does the Use of Alternative Service Delivery Models Enhance Access to Service?." Presented at National Society of Genetic Counselors 30th Annual Education Conference, San Diego, CA, US|USA. (October 2011)

"The Value of Genetic Counselors in Genetic Testing for Hereditary Breast-Ovarian Cancer." Presented at The National Society of Genetic Counselors 30th Annual Education Conference, San Diego, CA, US|USA. (October 2011)

"Health of Persons with Developmental Disabilities." Presented at State of Ohio 10th Annual MI/DD Conference, Columbus, OH, US|USA. (September 2012)

"Genetic Counselor Licensure and Quality Genetic Service Delivery." Presented at American College of Medical Genetics Annual Clinical Genetics Meeting, Phoenix, AZ, US|USA. (March 2013)

"Ethical, Legal, Social and Policy Issues." Presented at American Society of Human Genetics, Boston, MA, US|USA. (October 2013)

"The OSUWMC Adult Down Syndrome Clinic: Experiences and Lessons Learned." Presented at Healthcare Advisory Committee, Columbus, OH, US|USA. (March 2015)

"Variability of Expresion in SETX-related motor neuron disease: A Single Family, Multigenerational Evaluation." Presented at American Academy of Neurology Annual Meeting, Washington, DC, US|USA. (April 2015)

"Next Generation Sequencing Panels and Whole Exome Sequencing: Impact and Challenges." Presented at 16th Biennial Congress of the South African Society for Human Genetics, Pretoria, ZA|ZAF. (August 2015)

"Ethical Dilemmas in Genetics." Presented at 16th Biennal South African Human Genetics Conference, Pretoria, ZA|ZAF. (August 2015)

"Leveraging Licensure to Increase Access to Genetic Counseling Services and Increase Revenue." Presented at National Society of Genetic Counselors 34th Annual Education Conference, Pittsburgh, PA, US|USA. (October 2015)

Unpublished Works

Wagner KN, Nagaraja H, Allain DC, Quick A, Kolb S, Roggenbuck J.. Patients with Amyotrophic Lateral Sclerosis Have High Interest in and Limited Access to Genetic Testing. April 2016

Morales A, Allain DC, Arscott P, James E, MacCarric G, Murray B, Tichnell AR, Spencer S, Fitzgerald-Butt SM, Kushner JD, Munn C, Smith E, Spoonamore KG, Tandri HS, Kay WA.. Identifying and Managing Women at Risk for Cardiovascular Genetic Conditions in Pregnancy. May 2016

Advising

Advising

Noteworthy Graduate Narrative

As the chair of the Jane Engelberg Memorial Fellowship Advisory Committee (JEMF), the primary funding agency for the National Society of Genetic Counselors, I oversaw the development of the "JEMF Graduate Student Award Program," which has since become an annual national award provided to graduate students in training. Applicants submit a formal research proposal, which is reviewed and ranked by the JEMF Advisory Committee. The award supports ongoing work as part of a graduate thesis projects. During my tenure as chair, we provided awards to 36 graduate students, of which 32 recipients subsequently published thesis work. I was active advisor and mentor on a number of student thesis projects. 

I am a faculty adviser for graduate students in Ohio State's Genetic Counselor Graduate Training Program, and currently mentor two graduate students. I provide classroom and clinical instruction for the training program.

Academic Advisees

2014-present:
  • Karen Wernke, The Ohio State University
  • Andrew McFaden, The Ohio State University

Contact

Division of Human Genetics

Amy Ehrlich
Division Administrator
Amy.Ehrlich@osumc.edu
Phone: 614-293-7775
Fax: 614-293-2314

Division’s office:
2012 Kenny Rd. Rm. 250
Columbus, OH 43221

Schedule an appointment: 614-293-6694